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Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis

World Journal of Gastrointestinal Oncology 2023年第1期15卷 76-89页

作者： Yang Lu Xing-Ming Wang Ze-Shu Li Ai-Juan Wu wen-xia cheng Department of Oncology PKUCare Luzhong HospitalZibo 255400Shandong ProvinceChina Department of Oncology Zibo Maternal and Child Health HospitalZibo 255095Shandong ProvinceChina

BACKGROUND As reported,multiple circular RNAs(circRNAs)interfere with colorectal cancer(CRC)***,circRNA_0001658(circ_0001658)is focused on studying how it works in *** Clarify the expression pattern,biological function,and underlying mechanism of circ_0001658 of CRC *** In CRC-related chip data retrieved using the database named Gene Expression Omnibus,different expressions of circRNAs between CRC and normal tissue samples were *** Real-time PCR and Western blot ensured the analysis on circ_0001658,microRNA-590-5P(miR-590-5p),and methyltransferase-like 3(METTL3)mRNA expressions in tissues and *** counting kit-8 and flow cytometry were used to detect cell proliferation,apoptosis and *** targeting relations between circ_0001658,miR-590-5p,and METTL3 mRNA 3'-untranslated region were under the verification of bioinformatics prediction and dual luciferase-based reporter gene *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were employed on the downstream targets of miR-590-5p using the Database for Annotation,Visualization and Integrated Discovery *** Circ_0001658 and METTL3 mRNA was elevated in CRC tissues and cells,whereas miR-590-5p was ***_0001658 overexpression promoted the proliferation of HT29 cells,inhibited apoptosis,and accelerated the cell *** SW480 cells,knocking down circ_0001658 had the opposite ***_0001658 could specifically bind to miR-590-5p and negatively modulate its expressions;METTL3 is a miR-590-5p target that can be positively regulated by circ *** 0001658 was inversely associated with miR-590-5p expression while positively with METTL3 *** Circ_0001658 regulates the miR-590-5p/METTL 3-axis to increase CRC cell growth and decrease apoptosis.

关键词： Circ_0001658 miR-590-5p METTL3 Colorectal cancer Proliferation

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Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental Sciences 2024年第2期37卷 170-177页

作者： GU wen Fei SHI xia MA Xin YU Jun Lei XU Jin Chuan QIAN cheng cheng HU Zhi Dong ZHANG Hui Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples

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Market Equilibrium Based on Cloud-edge Collaboration

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 96-104页

作者： Tong cheng Haiwang Zhong Qing xia the State Key Laboratory of Power Systems the Department of Electrical EngineeringTsinghua UniversityBeijing 100084China

Market participants can only bid with lagged information disclosure under the existing market mechanism,which can lead to information asymmetry and irrational market behavior,thus influencing market *** promote rational bidding behavior of market participants and improve market efficiency,a novel electricity market mechanism based on cloudedge collaboration is proposed in this *** market information,called residual demand curve,is published to market participants in real-time on the cloud side,while participants on the edge side are allowed to adjust their bids according to the information disclosure prior to closure *** proposed mechanism can encourage rational bids in an incentive-compatible way through the process of dynamic equilibrium while protecting participants’*** paper further formulates the mathematical model of market equilibrium to simulate the process of each market participant’s strategic bidding behavior towards equilibrium.A case study based on the IEEE 30-bus system shows the proposed market mechanism can effectively guide bidding behavior of market participants,while condensing exchanged information and protecting privacy of participants.

关键词： Cloud-edge collaboration market mechanism residual demand curve strategic bidding

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Evaluation of the forest ecosystem health in Beijing area

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Forestry Studies in China 2007年第2期9卷 157-163页

作者： Ma Li Han Hai-rong Ma Qin-yan Liu Hong-wen xia Wei-wei cheng xiao-qin Key Laboratory for Silviculture and Conservation of Ministry of Education College of Natural Resources and Environment BeijingForestry University Beijing 100083 P. R. China

The evaluation of ecosystem health has become one of the main research topics of ecosystem science, thus more and more assessment methods and frameworks have been put forward in recent years. However, the attention people pay to ecosystem health is actually more about what the social functions the ecosystem affords, which depend on the integrity and maintenance of the ecosystem structure and function, and the intensity of disturbance from outside. Accordingly, this research commenced from three main aspects, selected the evaluation indices, and then established the Evaluation Index System of Beijing Forest Ecosystem Health （EIS-BFEH）. In the EIS-BFEH, each of the three foundations contained an easily-operated and standard sub-index system, which compounded the specific natural and social conditions of Beijing and was concrete enough to measure and evaluate. Then with the method of the Analytical Hierarchy Process （AHP）, the comprehensive index （CI） could be obtained, which represented the health of the forest ecosystem. As a case study, the forest ecosystems in the Badaling area were sampled, evaluated, compared and ranked by use of the EIS-BFEH. The result show that the health of natural forests is much better than that of plantations in the Badaling forest center： the average comprehensive index of the former is 7.9, while the latter is only 6.6. From the results, it could also be found that there are nine units in the healthy state, two units in the subhealthy state, and only one unit of Robiniapseudoacacia in the morbid state.

关键词： Beijing area forest ecosystem health evaluation Badaling Forest Center

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Effects of the Rainfall-Triggered Lisse Effect on the Stability of Loess Slopes

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Journal of Earth Science 2024年第4期35卷 1254-1262页

作者： Zhizhou Yang Donghui cheng Jun xia School of Water and Environment Chang’an UniversityXi’an710054China Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of the Ministry of Education Chang’an UniversityXi’an710054China Key Laboratory of Eco-Hydrology and Water Security in Arid and Semi-Arid Regions of the Ministry of Water Resources Chang’an UniversityXi’an710054China Key Laboratory of Water Cycle&Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China State Key Laboratory of Water Resources&Hydropower Engineering Sciences Wuhan UniversityWuhan430000China

This paper coupled a water-air two-phase hydrodynamic(WATPH)model with the Iverson’s method to analyze the influence of the Lisse effect on the fast groundwater pressure(P_(w))response and the slope ***,the sensitivities of the driving force and loess soil parameters were *** showed that the WATPH model simulated the height and rise of the depth to the water table reasonably *** depth to water table before rainfall(H0)had a significant impact on the Lisse effect and the slope *** the H_(0) was less than approximately 1 m,the rainfall triggered a significant Lisse effect and decreased the slope factor of safety(F_(s)).When the rainfall intensity(R_(i))was higher than the saturated hydraulic conductivity(K_(s)),the Lisse effect and the F_(s) slightly changed with the increase of the R_(i),and the slope tended to be unstable with continuous *** increasing K_(s),the Lisse effect noticeably increased,and the minimum F_(s) quickly *** analysis of the normalized sensitivity coefficient revealed that H_(0) had a dramatic impact on the Lisse effect and loess slope *** different R_(i) and K_(s) values had prominent influences on the Lisse effect and slight impacts on F_(s).

关键词： Lisse effect landslides safety factor rainfall

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Flow characteristics and bubble statistics during the fragmentation process of the ingested main cavity in plunging breaking waves

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Journal of Hydrodynamics 2024年第3期36卷 546-555页

作者： wen-bin Zhang Wei-wen Zhao De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

Plunging breaking waves play an important role in the exchange of heat,momentum,and mass between the atmosphere and *** this paper,a series of direct numerical simulations is conducted to investigate the fragmentation process of the ingested main cavity in plunging breaking *** two-phase Navier-Stokes equations are solved using the finite-volume method based on adaptive refinement *** free surface is captured using a geometrical volume of fluid *** 2-D,3-D simulations are *** flow fields at different stages of wave breaking are presented and quantitative analysis for bubbles is *** 2-D instantaneous vorticity field and local velocity field are visualized to discuss the general flow characteristics during the fragmentation *** a 2-D parametric study is conducted to investigate the differences in the flow characteristics during the fragmentation process under different wave parameters including initial wave steepness(ε),Bond number(Bo),and Reynolds number(Re).3-D vortex structures are shown to further investigate the mechanisms behind the differences in the flow *** bubble size distributions under two different initial wave steepness are also discussed with their relationship to the fragmentation process of the ingested main *** research offers a significant understanding of the distinct procedures and fundamental dynamics involved in wave breaking,enhancing our comprehension of this intricate event.

关键词： Plunging breaking waves multiphase flow bubble statistics

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Evolution of inner wall wrinkle defects in the sinking zone of a thick-walled steel tube during radial forging

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Advances in Manufacturing 2024年第2期12卷 396-408页

作者： Yu-Zhao Yang cheng Xu Li-xia Fan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094People’s Republic of China

An axial wrinkle defect was observed in the inner wall of the sinking zone of a thick-wall steel tube processed by cold radial *** can evolve into *** present study focuses on the evolution of wrinkles and the effects of process parameters on them using a three-dimensional radial forging process finite element model,radial forging experiments,and surface morphology *** results indicated that the vertical section angle of the hammer die and the size of the tube blank significantly affect the evolution of *** height-to-width ratioλwas introduced to describe the morphology of *** had an approximately linear relationship with the radius reduction in the sinking *** was a linear correlation between the growth slope ofλand the axial to circumferential strain ratio|εr/εθ|,which can predict theλunder few process *** the 30SiMn2MoVA steel,at the junction of the forging and sinking zones,the threshold ofλof the wrinkle that can evolve into a fissure is approximately 1.123.

关键词： Radial forging Inner wall Wrinkle defects Evolution Sinking zone

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Biodiversity of zooplankton in 0-3000 m waters from the eastern Indian Ocean in spring 2019 based on metabarcoding

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Water Biology and Security 2022年第1期1卷 41-52页

作者： xia-wen cheng Lan-Lan Zhang Fei Gao Ye-Hui Tan Rong xiang Zhuo-Ya Qiu Li-Jun He State Key Laboratory of Marine Resources Utilization in South China Sea College of Marine ScienceHainan UniversityHaikou570228China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou511458China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai200241China

To increase knowledge on zooplankton diversity in the deep sea,42 zooplankton samples(depths of 0–3000 m)were taken across five stations throughout the northeastern Indian Ocean using a vertical multi-plankton *** to metabarcoding results of the V4 region of the 18S rRNA gene,Copepoda,Hydrozoa and Malacostraca were present at all stations,while Polychaeta,Scyphozoa,and Thaliacea mainly appeared in the Bay of Bengal.A correlation heatmap showed that the abundance of surface species belonging to Copepoda,Gastropoda,Thaliacea,and Sagittoidea responded most closely to temperature,dissolved oxygen and chlorophyll-a,while the abundance of deep-water species belonging to Thecofilosea,Copepoda,Sagittoidea,and Polychaeta was negatively correlated with temperature,suggesting that temperature differences were driving depth-based variation in zooplankton community distributions in the tropical ***,Copepods are important for differentiating depth assemblages in the Indian *** minutus,Lucicutia ovalis,Heterostylites major and Metridia asymmetrica prefer the mesopelagic *** vertical distribution of zooplankton diversity showed a bimodal ***,communities between 200 and 400 m at stations ZS1,ZS3 and ZS4 differed greatly from those of 0–200 ***,at stations ZS2 and ZS5,communities between 200 and 400 m had high similarity with those of 0–200 m,possibly due to the influence of *** from this study significantly improve our understanding of zooplankton diversity and ecological functions in the deep sea.

关键词： Indian Ocean 18S rRNA Zooplankton diversity Depth profile Spatial variation

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Effect of BaO and MgO on structure and properties of aluminate slag with various CaO/Al_(2)0_(3)ratios

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Journal of Iron and Steel Research International 2024年第1期31卷 204-214页

作者： Yu-qi Kong Ting Wu wen-zhi xia wen Yang Hai-chuan Wang School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243032AnhuiChina Key Laboratory of Metallurgical Emission Reduction and Resource Recycling(Ministry of Education) Anhui University of TechnologyMa’anshan243002AnhuiChina

To provide theoretical guidance for performance stability control of low-reactive mold fluxes,the effects of BaO and MgO on the structure and properties of aluminate slag with various CaO/Al_(2)0_(3)(C/A)ratios were investigated using the Fourier transform infrared spectrometer,Raman spectroscope,hemispherical melting point instrument,rotational viscometer and X-ray *** results indicated that with BaO and MgO addition,the structure polymerization was first weakened and then enhanced at C/A of 1.1,and the transition contents corresponded to 8 wt.%BaO and 2 wt.%MgO,respectively,while the structure polymerization decreased continuously at C/A of *** the viscosity change was well consistent with the structure evolution,the polymerization degree played a more prominent role in the slag viscosity than superheat degree when the melting temperature difference was within 40℃.The break temperature decreased initially and then increased with augment of BaO and MgO at C/A of 1.1,while it manifested a decrease trend with BaO addition,and it decreased obviously but then turned to increase with MgO increment at C/A of *** crystallization phase and crystallization ratio kept stable with BaO increment,while the crystallization ratio rose greatly with MgO promoting LiAlO_(2)precipitation at C/A of *** crystal types of all experimental slags were mainly Ca_(12)Al_(14)O_(33)and CaF_(2)at C/A of 1.3,and the precipitation of crystalline phase BaAl2O4 demonstrated a rising trend,while that of Ca_(12)Al_(14)O_(33)gradually declined with BaO augment.

关键词： Aluminate slag Structure MgO BaO Viscosity Property

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On the global smooth solutions of 3D incompressible Hall-MHD equations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 319-327页

作者： YUE Gao-cheng SUN wen-da School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The present paper is devoted to the well-posedness issue for the 3D incompressible Hall-MHD system obtained from kinetic models. Our analysis strongly relies on the use of the Fourier analysis. We establish the global existence of smooth solutions for a class of large initial data, this result implies the initial velocity and magnetic field can be arbitrarily large.

关键词： 3D Hall-MHD well-posedness Fourier analysis

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