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Global research trends in cardiac arrest research:a visual analysis of the literature based on CiteSpace

World Journal of Emergency Medicine 2022年第4期13卷 290-296页

作者： Shi-jiao Yan Mei Chen Jing wen wen-ning fu Xing-yue Song Huan-jun Chen Ri-xing Wang Mei-ling Chen Xiao-tong Han Chuan-zhu Lyu School of Public Health Hainan Medical UniversityHaikou 570100China Research Unit of Island Emergency Medicine Chinese Academy of Medical Sciences(No.2019RU013)Hainan Medical UniversityHaikou 570100China Guizhou Center for Disease Control and Prevention Guiyang 550004China School of Nursing Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Key Laboratory of Emergency and Trauma Ministry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China Department of Emergency Hainan Clinical Research Center for Acute and Critical Diseasesthe Second Affiliated Hospital of Hainan Medical UniversityHaikou 570100China Emergency and Trauma College Hainan Medical UniversityHaikou 570100China Department of Emergency Medicine Hunan Provincial Institute of Emergency MedicineHunan Provincial Key Laboratory of Emergency and Critical Care MetabolomicsHunan Provincial People's Hospital/the First Affiliated HospitalHunan Normal UniversityChangsha 410000China Emergency Medicine Center Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China

BACKGROUND:The high morbidity,high mortality and low survival rate of cardiac arrest(CA)cause a heavy global *** aimed to analyze the changes in scientific output related to CA over the past two ***:We analyzed the scientific output related to CA from 2000 to 2020 via the Web of *** data were analyzed using CiteSpace ***:In total,28,312 articles relating to CA were identified in the Web of *** volume of scientific research output in the field of global CA research was mainly distributed in the Americas,Europe and Asia,covering a wide *** the 28,312 articles,the research content of the highly cited literature mainly focused on CA,mild hypothermia treatment,and prognosis of CA ***:Various scientific methods were applied to reveal scientific productivity,collaboration,and research hotspots in the CA research *** resuscitation(CPR),extracorporeal membrane oxygenation(ECMO),survival and target temperature management are research *** research on CA will continue to focus on its treatment and prognosis to improve the survival rate of CA patients.

关键词： Cardiac arrest Bibliometrics CiteSpace Research hotspots Cardiopulmonary resuscitation

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Study on the clogging mechanism of punching screen in sand control by the punching structure parameters

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Petroleum Science 2024年第1期21卷 609-620页

作者： fu-Cheng Deng fu-Lin Gui Bai-Tao Fan Lei wen Sheng-Hong Chen ning Gong Yun-Chen Xiao Zhi-Hui Xu Yangtze University Jingzhou434023HubeiChina CNOOC Research Institute Ltd. Beijing100028China CNOOC Ener Tech-Drilling&Production Co. Tianjin300457China Tianjin Branch of CNOOC Ltd. Tianjin300459China

As an independent sand control unit or a common protective shell of a high-quality screen,the punching screen is the outermost sand retaining unit of the sand control pipe which is used in geothermal well or oil and gas ***,most screens only consider the influence of the internal sand retaining medium parameters in the sand control performance design while ignoring the influence of the plugging of the punching screen on the overall sand retaining performance of the *** explore the clogging mechanism of the punching screen,this paper established the clogging mechanism calculation model of a single punching screen sand control unit by using the computational fluid mechanics-discrete element method(CFD-DEM)combined *** to the combined motion of particles and fluids,the influence of the internal flow state on particle motion and accumulation was *** results showed that(1)the clogging process of the punching sand control unit is divided into three stages:initial clogging,aggravation of clogging and stability of *** the initial stage of blockage,coarse particles form a loose bridge structure,and blockage often occurs preferentially at the streamline gathering place below chamfering inside the sand control *** the stage of blockage intensification,the particle mass develops into a relatively complete sand bridge,which develops from both ends of the opening to the center of the *** the stable plugging stage,the sand deposits show a“fan shape”and form a“V-shaped”gully inside the punching slot element.(2)Under a certain reservoir particle-size distribution,The slit length and opening height have a large influence on the permeability and blockage rate,while the slit width size has little influence on the permeability and blockage *** microscopic clogging mechanism and its law of the punching screen prevention unit are proposed in this study,which has some field guidance significance for the design of punching screen

关键词： Punching screen Plugging CFD-DEM Size parameter Sand control

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Design,synthesis,and biological evaluation of novel chrysin derivatives as poly(ADP-ribose)polymerase 1(PARP1)inhibitors for the treatment of breast cancer

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Chinese Journal of Natural Medicines 2024年第5期22卷 455-465页

作者： YANG Yao TONG Jing XIE Xianshun CAO Hong fu Yong LUO Yong LIU Shan CHEN wen YANG ning Hengyang Medical School University of South ChinaHengyang 421200China Emergency Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hengyang Medical School The Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Hemato-oncology Department Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China Department of Breast and Thyroid Surgery Hengyang Medical SchoolThe Second Affiliated HospitalUniversity of South ChinaHengyang 421200China

In this study,we reported the discovery and structure-activity relationship analysis of chrysin derivatives as a new class of inhibitors targeting poly(ADP-ribose)polymerase 1(PARP1).Among these derivatives,compound 5d emerged as the most effective chrysin-based inhibitor of PARP1,with an IC50 value of 108 nmol·L^(-1).This compound significantly inhibited the proliferation and migration of breast cancer cell lines HCC-1937 and MDA-MB-436 by inducing DNA ***,5d induced apoptosis and caused an extended G1/S-phase in these cell *** docking studies revealed that 5d possesses a strong binding affinity toward *** vivo,in a xenograft model,5d effectively reduced tumor growth by downregulating PARP1 ***,compound 5d shows promise as a potential therapeutic agent for the treatment of BRCA wild-type breast cancer.

关键词： Chrysin derivatives PARP1 Antitumor DNA damage Small molecules

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Availability analysis of private cloud safety computer platform based on the Markov process

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Transportation Safety and Environment 2024年第1期6卷 103-108页

作者： Limin fu Jiakun wen Southwest Jiaotong University The School of Information Science&TechnologyChengduSichuan 610097China CRSC Research&Design Institute Group Co. LtdBeijing 100070China

To ensure the correctness of train control system design and development,the ways of simulation,test and formalization were *** to the safe critical attribute of train control system,the characters related to system safety were propounded such as real time,hybrid,distribution(concurrence)and reactivity,and the specific formal methods associated with every character were introduced in *** analysis and classification of the methods were done based on their mathematical basis and applications,and their advantages and disadvantages were *** result indicates that every method has determinate limitations,which is determined by the essences of model checking and theory *** is pointed out that the presentation of new method,the expansion of existing methods and the integration of many methods will be the development trend of formalization in train control system.

关键词： safety computer Markov process cloud computing availability analysis

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Boron-doped carbon dots:Doping strategies,performance effects,and applications

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Chinese Chemical Letters 2024年第7期35卷 100-106页

作者： Qiang fu Shouhong Sun Kangzhi Lu ning Li Zhanhua Dong College of Engineering Qufu Normal UniversityRizhao 276826China

Due to their superior fluorescence,phosphorescence,and catalytic capabilities,carbon dots(CDs),an emerging class of fluorescent carbon nanomaterials,have a wide range of potential *** properties of CDs have recently been controlled extensively by heteroatom *** atoms have been effectively doped into the structure of CDs due to their similar size to carbon atoms and excellent electron-absorbing ability to further improve the performance of *** this review,we summarize the research progress of boron-doped CDs in recent years from the aspects of doping strategies,effects of boron doping on different performances of CDs and *** from the two aspects of single boron doping and boron and other atom co-doping,from different precursor materials to different synthesis methods,the doping strategies of boron-doped CDs are reviewed in ***,the effects of boron doping on the fluorescence,phosphorescence and catalytic performance of CDs and applications of boron-doped CDs in optical sensors,information encryption and anti-counterfeiting are ***,we further provide a prospect towards the future development of boron-doped CDs.

关键词： Carbon dots Boron-doped Luminescent material Doping strategies Performance effects

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Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-wen Sun fu-Shan Wang Yan Gao fu-Qing Wei Jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

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Constructing hierarchical ZSM-5 coated with small ZSM-5 crystals via oriented-attachment and in situ assembly for methanol-to-aromatics reaction

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 41-53页

作者： ning Yang Tingjun fu Chuntao Cao Xueqing Wu Huiling Zheng Zhong Li State Key Laboratory of Clean and Efficient Coal Utilization College of Chemical Engineering and TechnologyTaiyuan University of TechnologyTaiyuan 030024China

Developing hierarchical and nanoscale ZSM-5 catalysts for diffusion-limited reactions has received ever-increasing attention. Here, ZSM-5 architecture integrated with hierarchical pores and nanoscale crystals was successfully prepared via in situ self-assembly of nanoparticles-coated silicalite-1. First, the oriented attachment of amorphous nanoparticles on external surface of silicalite-1 was achieved by controlling the alkalinity of Si-Al coating solution. The partial exposure of the external surface of silicalite-1 ensured the uniform removal of silicon in the bulk phase for the creation of hierarchical pores during the subsequent desilication-recrystallization. The uniform removal of silicon species in the bulk phase was mainly due to the synergistic effect of surface protection and alkaline etching, which could be balanced by regulating the relative amount of tetrapropylammonium cation and OH– in desilication-recrystallization solution. Importantly, the removed silicon from silicalite-1 recrystallized and in situ assembled into final ZSM-5 nanocrystals induced by surface Si-Al nanoparticles. The hierarchical pores and nanoscale crystals on this integrated architecture not only promoted the removal of coke precursors from micropores but also provided large external specific surface (91 m^(2)·g^(-1)) for coke deposition. Consequently, a much longer catalytic lifetime was achieved for methanol-to-aromatics reaction compared to conventional hollow structure ZSM-5 (84 h vs 46 h), with relatively high stability.

关键词： hierarchical ZSM-5 nanocrystal integrated architecture diffusion coke

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Wireless electrical stimulation generated by piezoelectric nanomaterial promotes the dental pulp regeneration via regulating mitochondrial Ca^(2+)/PKA signaling pathway

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Journal of Materials Science & Technology 2024年第1期168卷 24-34页

作者： Jianmao Zheng Jiyuan Zuo Cairong Xiao Qining Guo Xiaobin fu Chengyun ning Peng Yu Guangdong Provincial Key Laboratory of Stomatology Hospital of StomatologySun Yat-Sen UniversityGuangzhou 510080China School of Materials Science and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510641China

The induction of dental pulp stem cells(DPSCs)into odontogenic differentiation is a cutting-edge method of dental pulp regeneration ***,it remains a challenge to develop biomaterials and ther-apies that can induce odontogenic ***,we propose a wireless electrical stimulation strat-egy to induce DPSCs odontogenic differentiation via K_(0.5)Na_(0.5)NbO_(3)piezoelectric nanoparticles(KNN)and polarized KNN(PKNN),which can be endocytosed by *** vitro,several odontogenic differentiation indexes were also increased in DPSCs treated with KNN and PKNN,and the increase was more obvious in the PKNN *** wireless electrical field promoted mitochondrial calcium concentration via mitochondrial calcium unidirectional transporter(MCU),increased the production of adenosine triphos-phate(ATP),and induced odontogenic differentiation through the activation of the cAMP-PKA signaling *** vivo,dental pulp-like tissue was induced by electrical stimulation wirelessly with KNN and PKNN,which was more clinically friendly compared with the wired device,and the induction was more obvious in the PKNN group consistent with in vitro *** conclusion,this work demonstrates the potential of PKNN as an effective stimulus that can induce odontogenic differentiation of DPSCs and be applied to dental pulp regeneration treatment.

关键词： Piezoelectric nanoparticles Dental pulp stem cells Odontogenic differentiation

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Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens

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Journal of Animal Science and Biotechnology 2024年第2期15卷 779-794页

作者： Mingkun Gao Chaoyong Liao Jianyang fu Zhonghua ning Zengpeng Lv Yuming Guo State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China National Engineering Laboratory for Animal Breeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Baicalin and probiotic cocktails are promising feed additives with broad application *** probiotic cocktails are known to enhance intestinal health,the potential synergistic impact of combining baicalin with probiotic cocktails on the gut health of broiler chickens remains largely ***,this study aims to investigate the influence of the combined administration of baicalin and probiotic cocktails on the composition of ileal and cecal microbiota in broiler chickens to elucidate the underlying mechanisms responsible for the healthpromoting *** A total of 3201-day-old male Arbor Acres broilers were divided into 4 groups,each with 8 replicates of 10 chicks per *** a period of 42 d,the birds were fed a basal diet or the same diet supplemented with 37.5 g/t baicalin(BC),1,000 g/t probiotic cocktails(PC),or a combination of both BC(37.5 g/t)and PC(1,000 g/t).The results demonstrated that BC+PC exhibited positive synergistic effects,enhancing intestinal morphology,immune function,and barrier *** was evidenced by increased VH/CD ratio,sIgA levels,and upregulated expression of occludin and claudin-1(Pning baicalin and probiotic *** cocktails enhanced the effects of baicalin and accelerated its metab

关键词： Baicalin Gut health Ileal microbiota Probiotic cocktails Synergistic effects

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Multi-scale modeling for prediction of mechanical performance in brazed GH99 thin-walled structure

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Chinese Journal of Aeronautics 2024年第7期37卷 550-563页

作者： Yazhou LIU Shengpeng HU Yanyu SONG Wei fu Xiaoguo SONG ning GUO Weimin LONG State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Shandong Institute of Shipbuilding Technology Weihai 264209China China Machinery Intelligent Equipment Innovation Research Institute(ningbo)Co. Ltd.Ningbo 315700China

Superalloy thin-walled structures are achieved mainly by brazing,but the deformation process of brazed joints is non-uniform,making it a challenging research *** paper records a thorough investigation of the effect of brazing parameters on the microstructure of joints and its mechanical properties,which mainly inquires into the deformation and fracture mechanisms in the shearing process of GH99/BNi-5a/GH99 *** macroscopic-microscopic deformation mechanism of the brazing interface during shearing was studied by Crystal Plasticity(CP)and Molecular Dynamics(MD)on the basis of the optimal brazing *** experimental results show that the brazing interface is mainly formed by(Ni,Cr,Co)(s,s)and possesses a shear strength of approximately 546 *** shearing fracture of the brazed joint occurs along the brazing seam,displaying the characteristics of intergranular *** simulations show that dislocations disassociate and transform into fine twinning with increased *** simulated the shear deformation process of the brazed *** multiscale simulation results are consistent with the experimental *** mechanical properties of thin-walled materials for brazing are predicted using MD and CP methods.

关键词： Multi-scale modeling Brazing Shear mechanisms Crystal plasticity GH99 superalloy

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