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Computational design of ratiometric two-photon fluorescent Zn2+probes based on quinoline and di-2-picolylamine moieties

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Chinese Physics B 2022年第5期31卷 253-260页

作者： Zhe Shao wen-ying zhang Ke Zhao School of Physics and Electronics Shandong Normal UniversityJinan 250358China

To improve two-photon absorption(TPA)response of a newly synthesized probe,a series of ratiometric two-photon fluorescent Zn^(2+) sensors based on quinoline and DPA moieties have been *** one-photon absorption,TPA,and emission properties of the experimental and designed probes before and after coordination with Zn^(2+) are investigated employing the density functional theory in combination with response *** design consists of two *** the first level of design,five probes are constructed through using several electron acceptors or donors to increase accepting or donating ability of the *** shows that all the designed probes have stronger TPA intensities at longer wavelengths with respect to the experimental probe because of the increased intra-molecular charge ***,it is found that the probe 4 built by adding an acyl unit has the largest TPA cross section among the designed structures due to the form of longer conjugated length and more linear *** dimethylamino terminal attached along the skeleton can improve TPA intensity more efficiently than two side amino ***,in the second level of design,a new probe 7 is formed by both an acyl unit and a dimethylamino *** exhibits that the TPA cross sections of probe 7 and its zinc complex increase ***,the fluorescence quantum yields of the designed probes4 and 7 are calculated in a new way,which makes use of the relation between the computed difference of dipole moment and the measured fluorescence quantum *** result shows that our design also improves the fluorescence quantum yield *** in all,the designed probes 4 and 7 not only possess enhanced TPA intensities but also have large differences of emission wavelength upon Zn^(2+) coordination and strong fluorescence intensity,which demonstrates that they are potential ratiometric two-photon fluorescent probes.

关键词： two-photon absorption fluorescent probe zinc ion intra-molecular charge transfer

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Endoscopic ultrasound-guided ethanol ablation therapy for tumors

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World Journal of Gastroenterology 2013年第22期19卷 3397-3403页

作者： wen-ying zhang Zhao-Shen Li Zhen-Dong Jin Department of Gastroenterology Changhai Hospital Second Military Medical University

Endoscopic ultrasonography (EUS) has evolved into a useful therapeutic tool for treating a broad range of tumors since being introduced into clinical practice as a diagnostic modality nearly three decades ago. In particular, EUS-guided fine-needle injection has proven a successful minimally invasive approach for treating benign lesions such as pancreatic cysts, relieving pancreatic pain through celiac plexus neurolysis, and controlling local tumor growth of unresectable malignancies by direct delivery of anti-tumor agents. One such ablative agent, ethanol, is capable of safely ablating solid or cystic lesions in hepatic tissues via percutaneous injection. Recent research and clinical interest has focused on the promise of EUS-guided ethanol ablation as a safe and effective method for treating pancreatic tumor patients with small lesions or who are poor operative candidates. Although it is not likely to replace radical resection of localized lesions or systemic treatment of metastatic tumors in all patients, EUS-guided ablation is an ideal method for patients who refuse or are not eligible for surgery. Moreover, this treatment modalitymay play an active role in the development of future pancreatic tumor treatments. This article reviews the most recent clinical applications of EUS-guided ethanol ablation in humans for treating pancreatic cystic tumors, pancreatic neuroendocrine tumors, and metastatic lesions.

关键词： Endoscopic ultrasonography Ethanol Tumor ablation Pancreas cancer Cystic tumor Neuroendocrine tumors Celiac plexus neurolysis

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Energy-optimal problem of multiple nonholonomic wheeled mobile robots via distributed event-triggered optimization algorithm

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Chinese Physics B 2019年第3期28卷 122-129页

作者： ying-wen zhang Jin-Huan Wang Yong Xu De-Dong Yang School of Science Hebei Province Key Laboratory of Big Data CalculationHebei University of TechnologyTianjin 300401China School of Artificial Intelligence Hebei University of TechnologyTianjin 300401China

The distributed event-triggered optimization problem for multiple nonholonomic robots has been studied to minimize the global battery energy consumption. Each robot possesses its own cost function which depends on the state of the hand position and represents battery energy consumption. By coordinate transformation, the dynamics of the hand positions can be formulated into two groups of first-order integrators. Then the distributed event-triggered optimization algorithm is designed such that the states of robots' hand positions exponentially converge to the optimizer of the global cost ***, the velocity and orientation of each robot are ensured to reach zero and a certain constant, respectively. Moreover, the inter-execution time is lower bounded and the Zeno behavior is therefore naturally avoided. Numerical simulations show the effectiveness of the proposed algorithm.

关键词： distributed optimization nonholonomic robots event-triggered energy-optimal consensus

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Saponin from Tupistra chinensis Bak Inhibits NF-κB Signaling in Sarcoma S-180 Cell Mouse Xenografts

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Current Medical Science 2018年第4期38卷 697-703页

作者： Tai-sheng YE Xiu-ping WANG Xian-mei zhang Man-ling zhang ying-wen zhang Department of Traditional Chinese Medicine Zhongnan Hospital Wuhan University Wuhan 430071 China Department of Integrated Traditional Chinese Medicine the Third Hospital of Wuhan Wuhan 430062 China

This study examined the effect of saponins from Tupistra chinensis Bak （STCB） on the growth of sarcoma S-180 cells in vitro and in mouse xenografts as well as the underlying mechanisms. Cell proliferation was assessed by MTT assay. Cell cycle distribution was determined by flow cytometry. Sarcoma S-180 tumor-bearing mice were treated with different doses of STCB with 10 μg/mL 5-fluorouracil （5-Fu） as a positive control. The activity of nuclear factor （NF）-κB was detected by gel mobility shift assay. The mRNA level of NF-κB was determined by real-time quantitative RT-PCR. The results showed that in vitro STCB inhibited the growth of S-180 cells in a concentration-dependent manner, which was accompanied by cell cycle arrest at S-phase. In vivo STCB significantly inhibited the growth of S-180 tumor mouse xenografts in a dose-dependent manner with apparent induction of cell apoptosis. Moreover, STCB inhibited the activity of NF-rd3 p65 and reduced the expression of NF-κB p65 mRNA in mouse xenografts. It was concluded that STCB inhibits the proliferation and cell cycle progression of S- 180 cells by suppressing NF-κB signaling in mouse xenografts. Our findings suggest STCB is a promising agent for the treatment of sarcoma.

关键词： Tupistra chinensis Bak S-180 cells proliferation nuclear factor-κB

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Validity and reliability testing of the Chinese (mainland) version of the 39-item Parkinson's Disease Questionnaire (PDQ-39)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第7期11卷 531-538页

作者： Wei LUO Xiao-hong GUI Bo WANG wen-ying zhang Zhi-yuan OUYANG Yi GUO Bao-rong zhang Mei-ping DING Department of Neurology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

The 39-item Parkinson's Disease Questionnaire (PDQ-39) has been tested in many languages, but not in Chinese mainland. We aimed to assess the Chinese (mainland) version of the PDQ-39. Seventy-one subjects with Parkinson's disease (PD) completed the PDQ-39 and the Medical Outcomes Study 36-item Short Form Health Survey (SF-36). All subjects were retested with the PDQ-39 a week later. The united Parkinson's disease rating scale (UPDRS) and the Hoehn and Yahr (H & Y) scale were also used to evaluate the subjects. Reliability was assessed by Cron- bach's α and intra-class correlation coefficient (ICC). Validity was examined in terms of agreement with SF-36, UPDRS, and H & Y scales. The Chinese (mainland) version of the PDQ-39 demonstrated acceptable reliability (Cronbach's α: 0.84-0.88; ICC: 0.56-0.82). The item-total correlations (0.33-0.88) and scaling success rates (77.56%) indicated satisfactory convergent and discriminant validity of the PDQ-39 items. The correlations between related constructs of the PDQ-39 and UPDRS (r=0.44-0.68) and between those of the PDQ-39 and SF-36 (r=(-0.46)-(-0.69)) were all statistically significant (P<0.01). Except for stigma, cognitions, and bodily discomfort, all other dimensions of the PDQ-39 significantly discriminated patients at different H & Y stages indicated by the H & Y scale. Although our observations indicate that some problematic subscales of this version of the PDQ-39 could be improved upon, this study suggests acceptable reliability and validity of the Chinese (mainland) version of the PDQ-39.

关键词： 39-item Parkinson’s Disease Questionnaire (PDQ-39) Quality of life Validity Reliability

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Proteiomic patterns for endometrial cancer using SELDI-TOF-MS

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第4期9卷 286-290页

作者： Li-rong ZHU wen-ying zhang Li YU Yan-hua ZHENG Jun HU Qin-ping LIAO Department of Gynecology Peking University First Hospital Beijing 100034 China Department of Gynecology 306 Hospital of People＇s Liberation Army Beijing 100101 China Department of Pathology 306 Hospital of People＇s Liberation Army Beijing 100101 China

Serum samples from endometrial cancer (EC) patients and healthy females were analyzed using surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) to discover the potential diagnostic biomarker for detection of EC. A preliminary training set of spectra derived from 40 EC patients and 30 healthy women were used to develop a proteomic model that effectively discriminated cancer patients from healthy women. The training set had a specificity of 100% and sensitivity of 92.5% in the EC detection. A blind test set, including 20 new cancer cases and 10 healthy women, was used to validate the sensitivity and specificity of this multivariate model, which had a corresponding results of 60% in specificity and 75% in sensitivity, respectively. The combination of SELDI-TOF-MS with bioinformatics tools could help find new biomarkers and establish the detection of EC with high sensitivity and specificity.

关键词： Biomarkers Surface-enhanced laser desorption-ionization time-of-flight mass spectrometry (SELDI-TOF-MS) Endometrial cancer (EC) Proteomics

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Characteristics of soil enzymes and the dominant species of repair trees in the reclamation of coal mine area

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 256-261页

作者： wen-ying zhang Duo-Xi YAO Zhi-Guo zhang Qing YANG Kui ZHAO Shi-Kai AN School of Earth and Environment Anhui University of Science and Technology Huainan 232001 China Department of Ecology and Environment Coal Engineering Technology Research Institute Huainan 232001 China

In order to study the soil enzyme content at the mine reclamation area and choose a tree species with superior restoration capabilities, this paper takes Huainan Datong Mine as the study area, and five different enzymes under nine tree species as the study subject. The different enzyme activity indexes were measured, and the correlation analysis and the principal component analysis （PCA） method were applied to evaluate and screen the tree species with advanced restoration. The results demonstrate that there are some correlations among the different soil enzymes, including some very significant positive correlations among urease, phosphatase, invertase and protease. The best species in terms of repair is privet, and the worst is Haltong. This study provides a scientific basis for the selection of restoration-capable tree species in the reclamation area of the coal mine.

关键词： reclamation area coal mine soil enzyme correlation analysis principal component analysis

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Long-term safety and efficacy of CART-20 cells in patients with refractory or relapsed B-cell non-Hodgkin lymphoma:5-years follow-up results of the phase I and IIa trials

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Signal Transduction and Targeted Therapy 2017年第1期2卷 85-88页

作者： wen-ying zhang Yang Liu Yao Wang Chun-meng Wang Qing-ming Yang Hong-li Zhu Wei-dong Han Biotherapeutic Department Chinese PLA General HospitalBeijingChina Department of Geriatric Hematology Chinese PLA General HospitalBeijingChina Department of Immunology Institute of Basic MedicineSchool of Life SciencesChinese PLA General HospitalBeijingChina

For refractory or relapsed(r/r)B-cell non-Hodgkin lymphoma(NHL),the response rates to conventional salvage chemotherapy are 27–44%.1 Chimeric antigen receptors(CARs)efficiently redirect T-cell specificity and cytotoxicity to cells expressing the targeted Ag in an HLA-independent manner.2 The early phase clinical trials of CART cells for(r/r)B-cell NHL have demonstrated promising results..

关键词： lymphoma specificity chemotherapy

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Application of Ultra-low-dose Incremental Gn Protocol in Controlled Ovarian Hyperstimulation of the Patients with Ovary Hyperreaction

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Journal of Reproduction and Contraception 2009年第3期20卷 145-152页

作者： Liang ZHU Song QUAN Fu-qi XING wen-ying zhang Department of Gynecology & Obstetrics the 306 Hospital of PLA Beijing 100101 China Assisted reproductive center Nan-fang Hospital Guangzhou 510515 China

Objective To explore the clinical outcome of ultra-low-dose incremental protocol in the controlled ovarian hyperstimulation （COH） for the ovary hyperreaction patient. Methods A prospective, randomized, controlled study was conducted between June 2006 and February 2008 on 120 women who underwent COH. The patients＇ clinic outcomes were compared between ultra-low-dose incremental protocal （experimental group, n=60） and other ovulation stimulating protocols （control group, n=60）. Results The mean number of large follicles （≥14 mm） on the day of oocytes retrivaling, the mean number of harvested oocytes and the incidence rate of OHSS were significantly lower in experimental group. However, the gonadotropin stimulating time was significantly longer in experimental group. And the rate of leading follicle punctuation was also higher in this group when compared with control group. The clinical pregnant rate, the mean number of gonadotropin ampoules, the cancel rate were similar in the two groups. Conclusion The application of ultra-low-dose incremental protocal in the COH for the ovarian hyperreaction patients is able to effectively reduce the risk of occurrence of OHSS under the precondition of assurance of pregnancy rate. It is a safe and more effective COH program.

关键词： incremental protocol ovarian hyperreaction COH

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Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma:an early phase IIa trial report

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Signal Transduction and Targeted Therapy 2016年第1期1卷 131-139页

作者： wen-ying zhang Yao Wang Ye-lei Guo Han-ren Dai Qing-ming Yang Ya-jing zhang Yan zhang Mei-xia Chen Chun-meng Wang Kai-chao Feng Su-xia Li Yang Liu Feng-xia Shi Can Luo Wei-dong Han Biotherapeutic Department Chinese PLA General HospitalBeijingChina Department of Immunology Institute of Basic MedicineSchool of Life SciencesChinese PLA General HospitalBeijingChina Department of Geriatric Hematology Chinese PLA General HospitalBeijingChina

Patients with relapsed or refractory non-Hodgkin lymphoma have a dismal *** Antigen Receptor(CAR)-modified T cells(CART cells)that targeted CD20 were effective in a phase I clinical trial for patients with advanced B-cell *** performed a phase IIa trial to further assess the safety and efficacy of administering autologous anti-CD20 CART(CART-20)cells to patients with refractory or relapsed CD20^(+)B-cell *** patients were enrolled,and seven patients underwent cytoreductive chemotherapy to debulk the tumors and deplete the lymphocytes before receiving T-cell *** overall objective response rate was 9 of 11(81.8%),with 6 complete remissions(CRs)and 3 partial remissions;no severe toxicity was *** median progression-free survival lasted for 46 months,and 1 patient had a 27-month continuous CR.A significant inverse correlation between the levels of the CAR gene and disease recurrence or progression was ***,the lesions in special sites,specifically the spleen and testicle,were refractory to CART-20 ***,these results together with our data from phase I strongly demonstrated the feasibility and efficacy of CART-20 treatment in lymphomas and suggest large-scale patient recruitment in a future *** study was registered at *** as NCT01735604.

关键词： patients lymphoma Antigen

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