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Human umbilical cord mesenchymal stem cells derivedexosomes on VEGF-A in hypoxic-induced mice retinal astrocytes and mice model of retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1238-1247页

作者： Xiao-Tian Zhang bo-wen zhao Yuan-Long Zhang Song Chen Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China

AIM:To observe the effect of human umbilical cord mesenchymal stem cells(hUCMSCs)secretions on the relevant factors in mouse retinal astrocytes,and to investigate the effect of hUCMSCs on the expression of vascular endothelial growth factor-A(VEGF-A)and to observe the therapeutic effect on the mouse model of retinopathy of prematurity(ROP).METHODS:Cultured hUCMSCs and extracted exosomes from them and then retinal astrocytes were divided into control group and hypoxia *** assay,flow cytometry,reverse transcription-polymerase chain reaction(RT-PCR)and Western blot were used to detect related *** mechanisms by which hUCMSCs exosomes affect VEGF-A expression in hypoxia-induced mouse retinal astrocytes were *** last,the efficacy of exosomes of UCMSCs in a mouse ROP model was ***6 was used to comprehensively process data ***:The secretion was successfully extracted from the culture supernatant of hUCMSCs by gradient *** oxygen species(ROS)and hypoxia inducible factor-1α(HIF-1α)of mice retinal astrocytes under different hypoxia time and the expression level of VEGF-A protein and VEGF-A mRNA increased,and the ROP cell model was established after 6h of *** secretions of medium and high concentrations of hUCMSCs can reduce ROS and HIF-1α,the expression levels of VEGF-A protein and VEGF-A mRNA are statistically significant and concentration *** with the ROP cell model group,the expression of phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signal pathway related factors in the hUCMSCs exocrine group is significantly *** intravitreal injection of the secretions of medium and high concentrations of hUCMSCs can reduce VEGF-A and HIF-1αin ROP model *** staining shows that the number of retinal neovascularization in ROP mice decreases with the increase of the dose of hUCMSCs ***:In a hypoxia induced

关键词： human umbilical cord mesenchymal stem cells retinal astrocytes retinopathy of prematurity vascular endothelial growth factor hypoxia inducible factor

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Overview of ferroptosis and pyroptosis in acute liver failure

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World Journal of Gastroenterology 2024年第34期30卷 3856-3861页

作者： Ya-wen Sun bo-wen zhao Hai-Fang Li Guang-Xiao Zhang College of Life Sciences Shandong Agricultural UniversityTai’an 271018Shandong ProvinceChina

In this editorial,we comment on the article by Zhou et al published in a recent *** specifically focus on the crucial roles of ferroptosis and pyroptosis in acute liver failure(ALF),a disease with high mortality *** is the result of increased intracellular reactive oxygen species due to iron accumulation,glutathione(GSH)depletion,and decreased GSH peroxidase 4 activity,while pyroptosis is a procedural cell death mediated by gasdermin D which initiates a sustained inflammatory *** this review,we describe the characteristics of ferroptosis and pyroptosis,and discuss the involvement of the two cell death modes in the onset and development of ***,we summarize several interfering methods from the perspective of ferroptosis and pyroptosis for the alleviation of *** observations might provide new targets and a theoretical basis for the treatment of ALF,which are also crucial for improving the prognosis of patients with ALF.

关键词： Acute liver failure Ferroptosis Pyroptosis Glutathione peroxidase 4 Gasdermin D

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Proteomic study of vitreous in proliferative diabetic retinopathy patients after treatment with aflibercept:a quantitative analysis based on 4D label-free technique

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 676-685页

作者： Ting-Ting Feng Xiang Gao An-Ran Liang bo-wen zhao Guang-Hui He Song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin Eye InstituteTianjin Eye HospitalTianjin 300020China Key Laboratory of Ophthalmology Anyang Eye HospitalAnyang 455000Henan ProvinceChina Department of Ophthalmology Jining No.1 People’s HospitalJining 272011Shandong ProvinceChina

AIM:To identify different metabolites,proteins and related pathways to elucidate the causes of proliferative diabetic retinopathy(PDR)and resistance to anti-vascular endothelial growth factor(VEGF)drugs,and to provide biomarkers for the diagnosis and treatment of ***:Vitreous specimens from patients with diabetic retinopathy were collected and analyzed by Liquid Chromatography-Mass Spectrometry(LC-MS/MS)analyses based on 4D label-free *** differentially expressed proteins(DEPs),Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway representation and protein interactions were ***:A total of 12 samples were *** proteomics results showed that a total of 58 proteins were identified as DEPs,of which 47 proteins were up-regulated and 11 proteins were *** found that C1q and tumor necrosis factor related protein 5(C1QTNF5),Clusterin(CLU),tissue inhibitor of metal protease 1(TIMP1)and signal regulatory protein alpha(SIRPα)can all be specifically regulated after aflibercept *** functional analysis showed that some DEPs are related to changes in inflammatory regulatory pathways caused by *** addition,protein-protein interaction(PPI)network evaluation revealed that TIMP1 plays a central role in neural *** addition,CD47/SIRPαmay become a key target to resolve anti-VEGF drug resistance in ***:Proteomic analysis is an approach of choice to explore the molecular mechanisms of *** data show that multiple proteins are differentially changed in PDR patients after intravitreal injection of aflibercept,among which C1QTNF5,CLU,TIMP1 and SIRPαmay become targets for future treatment of PDR and resolution of anti-VEGF resistance.

关键词： vitreous proliferative diabetic retinopathy proteome 4D label-free

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Cationic engineered nanodiamonds for efficient antibacterial surface with strong wear resistance

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Nano Research 2024年第3期17卷 939-948页

作者： Fu-Kui Li wen-bo zhao Yong Wang wen-Tao Huang Ya-Lun Ku Hang Liu Rui Guo Hui-Hui Yu Kai-Kai Liu Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of Educationand School of Physics&MicroelectronicsZhengzhou UniversityZhengzhou 450052China

The spread of diseases caused by bacterial adhesion and immobilization in public places constitutes a serious threat to public *** of bacteria spread by the construction of an antibacterial surface takes precedence over post-infection ***,we demonstrate an effective antibacterial surface with strong wear resistance by constructing cationic engineered nanodiamonds(C-NDs).The C-NDs with positive surface potentials interact effectively with bacteria through electrostatic interactions,where the C-NDs act on the phospholipid bilayer and lead to bacterial membrane collapse and rupture through hydrogen bonding and residual surface oxygen-containing reactive *** this case,bactericidal rate of 99.99%and bacterial biofilm inhibition rate of more than 80%can be achieved with the C-NDs concentration of 1 mg/*** addition,the C-NDs show outstanding antibacterial stability,retaining over 87%of the antibacterial effect after stimulation by adverse environments of heat,acid,and external ***,an antibacterial surface with high wear resistance obtained by integrating C-NDs with commercial plastics has been *** antibacterial surface with a mass fraction of 1 wt.%C-NDs improved abrasion resistance by 3981 times,with 99%killing of adherent *** work provides an effective strategy for highly efficient antibacterial wear-resistant surface,showing great practical applications in public health environments.

关键词： antibacterial surface cationic engineered nanodiamonds wear-resistant

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Multi-stage dual replica bit-line delay technique for process-variation-robust timing of low voltage SRAM sense amplifier

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Frontiers of Information Technology & Electronic Engineering 2015年第8期16卷 700-706页

作者： Chao WU Lu-ping XU Hua ZHANG wen-bo zhao School of Aerospace Science and Technology Xidian University

A multi-stage dual replica bit-line delay （MDRBD） technique is proposed for reducing access time by suppressing the sense-amplifier enable （SAE） timing variation of low voltage static randomaccess memory （SRAM） applications. Compared with the traditional technique, this strategy, using statistical theory, reduces the timing variation by using multi-stage ideas, meanwhile doubling the replica bit-fine （RBL） capacitance and discharge path simultaneously in each stage. At a supply voltage of 0.6 V, the simulation results show that the standard deviations of the SAE timing and cycle time with the proposed technique are 69.2% and 47.2%, respectively, smaller than that with a conventional RBL delay technique in TSMC 65 nm CMOS technology （Taiwan Semiconductor Manufacturing Company, Taiwan）.

关键词： Process-variation-robust Sense amplifier (SA) Replica bit-line (RBL) delay Timing variation

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A block zero-padding method based on DCFT for L1 parameter estimations in weak signal and high dynamic environments

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Frontiers of Information Technology & Electronic Engineering 2015年第9期16卷 796-804页

作者： Chao WU Lu-ping XU Hua ZHANG wen-bo zhao School of Aerospace Science and Technology Xidian University

Weak L1 signal acquisition in a high dynamic environment primarily faces a challenge： the integration peak is neg- atively influenced by the possible bit sign reversal every 20 ms and the frequency error. The block accumulating semi-coherent integration of correlations （BASIC） is a state-of-the-art method, but calculating the inter-block conjugate products restricts BASIC in a low signal-to-noise ratio （SNR） acquisition. We propose a block zero-padding method based on a discrete chirp-Fourier transform （DCFT） for parameter estimations in weak signal and high dynamic environments. Compared with the conventional receiver architecture that uses closed-loop acquisition and tracking, it is more suitable for open-loop acquisition. The proposed method combines DCFT and block zero-padding. In this way, the post-correlation signal is coherently post-integrated with the bit sequence stripped off, and the high dynamic parameters are precisely estimated using the threshold set based on a false alarm probability. In addition, the detection performance of the proposed method is analyzed. Simulation results show that compared with the BASIC method, the proposed method can precisely detect the high dynamic parameters in lower SNR when the length of the received signal is fixed.

关键词： Threshold detection Discrete chirp-Fourier transform Block zero-padding High dynamic Weak L1 signal acquisition

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An investigation on the dosimetric impact of hip prosthesis in radiotherapy

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Nuclear Science and Techniques 2016年第1期27卷 29-36页

作者： wen-Cheng Shao Yan-Ling Bai wen-bo zhao Pu-Nan Sun Feng-Li Liu Department of Radiation Physics Harbin Medical University Cancer Hospital Beijing Xiao Qing Environmental Engineering Co. LtdHarbin office School of physical science and technology Heilongjiang University

The objectives of this study are to evaluate the dosimetric impact of hip prosthesis using ELEKTA linac X-rays and compare the dose perturbations of metallic and nonmetallic hip prostheses. The local dose distributions of typical hip prostheses were calculated for 4, 8, and 15 MV beams by Geant4. Three prosthesis materials were selected in calculation to reveal the relation between material type and local dose perturbations of prostheses. Furthermore,the effect of nominal energy on prosthesis perturbation was also discussed and analyzed. Taking the calculated dose to the hip joint as reference, considerable differences were observed between prostheses and hip joints. In the prosthesis shadow region, the relative dose decreasing was up to 36, 21, and 16 % for the Co–Cr–Mo alloy, titanium alloy, and ceramic prostheses, respectively. In backscattering region, the relative dose increasing was about1–7 %. Overall, the results show that the dose perturbation effect of prostheses was mainly determined by material type, nominal energy, and density. Among these typical hip prostheses, ceramic prosthesis introduces the lowest dose perturbations.

关键词：髋关节剂量学假体放射治疗扰动效应 Geant4 X射线剂量直线加速器

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A network security entity recognition method based on feature template and CNN-BiLSTM-CRF

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Frontiers of Information Technology & Electronic Engineering 2019年第6期20卷 872-884页

作者： Ya QIN Guo-wei SHEN wen-bo zhao Yan-ping CHEN Miao YU Xin JIN College of Computer Science and Technology Guizhou University Guiyang 550025 China Guizhou Provincial Key Laboratory of Public Big Data Guiyang 550025 China Institute of Information Engineering Chinese Academy of Sciences Beijing 100093 China National Computer Network Emergency Response Technical Team/Coordination Center of China Beijing 100029 China

By network security threat intelligence analysis based on a security knowledge graph(SKG), multi-source threat intelligence data can be analyzed in a fine-grained manner. This has received extensive attention. It is difficult for traditional named entity recognition methods to identify mixed security entities in Chinese and English in the field of network security, and there are difficulties in accurately identifying network security entities because of insufficient features extracted. In this paper, we propose a novel FT-CNN-BiLSTM-CRF security entity recognition method based on a neural network CNN-BiLSTM-CRF model combined with a feature template(FT). The feature template is used to extract local context features, and a neural network model is used to automatically extract character features and text global features. Experimental results showed that our method can achieve an F-score of 86% on a large-scale network security dataset and outperforms other methods.

关键词： Network security entity Security knowledge graph (SKG) Entity recognition Feature template Neural network

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Abnormal Systemic and Ocular Responses to the Valsalva Manoeuvre in Primary Open-Angle Glaucoma:A Case for Autonomic Failure?

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Current Medical Science 2023年第2期43卷 376-383页

作者： Bin-bin LIU bo-wen zhao Fei-peng WU Tian HU Yin zhao Hong ZHANG Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This study aimed to examine the association of primary open-angle glaucoma(POAG)with autonomic dysfunction by assessing the differences in systemic and ocular responses to an autonomic provocation test,the Valsalva manoeuvre(VM),between POAG patients and normal *** Forty POAG and forty control subjects were subjected to the *** and ocular parameters were measured at baseline,phase 2,and phase 4 of the VM(VM2 and VM4),where VM2 and VM4 are sympathetic and parasympathetic nervous activation states,*** rate variability was used to assess the autonomic nervous activity,among which the high-frequency component(HF)and the low-frequency(LF)/HF ratio were used as indices of parasympathetic and sympathetic activation,*** POAG patients demonstrated higher sympathetic activation(LF/HF ratio median:2.17 vs.1.53,P=0.000)than controls at baseline and exhibited attenuated sympathetic and parasympathetic responses(a smaller change in LF/HF and HF values)during the VM than *** VM,the intraocular pressure(IOP),mean blood pressure(MAP),mean ocular perfusion pressure(MOPP),and the Schlemm’s canal area(SCAR)increased from baseline to VM2 and then decreased from VM2 to VM4 in both the POAG and control groups(all Pbove,the fluctuations in IOP,MAP,and MOPP were more pronounced in POAG than in controls(all P<0.05),while the changes in amplitudes of SCAR were smaller in POAG(P<0.05).Furthermore,from VM2 to VM4,the choroid thickness(ChT)in the POAG group was significantly decreased,while it was unchanged in normal subjects(P=0.258).A regression analysis showed a significant correlation of the baseline LF/HF with IOP change values(ΔIOP)from baseline to VM2 in POAG(R^(2)=0.147,P=0.014).Conclusion Patients with POAG showed more pronounced fluctuations in IOP,MAP,MOPP and ChT during the VM than *** reactions could be associated with autonomic dysfunction in POAG.

关键词： primary open-angle glaucoma Valsalva manoeuvre autonomic dysfunction intraocular pressure Schlemm’s canal

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Modified Cortex Mori Capsules improving the successful rate of functional filtering blebs after reclinical glaucoma filtering surgery

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World Journal of Clinical Cases 2019年第21期7卷 3436-3445页

作者： Jing Yu Li-Xin Qiu Guo-Ping Qing bo-wen zhao Hui Wang Beijing Tongren Eye Center Laboratory of Ophthalmology and Visual Science in Beijing Beijing Tongren HospitalCapital Medical University

BACKGROUND The major reason for filtering bleb failure or scarring of the bleb site is due to excessive scarring after glaucoma filtration surgery in the *** Chinese medicine has preeminence in the prevention of fibrosis formation through the regulation of systemic circulation and improvement of the properties of the inflammatory cells in the *** To examine the clinical efficacy of using the Modified Cortex Mori Capsules(MCMC;Chinese name:Jiawei Sangbaipi Capsules)in the success rate of functional filtering blebs after glaucoma filtering surgery in clinical *** Sixty resurgery glaucoma patients were randomly divided into two groups:30 patients in surgery with the placebo group and 30 patients in surgery with the MCMC *** took either the placebo or the MCMC 2 wk before and after *** morphology and function filtering bleb,visual acuity,intraocular pressure,postoperative complications,the success rate of filtration surgery and clinical efficacy were *** Fifty patients completed the *** percentage of functional filtering blebs in the surgery plus MCMC group was 84%at 6 mo after surgery,which was higher than surgery plus placebo group(64%,Pbo groups were 79%±8.3%and 57%±10.6%respectively(P<0.05).The visual acuity,intraocular pressure and the postoperative complications in the two groups had no significant *** Glaucoma filtering surgery while taking MCMC not only reduced excessive scar formation and increased the success rate of functional filtering blebs but also improved the success of glaucoma filtration operations.

关键词： Glaucoma Traditional Chinese medicine Modified Cortex Mori Capsules Jiawei Sangbaipi Capsules Filtering bleb Scar formation

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