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PHLDA2 reshapes the immune microenvironment and induces drug resistance in hepatocellular carcinoma

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Oncology Research 2024年第6期32卷 1063-1078页

作者： KUN FENG HAO PENG QINGPENG lv YEWEI ZHANG Hepatopancreatobiliary Center The Second Affiliated Hospital of Nanjing Medical UniversityNanjing210000China Medical School Southeast UniversityNanjing210000China

Hepatocellular carcinoma(HCC)is a malignancy known for its unfavorable *** dysregulation of the tumor microenvironment(TME)can affect the sensitivity to immunotherapy or chemotherapy,leading to treatment *** elucidation of PHLDA2’s involvement in HCC is imperative,and the clinical value of PHLDA2 is also ***,bioinformatics analysis was performed in multiple cohorts to explore the phenotype and mechanism through which PHLDA2 may affect the progression of ***,the expression and function of PHLDA2 were examined via the qRT-PCR,Western Blot,and MTT *** findings indicate a substantial upregulation of PHLDA2 in HCC,correlated with a poorer *** methylation levels of PHLDA2 were found to be lower in HCC tissues compared to normal liver ***,noteworthy associations were observed between PHLDA2 expression and immune infiltration in *** addition,PHLDA2 upregulation is closely associated with stemness features and immunotherapy or chemotherapy resistance in *** vitro experiments showed that sorafenib or cisplatin significantly up-regulated PHLDA2 mRNA levels,and PHLDA2 knockdown markedly decreased the sensitivity of HCC cells to chemotherapy ***,we found that TGF-βinduced the expression of PHLDA2 in *** GSEA and in vitro experiment indicated that PHLDA2 may promote the HCC progression via activating the AKT signaling *** study revealed the novel role of PHLDA2 as an independent prognostic factor,which plays an essential role in TME remodeling and treatment resistance in HCC.

关键词： HCC Immune infiltration Drug resistance TME PHLDA2

An Improved Harris Hawk Optimization Algorithm for Flexible Job Shop Scheduling Problem

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Computers, Materials & Continua 2024年第2期78卷 2337-2360页

作者： Zhaolin lv Yuexia Zhao Hongyue Kang Zhenyu Gao Yuhang Qin College of Systems Engineering National University of Defense TechnologyChangsha410073China College of Information Management Nanjing Agricultural UniversityNanjing210031China Department of Intelligent Supply Chain JD LogisticsBeijing100076China College of Intelligent Science and Technology National University of Defense TechnologyChangsha410073China

Flexible job shop scheduling problem(FJSP)is the core decision-making problem of intelligent manufacturing production *** Harris hawk optimization(HHO)algorithm,as a typical metaheuristic algorithm,has been widely employed to solve scheduling ***,HHO suffers from premature convergence when solving NP-hard ***,this paper proposes an improved HHO algorithm(GNHHO)to solve the *** introduces an elitism strategy,a chaotic mechanism,a nonlinear escaping energy update strategy,and a Gaussian random walk strategy to prevent premature convergence.A flexible job shop scheduling model is constructed,and the static and dynamic FJSP is investigated to minimize the *** paper chooses a two-segment encoding mode based on the job and the machine of the *** verify the effectiveness of GNHHO,this study tests it in 23 benchmark functions,10 standard job shop scheduling problems(JSPs),and 5 standard ***,this study collects data from an agricultural company and uses the GNHHO algorithm to optimize the company’s *** optimized scheduling scheme demonstrates significant improvements in makespan,with an advancement of 28.16%for static scheduling and 35.63%for dynamic ***,it achieves an average increase of 21.50%in the on-time order delivery *** results demonstrate that the performance of the GNHHO algorithm in solving FJSP is superior to some existing algorithms.

关键词： Flexible job shop scheduling improved Harris hawk optimization algorithm(GNHHO) premature convergence maximum completion time(makespan)

Bifurcation analysis of a diffusive predator-prey model with hyperbolic mortality and prey-taxis

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International Journal of Biomathematics 2024年第1期17卷 251-264页

作者： Yan Li Zhiyi lv Fengrong Zhang Hui Hao College of Science China University of Petroleum(East China)Qingdao 266580P.R.China

In this paper,we study a diffusive predator-prey model with hyperbolic mortality and prey-taxis under homogeneous Neumann boundary *** first analyze the influence of prey-taxis on the local stability of constant *** turns out that prey-taxis has influence on the stability of the unique positive constant equilibrium,but has no influence on the stability of the trivial equilibrium and the semi-trivial *** then derive Hopf bifurcation and steady state bifurcation related to prey-taxis,which imply that the prey-taxis plays an important role in the dynamics.

关键词： Predator-prey model prey-taxis Hopf bifurcation steady state bifurcation

Flow excitation mechanisms of unbalanced impeller forces after pump power-trip of ultra-high head pump-turbines

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Science China(Technological Sciences) 2024年第5期67卷 1602-1611页

作者： FU XiaoLong LI DeYou lv JingWei YANG Biao WANG HongJie WEI XianZhu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China State Key Laboratory of Hydro-Power Equipment Harbin Institute of Large Electrical MachineryHarbin150040China

To elucidate the dynamic mechanisms of unbalanced impellers in ultra-high head pump-turbines(PTs),this study employed a one-and three-dimensional coupled method to simulate the pump power-trip(PPT)process of an ultra-high head *** investigation revealed two novel pulsation frequency components,denoted as fDVand fINFT,associated with impeller *** pulsation intensities of these components were markedly higher than those of rotor-stator interaction frequency components in ultra-high head ***,the fDVcomponents exhibited pulsations at 1–2 times the rated rotation frequency of the impeller,spanning the entire transition ***,the fINFTcomponents constituted a complex frequency band with various frequency values,primarily occurring near conditions(Q=0,n=0,M=0,and d M/dt=0).These two pulsation frequency components were predominantly linked to the unsteady evolution of dean vortices inside the volute and complex transitions of the flow pattern within the impeller,*** is crucial to note that these unbalanced flow-induced impeller axial forces can elevate the risk of accidents where the rotor is subjected to significant upwind axial *** findings offer valuable insights into mitigating the risk of rotor lifting due to axial forces during PT events in ultra-high head PTs.

关键词： ultra-high head pump-turbine pump power-trip unbalanced impeller forces pressure pulsations flow pattern transitions

A Hybrid Integrated and Low-Cost Multi-Chip Broadband Doherty Power Amplifier Module for 5G Massive MIMO Application

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Engineering 2024年第7期38卷 223-232页

作者： Fei Huang Guansheng lv Huibo Wu wenhua Chen Zhenghe Feng Department of Electronic Engineering Tsinghua UniversityBeijing 100084China

In this paper,a hybrid integrated broadband Doherty power amplifier(DPA)based on a multi-chip module(MCM),whose active devices are fabricated using the gallium nitride(GaN)process and whose passive circuits are fabricated using the gallium arsenide(GaAs)integrated passive device(IPD)process,is proposed for 5G massive multiple-input multiple-output(MIMO)*** inverted DPA structure with a low-Q output network is proposed to achieve better bandwidth performance,and a single-driver architecture is adopted for a chip with high gain and small *** proposed DPA has a bandwidth of 4.4-5.0 GHz that can achieve a saturation of more than 45.0 *** gain compression from 37 dBm to saturation power is less than 4 dB,and the average power-added efficiency(PAE)is 36.3%with an 8.5 dB peak-to-average power ratio(PAPR)in 4.5-5.0 *** measured adjacent channel power ratio(ACPR)is better than50 dBc after digital predistortion(DPD),exhibiting satisfactory linearity.

关键词： 5G Doherty power amplifier Multi-input multi-output Multi-chip modules Hybrid integrated

Ultra-high sensitivity fiber optic microphone with corrugated graphene-oxide diaphragm for voice recognition

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Nano Research 2024年第8期17卷 7593-7602页

作者： Yang Liu Cheng Li Lingxiao Yu Zhengwei Wu Shangchun Fan Ruitao lv School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Shenzhen Institute of Beihang University Shenzhen 518063China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100190China

To avoid interference from unexpected background noises and obtain high fidelity voice signal,acoustic sensors with high sensitivity,flat frequency response,and high signal-to-noise ratio(SNR)are urgently needed for voice ***(GO)has received extensive attention due to its advantages of controllable thickness and high fracture ***,low mechanical sensitivity(SM)introduced by undesirable initial stress limits the performance of GO material in the field of voice *** alleviate the aforementioned issue,GO diaphragm with annular corrugations is *** means of the reusable copper mold machined by picosecond laser,the fabrication and transfer of corrugated GO diaphragm are realized,thus achieving a Fabry–Perot(F–P)acoustic *** from the structural advantage of the corrugated GO diaphragm,our F–P acoustic sensor exhibits high S_(M)(43.70 nm/Pa@17 kHz),flat frequency response(−3.2 to 3.7 dB within 300–3500 Hz),and high SNR(76.66 dB@1 kHz).In addition,further acoustic measurements also demonstrate other merits,including an excellent frequency detection resolution(0.01 Hz)and high time stability(output relative variation less than 6.7%for 90 min).Given the merits presented before,the fabricated F–P acoustic sensor with corrugated GO diaphragm can serve as a high-fidelity platform for acoustic detection and voice *** conjunction with the deep residual learning framework,high recognition accuracy of 98.4%is achieved by training and testing the data recorded by the fabricated F–P acoustic sensor.

关键词： corrugated graphene-oxide(GO)diaphragm Fabry-Perot(F-P)acoustic sensor mechanical sensitivity voice recognition

Overcoming the Na-ion conductivity bottleneck for the cost-competitive chloride solid electrolytes

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Journal of Energy Chemistry 2024年第8期95卷 1-8,I0001页

作者： lv Hu Hui Li Fang Chen Yating Liu Jinzhu Wang Cheng Ma Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Materials for Energy ConversionDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026AnhuiChina National Synchrotron Radiation Laboratory Hefei 230026AnhuiChina

Chloride solid electrolytes possess multiple advantages for the construction of safe,energy-dense allsolid-state sodium batteries,but presently the chlorides with sufficiently high cost-competitiveness for commercialization almost all exhibit low Na-ion conductivities of around 10^(-5)S cm^(-1)or ***,we report a chloride solid electrolyte,Na_(2.7)ZFCl_(5.3)O_(0.7),which reaches a Na-ion conductivity of 2.29×10^(-4)S cm^(-1)at 25℃without involving overly expensive raw materials such as rare-earth chlorides or Na_(2)*** addition to the efficient ion transport,Na_(2.7)ZrCl_(5.3)O_(0.7)also shows an excellent deformability surpassing that of the widely studied Na_(3)PS_(4),Na_(3)SbS_(4),and Na_(2)ZrCl_(6)solid *** combination of these advantages allows the all-solid-state cell based on Na_(2.7)ZrCl_(5.3)O_(0.7)and NaCrO_(2)to realize stable room-temperature cycling at a much higher specific current than those based on other non-viscoelastic chloride solid electrolytes in literature(120 mA g^(-1)vs.12-55 mA g^(-1));after 100 cycles at such a high rate,the Na_(2.7)ZFCl_(5.3)O_(0.7)-based cell can still deliver a discharge capacity of 80 mAh g^(-1)at25℃.

关键词： All-solid-state sodium batteries Ionic conductivities Solid electrolytes Chlorides High voltage stability

Characteristics of water alternating CO_(2)injection in low-permeability beach-bar sand reservoirs

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Energy Geoscience 2024年第1期5卷 224-229页

作者： Maolei Cui Rui Wang Zengmin Lun Chengyuan lv State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective Development Beijing100083China Key Laboratory of Marine Oil and Gas Reservoir Production SINOPECBeijing100083China Petroleum Exploration and Development Research Institute SINOPECBeijing100083China

Water flooding can be ineffective in highly heterogeneous low-permeability beach-bar sand *** introduction of CO_(2)flooding helps boost the oil production of the reservoirs but only in an early *** the late stage of flooding,gas channeling would *** alternating gas(CO_(2))(WAG)process can be used to delay gas channeling and improve the effect of CO_(2)injection,though its adaptability to beach-bar sand reservoirs remains *** order to clarify CO_(2)injection characteristics in these reservoirs,experiments were carried out in high-temperature high-pressure NMR on-line displacement experiment apparatus to simulate different flooding modes on synthetic cores that can reflect the vertical heterogeneity of beach-bar *** CO_(2)injection modes were implemented on these cores and the displacement characteristics and residual oil distribution features during both WAG injection and continuous CO_(2)injection were analyzed quantitatively and *** results show that the scheme of WAG injection after continuous CO_(2)injection can obtain better oil displacement efficiency than that of the scheme of continuous CO_(2)injection after WAG injection,but there is no significant difference in respect of oil displacement efficiency of WAG flooding between the mode of bar-injection e beach-production(injection into bar sand e production from beach sand)and the mode of beach-injection e beach-production(injection into and production from beach sand),with the former mode having a higher oil recovery *** wider pore-size distribution range of microscopic residual oil after WAG injection shows great potential of enhancing oil recovery from subsequent continuous gas *** WAG injection is implemented prior to continuous CO_(2)injection,the displacement effect of the latter is more *** research may provide a theoretical basis for CO_(2)EOR in this type of reservoirs.

关键词： Beach-bar sand Low permeability CO_(2)injection WAG NMR

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河南省非物质文化遗产名录英译研究

华北理工大学学报（社会科学版） 2024年第1期24卷 99-106页

作者：吕雯霞河南科技学院外国语学院河南新乡453003

非物质文化遗产名录英译是“一带一路”倡议、中国文化“走出去”等重大国家战略的一个重要组成部分。以《河南省公共服务领域英文译写参考(试行)》收录的河南非遗英译名录为研究对象,分析采用的翻译方法和实现的翻译效果。认为音译加... 详细信息

非物质文化遗产名录英译是“一带一路”倡议、中国文化“走出去”等重大国家战略的一个重要组成部分。以《河南省公共服务领域英文译写参考(试行)》收录的河南非遗英译名录为研究对象,分析采用的翻译方法和实现的翻译效果。认为音译加直译、直译、直译加注、音译加注和音译为使用频率最高的翻译方法,旨在保留非遗文化的异质性,为非遗名称英译统一术语、争取非遗名录英译规范化奠定了基础。最后,基于《试行》的翻译经验,从生态翻译学的角度提出非遗名录英译应遵循的三原则:重视生态系统的完整性、促进生态系统整体平衡以及维护中华传统文化生态系统的独特性。

关键词：非遗英译方法生态翻译学原则

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