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Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells

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World Journal of Gastroenterology 2006年第28期12卷 4478-4484页

作者： Jane C-J Chao Shih-wen Chiang Ching-Chiung Wang Ya-Hui Tsai Ming-Shun wu School of Nutrition and Health Sciences TaipJMedical University Taipei110 Taiwan China School of Pharmacy Taipei MedicalUniversity Taipei 110 Taiwan China Division of Internal Medicine Taipei Medical University-Wan Fang Hospital Taipei 116 Taiwan China

AIM： To investigate the effect of hot water-extracted Lydurn barbarum （LBE） and Rehrnannia glutinosa （RGE） on cell proliferation and apoptosis in rat and/or human hepatocellular carcinoma （HCC） cells. METHODS： Rat （H-4-Ⅱ-E） and human HCC （HA22T/ VGH） cell lines were incubated with various concentrations （0-10 g/L） of hot water-extracted LBE and RGE. After 6-24 h incubation, cell proliferation （n = 6） was measured by a colorimetric method. The apoptotic cells （n = 6） were detected by flow cytometry. The expression of p53 protein （n = 3） was determined by SDS-PAGE and Western blotting. RESULTS： Crude LBE （2-5 g/L） and RGE （2-10 g/L） dose-dependently inhibited proliferation of H-4-Ⅱ-E cells by 11% （P 〈 0.05） to 85% （P 〈 0.01） after 6-24 h treatment. Crude LBE at a dose of 5 g/L suppressed cell proliferation of H-4-Ⅱ-E cells more effectively than crude RGE after 6-24 h incubation （P 〈 0.01）. Crude LBE （2-10 g/L） and RGE （2-5 g/L） also dose-dependently inhibited proliferation of HA22T/VGH cells by 14%-43% （P 〈 0.01） after 24 h. Crude LBE at a dose of 10 g/L inhibited the proliferation of HA22T/VGH cells more effectively than crude RGE （56.8% ＋ 1.6% vs 70.3% ＋ 3.1% of control, P = 0.0003 〈 0.01）. The apoptotic cells significantly increased in H-4-Ⅱ-E cells after 24 h treatment with higher doses of crude LBE （2-5 g/L） and RGE （5-10 g/L）（P 〈 0.01）. The expression of p53 protein in H-4-Ⅱ-E cells was 119% and 143% of the control group compared with the LBE-treated （2, 5 g/L） groups, and 110% and 132% of the control group compared with the RGE -treated （5, 10 g/L） groups after 24 h. CONCLUSION： Hot water-extracted crude LBE （2-5 g/L） and RGE （5-10 g/L） inhibit proliferation and stimulate p53-mediated apoptosis in HCC cells.

关键词： Lycium barbarum extract Rehmannia glutinosa extract Proliferation Apoptosis Hepatocellular carcinoma

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Analysis of the independent-and interactive-photo-thermal effects on soybean flowering

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Journal of Integrative Agriculture 2015年第4期14卷 622-632页

作者： wu Ting-ting LI Jin-yu wu Cun-xiang SUN Shi MAO Ting-ting JIANG Bing-jun HOU wen-sheng HAN Tian-fu Key Laboratory of Soybean Biology(Beijing) Ministry of Agriculture/Institute of Crop ScienceChinese Academy of Agricultural Sciences

Soybean（Glycine max（L.） Merr.） is a typical short-day and warm season plant, and the interval between emergence and flowering has long been known to be regulated by environmental factors, primarily photoperiod and temperature. While the effects of photoperiod and temperature on soybean flowering have been extensively studied, a dissection of the component photo-thermal effects has not been documented for Chinese germplasm. Our objective of the current study was to evaluate the independent- and interactive-photo-thermal responses of 71 cultivars from 6 ecotypes spanning the soybean production regions in China. These cultivars were subjected in pot experiments to different temperature regimes by planting in spring（low temperature（LT）） and summer（high temperature（HT））, and integrating with short day（SD, 12 h）, natural day（ND, variable day-length）, and long day（LD, 16 h） treatments over two years. The duration of the vegetative phase from emergence to first bloom（R1） was recorded, and the photo-thermal response was calculated. The outcome of this characterization led to the following conclusions：（1） There were significant differences in photo-thermal response among the different ecotypes. High-latitude ecotypes were less sensitive to the independent- and interactive-photo-thermal effects than low-latitude ecotypes; and（2） there was an interaction between photoperiod and temperature, with the effect of photoperiod on thermal sensitivity being greater under the LD than the SD condition, and with the effect of temperature on photoperiodic sensitivity being greater under the LT than the HT condition. The strengths and limitations of this study are discussed in terms of implications for current knowledge and future research directions. The study provides better understanding of photo-thermal effects on flowering in soybean genotypes from different ecotypes throughout China and of the implications for their adaptation more broadly.

关键词： soybean flowering photoperiod temperature photo-thermal response

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Effects of Grassland Degradation and Re-vegetation on Carbon and Nitrogen Storage in the Soils of the Headwater Area Nature Reserve on the Qinghai-Tibetan Plateau,China

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Journal of Mountain Science 2015年第3期12卷 582-591页

作者： SU Xu-kun wu Yu DONG Shi-kui wen Lu LI Yuan-yuan WANG Xue-xia School of Environment Beijing Normal University

Both overgrazing and climate change contribute to grassland degradation in the alpine regions of China and negatively affect soil carbon and nitrogen pools. We quantified changes in soil organic carbon （SOC） and total nitrogen （TN） in black soil beach （BSB）. We measured SOC and TN in severely degraded and non-degraded grasslands to calculate differences in carbon and nitrogen storage, and field survey results were extrapolated to the entire headwaters area of the Qinghai-Tibetan Plateau （36.3xlos krn~） to determine SOC and TN losses from these grasslands. We also evaluated changes in SOC and TN in severely degraded grasslands that were artificially re-vegetated five, seven and nine years ago. Totally 92.43 Tg C and 7.08 Tg N were lost from the BSB in the headwater area, which was approximately 50% of the original C and N soil pools. Re-vegetation of the degraded grasslands in the headwater area would result in a gain of 32.71 Tg C in the soil after five years, a loss of 5.5a Tg C after seven years and an increase of 44.15 Tg C after nine years. The TN increased by 53.09% and 59.98% after five and nine years, respectively, while it decreased by 4.92% after seven years of re-vegetation. The results indicate that C and N stocks followed a ＂V＂ shaped pattern with re- vegetation time. Understanding plant-soil interactions during succession of artificially planting grassland ecosystems is essential for developing scientifically sound management strategies for the effectively re-vegetated BSB.

关键词： Black soil beach Grassland degradation Soil loss Revegetation Alpine grasslands Soil carbonsequestration Soil nitrogen sequestration

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Distribution of gamasid mites on small mammals in Yunnan Province, China

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Insect Science 2007年第1期14卷 71-78页

作者： LI-PU LUO XIAN-GUO GUO TI-JUN QIAN DIAN wu XING-YUANMEN wen-GE DONG Institute of Pathogens and Vectors Dali University Dali Yunnan China

An investigation of gamasid mites on the body surface of small mammals was carried out in Yunnan Province of China from 1990 to 2004. The small mammal hosts were captured from 25 counties which represent five geographical subregions, namely Middle Subregion of Hengduan Mountains, Southern Subregion of Hengduan Mountains, Eastern Plateau Subregion of Yunnan, Western Plateau Subregion of Yunnan and Southern Moun- tainous Subregion of Yunnan. The captured 10 803 small mammal hosts belong to nine families, 29 genera and 52 species in four orders （Rodentia, Insectivora, Scandentia and Lagomorpha）. A total of 68 571 gamasid mites were collected from the body surface of the captured small mammal hosts and all the gamasid mites were identified to 10 families, 33 genera and 112 species. This paper lists all the mite species, together with their taxonomic position （genera and families） and their corresponding hosts. Much more mite species were found in the Middle Subregion of Hengduan Mountains than in other geographical subregions. The total individuals of mites and small mammals in the Middle Subregion of Hengduan Mountains are also the most plentiful in the five geographical subregions. Three dominant mite species and three dominant small mammal hosts were determined as the dominant species in the investigated areas of Yunnan Province. The dominant hosts are Rattus flavipectus （which accounts for 34.85% of the total individuals）, Apodemus chevrieri （13.43%） and Rattus norvegicus （10.40%） while the dominant gamasid mite species are Laelaps nuttalli （Hirst, 1915）（27.84%）, Laelaps echidninus （Berlese, 1887）（18.38%） and Laelaps guizhouensis （Gu et Wang, 1981）（14.79%）. The results showed the high species diversity of gamasid mites in Yunnan Province and the uneven distribution feature in different subregions.

关键词： Arachnida China fauna gamasid mites small mammal Yunnan

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Flunarizine inhibits sensory neuron excitability by blocking voltage-gated Na＋ and Ca2＋ currents in trigeminal ganglion neurons

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Chinese Medical Journal 2011年第17期124卷 2649-2655页

作者： YE Qing WANG Qiang YAN Lan-yun wu wen-hui LIU Sha XIAO Hang WAN Qi Department of Neurology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Toxicology School of Public Health Nanjing Medical University Nanjing Jiangsu 210029 China

Background Although flunarizine has been widely used for migraine prophylaxis with clear success, the mechanisms of its actions in migraine prophylaxis are not completely understood. The aim of this study was to investigate the effects of flunarizine on tetrodotoxin-resistant Na＋ channels and high-voltage activated Ca2＋ channels of acutely isolated mouse trigeminal ganglion neurons. Methods Sodium currents and calcium currents in trigeminal ganglion neurons were monitored using whole-cell patch-clamp recordings. Paired Student＇s t test was used as appropriate to evaluate the statistical significance of differences between two group means. Results Both tetrodotoxin-resistant sodium currents and high-voltage activated calcium currents were blocked by flunarizine in a concentration-dependent manner with the concentration producing half-maximal current block values of 2.89 μmol/L and 2.73 μmol/L, respectively. The steady-state inactivation curves of tetrodotoxin-resistant sodium currents and high-voltage activated calcium currents were shifted towards more hyperpolarizing potentials after exposure to flunarizine. Furthermore, the actions of flunarizine in blocking tetrodotoxin-resistant sodium currents and high-voltage activated calcium currents were use-dependent, with effects enhanced at higher rates of channel activation. Conclusion Blockades of these currents might help explain the peripheral mechanism underlying the preventive effect of flunarizine on migraine attacks.

关键词： flunarizine migraine tetrodotoxin-resistant sodium currents high-voltage activated calcium currents trigeminal ganglion neurons

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MTHFR及ABCB1基因多态性与急性淋巴细胞白血病患儿大剂量甲氨蝶呤药物不良反应关系

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中国临床药理学杂志 2024年第13期40卷 1963-1967页

作者：徐蕊李静胡玉麦吾菊丹·阿力甫张瑞姜雯孙璇王琳赵军新疆医科大学第六附属医院药学部新疆维吾尔自治区乌鲁木齐830002 新疆医科大学第六附属医院全科医学科新疆维吾尔自治区乌鲁木齐830002 新疆医科大学第一附属医院药学部新疆维吾尔自治区乌鲁木齐830054 新疆药物临床研究重点实验室新疆维吾尔自治区乌鲁木齐830054

目的确定亚甲基四氢叶酸还原酶(MTHFR)C677T、A1298C及多药耐药1(ABCB1)C3435T基因多态性与急性淋巴细胞白血病(ALL)患儿大剂量甲氨蝶呤(HD-MTX)药物不良反应关系。方法收集用HD-MTX化疗的ALL患儿血样,用测序法检测MTHFR C677T、A1298C... 详细信息

目的确定亚甲基四氢叶酸还原酶(MTHFR)C677T、A1298C及多药耐药1(ABCB1)C3435T基因多态性与急性淋巴细胞白血病(ALL)患儿大剂量甲氨蝶呤(HD-MTX)药物不良反应关系。方法收集用HD-MTX化疗的ALL患儿血样,用测序法检测MTHFR C677T、A1298C和ABCB1 C3435T基因多态性,根据抗癌药物常见药物不良反应分级标准统一评价MTX化疗后的药物不良反应,统计分析MTHFR C677T、A1298C及ABCB1 C3435T基因多态性与HD-MTX药物不良反应的关系。结果MTHFR A1298C AC+CC型肝功能损伤(2级)风险高于AA型[比值比(OR)=2.350,95%置信区间(CI)=1.038~5.320,(P0.05)。ABCB1 C3435T CT型肝功能损伤(2级)风险高于TT型(OR 5.161,95%CI=1.371~19.424,P0.05)。未发现MTHFR C677T与HD-MTX药物不良反应有相关性(均P>0.05)。结论在用HD-MTX治疗ALL时,可通过检测MTHFR A1298C及ABCB1 C3435T基因型来预测药物不良反应,从而实施更加科学的个体化用药。

关键词：急性淋巴细胞白血病儿童大剂量甲氨蝶呤亚甲基四氢叶酸还原酶多药耐药1 药物不良反应

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Resting-state network complexity and magnitude changes in neonates with severe hypoxic ischemic encephalopathy

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Neural Regeneration Research 2019年第4期14卷 642-648页

作者： Hong-Xin Li Min Yu Ai-Bin Zheng Qin-Fen Zhang Guo-Wei Hua wen-juan Tu Li-Chi Zhang Department of Neonatology Changzhou Children's Hospital Nantong University Department of Children's Health Research Center Changzhou Children's Hospital Institute for Medical Imaging Technology School of Biomedical Engineering Shanghai Jiao Tong University Department of Radiology and BRIC University of North Carolina at Chapel Hill

Resting-state functional magnetic resonance imaging has revealed disrupted brain network connectivity in adults and teenagers with cerebral palsy. However, the specific brain networks implicated in neonatal cases remain poorly understood. In this study, we recruited 14 termborn infants with mild hypoxic ischemic encephalopathy and 14 term-born infants with severe hypoxic ischemic encephalopathy from Changzhou Children's Hospital, China. Resting-state functional magnetic resonance imaging data showed efficient small-world organization in whole-brain networks in both the mild and severe hypoxic ischemic encephalopathy groups. However, compared with the mild hypoxic ischemic encephalopathy group, the severe hypoxic ischemic encephalopathy group exhibited decreased local efficiency and a low clustering coefficient. The distribution of hub regions in the functional networks had fewer nodes in the severe hypoxic ischemic encephalopathy group compared with the mild hypoxic ischemic encephalopathy group. Moreover, nodal efficiency was reduced in the left rolandic operculum, left supramarginal gyrus, bilateral superior temporal gyrus, and right middle temporal gyrus. These results suggest that the topological structure of the resting state functional network in children with severe hypoxic ischemic encephalopathy is clearly distinct from that in children with mild hypoxic ischemic encephalopathy, and may be associated with impaired language, motion, and cognition. These data indicate that it may be possible to make early predictions regarding brain development in children with severe hypoxic ischemic encephalopathy, enabling early interventions targeting brain function. This study was approved by the Regional Ethics Review Boards of the Changzhou Children's Hospital(approval No. 2013-001) on January 31, 2013. Informed consent was obtained from the family members of the children. The trial was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR1800

关键词： nerve regeneration neonates hypoxic ischemic encephalopathy resting-state functional magnetic resonance imaging brain networks small-world organization brain functional connectivity local efficiency clustering coefficient neural regeneration

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Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis:A randomized,activecontrol,multicenter clinical trial

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World Journal of Stem Cells 2023年第12期15卷 1063-1076页

作者： Cong-Zi wu Zhen-Yu Shi Zhen wu wen-Jun Lin Wei-Bo Chen Xue-wen Jia Si-Cheng Xiang Hui-Hui Xu Qin-wen Ge Kai-Ao Zou Xu Wang Jia-Li Chen Ping-Er Wang wen-Hua Yuan Hong-Ting Jin Pei-Jian Tong Institute of Orthopaedics and Traumatology of Zhejiang Province The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina epartment of Orthopedic Surgery The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Orthopaedic Surgery Tongde Hospital of Zhejiang ProvinceHangzhou 310012China Department of Orthopaedic Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325015Zhejiang ProvinceChina Department of Orthopaedic Surgery Ruian Hospital of Traditional Chinese MedicineWenzhou 325299Zhejiang ProvinceChina Department of Orthopaedics Ningbo First HospitalNingbo 315010Zhejiang ProvinceChina The First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Osteoarthritis(OA)is the most prevalent form of degenerative whole-joint *** the final option of knee replacement,arthroscopic surgery was the most widely used joint-preserving surgical *** regenerative therapies,such as those involving platelet-rich plasma,mesenchymal stem cells,and microfragmented adipose tissue(MFAT),have been pushed to the forefront of treatment to prevent the progression of ***,MFAT has been successfully applied to treat different types of orthopedic *** To assess the efficacy and safety of MFAT with arthroscopic surgery in patients with knee OA(KOA).METHODS A randomized,multicenter study was conducted between June 2017 and November 2022 in 10 hospitals in Zhejiang,***,302 patients diagnosed with KOA(Kellgren-Lawrence grades 2-3)were randomized to the MFAT group(n=151,were administered MFAT following arthroscopic surgery),or the control group(n=151,were administered hyaluronic acid following arthroscopic surgery).The study outcomes were changes in the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,the visual analog scale(VAS)score,the Lequesne index score,the Whole-Organ Magnetic Resonance Imaging Score(WORMS),and safety over a 24-mo period from *** The changes in the WOMAC score(including the three subscale scores),VAS pain score,and Lequesne index score at the 24-mo mark were significantly different in the MFAT and control groups,as well as when comparing values at the posttreatment visit and those at baseline(P<0.001).The MFAT group consistently demonstrated significant decreases in the WOMAC pain scores and VAS scores at all follow-ups compared to the control group(P<0.05).Furthermore,the WOMAC stiffness score,WOMAC function score,and Lequesne index score differed significantly between the groups at 12 and 24 mo(P<0.05).However,no signicant between-group differences were observed in the WORMS at 24 mo(P=0.367).No serious adverse events

关键词： Osteoarthritis Microfragmented adipose tissue Lipogems Arthroscopic surgery Knee

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婴儿牛奶蛋白过敏的危险因素:一项多中心前瞻性巢式病例对照研究

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中国当代儿科杂志 2024年第3期26卷 230-235页

作者：侯林马紫君晁爽李中原张宇刘毅坚张俊红武文艳黄山雅美刘捷北京大学人民医院儿科北京100044 清华大学附属北京清华长庚医院儿科北京102218 解放军总医院第四医学中心儿科北京100089 北京市通州区妇幼保健院儿科北京101101 北京丰台医院儿科北京100070 空军特色医学中心儿科北京100142 北京华信医院(清华大学第一附属医院)儿科北京100016

目的探讨婴儿牛奶蛋白过敏(cow'smilkproteinallergy,CMPA)发生的危险因素。方法该研究为多中心前瞻性巢式病例对照研究。选取北京市7家医学中心0~12月龄婴儿为研究对象。共纳入CMPA婴儿200例,未发生CMPA的婴儿(对照组)799例。采用单因... 详细信息

目的探讨婴儿牛奶蛋白过敏(cow'smilkproteinallergy,CMPA)发生的危险因素。方法该研究为多中心前瞻性巢式病例对照研究。选取北京市7家医学中心0~12月龄婴儿为研究对象。共纳入CMPA婴儿200例,未发生CMPA的婴儿(对照组)799例。采用单因素和多因素logistic回归分析探讨CMPA发生的危险因素。结果单因素logistic回归分析显示,早产儿、低出生体重儿、第一胎、第一产、春季出生、夏季出生、混合/人工喂养、父母患过敏性疾病与婴儿CMPA患病风险增加有关(P<0.05)。多因素logistic回归分析显示,第一产(OR=1.89,95%CI:1.14~3.13)、春季出生(OR=3.42,95%CI:1.70~6.58)、夏季出生(OR=2.29,95%CI:1.22~4.27)、混合/人工喂养(OR=1.57,95%CI:1.10~2.26)、父亲或母亲有过敏史(OR=2.13,95%CI:1.51~3.02)、双亲有过敏史(OR=3.15,95%CI:1.78~5.56)是婴儿CMPA发生的危险因素(P<0.05)。结论第一产出生、春季出生、夏季出生、混合/人工喂养或有过敏家族史的婴儿CMPA的患病风险增加。

关键词：牛奶蛋白过敏危险因素食物过敏婴儿

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“Pincer movement”:Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2074-2088页

作者： Boyi Niu Yixian Zhou Kaixin Liao Ting wen Sixian Lao Guilan Quan Xin Pan Chuanbin wu School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 510632China

The therapeutic efficacy of cisplatin has been restricted by drug resistance of *** glutathione(GSH)detoxification of cisplatin under the catalysis of glutathione S-transferases(GST)plays important roles in the development of cisplatin ***,a strategy of“pincer movement”based on simultaneous GSH depletion and GST inhibition is proposed to enhance cisplatin-based ***,a redox-responsive nanomedicine based on disulfide-bridged degradable organosilica hybrid nanoparticles is developed and loaded with cisplatin and ethacrynic acid(EA),a GST *** to high level of intracellular GSH,the hybrid nanoparticles can be gradually degraded due to the break of disulfide bonds,which further promotes drug ***,the disulfide-mediated GSH depletion and EA-induced GST inhibition cooperatively prevent cellular detoxification of cisplatin and reverse drug ***,the nanomedicine is integrated into microneedles for intralesional drug delivery against cisplatin-resistant *** in vivo results show that the nanomedicine-loaded microneedles can achieve significant GSH depletion,GST inhibition,and consequent tumor growth ***,this research provides a promising strategy for the construction of new-type nanomedicines to overcome cisplatin resistance,which extends the biomedical application of organosilica hybrid nanomaterials and enables more efficient chemotherapy against drug-resistant cancers.

关键词： Cancer therapy Cisplatin Drug resistance Glutathione depletion Glutathione Stransferases Disulfide bonds Organosilica hybrid nanoparticles Ethacrynic acid

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