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Vedolizumab in Crohn’s disease with rectal fistulas and presacral abscess:A case report

World Journal of Gastroenterology 2021年第5期27卷 442-448页

作者： Heng Yeh Chia-Jung Kuo Ren-Chin Wu Chien-Ming Chen wen-sy tsai Ming-Yao Su Cheng-Tang Chiu Puo-Hsien Le School of Medicine Chang Gung UniversityTaoyuan City 333323Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Taiwan Association of the Study of Small Intestine Disease Taoyuan 333Taiwan Department of Pathology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Colon and Rectal Surgery Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Gastroenterology and Hepatology New Taipei City Municipal Tucheng HospitalNew Taipei City 236017Taiwan Liver Research Center Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan

BACKGROUND Fistula and intraabdominal abscess are common complications of Crohn’s disease(CD),but complex rectal fistula with abscess formation is *** necrosis factor antagonists combined with percutaneous drainage or surgical intervention is optimal treatment for fistulizing CD with intraabdominal *** is no study showing the efficacy of vedolizumab in such complicated *** SUMMARY A 47-year-old man has decompensated liver cirrhosis,Child *** suffered from abdominal pain,bloody diarrhea,fever,and body weight *** with rectoprostatic fistula,rectopresacral fistula,presacral abscess and cytomegalovirus(CMV)infection were *** received antibiotics,anti-viral therapy,transverse colostomy and vedolizumab *** months later,he had deep remission and complete fistula tracts *** Early vedolizumab and stool diversion are effective and safe in treating CD with complex rectal fistula with abscess formation.

关键词： Vedolizumab Crohn's disease Rectoprostatic fistula Rectal presacral fistula Presacral abscess Case report

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Membrane Proteins as Potential Colon Cancer Biomarkers: Verification of 4 Candidates from a Secretome Dataset

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Surgical Science 2014年第10期5卷 418-438页

作者： Sum-Fu Chiang Ming-Hung tsai Reiping Tang Ling-Ling Hsieh Jy-Ming Chiang Chien-Yuh Yeh Pao-Shiu Hsieh wen-sy tsai Ya-Ping Liu Ying Liang Jinn-Shiun Chen Jau-Song Yu Division of Colon and Rectal Surgery Chang Gung Memorial Hospital Linkou Chinese Taipei Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan Chinese Taipei Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Chinese Taipei College of Medicine Chang Gung University Linkou Chinese Taipei Department of Public Health Chang Gung University Taoyuan Chinese Taipei Pathology Core of the Chang Gung Molecular Medicine Research Center Taoyuan Chinese Taipei Department of Biochemistry and Molecular Biology Chang Gung University Taoyuan Chinese Taipei

Colorectal cancer (CRC) is an important health issue in Taiwan. There were over ten thousand newly diagnosed CRC patients each year. The outcome of late stage CRC still remains to be improved, and tumor markers are expected to improve CRC detection and management. From a colorectal cancer cell secretome database, we chose four proteins as candidates for clinical verification, including tumor-associated calcium signal transducer 2 (TROP2, TACSTD2), transmembrane 9 superfamily member 2 (TM9SF2), and tetraspanin-6 (TSPAN6), and tumor necrosis factor receptor superfamily member 16 (NGFR). Different groups of 30 CRC patients’ tissue samples collected from Chang Gung Memorial Hospital were analyzed by immunohistochemistry (IHC) for the four proteins, and the results were scored by pathologist. For all the four candidate proteins, marked differences of IHC score existed between tumor and adjacent non-tumor counterpart. However, there were only trends between higher protein expression levels and worse outcome. Three proteins (TROP2, TM9SF2 and NGFR) had trends between higher tissue expression and tumor stage or lymph node metastasis. Our study revealed that tissue expression of four proteins (TROP2, TM9SF2, TSPAN6, and NGFR) was markedly different between tumor and adjacent non-tumor counterparts. Overexpression of all these four proteins showed some trends with poorer survival.

关键词： Biomarker Colorectal Cancer Immunohistochemistry Membrane Protein Secretome Tetraspanin-6 Transmembrane 9 Superfamily Member 2 Tumor-Associated Calcium Signal Transducer 2 Tumor Necrosis Factor Receptor Superfamily Member 16 Verification

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Experimental Study on Young′s Modulus of Concrete

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Journal of Central South University 2000年第1期12卷 43-45页

作者： wen, sy Li, XB Cent S Univ Technol Coll Resources Environm & Civil Engn Changsha 410083 Peoples R China

Young′s Modulus of concrete is studied on the basis of triaxial compressive experiments. The authors proposed two empirical equations to calculate its static Young′s modulus and dynamic Young′s modulus when dynamic Poisson ratio μ d varies nearby 0.20.P wave velocity and elastic modulus have the same varying tendency as letter N. μ,μ d decrease with the increase of loading rate and μ d has a great effect on the parameters E d and E D.

关键词： concrete static Young′s modulus dynamic Young′s modulus P wave velocity

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High-throughput discovery of highly selective reversible hMAO-B inhibitors based on at-line nanofractionation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1772-1786页

作者： Yu Fan Jincai Wang Jingyi Jian Yalei wen Jiahao Li Hao Tian Jacques Crommen Wei Bi Tingting Zhang Zhengjin Jiang Institute of Pharmaceutical Analysis/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China/College of Pharmacy Jinan UniversityGuangzhou 510632China KU Leuven-University of Leuven Pharmaceutical AnalysisDepartment of Pharmaceutical and Pharmacological SciencesLeuven 3000Belgium Laboratory of Analytical Pharmaceutical Chemistry Department of Pharmaceutical SciencesCIRMUniversity of LiegeLiege B-4000Belgium Department of Neurology the First Affiliated Hospital of Jinan University/Clinical Neuroscience Institutethe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

Human monoamine oxidase B(hMAO-B)has emerged as a pivotal therapeutic target for Parkinson's *** to adverse effects and shortage of commercial drugs,there is a need for novel,highly selective,and reversible hMAO-B inhibitors with good blood-brain barrier *** this study,a high-throughput at-line nanofractionation screening platform was established with extracts from Chuanxiong Rhizoma,which resulted in the discovery of 75 active compounds,including phenolic acids,volatile oils,and phthalides,two of which were highly selective novel natural phthalide hMAO-B inhibitors that were potent,selective,reversible and had good blood‒brain *** docking and molecular dynamics simulations elucidated the inhibition ***(IC_(50)=103 nmol/L;SI=645)and neocnidilide(IC_(50)=131 nmol/L;SI=207)demonstrated their excellent potential as hMAO-B *** offset the limitations of deactivating enzymes associated with irreversible hMAO-B inhibitors such as *** SH-sy5Y cell assays,sedanolide(EC_(50)=0.962μmol/L)and neocnidilide(EC_(50)=1.161μmol/L)exhibited significant neuroprotective effects,comparable to the positive drugs rasagiline(EC_(50)=0.896μmol/L)and safinamide(EC_(50)=1.079μmol/L).These findings underscore the potential of sedanolide as a novel natural hMAO-B inhibitor that warrants further development as a promising drug candidate.

关键词： Human monoamine oxidase B inhibitors High-throughput screening At-linenanofractionation Parkinson's disease Cellular neuroprotection Traditional Chinese medicines(TCMs)

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Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1227-1235页

作者： wen-Jing Hu Gang Bai Yan Wang Dong-Mei Hong Jin-Hua Jiang Jia-Xun Li Yin Hua Xin-Yu Wang Ying Chen Intensive Care Unit Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Anesthesia and Perioperative Medicine Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical *** To develop a synthetic minority oversampling technique(SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer *** In this retrospective cohort study,we analyzed data from 611 elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October *** incidence of postoperative delirium was recorded for 7 d *** were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not.A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative *** SMOTE technique was applied to enhance the model by oversampling the delirium *** model’s predictive accuracy was then *** In our study involving 611 elderly patients with abdominal malignant tumors,multivariate logistic regression analysis identified significant risk factors for postoperative *** included the Charlson comorbidity index,American Society of Anesthesiologists classification,history of cerebrovascular disease,surgical duration,perioperative blood transfusion,and postoperative pain *** incidence rate of postoperative delirium in our study was 22.91%.The original predictive model(P1)exhibited an area under the receiver operating characteristic curve of *** comparison,the SMOTE-based logistic early warning model(P2),which utilized the SMOTE oversampling algorithm,showed a slightly lower but comparable area under the curve of 0.856,suggesting no significant difference in performance between the two predictive *** This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of tradi

关键词： Elderly patients Abdominal cancer Postoperative delirium synthetic minority oversampling technique Predictive modeling Surgical outcomes

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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Chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu Tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge wen-Ying Zhuang Gang Hu Ren Xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1-4 are ***,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-sy5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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关节置换术机器人手术系统的现状及发展趋势

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中国矫形外科杂志 2024年第19期32卷 1780-1785页

作者：卜延民赵慧雯郑得志罗文天津市天津医院关节外科

随着计算机视觉、深度学习等尖端科学技术的快速发展，关节置换术机器人手术系统在稳定性和准确性方面与关节置换术传统手术技术相比具有显著优势，有效地提高了手术治疗效果。随着关节置换术机器人手术系统的不断迭代更新，并与虚拟现... 详细信息

随着计算机视觉、深度学习等尖端科学技术的快速发展，关节置换术机器人手术系统在稳定性和准确性方面与关节置换术传统手术技术相比具有显著优势，有效地提高了手术治疗效果。随着关节置换术机器人手术系统的不断迭代更新，并与虚拟现实、人工智能等新兴技术相结合，产生了强大的术前规划和智能操作功能。当今市场上关节置换术机器人手术系统种类繁多，本文就关节置换术机器人手术系统的最新应用现状及今后发展趋势进行综述，阐述了关节置换术机器人手术系统在临床应用方面的优势和局限性，并提出可解决的方案，为今后关节置换术机器人手术系统的研究发展提供参考。

关键词：关节置换术机器人人工智能术前规划

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磁流变胶中磁性颗粒的运动仿真分析

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科学技术创新 2024年第9期 67-70页

作者：雷文邵阳学院机械与能源工程学院湖南邵阳

为了深入了解磁流变胶中磁性颗粒在外加磁场下形成磁链的过程,通过对磁性颗粒进行动力学分析,得出磁性颗粒的运动学模型,并通过COMSOL有限元分析软件对磁性颗粒进行磁场、固体力学、流场的多物理场耦合分析。得出磁性颗粒在磁化后会产... 详细信息

为了深入了解磁流变胶中磁性颗粒在外加磁场下形成磁链的过程,通过对磁性颗粒进行动力学分析,得出磁性颗粒的运动学模型,并通过COMSOL有限元分析软件对磁性颗粒进行磁场、固体力学、流场的多物理场耦合分析。得出磁性颗粒在磁化后会产生吸引域与排斥域,会与其他颗粒进行吸引与排斥运动,从而形成磁链。在相同外加磁场强度作用下,两个磁性颗粒之间的初始分布位置会影响其接触的时间,在0°~60°角度内,角度越大,接触的时间越长,当分布角度为90°时,两个磁性颗粒会发生排斥。

关键词：磁性颗粒运动仿真磁流变胶

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文艺评论助推创作繁荣的历史经验与现实意义——以“长安画派”为例

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陕西师范大学学报（哲学社会科学版） 2024年第1期53卷 45-51页

作者：刘艳卿孙文忠西北大学艺术学院陕西西安710127 四川文化艺术学院美术设计学院四川绵阳621000

优秀的文艺评论通过问题聚焦、理论阐释和思想引领,不仅对受众有导向、提升的作用,而且对艺术创作亦能产生镜鉴、助推的效果。作为文艺评论助推艺术创作繁荣的一个典型案例,20世纪五六十年代《美术》杂志所刊文艺评论文章与“长安画派... 详细信息

优秀的文艺评论通过问题聚焦、理论阐释和思想引领,不仅对受众有导向、提升的作用,而且对艺术创作亦能产生镜鉴、助推的效果。作为文艺评论助推艺术创作繁荣的一个典型案例,20世纪五六十年代《美术》杂志所刊文艺评论文章与“长安画派”绘画创作之历史钩沉,引起了新中国画推陈出新问题的激烈论争,触发了美术界关于文艺评论标准的讨论。由此延伸,建党百年以来,客观公正的文艺评论不断修正着文艺创作的发展路线,使得体现现实生活厚度,时代精神锐度和民族风格、中国气派高度的经典作品层出不穷。

关键词：文艺评论艺术创作《美术》长安画派

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基于ADSE知识循环系统的知识获取方式与企业创新绩效关系研究

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系统科学学报 2024年第1期32卷 128-135页

作者：侯佳雯马靖陈怀超中国人民大学商学院北京100872 太原理工大学经济管理学院山西太原030024

在ADSE(Acquisition,Digestion,Sharing,Exploitation,获取—消化—共享—应用)知识循环系统中,企业通过“内外兼修”的方式获得多样化的知识,不仅需要与外部利益相关者进行交流,而且需要在内部开展知识共享活动,共同助力于创新活动,推... 详细信息

在ADSE(Acquisition,Digestion,Sharing,Exploitation,获取—消化—共享—应用)知识循环系统中,企业通过“内外兼修”的方式获得多样化的知识,不仅需要与外部利益相关者进行交流,而且需要在内部开展知识共享活动,共同助力于创新活动,推进创新进程。基于ADSE知识循环系统,探究了外部知识获取和内部知识共享对企业创新绩效的直接影响以及吸收能力的中介作用。研究结果表明,不同知识获取方式在提升企业创新绩效中具有相同作用,即外部知识获取和内部知识共享均能够促进企业创新绩效提升;吸收能力在这一影响过程中发挥中介作用,遵循了“知识—能力—绩效”的影响路径。研究结论一方面验证了企业内外部的知识循环过程,并深化了企业创新问题在知识层面的相关研究,另一方面为企业开展有效的外部知识获取和内部知识共享活动提供建议,推动企业创新绩效的提升。

关键词： ADSE知识循环系统创新绩效外部知识获取内部知识共享吸收能力

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