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Druse Calcite Crystals Formed by Mesoproterozoic Paleo-Earthquake Activity in the Northern Margin of the North China Craton

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Journal of Earth Science 2024年第2期35卷 514-524页

作者： Yueshuang Du Zhiguang Zhou Guosheng Wang Chen Wu wenchao xu School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau Researchand Center for Excellence in Tibetan Plateau Earth SciencesChinese Academy of SciencesBeijing100101China No.1 Institute of Geological and Mineral Resources Survey Henan Bureau of Geo-Exploration&Mineral DevelopmentLuoyang471000China

The Meso-neoproterozoic Bayan Obo rift is located along the northern margin of the North China Craton,and was associated with the break-up of the Columbia *** rift evolution,syn-sedimentary deformation occurred due to tectonic activity and *** events are recorded in the Jianshan Formation of the Bayan Obo Group,Inner Mongolia,as soft sediment deformation structures in the central Bayan Obo *** calcite crystals and collapse breccias in the Jianshan Formation may provide information on the rift *** druse calcite crystals are idiomorphic-columnar in shape and associated with graphite,pyrite,and quartz.δ^(13)C values of the graphite are−20‰,indicative of biogenic deoxygenation and formation in *** druse calcite crystals are inorganic in origin and formed in water at a temperature of 55℃,based on calciteδ^(13)C andδ^(18)O *** calcite grew in paleo-caves containing fault breccias,with heat derived from *** such,the druse calcite crystals are important evidence for seismic *** collapse breccias(i.e.,fault breccias)and other indicators of slip show that displacement occurred from NE to SW,which is different from the paleocurrent direction in the Jianshan *** thickness of the collapse breccia is∼200 m,which represents the height of the fault *** strike of the fault scarp was NE-SW,based on the distribution of the collapse *** Bayan Obo and Yanliao rifts experienced rapid NW-SE extension,and developed similar deformation structures at ca.1.6 Ga related to break-up of the Columbia supercontinent.

关键词： North China Craton druse calcite crystals paleo-earthquake activity collapse breccia Bayan Obo rift Proterozoic

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BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

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Genes & Diseases 2024年第1期11卷 19-22页

作者： Zhenhai Li wenchao xu Feng Chen Jun Zhang Wei-Guo Zhu Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.

关键词： etoposide damage cancer

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内酯型槐糖脂促进HCFC-141b水合物生成

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化工进展 2024年第3期43卷 1199-1205页

作者：黄梦孙志高徐文超张焕然杨扬苏州科技大学环境科学与工程学院江苏苏州215009

蓄冷空调是降低电网峰谷差、实现电网负载侧调峰的一种重要手段,制冷剂水合物作为蓄冷介质具有蓄冷密度大和相变温度高的优点。HCFC-141b制冷剂是一种潜在的蓄冷物质,为了促进HCFC-141b制冷剂水合物的生成,实验研究了绿色环保表面活性... 详细信息

蓄冷空调是降低电网峰谷差、实现电网负载侧调峰的一种重要手段,制冷剂水合物作为蓄冷介质具有蓄冷密度大和相变温度高的优点。HCFC-141b制冷剂是一种潜在的蓄冷物质,为了促进HCFC-141b制冷剂水合物的生成,实验研究了绿色环保表面活性剂槐糖脂对HCFC-141b水合物生成的影响。研究结果表明,添加适量的内酯型槐糖脂可大幅度缩短HCFC-141b水合物形成的诱导时间。槐糖脂的添加量影响水合物的成核和生长过程,质量分数为0.5%是内酯型槐糖脂的最佳浓度,促进HCFC-141b水合物生成的平均诱导时间最短,约为153min。实验结果还表明水合物的生成具有随机性,添加内酯型槐糖脂可以改善水合物生成的随机性,0.5%(质量分数)的内酯型槐糖脂的诱导时间标准方差最小,水合物成核稳定性最好。内酯型槐糖脂的添加也影响HCFC-141b水合物的蓄冷量,当添加0.5%(质量分数)的内酯型槐糖脂时,HCFC-141b水合物的平均蓄冷量达到232.45kJ/kg。

关键词：水合物表面活性剂动力学制冷剂蓄冷内酯型槐糖脂

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Fatigue and impact analysis and multi-objective optimization design of Mg/Al assembled wheel considering riveting residual stress

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Frontiers of Mechanical Engineering 2022年第3期17卷 281-301页

作者： wenchao xu Dengfeng WANG State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun130022China

The multi-material assembled light alloy wheel presents an effective lightweight solution for new energy vehicles,but its riveting connection remains a *** address this problem,this paper proposed the explicit riveting-implicit springback-implicit fatigue/explicit impact sequence coupling simulation analysis method,analyzed the fatigue and impact performance of the punching riveting connected magnesium/aluminum alloy(Mg/Al)assembled wheel,and constructed some major evaluation *** accuracy of the proposed simulation method was verified by conducting physical experiments of single and cross lap *** punching riveting process parameters of the assembled wheel joints were defined as design variables,and the fatigue and impact performance of the assembled wheel was defined as the optimization *** connection-performance integration multi-objective optimization design of the assembled wheel considering riveting residual stress was designed via Taguchi experiment,grey relational analysis,analytic hierarchy process,principal component analysis,and entropy weighting *** optimization results of the three weighting methods were compared,and the optimal combination of design variables was *** fatigue and impact performance of the Mg/Al assembled wheel were effectively improved after optimization.

关键词： magnesium/aluminum assembled wheel riveting residual stress fatigue analysis impact analysis multi-objective optimization

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沥青抑烟净味剂功能性验证研究

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市政技术 2024年第6期42卷 244-249,255页

作者：郭猛许文超北京工业大学桥梁工程安全与韧性全国重点实验室北京100124 北京工业大学城市与工程安全减灾教育部重点实验室北京100124

该研究旨在探究物理吸附材料和化学抑制材料对沥青烟气中颗粒物和苯类有机物释放的影响,以减少沥青烟气对施工人员健康和环境造成的危害。在实验室内模拟了沥青实际使用情况,采用聚四氟乙烯滤膜和环己烷吸收液对沥青烟气进行收集,通过... 详细信息

该研究旨在探究物理吸附材料和化学抑制材料对沥青烟气中颗粒物和苯类有机物释放的影响,以减少沥青烟气对施工人员健康和环境造成的危害。在实验室内模拟了沥青实际使用情况,采用聚四氟乙烯滤膜和环己烷吸收液对沥青烟气进行收集,通过重量法和气相色谱质谱联用试验研究了活性炭和净味剂B的抑制效果,并进一步考虑了二者对沥青路用性能的影响。通过中心复合模型得到了复合抑烟净味剂的最佳配方,即活性炭掺量为3.28%,净味剂B掺量为3‰。通过红外光谱试验和核磁共振氢谱试验得到了抑烟净味剂对沥青微观结构的影响,结果表明净味剂B主要由酯类化合物组成,复合抑烟净味剂的主要原理是通过使支链碳链变长,提高沥青沸点,从而达到了抑烟净味的效果。

关键词：沥青烟抑烟净味材料抑烟性能净味性能抑烟净味原理

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基于改进VGG网络的单体热电池X光图像无损检测方法研究

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光电子．激光 2024年第2期35卷 180-190页

作者：徐文超张思祥白芳赵涛伊纪禄河北工业大学机械工程学院天津300130 天津商业大学信息工程学院天津300134 中国电子科技集团公司第十八研究所天津300381

为解决单体热电池生产中出现的安装错误、人工检测耗时耗力的问题,提出一个结合迁移学习和卷积神经网络(convolutional neural network, CNN)的单体热电池缺陷检测模型。首先,对数据集图像进行裁剪、加噪等预处理,以VGG16(visual geomet... 详细信息

为解决单体热电池生产中出现的安装错误、人工检测耗时耗力的问题,提出一个结合迁移学习和卷积神经网络(convolutional neural network, CNN)的单体热电池缺陷检测模型。首先,对数据集图像进行裁剪、加噪等预处理,以VGG16(visual geometry group 16)网络作为模型的骨干架构,在瓶颈层后增添选择性核(selective kernel, SK)卷积;然后,增添全局平均池化(global average pooling, GAP)层,增加Dropout层及添加L2正则化等微调操作,得到单体热电池缺陷检测模型Q-VGGNet;最后,在大型公开数据集ImageNet上进行预训练学习,将获得的权重参数迁移到单体热电池图像识别模型Q-VGGNet上。测试实验表明:6种网络模型对数据集缺陷图像的总体识别准确率分别达到了98.39%、94.44%、97.27%、96.34%、93.71%、95.61%,Q-VGGNet网络模型对合格图像和漏装负极、极耳断裂、漏装集流片3种缺陷图像识别准确率分别达到了99.6%,95.9%,99.6%和98.4%。检测结果表明:该方法能够更准确、快速地检测热电池缺陷,拥有良好的缺陷诊断能力,较传统方法提高近3%,为人工检测单体热电池缺陷提供了良好的解决途径。

关键词：迁移学习 VGG16网络缺陷识别单体热电池选择性核(SK)卷积

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下降速率对不稳定库岸边坡的内力影响分析

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科学技术创新 2024年第18期 161-164页

作者：代彦芹陈德令徐文超云南水利水电职业学院云南昆明浙江中水集团浙江嘉兴

位于金沙江电站库区范围的丽宁公路边坡,受库水位升降影响已发生多次崩塌滑坡,本文通过GEO-SLOPE软件,建立该区域丽宁公路边坡二维渗流稳定模型,模拟库岸在水库水位不同下降速率情况下的安全稳定情况,得出随着水库水位下降速率越大,库... 详细信息

位于金沙江电站库区范围的丽宁公路边坡,受库水位升降影响已发生多次崩塌滑坡,本文通过GEO-SLOPE软件,建立该区域丽宁公路边坡二维渗流稳定模型,模拟库岸在水库水位不同下降速率情况下的安全稳定情况,得出随着水库水位下降速率越大,库岸越不稳定,孔隙水压力越小,法向力抗剪力不断增大,土体安全系数会有所提高等规律,并提出相关的边坡防止措施,为该路段边坡的处理及之后新公路的修建提供相关依据。

关键词：不稳定库岸安全系数水位下降速率

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Nucleoside deaminases: the key players in base editing toolkit

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Biophysics Reports 2023年第6期9卷 325-337页

作者： Jiangchao Xiang wenchao xu Jing Wu Yaxin Luo Bei Yang Jia Chen Gene Editing Center School of Life Science and Technology Shanghai Tech University Shanghai Institute for Advanced Immunochemical Studies Shanghai Tech University Shanghai Clinical Research and Trial Center

The development of nucleoside deaminase-containing base editors realized targeted single base change with high efficiency and precision. Such nucleoside deaminases include adenosine and cytidine deaminases, which can catalyze adenosine-to-inosine(A-to-I) and cytidine-to-uridine(C-to-U) conversion respectively. These nucleoside deaminases are under the spotlight because of their vast application potential in gene editing. Recent advances in the engineering of current nucleoside deaminases and the discovery of new nucleoside deaminases greatly broaden the application scope and improve the editing specificity of base editors. In this review, we cover current knowledge about the deaminases used in base editors, including their key structural features, working mechanisms, optimization, and evolution.

关键词： Nucleoside deaminase Base editors

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Crack mechanism of ground fissures in loess layer of Fenwei Basin, China

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Journal of Mountain Science 2024年第5期21卷 1683-1696页

作者： LI Cong LU Quanzhong WANG Feiyong LUO wenchao xu Qiang School of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Key Laboratory of Western Mineral Resources and Geological Engineering Ministry of EducationXi’an 710054China Observation and Research Station of Ground Fissure and Land Subsidence Ministry of Natural ResourcesXi’an 710054China School of Engineering and Technology China University of GeosciencesBeijing 100083China

The Fenwei Basin, covered by loess, experiences severe ground fissure disasters. These disasters disrupt the continuity of the loess and pose significant threats to engineering construction safety along transportation routes. Nevertheless, the crack characteristics and the influence zone of ground fissures in the loess layer remain inadequately investigated. To effectively prevent and control ground fissure disasters, physical model tests and the PFC(particle flow code) numerical simulation method are used to investigate the crack mechanism of buried ground fissures in the loess layer. The results show that there are two main cracks in the layer profile, which have a Y-shape morphology. As the dip angle of the preset cracks increased from 60° to 90°, the main deformation zone at the surface gradually shifted towards the footwall. The process of crack propagation from depth to surface is divided into five stages. Additionally, the results confirm the accuracy of the width of the rupture zone d2in the footwall calculated by the cantilever beam theory. These findings can offer theoretical guidance for determining the avoidance distance of ground fissures in loess regions, as well as for implementing disaster prevention and corresponding control measures for various stages of buried ground fissure propagation.

关键词： Ground fissure Fenwei Basin Physical model test Particle flow code Crack propagation

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The remarkable effect of amino hydrogen on membrane permeability and organelle staining of 1,8-naphthalimide dyes

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Chinese Chemical Letters 2024年第2期35卷 347-351页

作者： Zhifeng Li Qinglong Qiao Ning xu Kai An wenchao Jiang Yi Tao Pengjun Bao Yinchan Zhang Zhaochao xu School of Chemistry Dalian University of TechnologyDalian 116024China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

Membrane permeability and intracellular diffusion of fluorescent probes determine staining selectivity of intracellular ***,the relationship between the molecular structure of fluorescent probes and their membrane permeability and intracellular distribution is poorly *** this paper,we reported a series of 1,8-naphthalimide dyes and carried out cell imaging experiments,and found that the presence of amino hydrogen in these dyes played a crucial role in their cell membrane permeability and intracellular *** secondary amino group containing compounds 1-4 show excellent membrane permeability and strong fluorescence in living *** the tertiary amine containing dyes 5 and 6 can hardly permeate the cell membrane though they show extremely similar structure with compounds *** 1 can selectively image lipid droplets by selecting the wavelength of excitation *** the specificity for lysosomes,2 and 4 have been used in long-term time-lapses imaging of lysosomal dynamics and tracking the process of lysosome-lysosome interaction,fusion and *** effect of hydrogen-containing amino substituent on the cell membrane permeability of fluorescent molecules is promising for the development of better biocompatible probes.

关键词： Amino hydrogen 1,8-Naphthalimide Cell permeability Lipid droplet Lysosome

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