Clinicopathological analysis of paraganglioma with literature review

作     者：Ning Feng Wen-Yan Zhang Xiao-Ting Wu 

作者机构：Department of Gastrointestinal Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Pathology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第24期

页      面：3003-3008页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 090502[农学-动物营养与饲料科学] 1002[医学-临床医学] 07[理学] 0905[农学-畜牧学] 09[农学] 

主　　题：Paraganglioma Retroperitoneal tumor Carcinoma Neuroendocrine tumors Neuroendocrine peptide Vimentin Survival analysis 

摘      要：AIM： To investigate the 152 cases of paragangliomas resected over the past 32 years in West China Hospital dinicopathologically. METHODS： All cases of paragangliomas diagnosed at the Department of Gastrointestinal Surgery and Department of Pathology, West China Hospital, China were reviewed. The pathological documents were supplied by the Department of Pathology, West China Hospital, and other necessary data were extracted from the hospital records. The statistical analyses were performed by survival analysis （Kaplan-Meier method）, descriptive statistical analyses and Х^2 analysis. RESULTS： The neuroendocrine marker vimentin was found to be selectively expressed in the benign tumors, and there were significant differences in the expression of those markers in both benign and malignant tumors. The survival analysis revealed that survival correlated significantly with the malignancy, metastasis and nodal status. CONCLUSION： Vimentin may be useful in the differential diagnosis between malignant and benign tumors. The difference in the expression of this marker in the tumors could be a clue to the future clinical diagnosis. The malignancy, metastasis and the nodal status may predict the prognosis of this disease.