检索结果-南通市图书馆

Cytotoxic terpenes from Abies sibirica

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2012年第11期23卷 1251-1253页

作者： Gui Rong Wang Yong Li Li Wei Dong Zhang xian wen yang wen Cong Liu Ji Ye Zhi Jun Zhu Hong Chen Department of Phytochemistry School of PharmacySecond Military Medical UniversityShanghai 200433China Department of Pharmacognosy Jilin Agricultural UniversityChangchun 130118China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

One new and 16 known compounds were isolated from Abies sibirica. Their structures were assigned mainly on the basis of NMR and MS spectroscopic data. In bioassay for anti-proliferative activity against four human tumor cells, compound 7 exhibited selective anti-proliferative activity against COLO-205 tumor cell with an IC50 value of 0.9 μg/mL.

关键词： Abies sibirica Pinaceae Terpenes Triterpene

ACTA2 mutation is responsible for multisystemic smooth muscle dysfunction syndrome with seizures:A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第29期9卷 8789-8796页

作者： wen-xian yang Hang-Hu Zhang Jia-Ni Hu Li Zhao Yan-Yun Li Xiao-Li Shao Department of Pediatrics Shaoxing University School of MedicineShaoxing 312000Zhejiang ProvinceChina Department of Pediatrics Shaoxing Peoples’HospitalThe First Affiliated Hospital of Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Department of Radiology Shaoxing Peoples’HospitalThe First Affiliated Hospital of Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina

BACKGROUND ACTA2 gene is a specific gene that encodes actinα*** smooth muscle dysfunction syndrome(MSMDS)is a multisystem disease characterized by aortic and cerebrovascular lesions caused by ACTA2 gene *** have been many reports of cardiac,pulmonary and cerebrovascular lesions caused by MSMDS;however,few studies have focused on seizures caused by *** SUMMARY Our patient was a girl aged 7 years and 8 mo with recurrent cough,asthma and seizures for 7 *** was diagnosed with severe pneumonia,congenital heart disease,cardiac insufficiency,and malnutrition in the local *** ultrasonography revealed congenital heart disease,patent ductus arteriosus(with a diameter of 0.68 cm),left coronary arteriectasis,patent oval foramen(0.12 cm),tricuspid and pulmonary regurgitation,and pulmonary *** magnetic resonance imaging and magnetic resonance angiography indicated stiffness in the brain vessels,together with multiple aberrant signaling shadows in bilateral paraventricular regions.A heterozygous mutation(c.536G>A)was identified in the ACTA2 gene,resulting in generation of ***,the girl was diagnosed with MSMDS combined with *** patient had 4 episodes of seizures before treatment,and no onset of seizure was reported after oral administration of sodium valproate for 1 *** MSMDS has a variety of clinical manifestations and unique cranial imaging *** injury and white matter injury may lead to *** detection can confirm the diagnosis and prevent missed diagnosis or misdiagnosis.

关键词： Multi-systemic smooth muscle dysfunction syndrome ACTA2 gene Seizures Gene detection Case report

Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2015年第10期5卷 806-811页

作者： xian-wen yang Hai-Xing Jiang Xiao-Li Huang Shi-Jia Ma Shan-Yu Qin Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical University

Objective: To assess the role of Th9 and Th17 cells in malignant ascites(MA).Methods: MA from 30 hepatic carcinoma patients and benign ascites from 30 cirrhotic patients were collected. Corresponding peripheral blood samples from these hepatic carcinoma and cirrhotic patients as well as 30 healthy subjects were collected. The frequency of Th9 and Th17 cells was tested by flow cytometry. Serum levels of interleukin(IL)-9 and IL-17 were examined by ***: The observed frequency of Th9 and Th17 cells, and the IL-9 and IL-17 serum levels were significantly higher in MA patients than those in cirrhotic patients and healthy control samples(P < 0.05). Moreover, the Th9 cells demonstrated positive correlation with Th17 cells as well as IL-9 in MA patients; however, this positive correlation was not observed in the cirrhotic patients or healthy control samples. The frequency of Th9 and Th17 cells was distinctly higher in MA patients presenting with stage III or IV malignancy and with lymph node or distant metastasis than those in patients in stage I or II and without distant metastasis(P < 0.05).Conclusions: The increased frequency of Th9 and Th17 cells in MA patients suggests that these two T cell subsets play a synergistic role in MA pathogenesis. This study also demonstrated that Th9 and Th17 cells may perform their biological functions in conjunction with IL-9 production.

关键词： ascites pathogenesis cirrhotic cytometry metastasi

neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2011年第2期1卷 81-86页

作者： Gang XU Fang ZHAO xian-wen yang Juan ZHOU Li-Xin yang Xiao-Ling SHEN Ying-Jie HU Qin-Shi ZHAO State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Tropical Medicine Institute Guangzhou University of Chinese MedicineGuangzhou 510405China Key Laboratory of Marine Bioresources Sustainable Utilization South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China

Salvia dugesii is an invasive plant in Yunnan,*** tentatively explore its utilization,a systematic phytochemical investigation was carried out on this plant,which led to the isolation of five new neo-clerodane diterpenoids,dugesins C-G(1-5),together with six known *** structures were determined by comprehensive NMR and MS spectroscopic *** was noteworthy that the eleven isolates,composed of five different carbocyclic systems derived from the neo-clerodane diterpenoid skeleton,were reported from the same plant for the first *** anti-feedantial,cytotoxic,and antiviral activities of the isolates were *** F(4)was tested to be a non-toxic antiviral compound against influenza virus FM1.

关键词： Salvia dugesii neo-clerodane diterpenoids dugesins antivirus

Effect of interrupted aging on mechanical properties and corrosion resistance of 7A75 aluminum alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2415-2430页

作者： xian-wen yang Ling-ying YE Yong ZHANG Quan-shi CHENG School of Materials Science and Engineering Central South UniversityChangsha 410083China Aerospace Precision Production Co. Ltd.Tianjin 300300China

The effects of interrupted aging on mechanical properties and corrosion resistance of 7A75 aluminum alloy extruded bar were investigated through various analyses,including electrical conductivity,mechanical properties,local corrosion properties,and slow strain rate tensile stress corrosion *** characterization techniques such as metallographic microscopy,scanning electron microscopy(SEM),and transmission electron microscopy(TEM)were also *** results indicate that the tensile strength of the alloy produced by T6I6 aging is similar to that produced by T6I4 aging,and it even exceeds 700 ***,the yield strength increases by 52.7 MPa,reaching 654.8 MPa after T6I6 aging *** maximum depths of intergranular corrosion(IGC)and exfoliation corrosion(EXCO)decrease from 116.3 and 468.5μm to 89.5 and 324.3μm,*** stress corrosion factor also decreases from 2.1%to 1.6%.These findings suggest that the alloy treated with T6I6 aging exhibits both high strength and excellent stress corrosion cracking ***,when the alloy is treated with T6I4,T6I6 and T6I7 aging,the sizes of grain boundary precipitates(GBPs)are found to be 5.2,18.4,and 32.8 nm,*** sizes of matrix precipitates are 4.8,5.7 and 15.7 nm,*** atomic fractions of Zn in GBPs are 9.92 at.%,8.23 at.%and 6.87 at.%,respectively,while the atomic fractions of Mg are 12.66 at.%,8.43 at.%and 7.00 at.%,***,the atomic fractions of Cu are 1.83 at.%,2.47 at.%and 3.41 at.%,respectively.

关键词： 7A75 aluminum alloy interrupted aging aging precipitation behavior mechanical properties intergranular corrosion exfoliation corrosion stress corrosion cracking

Comparison of resonant tunneling diodes grown on freestanding GaN substrates and sapphire substrates by plasma-assisted molecular-beam epitaxy

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2021年第12期30卷 550-555页

作者： xiang-Peng Zhou Hai-Bing Qiu wen-xian yang Shu-Long Lu Xue Zhang Shan Jin Xue-Fei Li Li-Feng Bian Hua Qin School of Microelectronics University of Science and Technology of ChinaHefei 230026China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

AlN/GaN resonant tunneling diodes(RTDs)were grown separately on freestanding Ga N(FS-GaN)substrates and sapphire substrates by plasma-assisted molecular-beam epitaxy(PA-MBE).Room temperature negative differential resistance(NDR)was obtained under forward bias for the RTDs grown on FS-GaN substrates,with the peak current densities(Jp)of 175-700 kA/cm^(2)and peak-to-valley current ratios(PVCRs)of *** resonant peaks were also observed for some RTDs at room *** effects of two types of substrates on epitaxy quality and device performance of GaN-based RTDs were firstly investigated systematically,showing that lower dislocation densities,flatter surface morphology,and steeper heterogeneous interfaces were the key factors to achieving NDR for RTDs.

关键词： resonant tunneling diodes negative differential resistance molecular beam epitaxy Ⅲ-nitrides

Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第4期33卷 2057-2059页

作者： Chun-Lan Xie Duo Zhang Kai-Qiang Guo Qing-xiang Yan Zheng-Biao Zou Zhi-Hui He Zhen Wu Xiao-Kun Zhang Hai-Feng Chen xian-wen yang Key Laboratory of Marine Biogenetic Resources Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China School of Pharmaceutical Sciences Xiamen UniversityXiamen 361102China

A novel meroterpenoid,named meroterpenthiazole A(1),was isolated from the deep-sea-derived Penicillium *** structure was established by extensive spectroscopic and computational *** A bears a rare benzothiazole moiety in *** 1 significantly inhibited retinoid X receptor(RXR)-α transcriptional effect(K_(D)=12.3 μmol/L) through a novel binding mechanism.

关键词： Deep-sea Fungus Penicillium allii-sativi Meroterpenoids Retinoid X receptor

Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第5期21卷 1531-1545页

作者： Dong-Hong Lu Xiao-Yun Guo Shan-Yu Qin Wei Luo Xiao-Li Huang Mei Chen Jia-Xu Wang Shi-Jia Ma xian-wen yang Hai-Xing Jiang Department of Gastroenterology The First Affiliated HospitalGuangxi Medical University

AIM:To investigate the effect of interleukin(IL)-22 onhepatic fibrosis in mice and the possible mechanism ***:Liver fibrosis was induced in male BALB/c mice by *** IL-22(rm IL-22) was administered intraperitoneally in CCl4-treated *** was assessed by histology and Masson *** activation of hepatic stellate cells(HSCs) was investigated by analysis of α-smooth muscle actin *** frequencies of T helper(Th) 22 cells,Th17 cells and Th1 cells,the expression of inflammatory cytokines [IL-22,IL-17 A,interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),IL-6,IL-1b] and transcription factors [aryl hydrocarbon receptor(AHR),RAR-related orphan receptor(RORγt),T-bet] m RNA in the liver were *** addition,the plasma levels of IL-22,IL-17 A,IFN-γ,TNF-α,IL-6 and IL-1b were ***:Significant elevations in circulating Th22 cells,Th17 cells,Th1 cells,IL-22,IL-17 A,and IFN-γ were observed in the hepatic fibrosis group compared with the control group(P < 0.01).Treatment with rm IL-22 in mice with hepatic fibrosis ameliorated the severity of hepatic fibrosis,which was confirmed by lower hepatic fibrosis pathological scores(P < 0.01).Rm IL-22 decreased the frequencies of Th22 cells(6.71% ± 0.97% vs 8.09% ± 0.74%,P < 0.01),Th17 cells(4.34% ± 0.37% vs 5.71% ± 0.24%,P < 0.01),Th1 cells(3.09% ± 0.49% vs 4.91% ± 0.73%,P < 0.01),and the levels of IL-22(56.23 ± 3.08 vs 70.29 ± 3.01,P < 0.01),IL-17A(30.74 ± 2.77 vs 45.68 ± 2.71,P < 0.01),and IFN-γ(74.78 ± 2.61 vs 124.89 ± 2.82,P < 0.01).Down-regulation of IL-22,IL-17 A,IFN-γ,TNF-α,IL-6,IL-1b,AHR RORγt,and T-bet gene expression in the liver was observed in the rm IL-22 group(P < 0.01).CONCLUSION:The frequencies of Th22,Th17 andTh1 cells are elevated in hepatic *** IL-22 can attenuate HSC activation and down-regulate the levels of inflammatory cytokines,thereby ameliorating liver fibrogenesis.

关键词： T helper 22 cells T helper 17 cells T helper 1 cel

Chemical constituents and chemotaxonomic study on the marine actinomycete Williamsia *** 1A11233

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical constituents and chemotaxonomic study on the marine...