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Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury

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Neural Regeneration Research 2022年第10期17卷 2157-2165页

作者： Ming-Xi Li Jing-wen weng Eric S.Ho Shing fung Chow Chi Kwan Tsang Clinical Neuroscience Institute The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineUniversity of Hong KongHong Kong Special Administrative RegionChina Department of Biology and Department of Computer Science Lafayette CollegeEastonPAUSA

Injuries to the central nervous system(CNS)such as stroke,brain,and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon *** brain has a surprising intrinsic capability of recovering itself after ***,the hostile extrinsic microenvironment significantly hinders axon *** advances have indicated that the inactivation of intrinsic regenerative pathways plays a pivotal role in the failure of most adult CNS neuronal ***,substantial evidence has convincingly demonstrated that the mechanistic target of rapamycin(mTOR)signaling is one of the most crucial intrinsic regenerative pathways that drive axonal regeneration and sprouting in various CNS *** this review,we will discuss the recent findings and highlight the critical roles of mTOR pathway in axon regeneration in different types of CNS ***,we will demonstrate that the reactivation of this regenerative pathway can be achieved by blocking the key mTOR signaling components such as phosphatase and tensin homolog(PTEN).Given that multiple mTOR signaling components are endogenous inhibitory factors of this pathway,we will discuss the promising potential of RNA-based therapeutics which are particularly suitable for this purpose,and the fact that they have attracted substantial attention recently after the success of coronavirus disease 2019 *** specifically tackle the blood-brain barrier issue,we will review the current technology to deliver these RNA therapeutics into the brain with a focus on nanoparticle *** will propose the clinical application of these RNA-mediated therapies in combination with the brain-targeted drug delivery approach against mTOR signaling components as an effective and feasible therapeutic strategy aiming to enhance axonal regeneration for functional recovery after CNS injury.

关键词： axon sprouting axon regeneration brain targeted drug delivery CNS injury ischemic stroke mTOR nanoparticle neural circuit reconstruction PTEN RNA-based therapeutics

Viscoelastic Property Evolution of Thermoplastic Polyurethane during Annealing Treatment and Its Correlation with Segmental Crystallization

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Chinese Journal of Polymer Science 2024年第12期42卷 1976-1985,I0010页

作者： Jian-wen Shan Yan-Bo Zhu Ling-Ling Ni Peng-Ju pan State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou310058China Department of Polymer Science and Engineering Zhejiang UniversityHangzhou310058China

Viscoelastic properties of thermoplastic polyurethane(TPU)is of fundamental importance for its *** this work,we prepared different TPUs from polycaprolactone(PCL)diol,diphenylmethane-4,4′-diisocyanate(MDI),and 1,4-butanediol(BDO),and investigated the viscoelastic behavior of three TPUs with different hard segment content during thermal annealing *** storage modulus(G′)of TPU increases over time in a medium annealing temperature(T_(a))region,but remains unchanged at both high and low temperature *** growth of loss modulus(G″)over time is slower than that of G′.At medium T_(a),both G′and G″increase during the repeating frequency(ω)sweep,due to the gradual crystallization of hard *** indicates that the crystallites primarily restrain the relaxation of unit with large *** increments of G′and G″are weakened when the content of hard segment in TPU is *** TPU with high content of hard segments,a complete high elastic platform with a width of 3 orders of magnitude was observed only through one frequency scan test at medium T_(a).In addition,the crystallites of hard segments grow up continuously during frequency scan test(isothermal annealing treatment)and cause the extreme increase in G′and G″withωin lowωregion.

关键词： Thermoplastic polyurethane Viscoelastic properties Annealing Crystalization

APPLICATION OF GRAY EVALUATION MODEL BASED ON AHP IN ATM SYSTEM

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Journal of Electronics(China) 2008年第3期25卷 428-432页

作者： Wu Zhijun pan wen College of Electronics ＆ Information Civil Aviation University of China Tianjin 300300 China

This paper presents a hierarchy model of Air Traffic Management (ATM) according to the security requirements in ATM system, analyzes it by grey assessment and Analytic Hierarchy Process (AHP), and evaluates it in details. It also provides theoretical support for building an effective evaluation system. The basic idea is to use AHP and Grey Assessment to obtain the weights of the indicators, and count grey evaluation coefficients with whitening function. The compositive clustering coefficients are obtained by combining the weights and the grey evaluation coefficients. Evaluation result can be gotten from the compositive clustering coefficients.

关键词： Air Traffic Management (ATM) Analytic Hierarchy Process (AHP) Grey System

Deep Learning Based Attack Detection for Cyber-Physical System Cybersecurity:A Survey

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IEEE/CAA Journal of Automatica Sinica 2022年第3期9卷 377-391页

作者： Jun Zhang Lei pan Qing-Long Han Chao Chen Sheng wen Yang Xiang IEEE the School of Science Computing and Engineering TechnologiesSwinburne University of Technology the School of Information Technology Deakin University the College of Science and Engineering James CookUniversity

With the booming of cyber attacks and cyber criminals against cyber-physical systems(CPSs),detecting these attacks remains *** might be the worst of times,but it might be the best of times because of opportunities brought by machine learning(ML),in particular deep learning(DL).In general,DL delivers superior performance to ML because of its layered setting and its effective algorithm for extract useful information from training *** models are adopted quickly to cyber attacks against CPS *** this survey,a holistic view of recently proposed DL solutions is provided to cyber attack detection in the CPS context.A six-step DL driven methodology is provided to summarize and analyze the surveyed literature for applying DL methods to detect cyber attacks against CPS *** methodology includes CPS scenario analysis,cyber attack identification,ML problem formulation,DL model customization,data acquisition for training,and performance *** reviewed works indicate great potential to detect cyber attacks against CPS through DL ***,excellent performance is achieved partly because of several highquality datasets that are readily available for public ***,challenges,opportunities,and research trends are pointed out for future research.

关键词： Cyber-physical system cybersecurity deep learning intrusion detection pattern classification

Porous yolk-shell structured Na_(3)(VO)_(2)(PO_(4))_(2)F microspheres with enhanced Na-ion storage properties

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Journal of Materials Science & Technology 2021年第24期83卷 83-89页

作者： Yameng Yin Cunyuan Pei Fangyu Xiong Yi pan Xiaoming Xu Bo wen Qinyou An State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu hydrogen ValleyFoshan528200China

Na_(3)(VO)_(2)(PO_(4))_(2)F(NVPOF)has been considered as one potential candidate for sodium-ion batteries because of its high operating voltage and theoretical ***,the poor intrinsic electronic conductivity significantly restricts its widespread *** response to this drawback,we adopt the optimization strategy of tuning the morphology and structure to boost the electrical conductivity and mitigate the capacity *** this paper,NVPOF microspheres with unique porous yolk-shell structure were fabricated via a facile one-step solvothermal method for the first *** monitoring the morphological evolution with time-dependent experiments,the self-sacrifice and Ostwald ripening mechanism from rough spheres to yolk-shell structure was *** from the favorable interwoven nanosheets shell,inner cavity and porous core structure,the resulting NVPOF electrode exhibits superior rate capability of 63 m A h g^(-1)at 20 C as well as outstanding long-cycling performance with the capacity retention up to 92.1%over 1000 cycles at 5 C.

关键词： Yolk-shell Na_(3)(VO)_(2)(PO_(4))_(2)F Microspheres Synthesis mechanism Sodium-ion batteries

Regulated polarization degree of upconversion luminescence and multiple anti-counterfeit applications

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Rare Metals 2024年第5期43卷 2172-2183页

作者： Dong-Ping wen Ping Chen Yi Liang Xiao-Ming Mo Cao-Feng pan Center On Nanoenergy Research Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China Key Laboratory of Micronano Energy and Sensor CAS Center for Excellence in NanoscienceBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100140China

Polarization upconversion luminescence(PUCL)of lanthanide ions(Ln^(3+))has been widely used in single particle tracking,microfluidics detection,three-dimensional displays,and so ***,no effective strategy has been developed for modulating *** we report a strategy to regulate PUCL in Ho^(3+)-doped NaYF4single nanorods based on the number of upconversion *** constructing a multiphoton upconversion system for Ho^(3+),we regulate the degree of polarization(DOP)of PUCL from 0.590 for two-photon luminescence to 0.929 for three-photon upconversion luminescence(UCL).Furthermore,our strategy is verified from cross-relaxation between Ho^(3+)and Yb^(3+),excitation wavelength,excitation power density,and local site *** this regulation strategy of PUCL has also been achieved in Tm^(3+),with the DOP ranging from 0.233 for two-photon luminescence to 0.925 for four-photon UCL Besides,multi-dimensional anti-counterfeiting display has been explored with *** work provides an effective strategy for regulating PUCL and also provides more opportunities for the development of polarization display optical encoding,anti-counterfeiting,and integrated optical devices.

关键词： Polarization upconversion luminescence Degree of polarization Population density of excited state Number of upconversion photons Polarization anti-counterfeitingdisplay

Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells

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International Journal of Ophthalmology(English edition) 2018年第2期11卷 189-195页

作者： Ya-Yu Chen Chia-Fang Tsai Ming-Chu Tsai wen-Kang Chen Yu-wen Hsu fung-Jou Lu Institute of Medicine College of MedicineChung Shan Medical UniversityTaichung City 40201TaiwanChina Department of Biotechnology TransWorld UniversityDouliu City 64063TaiwanChina Department of Applied Cosmetology Tainan Junior College of NursingTainan City 70043TaiwanChina Department of Optometry Da-Yeh UniversityChanghua 51591TaiwanChina Department of Ophthalmology Chung Shan Medical University HospitalTaichung City 40201TaiwanChina

AIM： To investigate the anti-fibrosis effect of rosmarinic acid（RA） in pterygium epithelial cells（PECs） to determine if RA is a potent agent for treating ***： The PECs（1×10-4 cells/mL） were treated with 100 μmol/L of RA for 1, 3 and 6h. After RA treatment, the cell viability was determined by staining with acridine orange/DAPI and analysis via a NucleoC ounter NC-3000. The protein expression levels of type I collagen, transforming growth factor beta-1（TGF-β1）, TGF-β type Ⅱ receptor（TGF-βRⅡ）, p-Smad1/5, p-Smad2, p-Smad3, and Smad4 of the cell lysates were measured by Western blot ***： The cell viability of PECs was significantly decreased after RA treatment（P〈0.01）. As the result, RA reduced the protein expression of typeⅠcollagen and TGF-β1 of PECs. Additionally, RA also inhibited TGF-β1/Smad signaling by decreasing the protein expressions of TGF-βRII, p-Smad1/5, p-Smad2, p-Smad3, and ***： This study demonstrate that RA could inhibit fibrosis of PECs by down-regulating type I collagen expression and TGF-β1/Smad signaling. Therefore, RA is a potent therapeutic agent for the treatment of pterygium.

关键词： fibrosis pterygium rosmarinic acid transforming growth factor beta-1 typeⅠcollagen

Chiral Phenol-2NO Ligand Cooperation with Achiral Organic Base in the Zn(II)-Catalyzed Asymmetric Alkylation Reaction of Indoles

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Chinese Journal of Chemistry 2024年第13期42卷 1474-1480页

作者： Ke-Lan Xu Yu-Heng Wang Xi-Rui Wang pan Hu Bo-wen pan wen-Jing Zhang Zi-Yue Chen Ying Zhou Xiong-Li Liu National&Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food Guizhou UniversityGuiyangGuizhou 550025China College of Pharmaceutical Sciences Guizhou University of Traditional Chinese MedicineGuiyangGuizhou 550025China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China

The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric ***,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that incorporate the advantages of both the phenol skeleton and pyrroloimidazolone-based N-oxide moiety,from readily available L-prolinamides in operationally simple two steps and up to 44%overall *** importantly,using an achiral quinoline derivative as an additive,the newly developed Phenol-2NO ligand could serve as the anioic ligand upon deprotonative activation to coordinate to Zn(II)to form a highly enantioselective catalyst for the asymmetric Michael-type Friedel-Crafts alkylation reaction of indoles with 2,*** yields(up to 90%)and high enantioselectivities(up to 99%ee)are obtained for a wide range of substrates under mild *** and DFT calculations revealed the reaction mechanism and the origins of the *** also represented the first activation of phenol-type ligand/metal complex by an achiral organic base as the additive in asymmetric catalysis.

关键词： Phenol-2NO C_(2)-Symmetric Rigid-featured Tridentate ligand Asymmetric catalysis Alkylation Synthesis design Heterocycles

Chinese Outward Foreign Direct Investment and Industrial Upgrading from the Perspective of Differences among Countries

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China & World Economy 2020年第3期28卷 1-28页

作者： Hao Chen Jiadong pan wen Xiao School of Economics and Management Zhejiang University of Science and TechnologyChina Zhejiang Institute of Administration China

This paper constructs a two-sector model to identify the effects of outward foreign direct investment(OFDI)in different countries on China s industrial upgrading and conducts an empirical analysis using provincial-level panel data from *** results show that China can benefit firom industrial upgrading via OFDI in developed countries by way of reverse technology spillover:This effect is significant in the eastern region,but not in the central and western *** can also benefit from industrial upgrading via OFDI in developing countries and countries along the Belt and Road through marginal industrial *** effect is more significant in the central region,followed by the western and eastern *** results imply that China should promote technology-seeking OFDI in developed countries,and enhance efficiency-seeking OFDI in developing countries,especially in countries along the Belt and Road.

关键词： industrial upgrading marginal industrial transfer outward foreign direct investment reverse technology spillover