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Silver-Catalyzed Three-Component Coupling of Carbon Dioxide, Amines and α-Diazoesters

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Chinese Journal of Chemistry 2018年第5期36卷 399-405页

作者： Chaorong Qi Donghao Yan wenfang xiong Huanfeng Jiang Key Lab of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of TechnoFogy Guangzhou Guangdong 510640 China State Key Lab of Luminescent Materials and Devices South China University of Technology Guangzhou Guangdong 510640 China

A silver-catalyzed three-component coupling reaction of carbon dioxide, amines and α-diazoesters has been developed for the first time. The novel reaction provides an efficient and practical methodology for the synthesis of a wide range of new α-carbamoyloxy esters, which are difficult to prepare by existing methods. The advantages of the method include the use of readily available starting materials, simple catalytic system, good atom economy and high functional group tolerance.

关键词： carbon dioxide fixation carbamates diazo compounds multicomponent reactions silver

Recent advances in fixation of CO_(2) into organic carbamates through multicomponent reaction strategies

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Chinese Journal of Catalysis 2022年第7期43卷 1598-1617页

作者： Lu Wang Chaorong Qi wenfang xiong Huanfeng Jiang Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641GuangdongChina

Carbon dioxide(CO_(2)) is the main greenhouse gas and also an ideal C1 feedstock in organic synthesis because it is abundant,nontoxic,nonflammable,and *** synthesis of organic carbamates using CO_(2) as a phosgene alternative has attracted extensive attention because of the importance of carbamates in organic synthesis and in the pharmaceutical and agrochemical *** recent decades,many multicomponent reaction strategies have been designed for constructing different types of organic carbamate *** of these methods rely on the in situ generation of carbamate anions from CO_(2) and amines,followed by reactions with other coupling *** strategies for acyclic carbamates include nucleophile‐electrophile coupling,nucleo‐phile‐nucleophile oxidative coupling,difunctionalization of unsaturated hydrocarbons,and C–H bond *** for the synthesizing cyclic carbamates include carboxylative cyclization of in situ‐generated unsaturated amines and difunctionalization of unsaturated amines with CO_(2) and other electrophilic *** review summarizes the recent advances in the synthesis of organic carbamates from CO_(2) using different multicomponent reaction *** perspectives and challenges in the incorporation of CO_(2) into carbamates are also presented.

关键词： Carbon dioxide Amines Carbamate Multicomponent reaction Synthetic strategy

Palladium-catalyzed regioselective cascade reaction of carbon dioxide,amines and allenes for the synthesis of functionalized carbamates

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Science China Chemistry 2020年第3期63卷 331-335页

作者： wenfang xiong Ruixiang Cheng Bowen Wu Wanqing Wu Chaorong Qi Huanfeng Jiang Key Lab of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510640China State Key Lab of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

A palladium-catalyzed regioselective three-component cascade reaction of carbon dioxide,amines and allenes has been developed,providing an expedient and practical method for the construction of a range of functionalized carbamates containing dihydrobenzofuran or indole moiety in moderate to excellent *** broad substrate scope,good functional group tolerance and excellent chemo-and regioselectivity are the features of the transformation.

关键词： palladium carbon dioxide three-component reaction carbamates allenes

体外膜氧合辅助发生急性肾损伤的危险因素分析

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中国体外循环杂志 2024年第1期22卷 8-12页

作者：熊文芳姚岚王辉韩钱鹏蒋沁娟岳阳市中心医院东茅岭院区重症监护室岳阳414000

目的探讨接受体外膜合(ECMO)治疗患者发生急性肾损伤(AKI)的危险因素。方法回顾性研究2015年11月至2024年1月在湖南省岳阳市中心医院收治的接受ECMO体外生命支持的31名患者,探讨AKI的危险因素。收集患者ECMO术前基本情况、ECMO期间相... 详细信息

目的探讨接受体外膜合(ECMO)治疗患者发生急性肾损伤(AKI)的危险因素。方法回顾性研究2015年11月至2024年1月在湖南省岳阳市中心医院收治的接受ECMO体外生命支持的31名患者,探讨AKI的危险因素。收集患者ECMO术前基本情况、ECMO期间相关临床情况等资料,根据患者是否发生AKI分为非AKI组和AKI组,分别通过单因素分析和logistic回归分析发现可能影响AKI的危险因素。结果单因素分析结果显示AKI患者16例(51.6%),AKI患者ECMO前高红细胞压积、ECMO初始流量、大面积心肌梗死、液体正平衡累计天数均与AKI相关。多因素分析结果显示,患者红细胞压积(OR 1.24,95%CI:1.027~1.488;P=0.025)、ECMO治疗期间液体正平衡累计天数(OR 2.23,95%CI:1.126~4.418;P=0.021)是ECMO患者发生AKI的危险因素。结论患者红细胞压积、ECMO治疗期间液体正平衡累计天数是接受ECMO患者发生AKI的危险因素。

关键词：体外膜氧合急性肾损伤危险因素液体管理

Niobium carbide(MXene)reduces UHMWPE particle-induced osteolysis

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Bioactive Materials 2022年第2期7卷 435-448页

作者： Kuo-Yang Sun Yizhang Wu Jia Xu wenfang xiong Wei Xu Jiawei Li Ziying Sun Zhongyang Lv XSWu Qing Jiang Hong-Ling Cai Dongquan Shi State Key Laboratory of Pharmaceutical Biotechnology Department of Sports Medicine and Adult Reconstructive SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School321 Zhongshan RoadNanjing210008JiangsuPR China Collaborative Innovation Center of Advanced Microstructures Laboratory of Solid State Microstructures and School of PhysicsNanjing UniversityNanjing210093China Drum Tower of Clinical Medicine Nanjing Medical UniversityNanjing210008JiangsuPR China Department of Gastroenterology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School321 Zhongshan RoadNanjing210008JiangsuPR China

Joint replacement surgery is one of the orthopedic surgeries with high successful rates;however,wear debris generated from prostheses can ultimately lead to periprosthetic osteolysis and failure of the *** implant-derived particulate debris such as ultrahigh molecular weight polyethylene(UHMWPE)can initiate the local immune response and recruit monocytic cells to phagocytose particles for generating reactive oxygen species(ROS).ROS induces osteoclastogenesis and macrophages to secrete cytokines which ultimately promote the development of *** this work,we develop the few-layered Nb_(2)C(FNC)as an antioxidant which possesses the feature of decreasing the production of cytokines and inhibiting osteoclastogenesis by its ROS ***,local injection of FNC attenuates the UHMWPE-induced osteolysis in a mouse calvarial *** sum,our results suggest that FNC can be used for treating osteolytic bone disease caused by excessive osteoclastogenesis.

关键词： Periprosthetic osteolysis MXene Niobium carbide Osteoclastogenesis Reactive oxygen species(ROS)

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钯催化二氧化碳为羰基源的羧基化反应

科学通报 2021年第7期66卷 757-772页

作者：熊文芳戚朝荣江焕峰华南理工大学化学与化工学院广东省功能分子工程重点实验室广州510640

二氧化碳是地球上蕴藏最为丰富的C1资源,其资源化利用一直是有机化学研究前沿及热点领域之一.其中,过渡金属催化以二氧化碳为羰基源的羧基化反应可以有效构建很多具有重要应用价值的羧酸及其衍生物,是实现二氧化碳资源化利用的理想途径... 详细信息

二氧化碳是地球上蕴藏最为丰富的C1资源,其资源化利用一直是有机化学研究前沿及热点领域之一.其中,过渡金属催化以二氧化碳为羰基源的羧基化反应可以有效构建很多具有重要应用价值的羧酸及其衍生物,是实现二氧化碳资源化利用的理想途径之一,日益受到科学家的关注.钯是有机合成中用途最广的重要过渡金属之一,钯催化剂具有高反应活性、高选择性等特点,在二氧化碳羧基化反应中发挥重要的作用.本文主要聚焦于钯催化二氧化碳参与的形成碳-碳键的羧基化反应,着重从反应机理出发,分别阐述了各类烯丙基、芳基和烯烃等试剂与二氧化碳羧基化反应研究进展,并对这些反应进行总结以及对未来的发展方向进行展望.

关键词：二氧化碳 C1资源钯催化羧基化反应

Direct Bromocarboxylation of Arynes Using Allyl Bromides and Carbon Dioxide

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Direct Bromocarboxylation of Arynes Using Allyl Bromides and...

Conversion of CO2 into useful chemicals using propargylic alcohols as coupling partners

中国化学会·第一届全国二氧化碳资源化利用学术会议

作者： Yu Zhang wenfang xiong Chaorong Qi Wanqing Wu Huanfeng Jiang Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical EngineeringSouth China University of Technology

An unprecedented three-component coupling involving arynes, allyl bromides, and CO2 is described, providing efficient and facile access to structurally diverse ortho-brominated aryl esters. Unlike conventional role played in organic synthesis as electrophile, organic bromides served as nucleophile in this reaction, affording a new approach to multicomponent reactions（MCRs） involving aryne intermediate. Additionally, Hammett analysis suggests that two reaction mechanisms exist, depending upon the electronic nature of the cinnamyl bromides used.（Figure 1）.

关键词： bromocarboxylation carbon dioxide arynes allyl bromides

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Conversion of CO2 into useful chemicals using propargylic al...

Base-Promoted Coupling of Carbon Dioxide,Amines and Diaryliodonium Salts:A Phosgene-Free Route to Arvl Carbamates

中国化学会第九届全国有机化学学术会议

作者： Chaorong Qi Lu Ouyang Xiaodong Tang wenfang xiong Huanfeng Jiang School of Chemistry and Chemical Engineering South China University of Technology

The conversion of carbon dioxide(CO)into valuable chemicals has received much attention in recent years not only because CO is one of the major anthropogenic greenhouse gas but also because it has been regarded as an ...

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Base-Promoted Coupling of Carbon Dioxide,Amines and Diarylio...