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N-glycan biosignatures as a potential diagnostic biomarker for earlystage pancreatic cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 659-669页

作者： Yan-Rong wen Xia-wen Lin yu-wen zhou Lei Xu Jun-Li Zhang Cui-Ying Chen Jian He Department of Nuclear Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Research and Development Sysdiagno(Nanjing)Biotech Co.LtdNanjing 210008Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis,with a 5-year survival rate of less than 10%,owing to its late-stage *** detection of pancreatic cancer(PC)can significantly increase survival *** To identify the serum biomarker signatures associated with early-stage PDAC by serum N-glycan *** An extensive patient cohort was used to determine a biomarker signature,in-cluding patients with PDAC that was well-defined at an early stage(stages I and II).The biomarker signature was derived from a case-control study using a case-cohort design consisting of 29 patients with stage I,22 with stage II,4 with stage III,16 with stage IV PDAC,and 88 *** used multiparametric analysis to identify early-stage PDAC N-glycan signatures and developed an N-glycan sig-nature-based diagnosis model called the“Glyco-model”.RESULTS The biomarker signature was created to discriminate samples derived from patients with PC from those of controls,with a receiver operating characteristic area under the curve of *** addition,the biomarker signature combined with cancer antigen 19-9 could discriminate patients with PDAC from controls,with a receiver operating characteristic area under the curve of ***-model demonstrated favorable diagnostic performance in all stages of *** diagnostic sensitivity for stage I PDAC was 89.66%.Core Tip:This study employed a patient cohort to investigate the N-glycan signature of early-stage pancreatic cancer(PC).Serum N-glycans analysis was conducted to identify the serum biomarker signature associated with early-stage pancreatic ductal adenocarcinoma(PDAC),resulting in the identification of nine early-stage PDAC N-glycan ***,utilizing these biosignatures,a diagnostic model named the“Glyco-model”was developed,demonstrating promising diagnostic performance across all stages of *** study revealed that the diagnostic sensitivity for stage I PDAC was determined to be 89.66%.Co

关键词： Glycomics N-glycans Biomarkers Pancreatic cancer Predictive modeling

Synthesis and Ceramic Conversion of Polysiloxazane to Silicon Oxynitride

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Journal of Materials Science & Technology 2001年第1期17卷 3-4页

作者： Junbao ZHANG Tingquan LEI Guangwu wen and yu zhou School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China Harbin Inst Technol Sch Mat Sci & Engn Harbin 150001 Peoples R China

Amorphous silicon oxynitride powders have been obtained by pyrolysis of polysiloxazane in a stream of anhydrous NH3 at the temperature up to 1000℃. The polysiloxazane is fabricated from ammonolysis of chloropolysiloxane that is produced by the hydrolysis of silicon tetrachloride. The conversion of polysiloxazane to silicon oxynitride and the structural features of the final powders have also been studied by infrared spectra, elemental composition and X-ray diffraction analysis and SEM observation.

关键词： Silicon Oxynitride silicon oxynitride structural features infrared spectra

Therapeutic targets and interventional strategies in COVID-19:mechanisms and clinical studies

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2723-2747页

作者： yu-wen zhou Yao Xie Lian-Sha Tang Dan Pu Ya-Juan Zhu Ji-Yan Liu Xue-Lei Ma Department of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Biotherapy Cancer CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Dermatovenerology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Lung Cancer Center West China HospitalSichuan UniversityChengduSichuan ProvinceChina

Owing to the limitations of the present efforts on drug discovery against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the lack of the understanding of the biological regulation mechanisms underlying COVID-19,alternative or novel therapeutic targets for COVID-19 treatment are still urgently ***-CoV-2 infection and immunity dysfunction are the two main courses driving the pathogenesis of *** the virus and host factors are potential targets for antiviral ***,in this study,the current therapeutic strategies of COVID-19 have been classified into"target virus"and"target host" *** drugs,emerging approaches,and promising potential targets are the implementations of the above two ***,a comprehensive review of the highly acclaimed old drugs was performed according to evidence-based medicine to provide recommendations for ***,their unavailability in the fight against COVID-19 was ***,a profound analysis of the emerging approaches was conducted,particularly all licensed vaccines and monoclonal antibodies(mAbs)enrolled in clinical trials against primary SARS-CoV-2 and mutant ***,the pros and cons of the present licensed vaccines were compared from different ***,the most promising potential targets were reviewed,and the update of the progress of treatments has been summarized based on these reviews.

关键词： drugs clinical immunity

Immune checkpoint inhibitor-associated ophthalmic adverse events: current understanding of its mechanisms,diagnosis, and management

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 646-656页

作者： yu-wen zhou Qian Xu Yan Wang Ruo-Lan Xia Ji-Yan Liu Xue-Lei Ma Department of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Medical Publishers West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oncology West China Hospitalthe First People’s Hospital of Long Quan Yi DistrictChengdu 610041Sichuan ProvinceChina

Immune checkpoint inhibitors(ICIs) targeting cytotoxic T-lymphocyte antigen 4 and programmed cell death protein 1 receptor/ligand have revolutionized cancer treatment, achieving unprecedented efficacy in numerous malignancies. Despite the excellent therapeutic effects of ICIs, medications, such as pembrolizumab, ipilimumab, nivolumab, atezolizumab, avelumab, and durvalumab, typically cause a broad spectrum of toxicity events termed as immune-related adverse events(ir AEs). Out of all ir AEs, ophthalmic adverse events occur infrequently and are not comprehensively recognized. The current understanding of ophthalmic ir AEs is mainly derived from case reports and case series. In this review, based on relevant articles in the literature and current evidence, we summarize the incidences, manifestations, diagnoses, underlying mechanisms, treatments, and outcomes of ophthalmic ir AEs and discuss possible management strategies. A better understanding of these features is critical for managing patients with ICI-associated ophthalmic adverse events.

关键词： immune checkpoint inhibitor ophthalmological adverse events uveitis neuro-ophthalmic toxicity retinopathy

Numerical Simulation for Induction Refining Process of Metallurgical-Grade Silicon in Vacuum Furnace

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Journal of Iron and Steel Research International 2012年第S1期19卷 77-81页

作者： L Guo-qiang MA wen-hui WANG Hua yu wen-zhou YANG Xi Faculty of Metallurgy and Energy Engineering Kunming University of Science and Technology National Laboratory for Vacuum Metallurgy Kunming University of Science and Technology MOE's Engineering Research Center of Metallurgical Energy Conservation and Emission Reduction Kunming University of Science and Technology

The temperature and velocity distribution of melting pool fields is very important effect to the silicon purification in vacuum induction furnace.A numerical model for the electromagnetic-thermal-hydrodynamic coupling fields have been developed by using the finite element method(FEM)and a 2D numerical simulation for electromagnetic、 temperature and velocity fields of metallurgical-grade silicon melting in vacuum induction furnace were performed with a software Multi-physics Comsol 3.5a in this *** results showed that the temperature field was dependent observably on input power of coils and induction heating times and the maximum temperature gradient in melting pool was 215K in holding *** the silicon molted gradually a clockwise vortex was come into being for electromagnetic stirring in the smelting *** variation of velocity field in melting silicon is mainly influenced with the change of the current intensity and power *** numerical predications of temperature distribution are in good agreement with experiments.

关键词： metallurgical-grade silicon vacuum induction refining multi-fields coupling numerical simulation

Expansive effects of aorta-gonad-mesonephros-derived stromal cells on hematopoietic stem cells from embryonic stem cells

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Chinese Medical Journal 2005年第23期118卷 1979-1986页

作者： FU Jin-rong LIU wen-li zhou yu-feng zhou Jian-feng SUN Han-ying LUO Li ZHANG Hen XU Hui-zhen Department of Hematology Tongji Hospital Tongji Medical SchoolHuazhong University of Science and Technology Wuhan 430030China

Background Hematopoietic stem cells （HSCs） give rise to all blood and immune cells and are used in clinical transplantation protocols to treat a wide variety of refractory diseases, but the amplification of HSCs has been difficult to achieve in vitro. In the present study, the expansive effects of aorta-gonad-mesonephros （AGM） region derived stromal cells on HSCs were explored, attempting to improve the efficiency of HSC transplantation in clinical practice.Methods The murine stromal cells were isolated from the AGM region of 12 days postcoitum （dpc） murine embryos and bone marrow（BM） of 6 weeks old mice, respectively. After identification with flow cytometry and immunocytochemistry, the stromal cells were co-cultured with ESCs-derived, cytokines-induced HSCs. The maintenance and expansion of ESCs-derived HSCs were evaluated by detecting the population of CD34^＋ and CD34^＋ Sca-1^＋ cells with flow cytometry and the blast colony-forming cells （BL-CFCs）, high proliferative potential colony-forming cells （HPP-CFCs） by using semi-solid medium colonial culture. Finally, the homing and hematopoietic reconstruction abilities of HSCs were evaluated using a murine model of HSC transplantation in vivo.Results AGM and BM-derived stromal cells were morphologically and phenotypically similar, and had the features of stromal cells. When co-cultured with AGM or BM stromal cells, more primitive progenitor cells （ HPP-CFCs ） could be detected in ESCs derived hematopoietic precursor cells, but BL-CFC＇ s expansion could be detected only when co-cultured with AGM-derived stromal cells. The population of CD34^＋ hematopoietic stem/ progenitor cells were expanded 3 times, but no significant expansion in the population of CD34^＋ Sca-1^＋ cells was noted when co-cultured with BM stromal cells. While both CD34^＋ hematopoietic stem/progenitor cells and CD34^＋ Sca-1^＋ cells were expanded 4 to 5 times respectively derived stromal cells, like BM-derived stromal cells, homing to BM in vivo. whe

关键词： hernatopoietic stern cells· embryonic stern cells· strornal cells

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纳米复合氧化物催化发光法测定空气中的甲醛

化学学报 2008年第8期66卷 943-946页

作者：周考文周宇孙月田雪娇北京联合大学生物化学工程学院北京100023

基于纳米复合氧化物上甲醛被催化氧化产生化学发光的现象,建立了直接测定空气中微量甲醛的方法.实验发现,甲醛在许多纳米级金属氧化物表面都有发光现象,但在纳米级钼钒钛(原子比为2∶3∶5)复合氧化物表面上有较高的发光强度和较好的选择... 详细信息

基于纳米复合氧化物上甲醛被催化氧化产生化学发光的现象,建立了直接测定空气中微量甲醛的方法.实验发现,甲醛在许多纳米级金属氧化物表面都有发光现象,但在纳米级钼钒钛(原子比为2∶3∶5)复合氧化物表面上有较高的发光强度和较好的选择性.最佳实验条件为:分析波长535nm,测定温度265℃,载气流速150mL/min.方法的检测限(3σ)为0.04mg/m3,线性范围为0.07～34mg/m3,相关系数为0.9994,回收率为98.2%～101.4%.对常见共存物的研究发现,除丙酮外,苯、氨、二氧化硫和乙醇不干扰测定.

关键词：甲醛催化发光纳米复合氧化物

Lung transplantation in a Chinese single center： 7 years of experience

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Chinese Medical Journal 2011年第7期124卷 978-982页

作者： HE wen-xin JIANG Ge-ning DING Jia-an GAO wen ZHU yu-ming zhou Xiao CHEN Chang WANG Hao FAN Jiang ZHANG Peng LIU Ming Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of Medicine Shanghai Key Laboratoryof Organ Transplantation Shanghai 200433 China

Background Lung transplantation （LT） is a viable option for patients with end-stage lung diseases, but in China, the supply is limited, and the experience with LT is rare too. This study aimed to evaluate the surviv... 详细信息

关键词： lung transplantation China survival complications

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大规模接种下接种单位服务能力配置研究进展

中国公共卫生 2021年第12期37卷 1827-1830页

作者：耿淑帆余文周中国疾病预防控制中心免疫规划中心免疫服务室北京100050

大规模接种下,接种单位需承担常规接种以外的接种任务,接种单位可能需扩增服务能力。研究表明疫苗冷藏容积、接种人员数量和门诊面积是接种单位服务能力的关键方面。本文重点关注以上3方面,综述接种单位服务能力的配置标准和需求测算方... 详细信息

大规模接种下,接种单位需承担常规接种以外的接种任务,接种单位可能需扩增服务能力。研究表明疫苗冷藏容积、接种人员数量和门诊面积是接种单位服务能力的关键方面。本文重点关注以上3方面,综述接种单位服务能力的配置标准和需求测算方法研究,总结接种单位服务能力现存问题,探讨现存问题对大规模接种可能产生的影响并讨论解决方法。

关键词：大规模接种接种单位服务能力