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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang lu Lv Tao long Hui-wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

Influence of gut bacteria on type 2 diabetes:Mechanisms and therapeutic strategy

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World Journal of Diabetes 2025年第1期16卷 27-33页

作者： Xue wen lu-Ming Qi Kui Zhao College of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina College of Materials and Chemical Engineering Southwest Forestry UniversityKunming 650224Yunnan ProvinceChina

The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic *** commentary examines the recent publication in World Journal of *** article explores the association between T2DM and gut microbiota,with a focus on the pathophysiological changes related to *** proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such *** editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic *** provides new insights for future research on gut-microbiota-based interventions for T2DM.

关键词： Type 2 diabetes Intestinal microbiome Intestinal axis Biological pathways Treatment Short-chain fatty acids

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碳酸锂肠溶片与裸片治疗躁狂症的比较

新药与临床 1989年第4期8卷 198-200页

作者：高哲石沈文龙陆玲子王诗喜上海市精神卫生中心分部上海201108

作者用碳酸锂肠溶片(用2号树脂包膜)与普通碳酸锂片对14名躁狂症患者进行了自身交叉对照研究。结果表明,碳酸锂肠溶片与普通碳酸锂片一样能为消化道良好吸收,2药血锂浓度及临床疗效均无明显差异(P>0.05),而肠溶片在治疗血药浓度范围内... 详细信息

作者用碳酸锂肠溶片(用2号树脂包膜)与普通碳酸锂片对14名躁狂症患者进行了自身交叉对照研究。结果表明,碳酸锂肠溶片与普通碳酸锂片一样能为消化道良好吸收,2药血锂浓度及临床疗效均无明显差异(P>0.05),而肠溶片在治疗血药浓度范围内的胃肠道副作用却明显低于普通片(P<0.05),值得在临床上推广应用。

关键词：碳酸锂情感性精神病树脂

Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第01期 89-136页

作者： wen Huang Zeng Lian Kening lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang Zhi-Lai Zhan Guang-lu Chang Yan Gao Xia Li wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

Generating Squeezed States in Solid State Circuits

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Communications in Theoretical Physics 2008年第5期49卷 1207-1210页

作者： wen Yi-Huo long Gui-lu Key Laboratory for Atomic and Molecular NanoSciences and Department of Physics Tsinghua University Beijing 100084 China Tsinghua National Laboratory for Information Science and Technology Beijing 100084 China

We propose a scheme for generating squeezed states in solid state circuits which consist a superconducting transmission line resonator （STLR）, a superconducting Cooper-pair box （CPB） and a nanoelectromechanical resonator （NMR）. The nonlinear interaction between the STLR and the CPB can be implemented by setting the external biased flux of the CPB at some certain points. The interaction Hamiltonian between the STLR and the NMR is derived by performing Fr ohlich transformation on tile total Hamiltonian of tile combined system. Just by adiabatically keeping the CPB at the ground state, we get the standard parametric down-conversion Hamiltonian, and the squeezed states of the STLR can be easily generated, which is similar to the three-wave mixing in quantum optics.

关键词： squeezed state solid-State circuit superconducting transmission line

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白炭黑制备新工艺研究

武汉工程大学学报 2009年第1期31卷 29-31页

作者：王慧舒琼龙文露徐旺生武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室湖北新型反应器与绿色化学工艺重点实验室湖北武汉430074

研究了白炭黑新的制备技术,即采用以碳酸氢铵和水玻璃为原料制备白炭黑.在制备中的副产物可通过加入某种化学试剂低成本回收,再作为反应的生产原料,从而实现了资源的循环利用,能耗的降低和废物的零排放.该法不仅能制备出高质量优质的白... 详细信息

研究了白炭黑新的制备技术,即采用以碳酸氢铵和水玻璃为原料制备白炭黑.在制备中的副产物可通过加入某种化学试剂低成本回收,再作为反应的生产原料,从而实现了资源的循环利用,能耗的降低和废物的零排放.该法不仅能制备出高质量优质的白炭黑,工艺简单,易形成工业化生产,而且符合绿色化工的环保思想.

关键词：沉淀法白炭黑水玻璃碳酸氢铵碳酸钠

Multi-Stage-Based Siamese Neural Network for Seal Image Recognition

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 405-423页

作者： Jianfeng lu Xiangye Huang Caijin Li Renlin Xin Shanqing Zhang Mahmoud Emam School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China Shangyu Institute of Science and Engineering Hangzhou Dianzi UniversityShaoxing312300China Faculty of Artificial Intelligence Menoufia UniversityShebin El-Koom32511Egypt

Seal authentication is an important task for verifying the authenticity of stamped seals used in various domains to protect legal documents from tampering and *** seal inspection is commonly audited manually to ensure document ***,manual assessment of seal images is tedious and laborintensive due to human errors,inconsistent placement,and completeness of the *** image recognition systems are inadequate enough to identify seal types accurately,necessitating a neural network-based method for seal image ***,neural network-based classification algorithms,such as Residual Networks(ResNet)andVisualGeometryGroup with 16 layers(VGG16)yield suboptimal recognition rates on stamp ***,the fixed training data categories make handling new categories to be a challenging *** paper proposes amulti-stage seal recognition algorithmbased on Siamese network to overcome these ***,the seal image is pre-processed by applying an image rotation correction module based on Histogram of Oriented Gradients(HOG).Secondly,the similarity between input seal image pairs is measured by utilizing a similarity comparison module based on the Siamese ***,we compare the results with the pre-stored standard seal template images in the database to obtain the seal *** evaluate the performance of the proposed method,we further create a new seal image dataset that contains two subsets with 210,000 valid labeled pairs in *** proposed work has a practical significance in industries where automatic seal authentication is essential as in legal,financial,and governmental sectors,where automatic seal recognition can enhance document security and streamline validation ***,the experimental results show that the proposed multi-stage method for seal image recognition outperforms state-of-the-art methods on the two established datasets.

关键词： Seal recognition seal authentication document tampering siamese network spatial transformer network similarity comparison network

Application of buckling-restrained braces in the seismic control of suspension bridges

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Earthquake Engineering and Engineering Vibration 2022年第2期21卷 543-557页

作者： long lu College of Environment and Civil Engineering Chengdu University of TechnologyChengdu 610059China

Buckling-restrained braces(BRBs)are widely used to improve the seismic performance of *** paper aims to introduce BRBs to suspension bridges and assess the seismic performance of bridges with *** the Dadu River Bridge as a case study,an FEA model of the bridge is established,and different seismic measures(BRBs between the deck and the tower,BRBs at the middle of the span to replace the inclined suspenders to connect the deck and the main cables,fluid viscous dampers(FVDs)between the deck and the tower,the combination of BRBs to replace the inclined suspenders as well as FVDs between the deck and the tower)are applied to the suspension *** influence of the parameters of BRBs on the seismic response of the suspension bridge is studied,and the performance of the bridge with BRBs is compared with that of the bridge with *** results indicate that the use of BRBs in place of the inclined suspenders is beneficial to reduce the displacement of the deck and limit the shear force and bending moment of the *** seismic performance of the suspension bridge with BRBs and FVDs is better than that of the bridge with BRBs or ***,the application of BRBs is a feasible method to improve the seismic performance of the suspension bridge.

关键词： buckling-restrained braces fluid viscous dampers suspension bridge seismic response earthquake