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Journal of Iron and Steel Research International 2019年第3期26卷 329-334页

作者： jin-zhu Song Wei Tang jie-wen Huang Zi-kang Wang Xin-min Fan Ke-hong Wang College of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094JiangsuChina Jiangsu Product Quality Testing&Inspection Institute Nanjing 210007JiangsuChina

Microstructure and mechanical properties of additively manufactured TC4 alloys were investigated,following boronizing *** treatment process was carried out at temperatures ranging from 950 to 1050°C and held for 8-15 *** microstructural features of fabricated boride layers were examined by optical *** phase compositions of the boride layers were analyzed by X-ray *** hardness profile through the boride layers was also *** results showed that the boride layer of additively manufactured TC4 had a thickness of 51 pm and was composed of an outer TiB2 layer on the top of TiB layer;TiB whiskers wedged into the matrix,forming a strong bond between the boride layer and *** diffusion activation energy was determined to be 80.9 kJ/*** matrix was found to transfer from needlelikeα'martensite phase toα+βbiphasic *** newly formed boride layer can reach 1680 HV in hardness,thus imparting a strong protection to 3D-printed part.

关键词： Additive manufacturing TC4 titanium alloy Boronizing Microstructure Microhardness

Expression of c-fos and oxidative stress on brain of rats reared on food from mercury-selenium coexisting mining area

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Journal of Environmental Sciences 2006年第4期18卷 788-792页

作者： CHENG jin-ping HU Wei-xuan LIU Xiao-jie ZHENG Min SHI Wei WANG wen-hua School of Environmental Science and Engineering Shanghai Jiaotong University Shanghai 200240 China Department oi Epidemiology National Institute for Minamata Disease Minamata Kumamoto 867-0008 Japan School of Public Heath Fudan University Shanghai 200032 China

Wanshan mercury mine is the largest mercury deposit in Guizhou Province of China, but there were few reports on mercury toxic＂ effect in the mining area. In order to study the neurotoxicity of food from Wanshan mercury mine area and probe into the effect of food from Wanshan mercury miner area on the changes of brain oxidative damage and expression of c-fos gene. The rats were exposed to mercury contaminated food for 20 d. The content of malondialdehyde （MDA）, superoxide dismutase （SOD）, GSH-peroxidase （GSH-px） and Glutathione （GSH） in rat brain was measured, and the effect of mercury contaminated rice on the expression of c-los mRNA in rat brain and the expression of c-FOS protein in cortex, hippocampus were observed using reverse transcription polymerase chain reaction （RT-PCR） and immunocytochemical methods. The results showed the levels of GSH, MDA, SOD and of GSH-dependent enzymes in the rat brain changed between exposure groups and control group; The mercury polluted rice induced significantly the expression of c-los mRNA; the c-FOS positive cells in hippocampus and cortex of exposure groups were significant different from control group （P〈0.01）. It could be concluded that oxidative stress signals could contribute to the induction of immediate early genes （IEGs）; free radicals and their by-products might not only cause oxidative damage, but also influenced gene expression; IEGs c-fos participated in the toxicity process of brain injury by mercury polluted food.

关键词： Wanshan mercury mine mercury polluted food oxidative damage c-fos

The putative NAD(P)H Nitroreductase,Rv3131,is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis

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Biomedical and Environmental Sciences 2022年第7期35卷 652-656页

作者： DONG wen Zhu SHI jin CHU Ping LIU Rong Mei wen Shu An ZHANG Ting Ting PANG Yu LU jie Department of Infectious Diseases The First People's Hospital of ZiyangZiyang 641300SichuanChina Department of Bacteriology and Immunology Beijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteBeijing 101149China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing 101149China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryMOE Key Laboratory of Major Diseases in ChildrenBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 101149China

Tuberculosis(TB),which is caused by the intracellular pathogen,Mycobacterium tuberculosis(Mtb),remains one of the deadliest infectious diseases worldwide,accounting for 1.45 million deaths in 2018[1].Thus,there is an increasing need to develop new antibiotics or to repurpose old drugs that have the potential to shorten the current duration of ***(MTZ)is a 5-nitroimidazole antibiotic that is mainly used in the treatment of anaerobic and protozoal infections[2].The action of mechanism for metronidazole has not been fully *** a prodrug,MTZ is inactive until taken up and reduced by anaerobic bacteria and *** is possible that the reduction of Mtz leads to the production of toxic metabolites,which bind to deoxyribonucleic acid and electron-transport proteins of microbial pathogens,thus blocking nucleic acid synthesis[3].The impressive potency of MTZ against anaerobic bacteria indicates the potential for killing Mtb under anaerobic conditions.A previous in vitro study demonstrated that MTZ has potent activity against tubercle bacilli under anaerobic conditions[4].In a non-human primate model,MTZ has been shown to prevent reactivation of latent Mtb infection,indicating the in vivo role in targeting Mtb within an anaerobic environment[5].Although there is strong evidence for the role of MTZ in affecting anaerobic bacilli,the mechanism of action has not been elucidated in Mtb considering that MTZ must be catalyzed to a nitro-free radical form with endogenous *** provide insight=into how MTZ is activated in anaerobic Mtb bacilli,we first characterized the nitroreductase gene,Rv3131,and identified the key residue conferring the activation of MTZ in Mtb.

关键词： Tuberculosis action latent

Multistep evolution from a metal–organic framework to ultrathin nanosheets

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Science Bulletin 2019年第14期64卷 964-967页

作者： Yun Li jin Huang Zong-wen Mo Xue-wen Zhang Xiao-Ning Cheng Li Gong Dong-Dong Zhou jie-Peng Zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry Sun Yat-Sen University Guangzhou 510275 China Instrumental Analysis and Research Center Sun Yat-Sen University Guangzhou 510275 China

Two-dimensional (2D) materials and ultrathin nanosheets have attracted tremendous research interests [1-4]. Exfoliation of porous coordination polymers (PCPs) or metal-organic frameworks (MOFs) with 2D coordination structures is emerging as a viable strategy for preparation of new types of 2D materials [5-8]. The relatively weak bonding within and strong interactions between 2D coordination networks are the main problems for successful exfoliation [9]. Pretreatments of the layered MOFs to expand the interlayer distances can be helpful [10-12]. Capturing the exfoliation intermediates and visualizing their structures are valuable for understanding the exfoliation mechanism and confirming the structures of the final 2D materials [11,12].

关键词： Two-dimensional (2D) porous coordination polymers (PCPs) metal-organic frameworks (MOFs)

Optimization of Hot Workability in Superaustenitic Stainless Steel 654SMO

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Journal of Iron and Steel Research International 2014年第10期21卷 975-982页

作者： En-xiang PU wen-jie ZHENG Zhi-gang SONG jin-zhong XIANG Xian-ping WEI School of Physics Science and Technology Yunnan University Central Iron and Steel Research Institute

Hot compression tests were conducted on a Gleeble-3800 machine in a temperature range of 950 to 1200 ℃ and a strain rate range of 0. 001 to 10 s-1 in order to study the hot deformation behaviour of superaustenitic stainless steel 654SMO. The results show that peak stress increases with decreasing temperature and increasing strain rate, and the apparent activation energy of this alloy was determined to be about 494 kJ/mol. The constitutive equation which can be used to relate the peak stress to the absolute temperature and strain rate was obtained. The processing maps for hot working developed on the basis of flow stress data and the dynamic materials model were adopted to op- timize the hot workability. It is found that the features of the maps obtained in the strain range of 0.2 to 1.0 are fun- damentally similar, indicating that the strain does not have a substantial influence on processing map. The combina- tion of processing map and mierostructural observations indicates that the favorable hot deformation conditions are located in two domains of processing map. The first domain occurs in the temperature range of 980 to 1035 ℃ and strain rate range of 0. 001 to 0.01 s-1 with a peak efficiency of 55%. The second domain appears in the temperature range of 1 120 to 1 180 ℃ and strain rate range of 0.3 to 3 s-1 with peak efficiency of 35%. Compared to other stable domains, the specimens deformed in these two domains exhibit full dynamic recrystallization grains with finer and more uniform sizes. An instability domain occurs at temperatures below 1 100 ℃ and strain rate above 0.1 s-1 , and flow instability is manifested in the form of flow localization.

关键词： 654SMO steel superaustenitic stainless steell processing mapl hot deformationl dynamic recrystallization

Prognostic factors and survival in patients with gastric stump cancer

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World Journal of Gastroenterology 2015年第6期21卷 1865-1871页

作者： Hua Huang Wei Wang Zhong Chen jie-jie jin Zi-wen Long Hong Cai Xiao-wen Liu Ye Zhou Ya-Nong Wang Department of Gastric Cancer and Soft Tissue Sarcoma Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University Department of Hepatobiliary Surgery Affiliated Hospital of Nantong University

AIM:To elucidate the clinicopathological characteristics and prognostic factors of gastric stump cancer(GSC).METHODS:The clinical data for 92 patients with GSC were collected at Fudan University Shanghai Cancer *** prognostic factors were analyzed with Cox proportional hazard ***:GSC tended to occur within 25 years following the primary surgery,when the initial disease is benign,whereas it primarily occurred within the first15 years post-operation for gastric *** with regular follow-up after primary surgery had a better survival *** multivariate Cox regression analysis revealed that Borrmann type?Ⅰ/Ⅱ(HR=3.165,95%CI:1.055-9.500,P=0.040)and radical resection(HR=1.780,95%CI:1.061-2.987,P=0.029)were independent prognostic factors for *** overall 1-,3-,and 5-year survival rates of the 92 patients were78.3%,45.6%and 27.6%,*** 1-,3-,and 5-year survival rates of those undergoing radical resection were 79.3%,52.2%,and 37.8%,*** 5-year survival rates for stages?Ⅰ,Ⅱ,Ⅲ,andⅣwere 85.7%,47.4%,16.0%,and 13.3%,respectively(P=0.005).CONCLUSION:The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign ***,close follow-up is *** overall survival of patients with GSC is poor,and curative resection can improve their prognosis.

关键词： Gastric stump cancer Clinicopathological character

Pretreatment with H_2O_2 Alleviates Aluminum-induced Oxidative Stress in Wheat Seedlings

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Journal of Integrative Plant Biology 2011年第1期53卷 44-53页

作者： Fang jie Xu Chong Wei jin wen jing Liu Yong Song Zhang Xian Yong Lin Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health College of Environmental & Resource Sciences Zhejiang University Hangzhou 310029 China Zhejiang Key Laboratory of Subtropical Soil Science and Plant Nutrition College of Environmental & Resources Science Zhejiang University Hangzhou 310029 China

Hydrogen peroxide （H2O2） is a key reactive oxygen species （ROS） in signal transduction pathways leading to activation of plant defenses against biotic and abiotic stresses. In this study, we investigated the effects of H2O2 pretreatment on aluminum （AI） induced antioxidant responses in root tips of two wheat （Triticum aestivum L.） genotypes, Yangmai-5 （AI-sensitive） and Jian-864 （AI-tolerant）. AI increased accumulation of H2O2 and O2^- leading to more predominant lipid peroxidation, programmed cell death and root elongation inhibition in Yangmai-5 than in Jian-864. However, H2O2 pretreatment alleviated AI- induced deleterious effects in both genotypes. Under AI stress, H2O2 pretreatment increased the activities of superoxide dismutase, catalase, peroxidase, ascorbate peroxidase and monodehydroascorbate reductase, glutathione reductase and glutathione peroxidase as well as the levels of ascorbate and glutathione more significantly in Yangmai-5 than in Jian-864. Furthermore, H2O2 pretreatment also in- creased the total antioxidant capacity evaluated as the 2, 2-diphenyl-l-picrylhydrazyl-radical scavenging activity and the ferric reducing/antioxidant power more significantly in Yangmai-5 than in Jian-864. Therefore, we conclude that H2O2 pretreatment improves wheat AI acclimation during subsequent AI exposure by enhancing the antioxidant defense capacity, which prevents ROS accumulation, and that the enhancement is greater in the AI-sensitive genotype than in the AI-tolerant genotype.

关键词： WHEAT OXIDATIVE stress HYDROGEN peroxide PLANT defenses EFFECT of aluminum on plants BIOACCUMULATION SEEDLINGS

Nano-Twinning and Martensitic Transformation Behaviors in 316L Austenitic Stainless Steel During Large Tensile Deformation

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Acta Metallurgica Sinica(English Letters) 2023年第5期36卷 758-770页

作者： jin-Wang Liu Xian Luo Bin Huang Yan-Qing Yang wen-jie Lu Xiao-Wei Yi Hong Wang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China

The evolutions of nano-twins and martensitic transformation in 316L austenitic stainless steel during large tensile deformation were studied by electron backscatter diffraction(EBSD)technology and transmission electron microscopy(TEM)in *** results show that due to the low stacking fault energy of the steel,phase transformation induced plasticity(TRIP)and twinning induced plasticity(TWIP)coexist during the tensile *** deformation firstly induces the formation of deformation twins,and dislocation pile-up is caused by the reduction of the dislocation mean free path(MFP)or grain refinement due to the twin boundaries,which further induces the martensitic *** the increase of tensile deformation,a large number of nano-twins andα’-martensite appear,and the width of nano-twins decreases gradually,meanwhile the frequency of the intersecting deformation twins *** martensitic transformation can be divided into two types:γ-austenite→α’-martensite andγ-austenite→ε-martensite.α’-martensite is mainly distributed near the twin boundaries,especially at the intersection of twins,whileε-martensite and stacking faults exist in the form of transition products between the twins and the matrix.

关键词： Austenitic stainless steel Intersecting-deformation twins Martensitic transformation High resolution transmission electron microscopy(HRTEM) Deformation mechanism

Research Progress of Angiogenesis in Atherosclerotic Plaque in Chinese Medicine and Western Medicine

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Chinese Journal of Integrative Medicine 2018年第12期24卷 950-955页

作者： MA Lan DAI jin CHEN jie CAI Hong-wen LI Jia-ying LI Xin-yao CHEN Shen-jie MAO Wei The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310053China

Angiogenesis in atherosclemtic plaque plays a critical role in the mechanism of atherosclerotic physiopathology. Present consensus shows that angiogenesis in atherosclerotic plaque is mainly resulted in hypoxia, inflammation and some pro-angiogenic factors. The homeostasis in plaque, which is hypoxic and infiltrated by inflammatory cells, may lead to angiogenesis, increase the plaque instability and the incidence rate of vascular events. This article reviews the progression of pathogenetic mechanism, physiopathological significance, relevant detecting technique and corresponding therapeutic methods of Chinese and Western medicine of angiogenesis in atherosclerotic plaque, so as to provide more theoretical basis for atherosclerotic clinical treatment.

关键词： angiogenesis atherosclerotic plaque Chinese medicine Western medicine

Quantum to classical transition induced by a classically small influence

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Chinese Physics B 2020年第8期29卷 151-156页

作者： wen-Lei Zhao Quanlin jie School of Science Jiangxi University of Science and TechnologyGanzhou 341000China Department of Physics Wuhan UniversityWuhan 430072China

We investigate the quantum to classical transition induced by two-particle interaction via a system of periodically kicked *** classical dynamics of particle 1 is almost unaffected in condition that its mass is much larger than that of particle ***,such classically weak influence leads to the quantum to classical transition of the dynamical behavior of particle ***,the quantum diffusion of this particle undergoes the transition from dynamical localization to the classically chaotic diffusion with the decrease of the effective Planck constantħ*** behind physics is due to the growth of entanglement in the *** classically very weak interaction leads to the exponential decay of purity in condition that the classical dynamics of external degrees freedom is strongly chaotic.

关键词： quantum to classical transition quantum decoherence quantum chaos