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Clinical significance of peripheral blood UL16 and DR-70 for the early diagnosis and prognostic evaluation of colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3832-3838页

作者： Zhi-Ping zong Chen Wu Department of Blood Transfusion Affiliated Hospital of Jiangnan UniversityWuxi 214000Jiangsu ProvinceChina Clinical Laboratory Jiangsu Province Official HospitalNanjing 210003Jiangsu ProvinceChina

BACKGROUND Early diagnosis of colorectal cancer(CRC)is of great significance to improve the survival rate and quality of life of patients,but early diagnosis of CRC requires more sensitive *** blood UL16-binding protein 2(ULBP2)and human fibrinogen degradation products(DR-70)are the main indicators for the diagnosis of malignant *** To assess ULBP2 and DR-70 potential for the early diagnosis and prognostic evaluation of CRC to provide a *** This study involved 60 patients with early-stage CRC(CRC group),50 patients with benign colorectal tumors(benign group),and 50 healthy patients(control group)enrolled at the Affiliated Hospital of Jiangnan University and Jiangsu Province Official Hospital between January,2020 and January,***2 and DR-70 levels in the blood were determined and differences among the three groups and early diagnostic values for CRC were *** with CRC were divided into the good prognosis and poor prognosis groups,and ULBP2 and DR-70 levels in the blood and diagnostic values were *** ULBP2 and DR-70 serum levels were significantly higher in the CRC group than in the control and benign groups(P0.05).Among the 60 patients with CRC followed up for two years,two died(3.33%)and 15 exhibited tumor metastasis,progression,or recurrence(25.00%).ULBP2 and DR-70 serum levels were significantly higher in the poor prognosis group than in the good prognosis group(P<0.05).A receiver operating characteristic curve was *** under the curve,sensitivity,and specificity of serum ULBP2 with DR-70 for the early diagnosis of CRC were higher than those of the single serum indices(P<0.05)in both the good and poor prognosis *** ULBP2 and DR-70 serum levels were significantly high in patients with early-stage *** improved the diagnostic rate of early-stage CRC and predicted patient prog

关键词： ULBP2 DR-70 Colorectal cancer Early diagnosis Prognosis

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Progress and Outlook of Carbon-supported Single-atom Electrocatalyst for Oxygen Reduction Reaction

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Chemical Research in Chinese Universities 2024年第3期40卷 462-474页

作者： WANG Chengbin LI Ping CHEN Dehong ZHANG Ruiyong WANG Lei zong Lingbo College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042P.R.China College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042P.R.China Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071P.R.China

Single-atom catalysts (SACs) have garnered extensive attention in the field of catalysis due to their exceptional inherent reaction activity, optimal utilization of metal atoms, etc. Controlled synthesis plays a crucial role in elucidating the structure-activity relationship of SACs. This paper reviews various synthetic strategies for SACs, encompassing defect engineering, metal-organic frameworks (MOFs) pyrolysis, and ion exchange. With specific examples, the significance of constructing catalysts at the atomic level is discussed, aiming to comprehensively understand the synthetic strategies of SACs. Finally, it addresses the challenges and prospects associated with controlled synthesis techniques for SACs as well as their future applications.

关键词： Single-atom catalyst Synthetic strategy Carbon support Oxygen reduction reaction

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A Single-Fluorophore Multicolor Molecular Sensor That Visually Identifies Organic Anions Including Phosphates

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CCS Chemistry 2024年第3期6卷 774-782页

作者： Zezhou zong Qi Zhang Da-Hui Qu Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237

Developing fluorescent sensors for small-molecule phosphates offers opportunities in optically detecting biorelevant reactions and ***,it remains elusive how to identify phosphates from other anions,such as carboxylates and sulfates,because current synthetic phosphate receptors lack *** we report the construction of a multicolor fluorescent sensor that can identify phosphates from other analogous *** key design principle is to take advantage of the highly sensitive conformation-dependent emissive wavelength of diphenyl-9,14-dihydrodibenzo[a,c]phenazine fluorophores to sense the minor structural differences between phosphates and other anions,for example,sulfates and *** effect of structural factors such as spacer length and urea versus thiourea has been investigated by comparing the optical properties and binding affinities with the phosphate *** strategy provides a simple and robust fluorescent sensing solution to optically analyze small-molecule phosphates with antiinterference performance.

关键词： fluorescent sensors photoluminescence host-guest chemistry supramolecular chemistry noncovalent bonds

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Highly Aligned Graphene Aerogels for Multifunctional Composites

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Nano-Micro Letters 2024年第6期16卷 276-342页

作者： Ying Wu Chao An Yaru Guo Yangyang zong Naisheng Jiang Qingbin Zheng Zhong‑Zhen Yu Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004People’s Republic of China School of Science and Engineering The Chinese University of Hong KongShenzhenShenzhenGuangdong 518172People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Stemming from the unique in-plane honeycomb lattice structure and the sp^(2)hybridized carbon atoms bonded by exceptionally strong carbon–carbon bonds,graphene exhibits remarkable anisotropic electrical,mechanical,and thermal *** maximize the utilization of graphene’s in-plane properties,pre-constructed and aligned structures,such as oriented aerogels,films,and fibers,have been *** unique combination of aligned structure,high surface area,excellent electrical conductivity,mechanical stability,thermal conductivity,and porous nature of highly aligned graphene aerogels allows for tailored and enhanced performance in specific directions,enabling advancements in diverse *** review provides a comprehensive overview of recent advances in highly aligned graphene aerogels and their *** highlights the fabrication methods of aligned graphene aerogels and the optimization of alignment which can be estimated both qualitatively and *** oriented scaffolds endow graphene aerogels and their composites with anisotropic properties,showing enhanced electrical,mechanical,and thermal properties along the alignment at the sacrifice of the perpendicular *** review showcases remarkable properties and applications of aligned graphene aerogels and their composites,such as their suitability for electronics,environmental applications,thermal management,and energy *** and potential opportunities are proposed to offer new insights into prospects of this material.

关键词： Highly aligned graphene aerogels Quantitative characterization of alignment Multifunctional composites Anisotropic properties Multifunctional applications

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Detecting short-term gravitational waves from post-merger hyper-massive neutron stars with a kilohertz detector

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Chinese Physics B 2024年第8期33卷 222-228页

作者：陈奕康朱宗宏 Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Department of Astronomy Beijing Normal UniversityBeijing 100875China

Gravitational waves emanating from binary neutron star inspirals,alongside electromagnetic transients resulting from the aftermath of the GW170817 merger,have been successfully ***,the intricate post-merger dynamics that bridge these two sets of observables remain *** includes if,and when,the post-merger remnant star collapses to a black hole,and what are the necessary conditions to power a short gamma-ray burst,and other observed electromagnetic *** focus is on the detection of gravitational wave(GW)emissions from hyper-massive neutron stars(NSs)formed through binary neutron star(BNS)*** several kilohertz GW detectors,we simulate BNS mergers within the detection limits of LIGO-Virgo-KARGA *** objective is to ascertain the fraction of simulated sources that may emit detectable post-merger GW *** kilohertz detectors equipped with a new cavity design,we estimate that approximately 1.1%-32%of sources would emit a detectable post-merger GW *** fraction is contingent on the mass converted into gravitational wave energy,ranging from 0.01M_(sun)to 0.1M_(sun).Furthermore,by evaluating other well-regarded proposed kilohertz GW detectors,we anticipate that the fraction can increase to as much as 2.1%-61%under optimal performance conditions.

关键词： neutron star mergers gravitational waves

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Application of electromagnetic metallurgy in continuous casting: A review

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Progress in Natural Science:Materials International 2024年第1期34卷 1-11页

作者： Jiale Li Yi Nian Xiang Liu Youcheng zong Xinyu Tang Chaojie Zhang Liqiang Zhang The Intelligent Metallurgy Research Institute School of Metallurgical Engineering Anhui University of Technology

The standards within the global steel industry are constantly advancing, necessitating increasingly rigorous quality control protocols during the continuous casting process. Central to the challenges faced in this domain are persistent defects such as central segregation, V-shaped segregation, and center porosity, which significantly impede the production of high-caliber steel products. The discipline of electromagnetic metallurgy has emerged as a critical solution in reducing these defects, thereby enhancing the efficiency and stability of continuous casting operations. Its demonstrated effectiveness has led to its widespread implementation across global and domestic steel production industries. This paper aims to deliver a comprehensive examination of electromagnetic metallurgy's impact on the final stages of solidification in continuous casting, along with its contributions to the heating and purification processes within the tundish. Additionally, it will explore the potential advancements and applications of this technology in the evolving sphere of continuous casting.

关键词： continuous casting Quality control Final electromagnetic stirring Induction heating Electromagnetic purification

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Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

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Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma Xing-Yao Yin Zhao-Yun zong Yuan-Yuan Tan Ya-Ming Yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is ***,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the ***,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical *** on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic ***,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked *** analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity ***,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip *** increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip *** comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness ***,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the or

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

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Finite Element Simulations of the Localized Failure and Fracture Propagation in Cohesive Materials with Friction

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 997-1015页

作者： Chengbao Hu Shilin Gong Bin Chen Zhongling zong Xingwang Bao Xiaojian Ru Department of Civil Engineering Hangzhou City UniversityHangzhou310015China Zhejiang Engineering Research Center of Intelligent Urban Infrastructure Hangzhou310015China Key Laboratory of Safe Construction and Intelligent Maintenance for Urban Shield Tunnels of Zhejiang Province Hangzhou310015China School of Civil and Ocean Engineering Jiangsu Ocean UniversityLianyungang222005China Institute of Municipal Engineering Hangzhou Shangcheng District Municipal Engineering Group Co.Ltd.Hangzhou310016China

Strain localization frequently occurs in cohesive materials with friction(e.g.,composites,soils,rocks)and is widely recognized as a fundamental cause of progressive structural ***,achieving high-fidelity simulation for this issue,particularly concerning strong discontinuities and tension-compression-shear behaviors within localized zones,remains significantly *** response,this study introduces an integrated algorithmwithin the finite element framework,merging a coupled cohesive zone model(CZM)with the nonlinear augmented finite elementmethod(N-AFEM).The coupledCZMcomprehensively describes tension-compression and compressionshear failure behaviors in cohesive,frictional materials,while the N-AFEM allows nonlinear coupled intraelement discontinuities without necessitating extra nodes or nodal *** CZM validation using existing experimental data,this integrated algorithm was utilized to analyze soil slope failure mechanisms involving a specific tensile strength and to assess the impact of mechanical parameters(e.g.,tensile strength,weighting factor,modulus)in soils.

关键词： FEM analysis strong discontinuity nonlinear soil rupture cohesive zone model tension-compression-shear coupling

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Laparoscopic surgery for trans-anal barotrauma: a case report

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World Journal of Emergency Medicine 2024年第5期15卷 425-427页

作者： Chengxi Liu Liang zong Huadong Zhu Jun Xu Emergency Department Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Trans-anal barotrauma resulting from the use of air guns is rare in the emergency *** diagnosis and timely treatment can yield a good *** first published case of trans-anal barotrauma caused by a manually operated force pump was reported in 1904.[1]Colorectal injuries have the potential to progress to high-mortality complications,such as abdominal infection,peritonitis,and septic shock.[2,3]Herein,we report a case of trans-anal barotrauma in a man who presented with pneumoperitoneum,pneumomediastinum,and *** performed laparoscopic exploration and loop ileostomy on this patient.

关键词： trauma diagnosis Laparoscopic

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Predicting dynamic compressive strength of frozen-thawed rocks by characteristic impedance and data-driven methods

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2591-2606页

作者： Shengtao Zhou zong-Xian Zhang Xuedong Luo Yifan Huang Zhi Yu Xiaowei Yang Faculty of Engineering China University of GeosciencesWuhan430074China Oulu Mining School University of OuluOulu90570Finland Zijin School of Geology and Mining Fuzhou UniversityFuzhou350116China Department of Earth Science&Engineering Imperial College LondonLondonSW72AZUK

In cold regions,the dynamic compressive strength(DCS)of rock damaged by freeze-thaw weathering significantly influences the stability of rock ***,testing the dynamic strength under freeze-thaw weathering conditions is often both time-consuming and ***,this study considers the effect of characteristic impedance on DCS and aims to quickly determine the DCS of frozen-thawed rocks through the application of machine-learning ***,a database of DCS for frozen-thawed rocks,comprising 216 rock specimens,was *** external load parameters(freeze-thaw cycle number,confining pressure,and impact pressure)and two rock parameters(characteristic impedance and porosity)were selected as input variables,with DCS as the predicted *** research optimized the kernel scale,penalty factor,and insensitive loss coefficient of the support vector regression(SVR)model using five swarm intelligent optimization algorithms,leading to the development of five hybrid *** addition,a statistical DCS prediction equation using multiple linear regression techniques was *** performance of the prediction models was comprehensively evaluated using two error indexes and two trend indexes.A sensitivity analysis based on the cosine amplitude method has also been *** results demonstrate that the proposed hybrid SVR-based models consistently provided accurate DCS *** these models,the SVR model optimized with the chameleon swarm algorithm exhibited the best performance,with metrics indicating its effectiveness,including root mean square error(RMSE)﹦3.9675,mean absolute error(MAE)﹦2.9673,coefficient of determination(R^(2))﹦0.98631,and variance accounted for(VAF)﹦*** suggests that the chameleon swarm algorithm yielded the most optimal results for enhancing SVR ***,impact pressure and characteristic impedance emerged as the two most influential parameters in DCS *** research is

关键词： Freeze-thaw cycle Characteristic impedance Dynamic compressive strength Machine learning Support vector regression

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