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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi wen Xin Xiong Ting Xu Qi wang Xiusheng Chen Xianxian zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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分布模型集成工具HLAWrapper的设计与实现

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系统仿真学报 2005年第1期17卷 245-248页

作者：雷永林赵雯王维平国防科技大学五院系统工程研究所湖南长沙410073

针对导弹等武器系统设计过程中经常遇到的复杂异构模型仿真集成问题,提出了基于模型包装器的分布模型集成方案,论述了集成框架设计时遇到的关键技术,包括模型包装器(HLAWrapper)、模型接口规范以及应用数据模块技术,最后给出了异构模型... 详细信息

针对导弹等武器系统设计过程中经常遇到的复杂异构模型仿真集成问题,提出了基于模型包装器的分布模型集成方案,论述了集成框架设计时遇到的关键技术,包括模型包装器(HLAWrapper)、模型接口规范以及应用数据模块技术,最后给出了异构模型分布集成框架的实现。

关键词：集成框架 HLAWrapper 应用数据模块模型接口规范

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Chinese Herbal 912 Compound Improves Microcirculatory Disturbances Induced by Endotoxin in Rats

Chinese Herbal 912 Compound Improves Microcirculatory Distur...

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全国中青年中西医结合学术（英语）交流会议

作者： wang Hong Zhang shu-wen zhao li-yie wang bao-en Dept. of Infection and Critical Care Medicine , Beijing Friendship Hospital 100050 Beijing, China

The present study investigated the effects of herbal 912 compound on microcirculatory disturbance induced by endotoxin in rat mesentery. The changes of blood speed and leukocytes behavior in postvenule vessel after endotoxin injection were observed by videomicroscopy continuously during the experiments. Herbal 912 compound significantly prevent the decreased of blood speed, leukocytes adherence and leukocytes thrombi formation in mesenteric postvenule vessel The result indicated that herbal 912 compound has protective effects to improve the microcirculatory disturbances induced by endotoxin in rat mesentery.

关键词： Endotoximia Microcirculation Rat mesentery 912 compound

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di wang zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Electrochemical behavior of tantalum in ethylene carbonate and aluminum chloride solvate ionic liquid

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Transactions of Nonferrous Metals Society of China 2020年第8期30卷 2283-2292页

作者： Ai-min LIU Meng-xia GUO Zi-yang LÜ Bao-guo ZHANG Feng-guo LIU wen-ju TAO You-jian YANG Xian-wei HU zhao-wen wang Yu-bao LIU Zhong-ning SHI Key Laboratory for Ecological Metallurgy of Multimetallic Mineral Ministry of EducationNortheastern UniversityShenyang 110819China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

To investigate the electrochemical reduction mechanism of Ta(Ⅴ)in ethylene carbonate and aluminum chloride(EC-AlCl3)solvate ionic liquid,cyclic voltammetry experiments were conducted on a tungsten working *** reduction peaks were observed in the cyclic voltammogram of the EC-AlCl3-TaCl5 ionic *** reduction peaks at-0.55,-0.72,and-1.12 V(vs Al)were related to the reduction of Ta(Ⅴ)to tantalum metal by three stages including the formation of Ta(Ⅳ)and Ta(Ⅲ)complex *** reduction of Ta(Ⅲ)to tantalum metal was an irreversible diffusion-controlled reaction with a diffusion coefficient of 3.7×10^-7 cm^2/s at 323 K,and the diffusion activation energy was 77 k J/***,the cathode products at 323 K were characterized by scanning electron microscopy,energy-dispersive spectroscopy,and X-ray photoelectron *** results showed that tantalum metal and tantalum oxides were obtained by potentiostatic electrodeposition at-0.8 V for 2 h.

关键词： electrochemical behavior ionic liquid cyclic voltammetry aluminum chloride tantalum

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不同程度睡眠剥夺对大鼠认知和脑线粒体呼吸功能的影响

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神经科学通报 2005年第3期21卷 204-209页

作者：窦伟赵忠新缪明永王文昭黄流清第二军医大学长征医院神经内科上海200003 第二军医大学生物化学与分子生物学研究室上海200433

目的研究不同程度睡眠剥夺对大鼠认知和脑线粒体呼吸功能的影响。方法成年SD大鼠分为5组,分别为对照组(自由睡眠,约每天12 h),每天允许睡眠9 h组,每天允许睡眠6 h组,每天允许睡眠3 h组,全天不睡眠组即0 h组。连续10个实验日,以改良多平... 详细信息

目的研究不同程度睡眠剥夺对大鼠认知和脑线粒体呼吸功能的影响。方法成年SD大鼠分为5组,分别为对照组(自由睡眠,约每天12 h),每天允许睡眠9 h组,每天允许睡眠6 h组,每天允许睡眠3 h组,全天不睡眠组即0 h组。连续10个实验日,以改良多平台睡眠剥夺法实施睡眠剥夺,以Y-型迷宫测试认知功能,断头处死后以Clark氧电极法测定脑线粒体呼吸功能。结果错误反应次数在各睡眠剥夺组均有显著增加。全天不睡眠组(0 h组)和严重睡眠限制组(3 h组)的每个研究日的错误反应次数与对照组相比,差异均有显著性(P<0.05)。睡眠剥夺各组的呼吸Ⅲ态(state 3 respiration, ST3)耗氧率有明显下降,与对照组相比差异有显著性(P<0.05)。呼吸Ⅳ态(state 4 respiration, ST4)耗氧率,只有全天不睡眠组(0h组)和对照组相比有显著降低(P<0.05)。结论不同程度的睡眠剥夺均会对认知功能及脑线粒体呼吸功能造成不利影响。

关键词：睡眠剥夺大鼠认知功能脑线粒体呼吸功能神经功能线粒体

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Influence of gut bacteria on type 2 diabetes:Mechanisms and therapeutic strategy

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World Journal of Diabetes 2025年第1期16卷 27-33页

作者： Xue wen Lu-Ming Qi Kui zhao College of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina College of Materials and Chemical Engineering Southwest Forestry UniversityKunming 650224Yunnan ProvinceChina

The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic *** commentary examines the recent publication in World Journal of *** article explores the association between T2DM and gut microbiota,with a focus on the pathophysiological changes related to *** proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such *** editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic *** provides new insights for future research on gut-microbiota-based interventions for T2DM.

关键词： Type 2 diabetes Intestinal microbiome Intestinal axis Biological pathways Treatment Short-chain fatty acids

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基于四叉树的地形数据二维显示与交互

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系统仿真学报 2003年第9期15卷 1272-1275页

作者：雷永林赵雯王维平国防科技大学五院系统工程研究所长沙410073

地形是合成自然环境中重要的组成部分,地形的二维显示对于创建想定以及二维仿真具有重要的意义。本文根据地形二维显示中遇到的实际问题,提出了基于四叉树的地形二维显示框架,将不同类型、各种规模、各种格式、大数据量的地形数据用该... 详细信息

地形是合成自然环境中重要的组成部分,地形的二维显示对于创建想定以及二维仿真具有重要的意义。本文根据地形二维显示中遇到的实际问题,提出了基于四叉树的地形二维显示框架,将不同类型、各种规模、各种格式、大数据量的地形数据用该显示框架统一组织起来,实现地形图的动态生成,解决了地形图的动态交互显示及实时查询问题。

关键词：合成环境地形显示框架四叉树

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Root canal therapy combined with endoscopic sinus surgery for odontogenic sinusitis:Efficacy comparison in a cohort study

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World Journal of Clinical Cases 2025年第5期13卷 13-21页

作者： Jun-wen Xiao Ping Yu Zhang zhao Department of Stomatology Wuhan No.9 HospitalWuhan 430081Hubei ProvinceChina Department of Otorhinolaryngology People's Hospital of Xishui CountyHuanggang 438200Hubei ProvinceChina Department of Otorhinolaryngology Hubei No.3 People’s Hospital of Jianghan UniversityWuhan 430033Hubei ProvinceChina

BACKGROUND Odontogenic maxillary sinusitis,often triggered by dental issues like periapical periodontitis,significantly contributes to chronic sinusitis,mainly affecting adults around 50 years old,emphasizing the need for a multidisciplinary diagnostic and treatment *** To investigate the therapeutic effect and clinical value of root canal therapy combined with nasal endoscopic surgery compared with simple root canal the-rapy in the treatment of severe odontogenic maxillary sinusitis caused by peria-pical *** The clinical data,diagnosis,and treatment of 200 patients with severe odonto-genic maxillary sinusitis caused by periapical periodontitis from October 2020 to October 2021 were analyzed *** them,63 patients were treated with simple root canal therapy as the control group,and 137 patients were treated with root canal therapy combined with nasal endoscopic surgery as the observation *** therapeutic effect,Lund-Kennedy endoscopic score,paranasal sinus Lund-Mackay score,complication rate,recurrence rate,and patient satisfaction were compared between the two *** First,we compared the effective rates:23 cases were cured,22 were improved,and 8 were ineffective in the control group,yielding a total effective rate of 84.90%.Meanwhile,97 cases were cured,34 improved,and 6 were ineffective in the observation group,resulting in a total effective rate of 95.62%.The observation group had a higher total effective rate compared with the control group(P0.05)was observed in this score between the two *** treatment,the Lund–Kennedy endoscopic score decreased in both *** Lund–Kennedy endoscopic score of the observation group at 3 and 6 mo after treatment was lower compared to that of the control group(P<0.05).Third,we compared the Lund–Mackay score of paranasal *** treatment,there was no si

关键词： Root canal therapy Nasal endoscopic surgery Periapical periodontitis Odontogenic maxillary sinusitis Therapeutic effect Clinical value

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BKIP-1 is a novel regulatory protein critical to SLO-1 function in vivo

BKIP-1 is a novel regulatory protein critical to SLO-1 funct...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Bo-Jun CHEN,Qian GE,Hai-Ying ZHAN,zhao-wen wang Department of Neuroscience,University of Connecticut Health Center,Farmington,CT 06030

The BK channel is a large-conductance potassium channel gated by both membrane potential and intracellular *** is almost ubiquitously expressed and performs many important physiological functions,including shaping action potential wave form and regulating neurotransmitter *** *** BK channel SLO-1 is expressed in most,if not all,neurons and several types of muscles(body-wall,vulval,and anal depressor muscles).BK channel functional properties are tuned to specific cellular needs through a variety of mechanisms,including association with auxiliary/regulatory *** BK channel auxiliary/regulatory proteins have been identified in mammals(known asβ1-,β2-,β3,andβ4-subunits) and Drosophila(known as Slob and dSLEP1).However,none of them has obvious homologues in *** is likely that there are other unidentified BK channel auxiliary/regulatory *** an attempt to identify the putative additional BK channel auxiliary/regulatory proteins,we performed a genetic screen for mutants that suppressed the lethargic phenotype caused by expressing a slo-1 gain-of-function(gf) *** analysis led to the identification of bkip-1(BK channel interacting protein 1),which encodes a putative integrative membrane protein distinct from any of the known BK channel auxiliary/regulatory proteins,bkip-1 mutants completely or near completely suppressed the lethargic phenotype of slo-l(gf),and were grossly indistinguishable from slo-1 loss-of-function(lf) mutants in locomotion *** expression pattern of bkip-1 was grossly indistinguishable from that of *** of postsynaptic currents at the neuromuscular junction showed that neurotransmitter release was similarly increased in bkip-1(lf) mutant as in slo-1(lf) mutant,and that bkip-1(lf) eliminated an inhibitory effect of slo-l(gf) on neurotransmitter release,slo-1 transcription was normal but SLO-1 protein level in the nerve ring was significantly reduced in bkip-1 ***-express

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