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Inhibition force of precipitates for promoting abnormal grain growth in magnetostrictive Fe83Ga17-(B,NbC) alloy sheets

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Rare Metals 2017年第11期36卷 886-893页

作者： Ji-Heng Li wen-lan zhang Chao Yuan Xiao-Qian Bao Xue-Xu Gao State Key Laboratory of Advanced Metals and Materials University of Science and Technology Beijing 100083 China

Inhibition force of precipitate particles for pro- moting abnormal grain growth in magnetostrictive Feg3Ga17-（B,NbC） alloy sheets was investigated in this study. After a continuous heating and a high-temperature annealing, the Fe83Gat7 ＋ 0.5 at% B alloy sheets do not occur significant abnormal grain growth. Correspondingly, textures of { 111 }〈112〉 and { 100}〈00l〉 in addition to the Goss texture are obtained in the final annealed alloy sheets. By contrast, after the same annealing processes, the size of {110} textured grains is very large in the final annealed Fe83Gaj7 ＋ 0.5 at% NbC alloy sheets due to the abnormal grain growth, which results in a sharp Goss texture. BN precipitates were introduced into Fes3Ga17 ＋ 0.2 at% B alloy sheets by nitriding annealing at 800℃ for 2 min under NH3 atmosphere. The abnormal grain growth of Goss grains is achieved in 0.2 at% B-doped Fe83Ga17 alloy sheets after a high-temperature annealing, which is attributed to the enhanced inhibition force by introducing BN precipitates. During the recrystallization annealing process, Fe2B precipitates is easy to coarsen and decom- pose at high temperature due to the low thermal stability, resulting in a decrease or even disappearance of the inhi- bition force. For NbC and BN precipitates, the thermal stability and hardness of particles are both better than those of Fe2B precipitates, leading to strong inhibition force. Because of the preferred Goss texture, the magnetostriction of 2.05 × 10-4 and 1.81 × 10 4 is obtained in the sec- ondary recrystallized Fe83Gal7 ＋ 0.5 at% NbC and Fes3Gaw ＋ 0.2 at% B alloy sheets, respectively.

关键词： Fe-Ga alloy Magnetostriction Grain growth Inhibition force Precipitates

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Microstructure and magnetostrictive performance of NbC-doped <100>oriented Fe-Ga alloys

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International Journal of Minerals,Metallurgy and Materials 2015年第1期22卷 52-58页

作者： Chao Yuan Ji-heng Li wen-lan zhang Xiao-qian Bao Xue-xu Gao State Key Laboratory of Advanced Metals and Materials University of Science and Technology Beijing

The〈100〉oriented Fe83Ga17 alloy rods with various NbC contents less than 1at%were prepared by the directional solidification method at a growth rate of 720 mm·h^-1. Low NbC-content was found to affect the oriented grain growth and slightly improve the〈100〉ori-entation. Flat grain boundaries in the alloys with low NbC contents less than 0.2at%became greatly curved at higher NbC contents, and a large amount of Nb-rich precipitates were observed in the alloys with high NbC contents. Small amounts of NbC, less than 0.2at%, resulted in an increase in magnetostrictive strain due to the improvement of the〈100〉orientation, and a high magnetostrictive strain value of 335 ×10^-6 under a pre-stress of 15 MPa was obtained in the 0.1at%NbC-doped alloys. The magnetostrictive performance obviously decreased with the NbC addition higher than 0.5at%, and the strain sensitivity under no pre-stress was lower than that in the binary Fe？Ga alloy.

关键词： iron gallium alloys magnetostriction texture niobium carbide directional solidification

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长三角地区与珠三角地区农村集体土地市场发育与运行比较研究——基于上海市松江区、金山区和广东省南海区、东莞市4地实证分析

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中国土地科学 2016年第10期30卷 64-71页

作者：文兰娇张安录华中农业大学土地管理学院湖北武汉430070

研究目的:测算农村集体建设用地市场化程度,对比分析长三角地区和珠三角地区集体土地市场发育情况。研究方法:加权平均法、调研分析法和对比分析法。研究结果:珠三角和长三角地区农村集体土地市场化水平分别为0.5571和0.5116;二者对应... 详细信息

研究目的:测算农村集体建设用地市场化程度,对比分析长三角地区和珠三角地区集体土地市场发育情况。研究方法:加权平均法、调研分析法和对比分析法。研究结果:珠三角和长三角地区农村集体土地市场化水平分别为0.5571和0.5116;二者对应综合集体土地价格水平分别为2631.99元/m^2和851.17元/m^2。研究结论:(1)从市场培育环境看,珠三角地区治理结构和市场配置更具优势,长三角地区农村土地市场是一种混合层级制的市场形态,而珠三角地区集体土地市场是完全开放的市场经济形态;(2)珠三角地区农村集体建设用地市场化程度比长三角地区略高,但是土地综合价格水平却比长三角地区高出很多,珠三角地区农村土地价值资产显化程度更高;(3)当前土地市场发育条件下,应将虚拟指标交易市场、出让/买卖市场(一级市场)和租赁市场(二级市场)纳入农村土地市场化测度的分析框架中。

关键词：土地经济农村集体土地市场市场化水平比较分析长三角地区珠三角地区

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye Xue-Zhi zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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面向教师培训的翻转课堂探究——以“PPT课件制作”课程为例

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现代教育技术 2017年第1期27卷 81-87页

作者：卜彩丽张文兰张宝辉朱苗陕西师范大学教育学院陕西西安710062 河南师范大学教育学院河南新乡453002

翻转课堂在国内经历了引介和理论研究阶段之后,目前正处于应用探索阶段。文章以"PPT课件制作"课程为例,对面向教师培训的翻转课堂进行了实证研究,发现:成人学习者对翻转课堂教学具有较高的满意度;翻转课堂可以提高学习者的学习投入,实... 详细信息

翻转课堂在国内经历了引介和理论研究阶段之后,目前正处于应用探索阶段。文章以"PPT课件制作"课程为例,对面向教师培训的翻转课堂进行了实证研究,发现:成人学习者对翻转课堂教学具有较高的满意度;翻转课堂可以提高学习者的学习投入,实现学习者的高阶能力培养和深度学习;影响翻转学习效果的主要因素是课前学习太费时间和课程学习任务重。据此,文章从课前学习任务、网络教学平台、学习者等三个方面提出了对策和建议,以便为后续相关研究提供借鉴。

关键词：翻转课堂教师培训实证研究高校教师

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： lan zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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脂肪间充质干细胞对博来霉素诱导的硬皮病小鼠模型的治疗作用

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北京大学学报（医学版） 2016年第6期48卷 970-976页

作者：窦晶莉白力庞春艳张文兰张伟王永福包头医学院第一附属医院风湿免疫科内蒙古自治区包头014010 内蒙古自治区自体免疫学重点实验室内蒙古自治区包头014010

目的:研究脂肪间充质干细胞(adipose tissue-derived stem cells,ADSCs)对博来霉素(bleomycin,BLM)诱导的硬皮病小鼠的治疗效果及其可能的作用机制。方法:选取C57BL/6J雌性小鼠24只,采用皮下注射BLM[2mg/(kg·d)]建立硬皮病小鼠模型,随... 详细信息

目的:研究脂肪间充质干细胞(adipose tissue-derived stem cells,ADSCs)对博来霉素(bleomycin,BLM)诱导的硬皮病小鼠的治疗效果及其可能的作用机制。方法:选取C57BL/6J雌性小鼠24只,采用皮下注射BLM[2mg/(kg·d)]建立硬皮病小鼠模型,随机分为正常对照组、BLM组、ADSCs(皮下)组和ADSCs(静脉)组,每组6只,正常对照组给予生理盐水2 m L/(kg·d)皮下注射,其余3组分别给予BLM皮下注射,连续3周,然后,ADSCs皮下和尾静脉注射组分别给予皮下和尾静脉注射ADSCs(2×105个细胞)治疗,每4天1次,共3次。流式细胞术检测小鼠脾细胞中的辅助T细胞17(T-helper 17,TH17)及调节性T细胞(regulatory T cell,Treg),实时荧光定量聚合酶联反应(polymerase chain reaction,PCR)法检测小鼠肺组织中相关细胞因子的表达水平,酶联免疫吸附法(enzyme-linked immuno sorbent assay,ELISA)检测小鼠血清中白介素(interleukin,IL)-6、转化生长因子β(transforming growth factor-β,TGF-β)的含量,苏木精-伊红染色(hematoxylin eosin staining,HE)观察小鼠的皮肤和肺组织病理学改变。结果:流式细胞术结果显示,BLM组较正常对照组小鼠脾细胞中TH17和Treg所占比例升高(15.30%±1.29%vs.4.32%±0.79%;9.90%±1.95%vs.5.18%±1.35%,P均0.05)。BLM组小鼠血清中TGF-β的含量较正常对照组升高[(33.95±2.49)ng/L vs.(28.8±2.29)ng/L,P0.05),经ADSCs治疗后TGF-β基因和蛋白的表达无明显变化[1.25±0.11,1.26±0.12 vs.1.17±0.11;(31.84±2.04)ng/L,(31.25±2.36)ng/L vs.(33.95±2.49)ng/L,P>0.05]。HE染色结果显示,BLM组与正常对照组相比,肺组织有大量炎性细胞浸润,肺泡间隔断裂或消失;皮肤真皮层增厚,有大量的胶原纤维积聚,经ADSCs治疗后小鼠肺组织炎症有所改善,皮肤的真皮层变薄,胶原纤维积聚减少。结论:ADSCs可以有效缓解硬皮病小鼠肺的炎症和皮肤的纤维化症状,其抗炎和抗纤维化作用与其免疫调节功能有关。

关键词：干细胞,间充质硬皮病免疫调节细胞因子类

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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妊娠期糖尿病孕妇大网膜下脂肪组织全基因组DNA甲基化研究

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中国全科医学 2017年第2期20卷 159-164页

作者：钱源孙浩肖雪祁文瑾张兰马润玫昆明医科大学第一附属医院妇产科产前诊断室云南省昆明市650032 中国医学科学院&北京协和医科大学医学生物学研究所云南省昆明市650031

背景大网膜下脂肪组织与妊娠期糖尿病(GDM)密切相关,目前,关于GDM孕妇大网膜下脂肪组织全基因组DNA甲基化研究较少。目的研究GDM孕妇和无GDM孕妇大网膜下脂肪组织全基因组DNA甲基化差异,为寻找GDM可能的致病基因提供线索。方法选取2012... 详细信息

背景大网膜下脂肪组织与妊娠期糖尿病(GDM)密切相关,目前,关于GDM孕妇大网膜下脂肪组织全基因组DNA甲基化研究较少。目的研究GDM孕妇和无GDM孕妇大网膜下脂肪组织全基因组DNA甲基化差异,为寻找GDM可能的致病基因提供线索。方法选取2012年1月—2014年5月于昆明医科大学第一附属医院妇产科门诊定期产前检查并入院分娩的GDM孕妇3例为病例组,同期健康孕妇3例为对照组。剖宫产术中剥离大网膜下脂肪组织,提取全基因组DNA。经变性和扩增后酶切扩增产物,将DNA片段与Illumina Methylation Bead Chip芯片进行杂交。根据Methylation Analysis Algorithms生成各样本每个位点的甲基化水平,经过偏差校正和位点过滤,得到甲基化水平。采用DAVID数据库对具有显著性差异的甲基化基因进行Gene Ontology(GO)和Kyoto Encyclopedia of Genes and Genomes(KEGG)信号通路分析。另分别选取同期GDM孕妇和无GDM孕妇各5例,验证候选基因启动子区域甲基化水平差异。结果病例组1 298个基因低甲基化,1 570个基因高甲基化,其中TMEM195、TCF7L2、IGF1、IGF1R甲基化可能与血糖调控密切相关,DGKG、NRXN3甲基化可能与体质指数(BMI)密切相关。GO功能分析显示,低甲基化基因参与的生物学过程主要是级联反应的活性调节、细胞凋亡调节及蛋白转运等,细胞成分主要为细胞外基质;高甲基化基因参与的生物学过程主要是抗原处理和呈递、主要组织相容复合体(MHC)Ⅱ参与的抗原处理和呈递,细胞成分主要为肌动骨架蛋白、MHC等。KEGG信号通路分析中,富集数>20.000的通路有抗原处理和呈递(富集数为23.142)、过氧化物酶体增殖物激活受体(PPAR)信号通路(富集数为22.068)。分别选取参与抗原处理和呈递、PPAR信号通路中的甲基化差异基因人类白细胞抗原G(HLA-G)、PPARGC1A进行验证。GDM孕妇大网膜下脂肪组织HLA-G启动子区域甲基化水平高于无GDM孕妇(t=4.968,P=0.001)。两者大网膜下脂肪组织PPARGC1A启动子区域甲基化水平比较,差异无统计学意义(t=0.929,P=0.380)。结论 GDM孕妇和健康孕妇大网膜下脂肪组织基因甲基化位点和水平存在显著差异,甲基化差异基因主要参与抗原处理和呈递及PPAR信号通路途径。

关键词：糖尿病,妊娠 DNA甲基化脂肪组织抗原呈递过氧化物酶体增殖物激活受体全基因组关联研究

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