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World Journal of Gastroenterology 2024年第38期30卷 4232-4238页

作者： Yi-Fan Jia Fei-Fan Chen Li yang Yun-Xia Ye Yi-Zhu Gao wen-yan zhang Jin-Lin yang Department of Gastroenterology and Hepatology University of Oxford Huaxi Joint Centre for Gastrointestinal CancerFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Emergency West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Composite tumors are neoplasms comprising two distinct,yet intermingling,cell *** paper reports a rare phenomenon where early gastric signet-ring cell carcinoma(SRCC)and gastric mucosa-associated lymphoid tissue(MALT)lymphoma coexist within the same *** SUMMARY A 40-year-old woman presented to the West China Hospital for examination,which revealed a whitish,shallow,and uneven mucosal lesion in the *** lesion was diagnosed as a poorly differentiated adenocarcinoma,including SRCC with atypical lymphoid hyperplasia associated with Helicobacter pylori infection,based on histopathological examination of the biopsy *** lesion was excised using segmental ***,histological exami-nation of the surgical specimen confirmed that it was a poorly differentiated gastric adenocarcinoma with features of SRCC and MALT *** two entities were stage I and coexisted in the same *** It is uncommon for gastric SRCC and MALT lymphoma to coexist without distinct *** resection is effective for these lesions.

关键词： Gastric cancer Composite tumors Early stage Signet-ring cell carcinoma Mucosa-associated lymphoid tissue lymphoma Case report

On Ekeland's Variational Principle for Set-Valued Mappings

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 141-148页

作者： Sheng-jie Li wen-yan zhang College of Mathematics and Science Chongqing University Chongqing 400044 China

In this paper, we derive a general vector Ekeland variational principle for set-valued mappings, which has a dosed relation to εk^0 -efficient points of set-valued optimization problems. The main result presented in ... 详细信息

关键词： Vector Ekeland variational principle nonlinear scalarization function metric space set-valued mapping

The Subvariety Lattice of the Join of Two Semigroup Varieties

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Acta Mathematica Sinica,English Series 2009年第6期25卷 971-982页

作者： wen Ting zhang yan Feng LUO Department of Mathematics Lanzhou University Lanzhou 730000 P. R. China

The join A ∨ B of two semigroup varieties A and B is investigated. The latrine of subvarieties of A ∨ B is completely described, It is shown that this lattice is finite and non-modular and that all varieties in it a... 详细信息

关键词： semigroups varieties identities lattice

DNA Sequencing by Capillary Electrophoresis Using Quasi-inter-penetrating Network Formed by Polyacrylamide and Poly(N-hydroxymethylacrylamide)

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Chinese Chemical Letters 2006年第8期17卷 1061-1064页

作者： wen Long zhang yan Mei WANG Department of Polymer Science and Engineering University of Science and Technology of China Hefei 230026

Quasi-interpenetrating network formed by polyacrylamide and poly （N-hydroxymethylacrylamide） was designed, synthesized, and tested for DNA sequencing by capillary electrophoresis. The performance of quasi-IPN on DNA... 详细信息

关键词： Capillary electrophoresis DNA sequencing quasi-interpenetrating network.

Response of nearshore circulation outside yangtze Estuary to El Nino events

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Water Science and Engineering 2016年第2期9卷 145-154页

作者： wen-yan zhang Zheng Gong Chang-kuan zhang Wei Tan State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 China CCCC Third Harbor Consultants Co. Ltd. Shanghai 210030 China Jiangsu Key Laboratory of Coast Ocean Resources Development and Environment Security Hohai University Nanjing 210098 China

With consideration of the comprehensive effects of runoff from the yangtze River, East China Sea background circulation, and tidal currents,a regional circulation model, including the yangtze Estuary, Hangzhou Bay, and adjacent sea areas was established. The 2002/2003 El Ni^no event was chosen for study of the anomalies of circulation outside the yangtze Estuary. The coastal and ocean current systems of the East China Sea and the current structure outside the yangtze Estuary were accurately described. The results of vertical circulation analysis basically coincide with those of horizontal circulation analysis, showing that the circulation outside the yangtze Estuary is mainly affected by the Taiwan warm current, runoff from the yangtze Estuary, and the tide-induced residual current. The El Ni^no event weakens yangtze Estuary circulation to a certain degree, and the impacts are more significant in summer than in winter. During the 2002/2003 El Ni^no event, the flux of the Taiwan warm current decreases, and the northward component of the Taiwan warm current decreases by half in February 2003 compared to the previous year. However, its path is relatively stable.

关键词： El Nino Princeton ocean model yangtze Estuary Circulation Taiwan warm current

Clinicopathological analysis of paraganglioma with literature review

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World Journal of Gastroenterology 2009年第24期15卷 3003-3008页

作者： Ning Feng wen-yan zhang Xiao-Ting Wu Department of Gastrointestinal Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Pathology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM： To investigate the 152 cases of paragangliomas resected over the past 32 years in West China Hospital dinicopathologically.METHODS： All cases of paragangliomas diagnosed at the Department of Gastrointestinal Surgery and Department of Pathology, West China Hospital, China were reviewed. The pathological documents were supplied by the Department of Pathology, West China Hospital, and other necessary data were extracted from the hospital records. The statistical analyses were performed by survival analysis （Kaplan-Meier method）, descriptive statistical analyses and Х^2 analysis.RESULTS： The neuroendocrine marker vimentin was found to be selectively expressed in the benign tumors, and there were significant differences in the expression of those markers in both benign and malignant tumors. The survival analysis revealed that survival correlated significantly with the malignancy, metastasis and nodal status.CONCLUSION： Vimentin may be useful in the differential diagnosis between malignant and benign tumors. The difference in the expression of this marker in the tumors could be a clue to the future clinical diagnosis. The malignancy, metastasis and the nodal status may predict the prognosis of this disease.

关键词： Paraganglioma Retroperitoneal tumor Carcinoma Neuroendocrine tumors Neuroendocrine peptide Vimentin Survival analysis

Clinical and genetic diagnosis of autosomal dominant osteopetrosis typeⅡin a Chinese family:A case report

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World Journal of Clinical Cases 2023年第3期11卷 700-708页

作者： Hong-Ping Gong yan Ren Pan-Pan Zha wen-yan zhang Jin zhang Zhi-wen zhang Chun Wang International Medical Center Ward General Practice Medical CenterSichuan University West China HospitalChengdu 610041Sichuan ProvinceChina Department of Endocrinology and Metabolism Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endocrinology and Metabolism The People’s Hospital of LeshanLeshan 614003Sichuan ProvinceChina

BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of ***,80%of autosomal dominant osteopetrosis type II(ADO-II)patients were usually affected by heterozygous dominant mutations in the chloride voltage-gated channel 7(ClCN7)gene and present early-onset osteoarthritis or recurrent *** this study,we report a case of persistent joint pain without bone injury or underlying *** SUMMARY We report a 53-year-old female with joint pain who was accidentally diagnosed with *** clinical diagnosis was based on increased bone density and typical radiographic *** heterozygous mutations in the ClCN7 and Tcell immune regulator 1(TCIRG1)genes by whole exome sequencing were identified in the patient and her *** missense mutation(c.857G>A)occurred in the CLCN7 gene p.R286Q,which is highly conserved across *** TCIRG1 gene point mutation(c.714-20G>A)in intron 7(near the splicing site of exon 7)had no effect on subsequent *** This ADO-II case had a pathogenic CLCN7 mutation and late onset without the usual clinical *** the diagnosis and assessment of the prognosis for osteopetrosis,genetic analysis is advised.

关键词： Osteopetrosis Autosomal dominant osteopetrosis typeⅡ Diagnosis Genetic analysis Case report

Sub-picosecond electron bunch length measurement using coherent transition radiation at SXFEL

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Nuclear Science and Techniques 2018年第5期29卷 104-109页

作者： Yu Bian wen-yan zhang Bo Liu Dong Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Longitudinal electron bunch length plays a significant role in single-pass free-electron lasers(FEL), as the high-gain FEL process depends strongly on the high peak current of electron bunches. Longitudinal electron bunch length was measured by detecting the interferogram of coherent transition radiation generated by electron bunches using a THz interferometer and a Golay cell(spectral range0.02-20 THz) at Shanghai X-ray free-electron laser. The detailed process of measurement and data analysis are discussed herein. Furthermore, the electron bunch length was estimated based on the dispersive strength R_(56) of the bunch compressor and the energy spread δ of electron bunches, which were obtained via experiments. The comparison showed that the measured bunch length was consistent with the estimated bunch length.

关键词： Electron bunch length THz interferometer Coherent transition radiation Beam diagnostics

Antitumor triterpene saponins from Anemone flaccida

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Chinese Chemical Letters 2008年第2期19卷 190-192页

作者： Lan Tian zhang yan wen zhang Yoshihisa Takaishi Hong Quan Duan School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China School of Pharmaceutical Sciences Basic Medical Research Center of Tianjin Tianjin Medical University Tianjin 300070 China Faculty of Pharmaceutical Sciences University of Tokushima Shomachi 1-78 Tokushima 770-8505 Japan

A new triterpenoid saponin, 3-O-[（6′-butyryl）-β-D-glucopyranosyl]-28-O-[α-L-rhamnopyranosyl-（1→4）-β-D-glucopyranosyl-（1→6）-β-D-glucopyranosyl] oleanolic acid, as well as three known triterpenoid saponins were isolated from the rhizomes of Anemone flaccida. Their structures were elucidated by spectroscopic methods. These compounds showed significant antitumor activities.

关键词： Anemone flaccida Triterpene saponins Cytotoxic activities

Multi-objective optimization and experiment of nylon cord rubber in expandable packer

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Petroleum Science 2021年第1期18卷 269-284页

作者： yan-wen zhang Han-Xiang Wang Jia-Qi Che Ming-Chao Du Hong-Jie zhang College of Mechanical and Electronic Engineering China University of Petroleum(East China)Qingdao 266580ShandongChina

Nylon cord rubber has the advantages of small residual deformation and is easy to lift and lower the tubing string in low-permeability oil and gas ***,it is associated with low-pressure resistance and poor sealing *** enhance the performance of nylon cord rubber,a three-dimensional numerical model of the nylon cord rubber was established and its accuracy experimentally *** Plackett-Burman test,the Steepest climbing test and the Response surface method were used to acquire the polynomial response surface model connecting structural parameters with bearing and sealing *** genetic algorithms,optimal structural parameters of nylon cord rubber were determined depending on field *** reliability of the optimized results was verified by laboratory *** was shown that after optimization,the bearing capacity of the expandable packer increased by 25%while the sealing performance increased by 66%.In addition,the bearing pressure was 70 MPa while the sealing pressure was 50 *** measurements effectively met the on-site requirements of high-pressure and fine fracturing in low-permeability oil and gas reservoirs.

关键词： Low-permeability reservoirs Nylon cord rubber Numerical simulation Response surface method Multi-objective genetic algorithm Laboratory test