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Hypothalamic-pituitary-adrenal axis function during perinatal depression

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Neuroscience Bulletin 2015年第3期31卷 338-350页

作者： Phillipe Leff Gelman Mónica flores-Ramos Margarita López-Martínez Carlos Cruz fuentes Juan Pablo Reyes Grajeda National Institute of Perinatology Mexico City National Council of Sciences and Technology (CONACy T) Mexico City National Institute of Psychiatry Mexico City National Institute of Genomic Medicine Mexico City

Abnormal function of the hypothalamic-pituitary-adrenal （HPA） axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol pro- inflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 1113-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby.

关键词： brain depression neuroendocrine pregnancy stress glucocorticoids

First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico

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Insect Science 2016年第6期23卷 829-834页

作者： Gustavo Ponce Iram P. Sanchez Selene M. Garcia Jose M. Torrado Saul Lozano-fuentes Beatriz Lopez-Monroy Adriana E. flores Facultad de Ciencias Biologicas Universidad Autonoma de Nuevo Leon A v. Universidad sin Cd. Universitaria San Nicolas de los GarzaN.L. 66455 Mexico Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO USA

The L1014F mutation in the voltage-sodium channel gene has been associated with resistance to DDT and pyrethroids in various arthropod species including mosquitoes. We determined the frequency of the L1014F kdr mutation in 16 field populations of Culex quinquefasciatus from Northeastern Mexico collected between 2008 and 2013. The L1014F was present in all populations analyzed with the lowest frequency （3.33%） corresponding to the population from Monclova collected in 2012, and the highest frequency （63.63%） from the Monterrey population collected in 2012. The presence of a kdr mutation in populations of Cx. quinquefasciatus from northeastern Mexico provides evidence ofpyrethroid resistance. This requires a special attention, considering that pyrethroid-based insecticides are commonly used in vector-control campaigns, especially against Aedes aegypti （L.）.

关键词： Culex quinquefasciatus insecticide resistance kdr L 1014F mutation

Exploring the adjustment to parasite pressure hypothesis: differences in uropygial gland volume and haemosporidian infection in palearctic and neotropical birds

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Current Zoology 2021年第2期67卷 147-156页

作者： Sergio MAGALLANES Anders Pape MøLLER Charlene LUJÁN-VEGA Esteban FONG Daniel VECCO wendy flores-SAAVEDRA Luz GARCÍA-LONGORIAA Florentino DE LOPE JoséA.IANNACONE Alfonso MARZAL Department of Anatomy Cellular Biology and ZoologyUniversity of ExtremaduraAvda.de Elvas S/NBadajoz ES-06006Spain Ecologie Systématique Evolution UniversitéParis-SudOrsay 91400France Key Laboratory for Biodiversity Science and Ecological Engineering of Ministry of Education College of Life SciencesBeiing Normal UniversityBeiing 100875China Pharmacology and Toxicology Graduate Group University of CaliforniaDavisDavisCA 95616USA EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Perú Centro Urku de Estudios Amazónicos Tarapoto 22202Perú Universidad Nacional Agraria La Molina Lima 15024Perú Molecular Ecology and Evolution Lab Department of BiologyLund UniversityLund 22100Sweden Laboratorio de Ingenieria Ambiental Universidad Cientifica del Sur-Villa el SalvadorLima 15067Perú Laboratorio de Invertebrados Universidad Ricardo PalmaSantiago de Surco 15039Perú

Parasites are globally widespread pathogenic organisms,which impose im portant selective forces upon their hosts.Thus,in accordance with the A djustm ent to parasite pressure hypothesis,it is expected that defenses among hosts vary relative to the selective pressure imposed by parasites.According to the latitudinal gradient in diversity,species richness and abundance of parasites peak near the equator.The uropygial gland is an im portant defensive exocrine gland against pathogens in birds.Size of the uropygial gland has been proposed to vary among species of birds because of divergent selection by pathogens on their hosts.Therefore,we should expect that bird species from the tropics should have relatively larger uropygial glands for their body size than species from higher latitudes.However,this hypothesis has not yet been explored.Here,we analyze the size of the uropygial gland of 1719 individual birds belonging to 36 bird species from 3 Neotropical(Peru)and 3 temperate areas(Spain).Relative uropygial gland volum e was 12.52%larger in bird species from the tropics than from temperate areas.This finding is consistent w ith the relative size of this defensive organ being driven by selective pressures imposed by parasites.We also explored the potential role of this gland as a means of avoiding haemosporidian infection,showing that species with large uropygial glands for their body size tend to have lower mean prevalence of haemosporidian infection,regardless o f their geographical origin.This result provides additional support for the assum ption that secretions from the uropygial gland reduce the likelihood of becoming infected with haemosporidians.

关键词： adjustment to parasite pressure hypothesis malaria Neotropical region preen oil temperate region

The Immune System and the Role of Inflammation in Perinatal Depression

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Neuroscience Bulletin 2016年第4期32卷 398-420页

作者： Philippe Leff-Gelman Ismael Mancilla-Herrera Monica flores-Ramos Carlos Cruz-fuentes Juan Pablo Reyes-Grajeda maría del pilar garcía-cuétara Marielle Danitza Bugnot-Perez David Ellioth Pulido-Ascencio National Institute of Perinatology Mexico City Mexico National Institute of Psychiatry Mexico City Mexico National Institute of Genomic Medicine Mexico CityMexico Faculty of Psychology Anahuac University HuixquilucanMexico National Council of Science and Technology Mexico CityMexico

Major depression during pregnancy is a common psychiatric disorder that arises from a complex and mul- tifactorial etiology. Psychosocial stress, sex, hormones, and genetic vulnerability increase the risk for triggering mood disorders. Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic-pituitary-adrenal axis hyperactivity. Dysregulation of this intricate neu- roimmune communication network during pregnancy modifies the maternal milieu, enhancing the emergence of depressive symptoms and negative obstetric and neu- ropsychiatric outcomes. Although several studies have clearly demonstrated the role of the innate immune system in major depression, it is still unclear how the placenta, the brain, and the monoaminergic and neuroendocrine systems interact during perinatal depression. Thus, in the present review we describe the cellular and molecular interactions between these systems in major depression during preg- nancy, proposing that the same stress-related mechanisms involved in the activation of the NLRP3 inflammasome in microglia and peripheral myeloid cells in depressed patients operate in a similar fashion in the neuroimmune placenta during perinatal depression. Thus, activation of Toll-like receptor 2 and 4 signaling and the NLRP3 inflammasome in placental immune cells may promote a shift of the Thl/Th2 bias towards a predominant Thl/Thl7 inflammatory response, associated with increased secretion of pro-inflammatory cytokines, among other secreted autocrine and paracrine mediators, which play a crucial role in triggering and/or exacerbating depressive symptoms during pregnancy.

关键词： Depression Pregnancy Immune systemInflammation Cytokine Serotonin Indoleamine dioxygenase Glucocorticoid Brain Placenta

Atmospheric-pressure dielectric barrier discharge generation by a full-bridge flying capacitor multilevel inverter

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Plasma Science and Technology 2017年第7期19卷 40-49页

作者： Rosendo PE?A-EGUILUZ José A LóPEZ-FERNáNDEZ Antonio MERCADO-CABRERA Bethsabet JARAMILLO-SIERRA Régulo LóPEZ-CALLEJAS Benjamín RODRíGUEZ-MéNDEZ Raúl VALENCIA-ALVARADO Allan A flores-fuentes Arturo E MU?OZ-CASTRO Plasma Physics Laboratory Instituto Nacional de Investigaciones Nucleares Tecnológico de Estudios Superiores de Tianguistenco Universidad Autónoma del Estado de México

A new configuration of a resonant full-bridge flying capacitor multicell inverter has been designed and constructed with the aim of achieving an extended output voltage frequency range with low harmonic distortion and reduced semiconductor commutation losses. This configuration was tested as a power supply for two different coaxial dielectric barrier discharge reactors, one of them employed for electric characterization and the other one for inorganic compound elimination in an aqueous solution. Two different gas mixtures, 90% Ar-10% 02 and 80% Ar-20% 02, were individually supplied during the experiments; the results showed a high- efficiency removal of meta-cresol （m-cresol） to the order of 98%, which was obtained by adding more oxygen to the plasma gas mixture.

关键词： plasma applications water pollution plasma sources power supply circuits electricdischarges

Cerium extraction by metallothermic reduction using cerium oxide powder injection

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Journal of Rare Earths 2011年第1期29卷 74-76页

作者： J.S.Luna A A.flores V R.Muiz V A.F.fuentes J.Torres N.Rodríguez R J.C.Ortiz P.Orozco CINVESTAV Unidad Saltillo Saltillo-Monterrey Highway Km.13.5P.O.Box 66325000SaltilloCoahuilaMéxico Faculty of Engineering Autonomous Univer-sity of CoahuilaCamporedondo UnitSaltilloCoahuilaMéxico Department of Metal Mechanics Technological Institute of SaltilloV.Carranza Blvd 2400SaltilloCoahuilaZC 25280México Academic Unit of Engineering Autonomous University of CoahuilaLopez Velarde Av.ZacatecasZac.ZC 98060

This work presented the feasibility of cerium recovery by Al-Mg alloy through the metallothermic reduction of CeO2 to obtain a master alloy Al-4%Ce. The master alloy obtained in this investigation was for the grain refinement and modification of Al-Si alloys. The reagent was incorporated into a molten alloy using the submerged powder injection technique, and metallic samples were obtained during injection. Chemical and microstructural analyses （by inductively coupled plasma （ICP） and scanning electron microscopy （SEM）, respectively） confirmed the possibility of Ce uptake in the bath （0 to 4 wt.%）, as CeO2 was reduced through metallothermic reactions in the molten alloys. Based on the characterization of reaction products, the sequence of the reaction was proposed.

关键词： cerium recovery metallothermic reduction reaction products rare earths

Interaction Between Heficoverpa zea Damage with Corncob Diseases on Genetically Modified Corn in Sinaloa, México

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Journal of Life Sciences 2014年第4期8卷 329-334页

作者： Luis A. Aguirre Uribe Gustavo A. Frías Trevino Agustín Hernández Juárez Mariano flores Davila Emesto Cerna Chavez Jerónimo Landeros flores Yisa M. Ochoa fuentes Plant Health Department Universidad A utónoma Agraria Antonio Narro Buenavista Saltillo 25315 Coahuila México

Antioxidant drugs to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis:What does evidence suggest?

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World Journal of Gastroenterology 2015年第21期21卷 6745-6753页

作者： Clotilde fuentes-Orozco Carlos Davalos-Cobian Jesus Garcia-Correa Gabriela Ambriz-Gonzalez Michel Dassaejv Macias-Amezcua Jesus Garcia-Renteria Jorge Rendon-Felix Mariana Chavez-Tostado Lizbeth Araceli Cuesta-Marquez Andrea Socorro Alvarez-Villasenor Ana Olivia Cortes-flores Alejandro Gonzalez-Ojeda Research Unit in Clinical Epidemiology Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Department Gastrointestinal Endoscopy Specialties Hospital of the Western Medical CenterMedical Unit of High SpecialtyMexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Department of Pediatric Surgery.Children’s Hospital.Western National Medical Center Mexican Institute of Social Security Guadalajara Jalisco 44340 Mexico Health Research Coor-dination.Mexican Institute of Social Security Baja Californa Sur 23000 Mexico

AIM:To determine whether or not the use of antioxidant supplementation aids in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.METHODS:A systematic review of randomized controlled trials(RCTs) was made to evaluate the preventive effect of prophylactic antioxidant supplementation in post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP).The inclusion criteria included:acute post-endoscopic retrograde cholangiopancreatography pancreatitis in adults; randomized clinical trials with the use of any antioxidant as an intervention compared with placebo,to reduce PEP.The outcome measure was the incidence and severity of PEP.Twelve RCTs involving 3110 patients since 1999 wereincluded.The antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),N-acetylcysteine(NAC) in three trials,and allopurinol in six trials.The group of patients treated with NAC received different doses; either oral or intravenous,and allopurinol-treated patients received five different oral doses in two different administration periods.The results are expressed with raw numbers,proportions,as well as mean and standard deviations.The incidence of pancreatitis between groups was analyzed with Pearson's χ2 test or Fisher's exact test(F).The main outcome is expressed as relative risks and 95%CI.RESULTS:The incidence of pancreatitis in all antioxidant treatment groups was 8.6%,whereas it was 9.7% in the control group.The antioxidants used were selenite,β-carotene,and pentoxifylline(each one in one trial),NAC in three trials,and allopurinol in six trials.In allopurinol trials,three different dosifications were used; two trials reported a low dosage(of less than 400 mg),two trials reported a moderate dose(600 mg) and the remaining two employed higher doses(more than 900 mg).Supplementation was not associated with a significant reduction in the incidence of PEP [relative risk(RR) = 0.93; 95%CI:0.82-1.06; P = 0.28].In addition,the incidences of PEP in patients treated with allopurino

关键词： Antioxidant drugs Endoscopic retrograde cholangiopancreatography Pancreatitis Prophylaxis

Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo fuentes Paola Montenegro Ebert Poquioma Raul Alatrista Claudio J flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(H.pylori)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively studied.Analysis of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive information.AIM To determine the rates of deficient mismatch-repair(dMMR),HER2-status and H.pylori infection and their association with TIL levels in GC.METHODS Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)compartments.The density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).H.pylori infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of samples.RESULTS dMMR was found in 34.4%,HER2+in 5%and H.pylori-positive in 55.7%of samples.High IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)densities.HER2-was associated with high IT-CD8(P=0.009).H.pylorinegative was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and H.pylori-negativity.Low CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair