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Cellular journey of nanomaterials:Theories,trafficking,and kinetics Cellular journey of nanomaterials:Theories,trafficking,andkinetics

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Aggregate 2023年第6期4卷 11-26页

作者： Xiangrui wang wen-xiong wang School of Energy and Environment and State Key Laboratory of Marine Pollution City University of Hong KongHong KongChina Research Centre for the Oceans and Human Health City University of Hong Kong Shenzhen Research InstituteShenzhenChina

Engineered nanomaterials(NMs)are increasingly fabricated in various fields involv-ing consumer goods,waste management,and biomedical applications such as drug delivery,diagnosis,and treatment of pathological *** these NMs are intentionally or unexpectedly in contact with the human body,there are growing concerns about their intracellular journey,especially considering the therapeu-tic or deleterious effects after they cross the cell *** this review,the cellular journey of NMs including internalization,intracellular trafficking,and depo-sition/exocytosis is systematically *** work highlights the accumulation of NMs in cells not only depends on the moment of NMs crossing the cell membrane but also at the following trafficking and exocytosis process.A deeper understanding of the cellular journey of NMs implies that an alternative strategy to fabricate spe-cific targeting NMs is to bypass a few pathways of intracellular trafficking to achieve potent therapeutic effects with minimal *** comprehensively reviewing the cellular journey of NMs,current progress and application scenarios of kinetic models are ***,this review focuses on the bottleneck problems and the corresponding solution technologies for studying the cellular journey of *** progresses on the cellular journey of NMs provide new insights into the fab-rication of biomedical NMs and facilitate technology development for probing the nano-cell interaction with high temporal-spatial resolution.

关键词： cellular journey exocytosis intracellulartrafficking kineticmodel

Human Exposure to Microplastics and Its Associated Health Risks

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Environment & Health 2023年第3期1卷 139-149页

作者： Anqi Sun wen-xiong wang School of Energy and Environment and State Key Laboratory of Marine Pollution City University of Hong KongKowloonHong Kong 518057China Research Centre for the Oceans and Human Health City University of Hong Kong Shenzhen Research InstituteShenzhen 518057China

Microplastics are a globally emerging contaminant in the environment,but little is known about the potential risks of microplastics to human *** exposure routes of microplastics to humans include ingestion,inhalation,and dermal penetration,with the last of these needing equal attention as the other two main *** showed the presence of microplastics in human-derived biological samples(i.e.,excrement,biofluids,and tissues).Most of the toxicological studies of microplastics on humans were based on laboratory rodents and human-derived *** homeostasis,intestinal microflora,and the reproductive,immune,and nervous systems were regarded as targets of *** toxicity of microplastics on microstructures including lysosomes,mitochondria,endoplasmic reticulum,and the nucleus further revealed the potential risks of microplastics on human health at the cellular *** a carrier,microplastics also had the potential to magnify the toxicity of other contaminants in the environment(e.g.,plasticizer,metals,antibiotics,and microorganisms).Studies of microplastics at environmentally realistic conditions are still in their infancy with many unsolved questions to predict their risks on human health.

关键词： Microplastics cell lines human health risk toxicit

从金属纳米颗粒的理化性质以及生物吸收动力学角度探究金属纳米颗粒对水生生物的毒性(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第8期15卷 573-592页

作者： Jian wang wen-xiong wang Division of Life Science The Hong Kong University of Science and Technology

研究目的:研究金属纳米颗粒在进入水体后的一系列动力学过程对金属纳米颗粒的生物可利用性和毒性可能产生的影响。研究方法:针对在毒性测试中金属纳米颗粒的解析现象,选取三种常见的金属纳米颗粒(纳米氧化锌、纳米银和纳米二氧化钛),总... 详细信息

研究目的:研究金属纳米颗粒在进入水体后的一系列动力学过程对金属纳米颗粒的生物可利用性和毒性可能产生的影响。研究方法:针对在毒性测试中金属纳米颗粒的解析现象,选取三种常见的金属纳米颗粒(纳米氧化锌、纳米银和纳米二氧化钛),总结了它们在毒性测试中的解析动力学、溶解性以及毒性。同时,综合水生生物对金属纳米颗粒以及离子的吸收动力学,利用动态模型进行模拟,阐述解离的离子在生物对金属纳米颗粒吸收中的贡献。重要结论:在评价金属纳米颗粒和解析离子对水生生物的生物利用度和毒性的测试过程中,需要综合考虑金属纳米颗粒的理化性质以及生物吸收动力学过程。

关键词：金属纳米颗粒解析动力学水生生物毒性

Cistanche deserticola decoction alleviates the testicular toxicity induced by hydroxyurea in male mice

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Asian Journal of Andrology 2013年第6期15卷 838-840,I0011页

作者： Li Gu wen-Ting xiong Chao wang Hong-Xia Sun Guo-Fu Li Xin Liu Food and Health Engineering Research Center of State Education Ministry Sun Yat-Sen University Guangzhou 510275 China

This study aimed to evaluate testicular toxicity induced by hydroxyurea （HU） and the possible counteracting effect of an aqueous extract of Cistanche deserticola （CD）. HU is an antineoplastic drug that has potential reproductive toxicity, and Herba Cistanche has been used as a tonic for the reproductive system for thousands of years. Sixty mice were randomly divided into five groups. Except mice in normal group, the rest received HU （400 mg kg^-1 body weight） intragastrically. Meanwhile, mice in normal and HU control groups received purified water, and the rest received intragastrically three doses of CD decoctions （1.5, 3.0 and 6.0 g crude drug kg^-1 body weight, respectively） daily for 4 weeks. Severe testes lesions were observed, testes weight （P〈0.01） and serum luteinising hormone levels （P〈0.0 1） were also decreased significantly, in the HU groups. Three doses of CD decoctions alleviated the spermatogenetic cell degeneration induced by HU and modulated the serum sex hormones levels to some extent.

关键词： Cistanche deserticola hormones hydroxyurea semin iferous tubule

Disturbing ion regulation and excretion in medaka gills by microplastics: Insights from the gut-gill axis

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Disturbing ion regulation and excretion in medaka gills by m...

In Situ Generation of N-Heteroaromatic Polymers:Metal-Free Multicomponent Polymerization for Photopatterning,Morphological Imaging,and Cr(Ⅵ)Sensing

第四届全国（海洋）环境微塑料污染与管控学术研讨会

作者： Siwen Zheng wen-xiong wang School of Energy and Environment and State Key Laboratory of Marine Pollution City University of Hong Kong Research Centre for the Oceans and Human Health City University of Hong Kong Shenzhen Research Institute

The accumulation of microplastics（MPs） in fish gills has been widely recognized,however, whether such stress could thereby impact the physiological responses of fish gills is still unknown. We investigated the impacts of three sizes（400 nm, 4 μm, 20 μm） of polystyrene（PS）MPs on ion（Na, K, Cl） regulation and ammonia excretion in medaka Oryzias *** increased net Na and K flux rates were observed transiently during 0–3 h and 3–9h, but not during 9–24 h, suggesting that the physiological resilience of fish gills regarding Na and K regulation was unaffected upon the exposure to PS-MPs, probably evidenced by the increased secretion of mucus. However, the Clregulation and ammonia excretion were significantly impaired, partly in consistent with the damages of ionocytes. The adverse impacts of PS-MPs on Clregulation and ammonia excretion were size-dependent, with significant disturbances observed in 4 μm and 20 μm treated group for Clregulation, but only in 20 μm treated group for ammonia excretion. The specific enrichment of Shinella and lower abundance of function profiles related to ion transport and metabolism might be responsible for the specific disturbance of Clregulation found in the 4 μm treated group. The enrichment of Gemmobacter also accounted for the disturbances of ammonia excretion in 20 μm treated group. Our results highlighted the impacts of PS-MPs on the physiological functions in fish gills.

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CCS Chemistry 2022年第7期4卷 2308-2320页

作者： Yubing Hu Neng Yan Xiaolin Liu Lingyu Pei Canbin Ye wen-xiong wang Jacky W.Y.Lam Ben Zhong Tang Department of Chemistry The Hong Kong Branch of ChineseNational Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyThe Hong Kong University of Science and TechnologyGuangdong-Hong Kong-Macro Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsClear Water BayKowloonHong Kong 999077 HKUST-Shenzhen Research Institute NanshanShenzhen 518057 School of Energy and Environment State Key Laboratory of Marine PollutionCity University of Hong KongKowloonHong Kong 999077 Center for Aggregation-Induced Emission From Molecular AggregatesSCUT-HKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640 Shenzhen Institute of Molecular Aggregate Science and Engineering School of Science and EngineeringThe Chinese University of Hong KongShenzhenGuangdong 518172 AIE Institute Guangzhou Development DistinctHuangpuGuangzhou 510530

Electron-deficient N-heteroaromatic polymers are crucial for the high-tech applications of organicmaterials,especially in the electronic and optoelectronic ***,the development of new polymerizations to afford adaptable electron-donating-accepting scaffolds in N-heteroaromatic polymers is in high ***,we have developed metal-free multicomponent polymerizations of diynes,diamines,and glyoxylates successfully for in situ generation of poly(quinoline)s with high molecular weights(Mw up to 16,900)in nearly quantitative *** tuning the electron distributions of the polymer backbones,the resulting poly(quinoline)s showed various aggregation-induced behaviors and photoresponsive abilities:The thin films of the poly(quinoline)s could be fabricated readily intowell-resolved photopatterns by photolithography *** could be utilized as fluorescent probes to visualize themorphologies of polymer materials directly;these include spherulites and microphase separation of polymer *** nanoparticles demonstrated sensitive and highly selective fluorescence quenching to hexavalent chromium ion Cr(Ⅵ),thereby providing access for biological imaging of Cr(Ⅵ)in unicellular algae.

关键词： heteroaromatic polymers multicomponent polymerization morphology photopatterns chromium sensor

Studies on the Developmental Genetics of Tiller Number in Three-line Indica Hybrid Rice

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Agricultural Sciences in China 2002年第8期1卷 837-844页

作者： LIANG Kang-jing, LIN wen-xiong, wang Xue-ren, CHEN Zhi-xiong, GUO Yu-chun, LIANG Yi-yuan, CHEN Fang-yu and LI Ya-juan( College of Crop Science, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R . China ) College of Crop Science Fujian Agriculture and Forestry University Fuzhou 350002 P.R. China

Following NCI design, the developmental genetic behavior of tiller number (TN) in three-line indica hybrid rice was studied using additive-dominance developmental genetic models and the corresponding statistical methods. The results showed that dominance effects were predominant for TN. The expression of those additive effects were affected by environment and genotype interaction, but the expression of dominance effects were not affected. Heterosis was the strongest in the middle developmental periods of TN. Additive effects and dominance effects were selectively expressed throughout in the entire tillering developmental stage. Analysis of genetic correlation between TN at different stages and the productive panicles indicated that a close correlation appeared earlier in the populations with higher heterosis than in those with less heterosis. Utilization of heterosis at the middle tillering stage might enhance the final biomass but reduce the percentage of productive panicles.

关键词： Three-line indica hybrid rice Tiller number Developmental genetics Genetic variance Heterosis

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi wen Xin xiong Ting Xu Qi wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

Sensitivity of different life traits of a marine harpacticoid copepod Tigriopus japonicus to polychlorinated biphenyls:A two generational study

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Sensitivity of different life traits of a marine harpacticoi...