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Changes in the esophagogastric junction outflow obstruction manometric feature based on the Chicago Classification updates

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World Journal of Gastroenterology 2022年第30期28卷 4163-4173页

作者： Yue-Yuan Li wen-ting lu Jian-Xiang Liu Li-Hong Wu Meng Chen Hong-Mei Jiao Department of Geriatrics Peking University First HospitalBeijing 100034China Department of Gastroenterology and Hepatology Peking University First HospitalBeijing 100034China

BACKGROUND The critical diagnostic criteria for esophagogastric junction outflow obstruction(EGJOO)were published in the latest Chicago Classification version 4.0(CCv4.0).In addition to the previous criterion[elevated integrated relaxation pressure(IRP)in supine position],manometric diagnosis of EGJOO requires meeting the criteria of elevated median-IRP during upright wet swallows and elevated intrabolus ***,with the diagnostic criteria modification,the change in manometric features of EGJOO remained *** To evaluate the esophageal motility characteristics of patients with EGJOO and select valuable parameters for confirming the diagnosis of *** We performed a retrospective analysis of 370 patients who underwent highresolution manometry with 5 mL water swallows×10 in supine,×5 in upright position and the rapid drink challenge(RDC)with 200 mL water from November 2016 to November 2021 at Peking University First ***-one patients with elevated integrated supine IRP and evidence of peristalsis were enrolled,with 24 patients meeting the updated manometric EGJOO diagnosis(CCv4.0)as the EGJOO group and 27 patients not meeting the updated EGJOO criteria as the isolated supine IRP elevated group(either normal median IRP in upright position or less than 20%of supine swallows with elevated IBP).Forty-six patients with normal manometric features were collected as the normal high-resolution manometry(HRM)*** esophageal sphincter(UES),esophageal body,and lower esophageal sphincter(LES)parameters were compared between *** Compared with the normal HRM group,patients with EGJOO(CCv4.0)had significantly lower proximal esophageal contractile integral(PECI)and proximal esophageal length(PEL),with elevated IRP on RDC(P<0.05 for each comparison),while isolated supine IRP elevated patients had no such *** with EGJOO also had more significant abnormalities in the esophagogastric junction than isolated supine IRP elevate

关键词： Esophagogastric junction outflow obstruction High-resolution manometry Esophageal motility disorders Upper esophageal sphincter Proximal esophagus

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Study on the Stimulated Reservoir Volume Technology in Tight Carbonate Reservoir

Study on the Stimulated Reservoir Volume Technology in Tight...

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2014 International Conference on Green Materials and Environmental Engineering (GMEE2014)

作者： Heng Zheng Ning Cheng Zhong-wei Cao wen-ting lu Jun-sheng Sun The Branch of Key Laboratory of CNPC for Oil and Gas Production Yangtze University Yangtze university institute of petroleum engineering Engineering Technology Research Institute of Xinjiang Oilfield Company Xinjiang Oilfield Company Shixi Oilfield of Xinjiang oilfield

In the development of carbonate reservoir, it usually uses acid fracturing to improve the production. Because of the limitation of, the production rates from the wells are very low. Based on the "stimulated reservoir volume" which is used in the development of unconventional reservoirs, combined with the characteristics of tight carbonate reservoirs, in the early stage with low viscosity liquid, large pump scheme, small size proppant and pulse type sand to form complex fracture network. In the later, with high viscosity liquid, high sand rate, large size proppant, and continuous type sand to enlarge the stimulated volume and conductivity. Based on the experimental evaluation, the fracture design was optimized, and it will provide a reference for the stimulation of tight carbonate reservoir.

关键词： Tight carbonate reservoir Stimulated reservoir volume Stimulated volume Conductivity

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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang lu-Yu Liu Sha-Sha Cui ting-ting Li Xiao-Meng Yang Zhijuan Liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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猪圆环病毒2型诱导小鼠体内免疫细胞氧化胁迫模型的建立

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中国畜牧兽医 2017年第2期44卷 402-410页

作者：杨剑尹丹罗文涓李璐文露婷郝祝兵韦英益曾芸胡庭俊广西大学动物科学技术学院南宁530005

试验旨在建立猪圆环病毒2型(PCV2)诱导的小鼠体内免疫细胞氧化胁迫模型。筛选PCV2感染剂量及感染时间,采用腹腔注射、滴鼻和灌胃3种途径联合方式于第1、2、3天或第1、3、5、7天给予昆明系小鼠感染PCV2病毒原液或10-1 PCV2病毒液,分别于... 详细信息

试验旨在建立猪圆环病毒2型(PCV2)诱导的小鼠体内免疫细胞氧化胁迫模型。筛选PCV2感染剂量及感染时间,采用腹腔注射、滴鼻和灌胃3种途径联合方式于第1、2、3天或第1、3、5、7天给予昆明系小鼠感染PCV2病毒原液或10-1 PCV2病毒液,分别于感染后7、14、21d剖杀小鼠,测定活性氧(ROS)、总谷胱甘肽(T-GSH)、还原型谷胱甘肽(GSH)、氧化型谷胱甘肽(GSSG)水平及黄嘌呤氧化酶(XOD)、髓过氧化物酶(MPO)、诱导型一氧化氮合酶(iNOS)活性,探讨PCV2感染时间与活性氧水平变化的关系,建立免疫细胞氧化胁迫动物模型。结果显示,第1、2、3天每天经3种途径联合感染PCV2病毒原液,1mL/只,为后续试验感染最佳方案。PCV2感染小鼠3个时间点细胞内ROS水平较空白对照组均极显著升高(P<0.01),感染后7、14dGSH水平显著降低(P<0.05);感染后7dGSSG水平极显著高于空白对照组(P<0.01);感染后7dT-GSH水平显著低于空白对照组(P<0.05),感染后14dT-GSH水平极显著低于空白对照组(P<0.01)。感染后7d脾脏XOD、MPO、iNOS活性与空白对照组相比均存在显著差异(P<0.05)。结果表明,PCV2成功感染小鼠,试验感染方案为第1、2、3天每天经3种途径联合感染PCV2病毒原液,1mL/只,且用PCV2病毒原液感染7d是建立小鼠体内免疫细胞氧化胁迫模型的最佳条件。

关键词：猪圆环病毒2型小鼠免疫细胞氧化胁迫模型

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补充性肠外营养对重症患者临床结局的影响

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世界华人消化杂志 2017年第7期25卷 644-648页

作者：陆文婷张佳欢浙江省同德医院重症医学科浙江省杭州市310002

目的探讨补充性肠外营养(supplemental parenteral nutrition,SPN)对重症患者的临床价值.方法回顾性分析浙江省立同德医院2014-06/2016-06收治的108例重症患者的临床资料.根据是否实施肠内营养(enteral nutrition,EN)联合SPN,分为单纯EN... 详细信息

目的探讨补充性肠外营养(supplemental parenteral nutrition,SPN)对重症患者的临床价值.方法回顾性分析浙江省立同德医院2014-06/2016-06收治的108例重症患者的临床资料.根据是否实施肠内营养(enteral nutrition,EN)联合SPN,分为单纯EN组(对照组)和EN联合S P N组(观察组),比较两组患者的临床资料,观察SPN对重症患者的临床价值.结果与对照组相比,经SPN治疗1 wk后,观察组血浆白蛋白、前白蛋白及血红蛋白水平均明显高于对照组,差异有统计学意义(P0.05).观察组感染发生率及住院时间明显低于对照组,差异有统计学意义(P0.05).结论SPN能有效改善患者的营养不良状态,减少感染发生率,缩短住院时间.

关键词：补充性肠外营养肠内营养重症营养不良并发症

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山豆根多糖对人工感染罗非鱼链球菌病的预防效果

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饲料研究 2021年第15期44卷 68-72页

作者：陈奇文露婷李旻梁万文黄姻陈忠林勇胡庭俊广西大学动物科学技术学院广西南宁530005 广西水产科学研究院广西南宁530021

试验研究山豆根多糖(SSP)对罗非鱼链球菌病的预防效果。从形态学、生化鉴定和双重PCR鉴定无乳链球菌GX107,测定LD_(50)。将罗非鱼分为6组(0.1%SSP、0.2%SSP、0.4%SSP、0.4%APS、无乳链球菌感染组、空白对照组),每组4个重复,每个重复20... 详细信息

试验研究山豆根多糖(SSP)对罗非鱼链球菌病的预防效果。从形态学、生化鉴定和双重PCR鉴定无乳链球菌GX107,测定LD_(50)。将罗非鱼分为6组(0.1%SSP、0.2%SSP、0.4%SSP、0.4%APS、无乳链球菌感染组、空白对照组),每组4个重复,每个重复20尾鱼。试验组饲喂混有不同剂量(0.1%、0.2%、0.4%)SSP的饲料,黄芪多糖(APS)对照组饲喂含0.4%黄芪多糖的饲料,无乳链球菌感染组和空白对照组投喂基础饲料。试验组和感染组以10倍的LD_(50)浓度的无乳链球菌GX107腹腔注射,空白对照组注射等量生理盐水,计算各组保护率和死亡率。结果显示,该菌在BA血平板上,出现β溶血环,在BHIA培养基上出现灰白或白色湿润凸起菌落,过氧化氢酶试验为阳性,双重PCR鉴定为无乳链球菌。感染无乳链球菌的罗非鱼肝脏、脾脏、肾脏、胆不同程度地水肿,LD_(50)为6.61×10^(5)CFU/mL。10倍LD_(50)浓度的无乳链球菌感染罗非鱼,死亡率为85.71%,添加SSP可极显著降低死亡率(P<0.01),其中0.2%的SSP保护率最高,为61.9%。研究表明,不同剂量的SSP对链球菌感染的罗非鱼能有着不同程度保护效果,可以有效降低罗非鱼感染无乳链球菌后的死亡率。

关键词：罗非鱼山豆根多糖预防作用链球菌病

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Estimated prevalence and sociodemographic correlates of mental disorders in medical students of Hebei Province,China:A crosssectional study

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World Journal of Psychiatry 2023年第5期13卷 215-225页

作者： wen-ting lu Pei-Hua Hu Na Li Lan Wang Ran Wang Zeng Wang Mei Song Tian-Yu Zhao Shi-Jie Guo Fan-Fan Huang Bu-Fan Liu Ruo-Jia Ren Li Yang Quan Lin Yue-Hang Xu Na Jin Huan Chen Yuan-Yuan Gao Zhi-Feng Wu Guang-Yu Shi Da-Peng Liu Zhong-Qi Pan Chun-Chao Du Cui-Xia An Xue-Yi Wang Mental Health Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Technical Innovation Center Mental Health Assessment and InterventionShijiazhuang 050031Hebei ProvinceChina Hebei Clinical Research Center of Mental Disorders Institute of Mental HealthShijiazhuang 050031Hebei ProvinceChina Counseling and Mental Health Research Center Hebei Medical UniversityShijiazhuang 050031Hebei ProvinceChina Hebei Saitron Information Technology Co. LtdCangzhou 060000Hebei ProvinceChina

BACKGROUND In China,the identification rate and treatment rate of mental disorders are low,and there are few surveys on the prevalence of mental disorders among college students using diagnostic tools such as Mini-International Neuropsychiatric Interview(MINI),so the prevalence and treatment of mental disorders among college students are *** To estimate prevalence of mental disorders among medical students in Hebei Province,and provide guidance for improving their mental *** This was a cross-sectional study based on an Internet-based *** levels of medical students in Hebei Province were randomly selected(by cluster sampling)for *** the information network assessment system,the subjects scanned the 2D code with their mobile phones,clicked to sign the informed consent,and answered a scale.A self-designed general status questionnaire was used to collect information about age,gender,ethnicity,grade,and origin of *** MINI *** used to investigate mental *** analysis was performed with SPSS *** significant findings were determined using a two-tailed P value of *** A total of 7117 subjects completed the survey between October 11 and November 7,*** estimated prevalence of any mental disorders within 12 mo was 7.4%.Mood disorders were the most common category(4.3%),followed by anxiety disorders(3.9%);15.0%had been to psychological counseling,while only 5.7%had been to a psychiatric consultation,and only 10%had received drug therapy in the past 12 *** Although the estimated prevalence of mental disorders in medical students is lower than in the general population,the rate of adequate treatment is *** determined that improving the mental health of medical students is an urgent matter.

关键词： Hebei sectional college

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奶牛结合珠蛋白核酸适配体的筛选及鉴定

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中国兽医学报 2016年第6期36卷 1008-1014页

作者：曹立亭黎春秀文露婷罗艺晨马跃仲崇华西南大学荣昌校区动物医学系重庆荣昌402460 西南大学荣昌校区动物科学系重庆荣昌402460

核酸适配体作为一种优于单克隆抗体的新型识别分子,具有更高的分辨率,能识别配体间一个基团的细微差别,且所需的结合活性位点更小。本研究利用指数级富集配体进化技术(SELEX)筛选特异性结合于奶牛结合珠蛋白(HP)的DNA适配体,并对筛取的... 详细信息

核酸适配体作为一种优于单克隆抗体的新型识别分子,具有更高的分辨率,能识别配体间一个基团的细微差别,且所需的结合活性位点更小。本研究利用指数级富集配体进化技术(SELEX)筛选特异性结合于奶牛结合珠蛋白(HP)的DNA适配体,并对筛取的适配体进行特性分析。体外构建全长80bp中间含40bp随机序列的单链DNA(ssDNA)文库,通过对循环次数、退火温度及引物比例的优化,建立了适合的筛选体系;以超滤离心管为介质,HP蛋白为靶标,对随机ssDNA文库进行反复的SELEX筛选,从单链DNA文库中筛选能特异性结合HP蛋白的核酸适配体;利用DNAMAN和RNAstructure软件对获得核酸适配体进行一级结构和二级结构分析。结果表明,经过体外8轮筛选,随机ssDNA文库与HP蛋白的结合率由1.86%上升到31.35%,特异性核酸达到最大富集;经克隆和测序,获得了能与HP蛋白特异性结合的5个家族的DNA适配体,同源性均达70%以上,RNAstructure分析其二级结构主要以茎环结构为主,表明ssDNA形成不同的茎环结构可能是适配体与HP蛋白特异性作用的结构基础。初步建立HP蛋白核酸适配体库,筛选到与HP蛋白特异性结合的核酸适配体,为制备以HP为检测靶标的奶牛隐性乳腺炎检测试剂盒奠定基础。

关键词：奶牛乳腺炎结合珠蛋白 SELEX DNA适配体

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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痰热清注射液对脂多糖诱导大鼠气道粘液高分泌（英文）

痰热清注射液对脂多糖诱导大鼠气道粘液高分泌（英文）

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贵州省中西医结合学会呼吸专业委员会2015年年会

作者： Shou-jin Dong Yun-qing Zhong wen-ting lu Kun Yang Mao-juan Liu Xiao-ling Xiong Bing Mao Department of Integrated Traditional Chinese and Western Medicine West China HospitalWest China Medical SchoolSichuan University Department of Pneumology Chengdu First People's HospitalChengdu Integrated Traditional Chinese and Western Medicine Hospital Department of Pneumology The First Affiliated Hospital of Guangxi Traditional Chinese Medical University Department of geratology Sichuan Hospital of Integrated Traditional Chinese and Western Medicine Department of geratology Chengdu University of Traditional Chinese Medicine

Background:Tanreqing injection,a Chinese herbal formulation comprising Radix Scutellariae,Fructus Forsythiae,Flos Lonicerae,Antelope horn,and Bear bile powder,has been used to treat bronchitis and pneumonia for many years in ***,its anti-mucus-hypersecretion mechanism has yet not been fully *** aim to assess the effect and dose-response relationships of Tanreqing injection on lipopolysacchaide(LPS) induced airway mucus hypersecretion in *** and methods:Forty-eight male rats were randomly divided into four groups(12 per group).A rat model of airway mucus hypersecretion was generated with *** injection was given by intratracheal instillation,and bronchoalveolar lavage fluid(BALF)from the right lung was *** total protein was determined by bicinchoninic acid disodium assay(BCA).Muc5 ac was measured using enzyme linked immunosorbent assay(ELISA) and *** expression of muc5ac mRNA was detected by real-time polyermase chain reaction(RT-PCR).The middle lobe of the right lung was stained with alcian blue-periodic acid sthiff(AB-PAS) and positive staining relative shading area ***:LPS caused airway mucus hypersecretion,The LPS-induced airway mucus hypersecretion increased beginning at 24 hr,and peaked at96 *** injection could inhibit airway mucus hypersecretion,and suppress the expression of muc5 ac ***:Tanreqing injection inhibits airway mucus hypersecretion in a certain dose-dependent trend.

关键词： Tanreqing injection Iipopolysaccharides airway mucus hypersecretion dose-response relationship

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