检索结果-南通市图书馆

Sensory innervation around immediately vs. delayed loaded implants: a pilot study

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2015年第1期7卷 49-55页

作者： Yan Huang Jeroen van Dessel wendy Martens Ivo Lambrichts Wei-Jian Zhong Guo-Wu Ma Dan Lin Xin Liang Reinhilde Jacobs Department of Imaging & Pathology Faculty of Medicine University of Leuven and Oral & Maxillo-facial Surgery University Hospitals Leuven State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Biomedical Research Institute Hasselt University School of Stomatology Dalian Medical University Center for Statistics Hasselt University

Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks （third maxillary incisor, third and fourth mandibular premolar）： immediate implant placement and immediate loading （liP＋ IL）; delayed implant placement and delayed loading （DIP＋DL）; delayed implant placement and immediate loading （DIP＋IL）; and natural extraction socket healing （control）. Histomorphometry was performed in the peri-implant bone and soft tissues within 300 pm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the peri-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP＋IL showed a higher innervation （in ***^-2, 5.94±1.12 vs. 3.15±0.63, P〈0.001） and smaller fibre diameter （in pm, 1.37±0.05 vs. 1.64±0.13, P=0.016）, smaller axon diameter （in pm, 0.89±0.05 vs. 1.24±0,10, P=0.009） and g-ratio （0.64±0.04 vs. 0.76±0.05, P〈0.001） in the middle region around the implants. Compared with DIP＋IL in the mandible, IIP＋IL had a higher nerve density （in ***^-2, 13.23±2.54 vs. 9.64±1.86, P=0.027）, greater fibre diameter （in pm, 1.32±0.02 vs. 1.20±0.04, P=0.021）, greater axon diameter （in μm, 0.92±0.01 vs. 0.89±0.03, P=-0.035） and lower g-ratio （0.69±0.01 vs. 0.74±0.01, P=-0.033） in the apical region around the implants. It may be assumed that the treatment protocol with liP＋ IL is the preferred method to allow optimized peri-implant re-i

关键词： animal experiments dental implants histomorphometry immediate loading mechanoreceptor myelinated nerve fibres osseoperception

Submaximal oxygen uptake kinetics, functional mobility, and physical activity in older adults with heart failure and reduced ejection fraction

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2016年第5期13卷 450-457页

作者： Scott L Hummel John Herald Craig Alpert Kimberlee A Gretebeck wendy S Champoux Donald R Dengel Peter V Vaitkevicius Neil B Alexander Department of lnternal Medicine University of Michigan Ann Arbor MI USA VA Ann Arbor Healthcare System Ann Arbor MI USA School of Nursing University of Wisconsin-Madison Madison WI USA William Beaumont School of Medicine Oakland University Royal Oak MI USA School of Kinesiology University of Minnesota Minneapolis MN USA Aspirus Health System Ontanagon ML USA

Background Submaximal oxygen uptake measures are more feasible and may better predict clinical cardiac outcomes than maximal tests in older adults with heart failure （HF）. We examined relationships between maximal oxygen uptake, submaximal oxygen kinetics, fianctional mobility, and physical activity in older adults with HF and reduced ejection fraction. Methods Older adults with HF and reduced ejection fraction （n = 25, age 75 ：i： 7 years） were compared to 25 healthy ageand gender-matched controls. Assessments included a maximal treadmill test for peak oxygen uptake （VO2p^ak）, oxygen uptake kinetics at onset of and on recovery from a submaximal treadmill test, functional mobility testing [Get Up and Go （GUG）, Comfortable Gait Speed （CGS）, Unipedal Stance （US）], and self-reported physical activity （PA）. Results Compared to controls, HF had worse performance on GUG, CGS, and US, greater delays in submaximal oxygen uptake kinetics, and lower PA. In controls, VO2peak was more strongly associated with functional mobility and PA than submaximal oxygen uptake kinetics. In HF patients, submaximal oxygen uptake kinetics were similarly associated with GUG and CGS as VO2peak, but weakly associated with PA. Conclusions Based on their mobility performance, older HF patients with reduced ejection fraction are at risk for adverse functional outcomes. In this population, submaximal oxygen uptake measures may be equivalent to VO2 peak in predicting functional mobility, and in addition to being more feasible, may provide better insight into how aerobic function relates to mobility in older adults with HF.

关键词： Aging Congestive heart failure Mobility Oxygen uptake The elderly

Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第23期18卷 2914-2928页

作者： Xiao-Jun Zhang Feung Ping Leung wendy WL Hsiao Shun Tan Shao Li Hong-Xi Xu Joseph JY Sung Zhao-Xiang Bian School of Chinese Medicine HongKong Baptist University Hong Kong China Ministry of Education Key Laboratory of Bioinformat- ics and Bioinformatics Division TNLIST/Department of Auto- mation Tsinghua University Beijing 100084 China Shanghai University of Traditional Chinese Medi- cine Shanghai 200032 China Faculty of Medicine The Chinese University of Hong Kong Hong Kong China

AIM: To investigate proteomic changes in spinal cord and dorsal root ganglia (DRG) of rats with trinitrobenzene sulfonic acid (TNBS)-induced colitis. METHODS: The colonic myeloperoxidase (MPO) activity and tumor necrosis factor-(TNF- ) level were determined. A two-dimensional electrophoresis (2-DE)-based proteomic technique was used to profile the global protein expression changes in the DRG and spinal cord of the rats with acute colitis induced by intracolonic injection of TNBS. RESULTS: TNBS group showed significantly elevated colonic MPO activity and increased TNF-level. The proteins derived from lumbosacral enlargement of the spinal cord and DRG were resolved by 2-DE; and 26 and 19 proteins that displayed significantly different expression levels in the DRG and spinal cord were identified respectively. Altered proteins were found to be involved in a number of biological functions, such as inflammation/immunity, cell signaling, redox regulation, sulfate transport and cellular metabolism. The over-expression of the protein similar to potassium channel tetramerisation domain containing protein 12 (Kctd 12) and low expression of proteasome subunit type-1 (psma) were validated by Western blotting analysis. CONCLUSION: TNBS-induced colitis has a profound impact on protein profiling in the nervous system. This result helps understand the neurological pathogenesis of inflammatory bowel disease.

关键词： Inflammatory bowel disease Trinitrobenzenesulfonic acid Two-dimensional electrophoresis-basedproteomic technique Dorsal root ganglia Spinal cord

Neuropathic pain-like symptoms and pre-surgery radiographic severity contribute to patient satisfaction 4.8 years post-total joint replacement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2017年第10期8卷 761-769页

作者： Sophie C Warner Helen Richardson wendy Jenkins Thomas Kurien Michael Doherty Ana M Valdes Academic Rheumatology University of NottinghamClinical Sciences BuildingNottingham City Hospital Department of Cardiovascular Sciences University of Leicester and National Institute for Health Res-earchLeicester Cardiovascular Biomedical Research Unit Arthritis Research UK Pain Centre Academic Division of Trauma and Orthopaedics Queens Medical Centre

AIM To investigate a comprehensive range of factors that contribute to long-term patient satisfaction post-total joint replacement(TJR) in people who had undergone knee or hip replacement for *** Participants(n = 1151) were recruited from Nottinghamshire post-total hip or knee replacement. Questionnaire assessment included medication use, the pain-DETECT questionnaire(PDQ) to assess neuropathic pain-like symptoms(NP) and TJR satisfaction measured on average 4.8 years post-TJR. Individual factors were tested for an association with post-TJR satisfaction, before incorporating all factors into a full model. Data reduction was carried out using LASSO and receiveroperator characteristic(ROC) curve analysis was used to quantify the contribution of variables to post-TJR *** After data reduction, the best fitting model for post-TJR satisfaction included various measures of pain, history of revision surgery, smoking, pre-surgical X-ray severity, WOMAC function scores and various comorbidities. ROC analysis of this model gave AUC = 0.83(95%CI: 0.80-0.85). PDQ scores were found to capture much of the variation in post-TJR satisfaction outcomes: AUC = 0.79(0.75-0.82). Pre-surgical radiographic severity was associated with higher post-TJR satisfaction: OR_(satisfied) = 2.06(95%CI: 1.15-3.69), P = *** These results highlight the importance of pre-surgical radiographic severity, post-TJR function, analgesic medication use and NP in terms of post-TJR satisfaction. The PDQ appears to be a useful tool in capturing factors that contribute to post-TJR satisfaction.

关键词： Osteoarthritis Patient satisfaction Total joint arthroplasty Neuropathic pain Surgery outcomes

利用混合信号FPGA和先进的软件工具实现简易系统设计

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

电子技术应用 2010年第9期36卷 11-14页

作者： wendy Lockhart 爱特公司

单芯片嵌入式处理器的设计流程需要进行三类设计:FPGA设计、嵌入式设计和模拟设计。Actel Smart-FusionTM智能混合信号FPGA是目前唯一集成了FPGA、ARM Cortex-M3处理器硬核和可编程模拟的FPGA。该器件的架构具有清晰的功能性边界和明确... 详细信息

单芯片嵌入式处理器的设计流程需要进行三类设计:FPGA设计、嵌入式设计和模拟设计。Actel Smart-FusionTM智能混合信号FPGA是目前唯一集成了FPGA、ARM Cortex-M3处理器硬核和可编程模拟的FPGA。该器件的架构具有清晰的功能性边界和明确定义的接口,有助于简化设计边界。利用创新的设计工具,所有设计人员都能够并行进行自己的设计部分,避免设计周期延长与FP-GA中软核处理器的协作问题。

关键词：智能混合信号FPGA Actel SmartFusionTM 设计工具 ARM Cortex-M3处理器设计流程

Test Review： The Versant Spanish^TM Test

在线全文

学校读者我要写书评

暂无评论

英语考试研究 2011年第5期 60-64页

作者： Janna Fox wendy Fraser Carleton University Canada

Annual Report of PR Industry Survey 2007

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际公关 2008年第5期 93-95页

作者： wendy Chen John Chen Deputy Secretary-general of CIPRA & Executive Deputy Director of PR Agencies Committee

Under the supervision of PR Agencies Committee of China International Pub-lic Relations Association(CIPRA),the PR Industry Survey 2007 has been conducted by Research&Development section of CIPRA from January 21st to M... 详细信息

关键词： PR CIPRA Annual Report of PR Industry Survey 2007

Spontaneous regression of mantle cell lymphoma: a report of four cases

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2018年第1期38卷 329-334页

作者： Haige Ye Aakash Desai Tiejun Gong Dongfeng Zeng Krystle Nomie wendy Chen Wei Wang Jorge Romaguera Michael L.Wang Department of Hematology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000ZhejiangP.R.China Department of Lymphoma/Myeloma The University of Texas MD Anderson Cancer Center1515 Holcombe BlvdHoustonTX 77030USA The University of Texas Health Sci-ence Center HoustonTX 77030USA Institute of Hematology and Oncology Harbin First HospitalHarbin 150000HeilongjiangP.R.China Department of Hematology Da Ping HospitalResearch Institute of SurgeryChongqing Third Military Medical UniversityChongqing 404100P.R.China

Background:Spontaneous regression has been reported in some indolent forms of *** cell lym-phoma(MCL)is an aggressive lymphoid neoplasm and has a poor ***,approximately 30%of MCL patients can exhibit indolent clinical *** date,complete spontaneous regression of MCL has not been *** presentation:We describe four cases of spontaneous regression of *** the time of presentation,these patients were asymptomatic,with lymph node enlargement and mild to moderate fluorodeoxyglucose(FDG)uptake on FDG-positron emission tomography combined with computed *** of the possible mechanisms of spontaneous regression of the tumor could be due to the host immune response through humoral and cellular immunity,which may have a role in the clearance of tumor ***:In this report,we support the use of a“wait and watch”strategy for MCL patients with no risk factors and indolent *** strategy helps spare patients from further potentially harmful *** addition,we describe the phenomenon of spontaneous regression in MCL patients who are asymptomatic and have low-volume disease.

关键词： Mantle cell lymphoma Spontaneous regression

New language outcome measures for Mandarin speaking children with hearing loss

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2016年第1期11卷 24-32页

作者： Xueman Liu Jill de Villiers wendy Lee Chunyan Ning Eric Rolfhus Teresa Hutchings Fan Jiang Yiwen Zhang University of Texas at Dallas Communication Sciences and Disorders Bethel Hearing and Speaking Training Center Research and Development Smith College Psychology and Philosophy Bethel Hearing and Speaking Training Center Research and Development Tianjin Normal University Institute of Linguistics Bethel Hearing and Speaking Training Center Research and Development Bethel Hearing and Speaking Training Center Research and Development Shanghai Children's Medical Center Department of Developmental and Behavioral Pediatrics

Objective:The paper discusses recent evidence on the assessment of language outcomes in children with hearing loss acquiring oral language. Methods: Research emphasizes that language tests must be specific enough to capture subtle deficits in vocabulary and grammar learning at different developmental ages. The Diagnostic Receptive and Expressive Assessment of Mandarin (DREAM) was carefully designed to be a comprehensive standardized Mandarin assessment normed in China's Mainland. Results:This paper summarizes the evidence-based item design process and validity and reliability results of DREAM. A pilot study reported here shows that DREAM provided detailed information about hearing impaired children's language abilities and can be used to aid intervention planning to maximize progress. Conclusion: DREAM represents an example of translational science, transferring methods from empirical studies of language acquisition in research environments into applied domains such as assessment and intervention. Research on outcomes in China will advance significantly with the availability of evidence-based comprehensive language tests that measure a sufficient age range of skills, are normed on Mandarin speaking children in China's Mainland, and are designed to capture features central to Mandarin language acquisition.

关键词： Standardized language test Language development Outcome assessment Mandarin DREAM