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Maternal Lead Exposure Induces Down-regulation of Hippocampal Insulin-degrading Enzyme and Nerve Growth Factor Expression in Mouse Pups

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Biomedical and Environmental Sciences 2017年第3期30卷 215-219页

作者： LI Xing LI Ning SUN hua Lei YIN Jun TAO Yu Chang MAO Zhen Xing YU Zeng Li LI wen Jie John D BOGDEN College of Public Health Zhengzhou University College of Food Science and Technology Henan Agriculture University Department of Microbiology Biochemistryand Molecular GeneticsRutgers New Jersey Medical School

Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease （AD）. Exposure to lead during the critical phase of brain development has been linked with mental retardatio... 详细信息

关键词： AD Maternal Lead Exposure Induces Down-regulation of Hippocampal Insulin-degrading Enzyme and Nerve Growth Factor Expression in Mouse Pups IDE NGF

Interactions of Vitamin D Receptor Polymorphisms with Hypertriglyceridemia and Obesity in Chinese Individuals Susceptible to Hypertension and Diabetes Comorbidity

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Biomedical and Environmental Sciences 2023年第2期36卷 196-200页

作者： SUN hua Lei ZHAO Tong ZHANG Dong Dong FENG Ming Ming XU Ze huaNG Hao Yue ZHANG Luo Ya LI wen Jie LI Xing DUAN Jia Yu LI Jia Department of Nutrition the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450001HenanChina Department of Integrated Traditional and Western Nephrology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052HenanChina Research Institute of Nephrology Zhengzhou UniversityZhengzhou 450052HenanChina Department of Nutrition and Food Hygiene College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina

Hypertension(HTN)and type 2 diabetes mellitus(T2DM)are interconnected metabolic diseases[1,2]that considerably increase susceptibility to microvascular and macrovascular *** many patients,HTN and diabetes comorbidity(HDC)is caused by mutual pathogenic pathways,such as endothelial dysfunction,atherosclerosis,oxidative stress,and vascular inflammation[1].Hence.

关键词： morbidity inflammation diseases

温阳健脾方联合恩替卡韦治疗乙型肝炎肝硬化失代偿期的疗效及对血清炎性因子和肠黏膜屏障功能的影响

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中国药物与临床 2024年第13期24卷 822-827页

作者：沈初孔俊姚任华浙江省医疗健康集团杭州医院杭州杭钢医院中医科浙江杭州310000

目的探究温阳健脾方+恩替卡韦治疗乙型肝炎肝硬化失代偿期效果。方法选取2020年5月至2022年5月杭州杭钢医院148例乙型肝炎肝硬化失代偿期患者,按治疗方法分组,对照组(74例)接受恩替卡韦治疗,研究组(74例)在此基础上加用温阳健脾方治疗... 详细信息

目的探究温阳健脾方+恩替卡韦治疗乙型肝炎肝硬化失代偿期效果。方法选取2020年5月至2022年5月杭州杭钢医院148例乙型肝炎肝硬化失代偿期患者,按治疗方法分组,对照组(74例)接受恩替卡韦治疗,研究组(74例)在此基础上加用温阳健脾方治疗。比较2组疗效、肝功能、乙型肝炎病毒、肝纤维化指标、炎性因子、肠黏膜屏障功能相关指标及不良反应。结果研究组治疗总有效率96%,比对照组的85%高(χ^(2)=5.049,P0.05)。结论温阳健脾方联合恩替卡韦治疗乙型肝炎肝硬化失代偿期疗效确切,可降低患者炎性因子水平,修复肠黏膜屏障,抑制病毒复制,且联合用药不会增加不良反应,用药安全。

关键词：乙型肝炎肝硬化温阳健脾方恩替卡韦肿瘤坏死因子-α

从精准医学与辨证论治初探类风湿关节炎的个体化诊疗

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时珍国医国药 2024年第1期35卷 154-156页

作者：吕柳马玉草黄正慧刘春平朱华超朱振红方锦颖王艺文刘明煊王海隆北京中医药大学东直门医院北京100700

类风湿关节炎(Rheumatoid Arthritis, RA)是一种慢性系统性自身免疫疾病。近年来精准医学和个体化诊疗RA成为探讨与研究的热点,而辨证论治是中医最具特色的诊断与治疗方法,突出个体化诊治疾病的中医思路。在一定程度上,精准医学提出的... 详细信息

类风湿关节炎(Rheumatoid Arthritis, RA)是一种慢性系统性自身免疫疾病。近年来精准医学和个体化诊疗RA成为探讨与研究的热点,而辨证论治是中医最具特色的诊断与治疗方法,突出个体化诊治疾病的中医思路。在一定程度上,精准医学提出的的疾病个体化诊疗,与中医辨证论治的思想有异曲同工之妙,精准医学背景下的辨证论治是RA未来中医个体化诊疗的发展前景和方向。文章从不同角度探讨辨证论治与精准医学,以期为RA的中医个体化诊疗提供新的思路。

关键词：类风湿关节炎精准医学辨证论治个体化诊疗

A Rigidity Measurement of Pseudo-Rapidity Spectrum of Produced Particles in High Energy Nucleus-Nucleus Collisions

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Chinese Physics Letters 1998年第8期15卷 566-567页

作者： ZHOU dai-cui CAI XU LI Yun-de LIU Lian-shou QIAN Wan-yan WANG Xiao-rong YANG Chun-bin YAN wen-biao Institute of Particle Physics Huazhong Normal UniversityWuhan 430079

A new concept,rigidity of pseudo-rapidity spectrum,is extended into the study of the multiplicity fluctuations in high energy nucleus-nucleus *** using the novel method to analyze the data of l6O-Em at 14.6,60,and 200A GeV,and ^(32)S-Em at 200A GeV,it is found that the rigidity of pseudo-rapidity spectrum in the central domain of pseudo-rapidity might be a mixture of Poisson type and Wigner one.

关键词： rigidity spectrum Collisions

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一个超混沌系统及其投影同步

电子学报 2009年第3期37卷 654-657页

作者：李华青罗小华代祥光重庆邮电大学数理学院重庆400065 重庆邮电大学通信与信息工程学院重庆400065 重庆邮电大学移通学院重庆400065

通过在Lorenz系统中加入两个控制器构造出一个五维超混沌系统,系统的超混沌特性通过Lyapunov指数得到验证,对系统的平衡点和耗散性进行了分析.基于线性系统的稳定性准则,利用线性分离方法实现了该超混沌系统的投影同步.

关键词：超混沌系统 Lyapunov指数线性分离投影同步

Effect of thalidomide combined with CHOP on immune function, angiogenesis and inflammatory factors in patients with diffuse large B-cell lymphoma

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Journal of Hainan Medical University 2019年第18期25卷 20-24页

作者： Yun Wan Yu-gang Xing Liang-hua Wang An-wei dai Department of Oncology Kunshan Hospital of Traditional Chinese MedicineKunshan Affiliated Hospital of Nanjing University of Chinese MedicineKunshan 215300JiangsuChina

Objective:To mainly explore the effect of thalidomide combined with CHOP chemotherapy regimen on immunoglobulin,VEGF,lactate dehydrogenase,inflammatory factors and other related factors in patients with diffuse large B-cell ***:A total of 83 patients with diffuse large B-cell lymphoma admitted to the Department of Hematology and Oncology in our hospital from December 2012 to December 2018 were *** chemotherapy was given to 40 patients in the chemotherapy *** 43 patients in the thalidomide group were treated with thalidomide combined with CHOP *** IgG,IgA,IgM,vascular endothelial growth factor(VEGF),tumor necrosis factor(TNF-α),lactate dehydrogenase(LDH),β2 microglobulin(β2-MG),Th17 cell ratio and natural killer cell(NK)ratio were measured before and after ***:There were no significant differences in immunoglobulin,inflammatory cytokines and other related factors between the two groups before treatment(P>0.05).After 6 cycles of treatment,the levels of immunoglobulin IgG,IgA,IgM,VEGF,LDH,β2-MG and the ratio of NK cells in the chemotherapy group were significantly lower than those before treatment(P<0.05);TNF-αand the ratio of Th17 cells were significantly higher than that those before *** levels of IgG,IgA,IgM,VEGF,LDH andβ2-MG in the thalidomide group were significantly lower than those before treatment(P<0.05).The levels of TNF-α,Th17 cells and NK cell rates were significantly higher than those before treatment(P<0.05).In addition,the levels of IgG,IgA,IgM,VEGF,LDH andβ2-MG in the thalidomide group were significantly lower than those in the chemotherapy group(P<0.05),and the level of TNF-α,the rates of Th17 cells and NK cells were significantly higher than those in the chemotherapy group(P<0.05).Conclusion:Thalidomide combined with CHOP chemotherapy has a significant therapeutic effect on diffuse large B-cell *** combined with CHOP chemotherapy can significantly reduce the

关键词： Thalidomide Diffuse large b B-cell lymphoma Immune function VEGF Inflammatory cytokines

Myocardial infarction secondary prevention study (MISPS)

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Journal of Geriatric Cardiology 2006年第2期3卷 116-119页

作者： Hongcai SHANG Guohua dai Junhua HANG Yaozu XIANG Yang WANG Junping ZHANG Wuxun DU Jingyuan MAO Chen YAO Weiliang wenG Tiancai wen Boli ZHANG Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China First Hospital of Peking University Beijing 100700 China Chinese Academy of Traditonal Chinese Medicine Beijing 100700 China Chinese Academy of Traditonal Chinese Medicine Beijing 100700 China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China

Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are *** YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries.

关键词： Myocardial infarction secondary prevention study MISPS MACE

Gut-lung crosstalk in pulmonary involvement with inflammatory bowel diseases

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World Journal of Gastroenterology 2013年第40期19卷 6794-6804页

作者： Hui Wang Jing-Shi Liu Shao-hua Peng Xi-Yun Deng De-Mao Zhu Sara Javidiparsijani Gui-Rong Wang dai-Qiang Li Long-Xuan Li Yi-Chun Wang Jun-Ming Luo Department of Radiation Oncology the Affiliated Hunan Provincial Tumor HospitalXiangya Medical SchoolCentral South University Department of Anesthesiology the Affiliated Hunan Provincial Tumor Hospital at Central South University Department of Pathology Medical College of Hunan Normal University Department of Pathology Changsha Central Hospital Department of Surgery SUNY Upstate Medical University Department of Pathology the Second Affiliated HospitalXiangya Medical SchoolCentral South University Department of Neurology Guangdong Medical College Affiliated Hospital Department of Pathology Qinghai Provincial People's Hospital

Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously *** evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the *** there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.

关键词： Inflammatory bowel disease Pulmonary symptoms Gut-lung crosstalk Biao-Li relationship Social manner