Application of Ultra-low-dose Incremental Gn Protocol in Controlled Ovarian Hyperstimulation of the Patients with Ovary Hyperreaction
Application of Ultra-low-dose Incremental Gn Protocol in Controlled Ovarian Hyperstimulation of the Patients with Ovary Hyperreaction作者机构：Department of Gynecology & Obstetrics the 306 Hospital of PLA Beijing 100101 China Assisted reproductive center Nan-fang Hospital Guangzhou 510515 China
出 版 物：《Journal of Reproduction and Contraception》 (生殖与避孕（英文版）)
年 卷 期：2009年第20卷第3期
页 面：145-152页
学科分类：0710[理学-生物学] 0832[工学-食品科学与工程（可授工学、农学学位）] 07[理学] 08[工学] 071002[理学-动物学] 083203[工学-农产品加工及贮藏工程]
主 题：incremental protocol ovarian hyperreaction COH
摘 要：Objective To explore the clinical outcome of ultra-low-dose incremental protocol in the controlled ovarian hyperstimulation （COH） for the ovary hyperreaction patient. Methods A prospective, randomized, controlled study was conducted between June 2006 and February 2008 on 120 women who underwent COH. The patients＇ clinic outcomes were compared between ultra-low-dose incremental protocal （experimental group, n=60） and other ovulation stimulating protocols （control group, n=60）. Results The mean number of large follicles （≥14 mm） on the day of oocytes retrivaling, the mean number of harvested oocytes and the incidence rate of OHSS were significantly lower in experimental group. However, the gonadotropin stimulating time was significantly longer in experimental group. And the rate of leading follicle punctuation was also higher in this group when compared with control group. The clinical pregnant rate, the mean number of gonadotropin ampoules, the cancel rate were similar in the two groups. Conclusion The application of ultra-low-dose incremental protocal in the COH for the ovarian hyperreaction patients is able to effectively reduce the risk of occurrence of OHSS under the precondition of assurance of pregnancy rate. It is a safe and more effective COH program.
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