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New strategies for asymmetric photocatalysis: asymmetric organocatalytic/photoredox relay catalysis for efficient synthesis of polycyclic compounds containing vicinal amino alcohols

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Science China Chemistry 2024年第3期67卷 945-952页

作者： Jia-Lu Zhang wen-Bo he xiu-Qin Hu Peng-Fei Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Veterinary Etiological Biology College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China

An asymmetric catalytic strategy in photocatalysis utilizing a chirality-induced approach through an organocatalytic/photoredox relay catalysis strategy is successfully achieved for the rapid construction of polycyclic compounds containing vicinal amino alcohols in a one-pot protocol. This methodology facilitates the efficient synthesis of diverse substituted polycyclic tetrahydroquinoline and benzofuran-derived vicinal amino alcohols, each containing five consecutive chiral centers, with high yields,excellent diastereoselectivities and enantioselectivities(up to 95% yield, >20:1 dr and 98% ee), under mild reaction conditions driven by sequential bifunctional squaramide organocatalyst-catalyzed [4+2] annulation and photocatalyst-catalyzed ketyl radical addition cyclization reaction process. Furthermore, investigations into the stereoselectivity mechanism and high-resolution mass spectrometry(HRMS) experiments on free radical trapping have provided evidence for elucidating the detailed mechanism of chirality-induced processes and chiral intermediate conversions in this procedure.

关键词： enantioselective photocatalysis asymmetric organocatalytic/photocatalysis relay catalysis five consecutive chiral centers chirality-induced strategy chirality vicinal amino alcohols

A combined Liouville integrable hierarchy associated with a fourth-order matrix spectral problem

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Communications in Theoretical Physics 2024年第7期76卷 1-8页

作者： wen-xiu Ma Department of Mathematics Zhejiang Normal UniversityJinhua 321004China Department of Mathematics King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics and Statistics University of South Florida TampaFL 33620-5700United States of America Material Science Innovation and Modelling Department of Mathematical SciencesNorth-West UniversityMafikeng CampusMmabatho 2735South Africa

This paper aims to propose a fourth-order matrix spectral problem involving four potentials and generate an associated Liouville integrable hierarchy via the zero curvature formulation.A bi-Hamiltonian formulation is furnished by applying the trace identity and a recursion operator is explicitly worked out,which exhibits the Liouville integrability of each model in the resulting *** specific examples,consisting of novel generalized combined nonlinear Schrodinger equations and modified Korteweg-de Vries equations,are given.

关键词： integrable hierarchy Hamiltonian structure zero curvature equation Lax pair matrix spectral problem

Morphology Study for GeV Emission of Nearby Supernova Remnant G332.5-5.6

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Research in Astronomy and Astrophysics 2024年第4期24卷 134-140页

作者： Ming-Hong Luo Qing-wen Tang xiu-Rong Mo Department of Physics School of Physics and Materials ScienceNanchang UniversityNanchang 330031China

A spatial template is important to study nearby supernova remnants(SNRs).For SNR G332.5-5.6,we report a Gaussian disk with a radius of about 1°.06 to be a potential good spatial model in the γ-ray *** this new Gaussian disk,its GeV lightcurve shows a significant variability of about seven *** γ-ray observations of this SNR could be explained well either by a leptonic model or a hadronic model,in which a flat spectrum for the ejected electrons/protons is required.

关键词： ISM:supernova remnants gamma rays:ISM

An Intelligent MCGDM Model in Green Suppliers Selection Using Interactional Aggregation Operators for Interval-Valued Pythagorean Fuzzy Soft Sets

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1829-1862页

作者： Rana Muhammad Zulqarnain wen-xiu Ma Imran Siddique Hijaz Ahmad Sameh Askar School of Mathematical Sciences Zhejiang Normal UniversityJinhua321004China Department of Mathematics and Statistics University of South FloridaTampaFL 33620-5700USA School of Mathematical and Statistical Sciences North-West UniversityMafikeng CampusMmabatho2735South Africa Department of Mathematics University of SargodhaSargodha40100Pakistan Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele IIRoma00186Italy Near East University Operational Research Center in HealthcareNicosia/Mersin99138Turkey Department of Statistics and Operations Research College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Green supplier selection is an important debate in green supply chain management(GSCM),attracting global attention from scholars,especially companies and *** frequently search for new ideas and strategies to assist them in realizing sustainable *** of the speculative character of human opinions,supplier selection frequently includes unreliable data,and the interval-valued Pythagorean fuzzy soft set(IVPFSS)provides an exceptional capacity to cope with excessive fuzziness,inconsistency,and inexactness through the decision-making *** main goal of this study is to come up with new operational laws for interval-valued Pythagorean fuzzy soft numbers(IVPFSNs)and create two interaction operators-the intervalvalued Pythagorean fuzzy soft interaction weighted average(IVPFSIWA)and the interval-valued Pythagorean fuzzy soft interaction weighted geometric(IVPFSIWG)operators,and analyze their *** operators are highly advantageous in addressing uncertain problems by considering membership and non-membership values within intervals,providing a superior solution to other ***,specialist judgments were calculated by the MCGDM technique,supporting the use of interaction AOs to regulate the interdependence and fundamental partiality of green supplier assessment ***,a statistical clarification of the planned method for green supplier selection is presented.

关键词： Interval-valued Pythagorean fuzzy soft set IVPFSIWA operator IVPFSIWG operator MCGDM SCM

Survival prognostic analysis of laparoscopic D2 radical resection for locally advanced gastric cancer: A multicenter cohort study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2451-2460页

作者： xiu-Ming Sun Kui Liu wen Wu Chao Meng Department of Pain Management Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of hepatobiliary Surgery Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND With the development of minimally invasive surgical techniques,the use of laparoscopic D2 radical surgery for the treatment of locally advanced gastric cancer(GC)has gradually ***,the effect of this procedure on survival and prognosis remains *** study evaluated the survival and prognosis of patients receiving laparoscopic D2 radical resection for the treatment of locally advanced GC to provide more reliable clinical evidence,guide clinical decision-making,optimize treatment strategies,and improve the survival rate and quality of life of *** A retrospective cohort study was *** data from 652 patients with locally advanced GC in our hospitals from December 2013 to December 2023 were *** were 442 males and 210 *** mean age was 57±12 *** patients underwent a laparoscopic D2 radical operation for distal *** patients were followed up in the outpatient department and by telephone to determine their tumor recurrence,metastasis,and *** follow-up period ended in December *** distributed data are expressed as the mean±SD,and normally distributed data are expressed as M(Q1,Q3)or M(range).Statistical data are expressed as absolute numbers or percentages;theχ^(2) test was used for comparisons between groups,and the Mann-Whitney U nonparametric test was used for comparisons of rank *** life table method was used to calculate the survival rate,the Kaplan-Meier method was used to construct survival curves,the log rank test was used for survival analysis,and the Cox risk regression model was used for univariate and multifactor *** The median overall survival(OS)time for the 652 patients was 81 months,with a 10-year OS rate of 46.1%.Patients with TNM stages II and III had 10-year OS rates of 59.6%and 37.5%,respectively,which were significantly different(P<0.05).Univariate analysis indicated that factors such as age,maximum tumor diameter,tum

关键词： Gastric neoplasms Chinese Laparoscopic Gastrointestinal Surgery Study Group Laparoscopic surgery Locally advanced gastric cancer D2 lymph node dissection

QBIoT:A Quantum Blockchain Framework for IoT with an Improved Proof-of-Authority Consensus Algorithm and a Public-Key Quantum Signature

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Computers, Materials & Continua 2024年第7期80卷 1727-1751页

作者： Ang Liu Qing Zhang Shengwei Xu Huamin Feng xiu-bo Chen wen Liu Network and Information Management Division Beijing Electronic Science and Technology InstituteBeijing100070China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Institute Beijing Electronic Science and Technology InstituteBeijing100070China General Office Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China

The Internet of Things(IoT)is a network system that connects physical devices through the Internet,allowing them to ***,IoT has become an integral part of our lives,offering convenience and smart ***,the growing number of IoT devices has brought about a corresponding increase in cybersecurity threats,such as device vulnerabilities,data privacy concerns,and network *** blockchain technology with IoT has proven to be a promising approach to enhance IoT ***,the emergence of quantum computing poses a significant challenge to the security of traditional classical cryptography used in blockchain,potentially exposing it to quantum *** support the growth of the IoT industry,mitigate quantum threats,and safeguard IoT data,this study proposes a robust blockchain solution for IoT that incorporates both classical and post-quantum security ***,we present the Quantum-Enhanced Blockchain Architecture for IoT(QBIoT)to ensure secure data sharing and integrity ***,we propose an improved Proof of Authority consensus algorithm called“Proof of Authority with Random Election”(PoARE),implemented within QBIoT for leader selection and new block ***,we develop a publickey quantum signature protocol for transaction verification in the ***,a comprehensive security analysis of QBIoT demonstrates its resilience against cyber threats from both classical and quantum *** summary,this research introduces an innovative quantum-enhanced blockchain solution to address quantum security concernswithin the realmof *** proposedQBIoT framework contributes to the ongoing development of quantum blockchain technology and offers valuable insights for future research on IoT security.

关键词： IoT quantum blockchain public-key quantum signature quantum hash function

Adrenocorticotropic hormone combined with magnesium sulfate therapy for infantile epileptic spasms syndrome:a real-world study

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World Journal of Pediatrics 2024年第8期20卷 834-847页

作者： wen he Qiu-Hong Wang Jiu-Wei Li Yang-Yang Wang Xiao-Mei Luo Lin Wan Jing Wang xiu-Yu Shi Wei-Hua Zhang Fang Fang Li-Ping Zou Senior Department of Pediatrics the Seventh Medical Center of Chinese PLA General HospitalDepartment of Pediatricsthe First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Infantile epileptic spasms syndrome(IESS)is a serious disease in infants,and it usually evolves to other epilepsy types or syndromes,especially refractory or super-refractory focal *** adrenocorticotropic hormone(ACTH)is one of the first-line and effective treatment plans for IESS,it has serious side effects and is not sufficiently *** A retrospective study of the clinical outcomes of ACTH combined with magnesium sulfate(MgSO4)therapy for IESS in two hospital centers was *** major outcome of the single and combined treatment was evaluated by changes in seizure frequency and improvements in hypsarrhythmia electroencephalography(EEG).To reduce the confounding bias between the two groups,we used SPSS for the propensity score matching(PSM)*** We initially recruited 1205 IESS patients from two Chinese hospitals and treated them with ACTH combined with MgSO4 and ACTH *** 1005 patients were enrolled in the treatment(ACTH combined with MgSO4:744,ACTH:261),and both treatment plans had a more than 55%response ***,compared to patients treated with ACTH alone,those patients treated with ACTH combined with MgSO4 had better performance in terms of the seizure frequency and hypsarrhythmia *** PSM,the two groups also showed significant differences in responder rate[70.8%(95%confidence interval,CI)=66.7%–74.8%)vs.53.8%(95%CI=47.4%–60.2%),Phe lead time to treatment and the number of antiseizure medications taken before treatment were two factors that may affect the clinical *** with less than 3 months of lead time responded to the treatment much better than those with>3 months(Phe overall incidence of adverse reactions in the ACTH combined with MgSO4 group was much lower than that in the ACTH group(31.4%vs.63.1%,Phe treatment,only

关键词： Adrenocorticotropic hormone Clinical trial Infantile epileptic spasms syndrome Magnesium sulfate Real-world study

Rhodium-Catalyzed Regioselective C-O and C-C Bonds Formation of 3-Oxopent-4-enenitriles with Alkynes for the Synthesis of Polysubstituted 2H-Pyrans

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Chinese Journal of Chemistry 2024年第17期42卷 1986-1992页

作者： Kelu Yan Xiao Liu Jiangwei wen Qiuyun Li Junjie Wang Yang Zheng xiu Wang Key Laboratory of Life-Organic Analysis of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufuShandong273165China Faculty of Chemistry and Chemical Engineering Yancheng Institute of TechnologyYanchengJiangsu 224051China

The rhodium-catalyzed C-H bond activation and cyclization of 3-oxopent-4-enenitriles with alkynes proceed *** 2H-pyrans with multiple substituents are achieved in good yields through regioselective formation of C-O and C-C *** involving hydroxy-alkynoates resulted in products with a furo[3,4-b]pyran skeleton via further intramolecular ester exchange *** from the traditional"1-oxatrienes pathway",this method for the synthesis of useful 2H-pyrans possesses certain highlights in terms of readily available substrates,stable and easily derivatized products,gentle and convenient operation process,and step and atomeconomy.

关键词： Rhodium/C-H activation 3-Oxopent-4-enenitriles Alkynes 2H-Pyrans Transition metals Regioselectivity Cyclization Comprehensive Summary

Current and future research directions in cellular metabolism of colorectal cancer:A bibliometric analysis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3732-3737页

作者： Bo-wen Jiang xiu-Hua Zhang Rui Ma wen-Yu Luan Yan-Dong Miao Department of Emergency Yantai Affiliated Hospital of Binzhou Medical UniversityThe Second Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina Department of Oncology Laiyang Central HospitalYantai 265200Shandong ProvinceChina Department of Cancer Center Yantai Affiliated Hospital of Binzhou Medical UniversityThe Second Medical College of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina

The primary aim of this study was to analyze the evolving trends and key focal points in research on cellular metabolism of colorectal cancer(CRC).Relevant publications on cellular metabolism in CRC were sourced from the Science Citation Index Expanded within the Web of Science Core Collection *** analysis and visualization were conducted using VOSviewer(version 1.6.18)software and CiteSpace 6.1.R6(64-bit)Basic.A comprehensive compilation of 4722 English-language publications,covering the period from January 1,1991 to December 31,2022,was carefully identified and included in the *** the authors,“Ogino,Shuji”contributed the most publications in this field,while“Giovannucci,E”garnered the highest number of *** journal“Cancer Research”ranked first in both publication volume and ***,“Shanghai Jiao Tong University”emerged as the top contributor in terms of published articles,while“Harvard University”led in citation *** country-based analysis,the United States held the top position in both publication output and citations,closely followed by *** increasing recognition of the significance of cellular metabolism in CRC underscores its potential for novel therapeutic approaches aimed at improving CRC management and prognosis.

关键词： Cellular metabolism Colorectal cancer Bibliometric analysis Metabolic reprogramming Cellular metabolism