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Correlation-driven threefold topological phase transition in monolayer OsBr_(2)

Frontiers of physics 2023年第3期18卷 121-130页

作者： San-Dong Guo Yu-Ling Tao wen-qi mu Bang-Gui Liu School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

Spin–orbit coupling(SOC)combined with electronic correlation can induce topological phase transition,producing novel electronic ***,we investigate the impact of SOC combined with correlation effects on physical properties of monolayer OsBr_(2),based on first-principles calculations with generalized gradient approximation plus U(GGA+U)*** intrinsic out-of-plane magnetic anisotropy,OsBr_(2)undergoes threefold topological phase transition with increasing U,and valleypolarized quantum anomalous Hall insulator(VQAHI)to half-valley-metal dxy dx2−y2 dz2¯6m2(HVM)to ferrovalley insulator(FVI)to HVM to VQAHI to HVM to FVI transitions can be *** topological phase transitions are connected with sign-reversible Berry curvature and band inversion between/and *** to symmetry,piezoelectric polarization of OsBr_(2)is confined along the in-plane armchair direction,and only one d11 is *** a given material,the correlation strength should be fixed,and OsBr_(2)may be a piezoelectric VQAHI(PVQAHI),piezoelectric HVM(PHVM)or piezoelectric FVI(PFVI).The valley polarization can be flipped by reversing the magnetization of Os atoms,and the ferrovalley(FV)and nontrivial topological properties will be suppressed by manipulating out-of-plane magnetization to in-plane *** considered reasonable U range,the estimated Curie temperatures all are higher than room *** findings provide a comprehensive understanding on possible electronic states of OsBr_(2),and confirm that strong SOC combined with electronic correlation can induce multiple quantum phase transition.

关键词： correlation SOC phase transition piezoelectricity

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舰载直升机通用矩阵式系留座优化设计方法研究

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舰船科学技术 2018年第8期40卷 133-136,140页

作者：朱枫安强林温其穆中国船舶工业系统工程研究院北京100094

为提高舰载直升机系留保障的通用性,舰船采用矩阵式系留座。针对矩阵式系留座的设计,建立了矩阵式系留座优化模型,与传统优化算法相比,该模型兼顾考虑两型舰载直升机的系留强度,采用了双目标模糊策略,使用罚函数处理索具长度约束和系留... 详细信息

为提高舰载直升机系留保障的通用性,舰船采用矩阵式系留座。针对矩阵式系留座的设计,建立了矩阵式系留座优化模型,与传统优化算法相比,该模型兼顾考虑两型舰载直升机的系留强度,采用了双目标模糊策略,使用罚函数处理索具长度约束和系留许用载荷约束,并基于粒子群算法进行寻优。通过某保障两型舰载直升机的舰船矩阵式系留座仿真算例分析,验证了模型和算法的可行性和优化效果。

关键词：舰载直升机矩阵式系留座粒子群算法双目标优化

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类比推理的功能性磁共振成像与主成份分析(英文)

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西部医学 2008年第1期20卷 171-176页

作者：母一嘉母其文美国南卡罗纳州立学术重点学校生命科学部四川省南充市中心医院放射科

研究背景:功能性成像已经应用于人脑类比推理研究。但是,由于较小的研究样品,这些研究结果不大一致。方法利用功能性磁共振成像,我们测量了24例健康人的类比推理脑活动。这些功能性磁共振成像数据由统计参数软件(SPM I)处理与主成份分... 详细信息

研究背景:功能性成像已经应用于人脑类比推理研究。但是,由于较小的研究样品,这些研究结果不大一致。方法利用功能性磁共振成像,我们测量了24例健康人的类比推理脑活动。这些功能性磁共振成像数据由统计参数软件(SPM I)处理与主成份分析。结果阳性活动见于双侧大脑半球腹外侧、背外侧前额叶、后顶叶及小脑半球;阴性结果见于双侧大脑半球内前额叶、顶枕颞区、扣带回后部及上顶叶。主成份分析表明仅仅只有一个主成份具有大于1.0的特征值,这个成份可以解释93%的总方差。所有的阳性及阴性活动区被包括在这个主成份中。结论人脑的类比推理活动可能是一个由双侧大脑半球内多个阳性及阴性活动区组成的神经网络调节,包括双侧前额叶及后顶叶。

关键词：人脑类比推理功能性核磁共振大脑半球

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边缘计算的安全挑战与解决方法综述

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计算机系统应用 2024年第11期33卷 38-47页

作者：温木奇温武少广东白云学院电气与信息工程学院广州510450 中山大学计算机学院广州510006

相比集中式的云计算框架,边缘计算在云中心和现场智能设备之间部署了额外的“边缘服务器”,支持现场智能设备快速、高效地完成运算任务和事件处理.边缘计算系统中,现场智能设备数量庞大、边缘计算服务器繁杂,它们存储的数据敏感和私密... 详细信息

相比集中式的云计算框架,边缘计算在云中心和现场智能设备之间部署了额外的“边缘服务器”,支持现场智能设备快速、高效地完成运算任务和事件处理.边缘计算系统中,现场智能设备数量庞大、边缘计算服务器繁杂,它们存储的数据敏感和私密性要求高.边缘计算系统的这些特点,给网络安全防护带来困难.解决边缘计算系统的信息和网络安全是边缘计算技术大规模产业化的关键.而由于边缘服务器设备和现场智能设备的计算能力、网络能力和存储能力的局限,传统的计算机网络安全技术不能完全满足要求.分析适合边缘计算系统的联邦学习、轻量加密、混淆与虚拟位置信息、匿名身份认证等有效的敏感数据保护技术,以及探讨人工智能和区块链等新技术在边缘计算防范恶意攻击的应用,助力边缘计算的产业化发展.

关键词：边缘计算数据保护联邦学习区块链内生安全架构

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Influence of gut bacteria on type 2 diabetes:Mechanisms and therapeutic strategy

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World Journal of Diabetes 2025年第1期16卷 27-33页

作者： Xue wen Lu-Ming qi Kui Zhao College of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina College of Materials and Chemical Engineering Southwest Forestry UniversityKunming 650224Yunnan ProvinceChina

The onset and progression of type 2 diabetes mellitus(T2DM)are strongly associated with imbalances in gut bacteria,making the gut microbiome a new potential therapeutic *** commentary examines the recent publication in World Journal of *** article explores the association between T2DM and gut microbiota,with a focus on the pathophysiological changes related to *** proposes innovative microbiome-targeted therapeutic strategies and evaluates the challenges and future directions of such *** editorial summarizes the key points of their discussion of the role of the gut microbiome in T2DM and elaborates on the influence of specific gut microbial species on the disease through the host–microbiota metabolic *** provides new insights for future research on gut-microbiota-based interventions for T2DM.

关键词： Type 2 diabetes Intestinal microbiome Intestinal axis Biological pathways Treatment Short-chain fatty acids

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Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi wen Xin Xiong Ting Xu qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-wen Pan Jun-qing qi qiang Zhou Wei-Feng Tang Guo-wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-qi Zhang Yu-Ying Tan Li Zhang wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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卵胎生硬骨鱼许氏平鲉繁殖生物学研究进展

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 106-115页

作者：齐鑫杨欣琳温海深中国海洋大学水产学院山东青岛266003

卵胎生作为卵生向胎生进化的中间状态,具有子代成活率高的特性。因此,卵胎生许氏平鲉成为我国重要的北方海水养殖对象之一。然而,大量养殖该物种又带来了一些繁殖过程中的实际问题。比如,网箱养殖的亲鱼出现明显的交配失败,导致其子代... 详细信息

卵胎生作为卵生向胎生进化的中间状态,具有子代成活率高的特性。因此,卵胎生许氏平鲉成为我国重要的北方海水养殖对象之一。然而,大量养殖该物种又带来了一些繁殖过程中的实际问题。比如,网箱养殖的亲鱼出现明显的交配失败,导致其子代出生率极低;妊娠期亲鱼母胎器官发育障碍,导致仔鱼胎死腹中;早产、难产导致的亲鱼、仔鱼大量死亡等。本综述将针对上述问题,分别探讨许氏平鲉交配发生、妊娠维持及分娩启动相关的内分泌调控机制,以期为后续研究提供潜在思路,最终实现水产养殖问题的解决。

关键词：卵胎生许氏平鲉繁殖生理

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