Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect

作     者：Chun-Lan Xie Duo Zhang Kai-Qiang Guo Qing-Xiang Yan Zheng-Biao Zou Zhi-Hui He Zhen Wu Xiao-Kun Zhang Hai-Feng Chen Xian-Wen Yang Chun-Lan Xie;Duo Zhang;Kai-Qiang Guo;Qing-Xiang Yan;Zheng-Biao Zou;Zhi-Hui He;Zhen Wu;Xiao-Kun Zhang;Hai-Feng Chen;Xian-Wen Yang

作者机构：Key Laboratory of Marine Biogenetic ResourcesThird Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China School of Pharmaceutical SciencesXiamen UniversityXiamen 361102China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第4期

页      面：2057-2059页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China (No. 22177143) the COMRA program (No. DY135-B2–08) 

主　　题：Deep-sea Fungus Penicillium allii-sativi Meroterpenoids Retinoid X receptor 

摘      要：A novel meroterpenoid,named meroterpenthiazole A(1),was isolated from the deep-sea-derived Penicillium *** structure was established by extensive spectroscopic and computational *** A bears a rare benzothiazole moiety in *** 1 significantly inhibited retinoid X receptor(RXR)-α transcriptional effect(K_(D)=12.3 μmol/L) through a novel binding mechanism.