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Studies on the Crystal Structure and Photoluminescence of a Mercury(Ⅱ)Complex Based on a Novel Pyridine ligand

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Chinese Journal of Structural Chemistry 2010年第7期29卷 1029-1032页

作者： WU Jie-Ying zhou wen li Wei-Jie zhou Hong-Ping TIAN Yu-Peng Department of Chemistry Key Laboratory of Functional Inorganic Materials Chemistry of Anhui Province Anhui University Hefei 230039 China

A novel mercury（H） complex HgL2Br2 was prepared from HgBr2 and the organic ligand 2-（N-methyl-N-（4-（（E）-2-（pyridine-4-yl）vinyl）phenyl）amino）ethanol （L）. The ligand was synthesized and then characterized by FT-IR spectroscopy, tH NMR, mass spectrum and elemental analysis, while the single-crystal diffraction data of the complex were collected on a Siemens Smart CCD diffractometer. The complex crystallizes in triclinic space group PI with a = 5.367（5）, b = 12.466（5）, c = 23.945（5） A, α = 90.812（5）, β = 96.318（4）, γ = 96.093（5）°, Z = 2, Dc = 1.817 ***3,μ = 7.395 mm^-1, S = 0.825, and the final R= 0.0396. The Hg（Ⅱ） ion in the distorted tetrahedral mercury（Ⅱ） complex C32H36HgBr2N4O2 is coordinated by two N atoms from the two ligands together with two bromide ions. Solid-state emission of the ligand and its complex has been investigated at room temperature.

关键词： mercury(Ⅱ) complex single-photon fluorescence crystal structure

THE VOID FRACTION DISTRIBUTION IN TWO-DIMENSIONAL GAS-liQUID TWO PHASE FLOW USING IMAGE PROCESS METHOD

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Journal of Hydrodynamics 2006年第2期18卷 127-134页

作者： ZHAO Ke-yu CHENG wen liAO Wei-li zhou Xiao-de College of Water Resource and Architectural Engineering Northwest Agriculture and Forestry University Xi＇an 712100 China Environment Research Institute Xi＇ an University of Technology Xi＇an 710048 China

An image processing method for measuring the instantaneous two-dimensional （2D） local void fraction at high bubble number density was proposed. It was based on computing a correlation between the locally averaged brightness of the bubble plume images and the real void fraction. The method was tested using the 2D distribution of local void fraction from visualized image, where a correlation between the locally averaged brightness and the projection void fraction was derived by introducing an ideal of overlapping probability of the bubble-images under various conditions. This research was used to study the behavior of the bubbly flows with aspect ratio of 1.0,1.5, and 2.0. The present method was applied to the instantaneous measurement. The void fraction for bubble plumes of three different aspect ratios with three different bubble generating flow rates were measured for the clarification of the effect of the bubble on the behavior of the bubbly flows. Dependency of the void fraction on the gas flow rate was measured and compared to other results from the literature. In the range of our experiments, it was observed that not only does an aspect ratio of the tank affect the structure of the plume, but also the gas flow rate in the tank affects the structure of the plume.

关键词： local void fraction gas-liquid two-phase flow,brightness aspect ratio the projection void fraction

Low dose effects on cultured mammalian cells...

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Nuclear Science and Techniques 2000年第4期11卷 276-279页

作者： WANG Ju-Fang, li wen-Jian, zhou Guang-Ming, HE Jing, li Qiang, DANG Bing-Rong, li Xing-lin, XIE Hong-Mei, WEI Zeng-Quan (Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000) 中科院近代物理所甘肃兰州 730000

The low dose effects induced by carbon ions on Chinese hamster V79 cells and murine melanoma B16 cells were investigated in this paper. Both cell lines were divided into four groups for irradiation: (1) control, (2) 0.02 Gy or 0.05 Gy(D1), (3) 1 Gy(D2), (4) D1+D2. The survivors and micronuclei were studied as biological endpoints. The results of group (1) and group (2) showed that there were no obvious differences on micronucleus frequency but there were significant increases when irradiation dose was 0.02Gy on colony formation efficiency. Although low dose ion irradiation could not contribute to DNA damages, it could enhance the colony formation efficiency. In the study of group (3) and (4), when the ion dose was 0.02 Gy, there were evident increases on surviving fraction and decreases on micronucleus frequency, but there were no statistical changes on these endpoints when the ion dose was 0.05Gy. This meant that high LET radiation could induce the adaptive response of cultured cells, furthermore, in the range of inducing ion dose , low dose irradiation was more profitable than high dose one.

关键词：哺乳动物细胞 DNA 离子辐射低剂量效应辐射效应碳离子

Expansive effects of aorta-gonad-mesonephros-derived stromal cells on hematopoietic stem cells from embryonic stem cells

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Chinese Medical Journal 2005年第23期118卷 1979-1986页

作者： FU Jin-rong liU wen-li zhou Yu-feng zhou Jian-feng SUN Han-ying LUO li ZHANG Hen XU Hui-zhen Department of Hematology Tongji Hospital Tongji Medical SchoolHuazhong University of Science and Technology Wuhan 430030China

Background Hematopoietic stem cells （HSCs） give rise to all blood and immune cells and are used in clinical transplantation protocols to treat a wide variety of refractory diseases, but the amplification of HSCs has been difficult to achieve in vitro. In the present study, the expansive effects of aorta-gonad-mesonephros （AGM） region derived stromal cells on HSCs were explored, attempting to improve the efficiency of HSC transplantation in clinical practice.Methods The murine stromal cells were isolated from the AGM region of 12 days postcoitum （dpc） murine embryos and bone marrow（BM） of 6 weeks old mice, respectively. After identification with flow cytometry and immunocytochemistry, the stromal cells were co-cultured with ESCs-derived, cytokines-induced HSCs. The maintenance and expansion of ESCs-derived HSCs were evaluated by detecting the population of CD34^＋ and CD34^＋ Sca-1^＋ cells with flow cytometry and the blast colony-forming cells （BL-CFCs）, high proliferative potential colony-forming cells （HPP-CFCs） by using semi-solid medium colonial culture. Finally, the homing and hematopoietic reconstruction abilities of HSCs were evaluated using a murine model of HSC transplantation in vivo.Results AGM and BM-derived stromal cells were morphologically and phenotypically similar, and had the features of stromal cells. When co-cultured with AGM or BM stromal cells, more primitive progenitor cells （ HPP-CFCs ） could be detected in ESCs derived hematopoietic precursor cells, but BL-CFC＇ s expansion could be detected only when co-cultured with AGM-derived stromal cells. The population of CD34^＋ hematopoietic stem/ progenitor cells were expanded 3 times, but no significant expansion in the population of CD34^＋ Sca-1^＋ cells was noted when co-cultured with BM stromal cells. While both CD34^＋ hematopoietic stem/progenitor cells and CD34^＋ Sca-1^＋ cells were expanded 4 to 5 times respectively derived stromal cells, like BM-derived stromal cells, homing to BM in vivo. whe

关键词： hernatopoietic stern cells· embryonic stern cells· strornal cells

急倾斜特厚煤层水平分段开采老顶断裂力学模型

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煤炭学报 2008年第6期33卷 606-608页

作者：鞠文君李文洲北京交通大学地下工程研究中心北京100044 煤炭科学研究总院开采设计研究分院北京100013

通过对急倾斜特厚煤层水平分段开采老顶破坏特点的分析,建立了老顶沿倾斜方向悬臂梁断裂的力学模型,推导得出老顶岩层悬臂梁能量表达式,提出了爆破断顶矿压防治技术,并在甘肃华亭煤矿试验成功.

关键词：急倾斜特厚煤层水平分段综放开采悬臂梁结构爆破断项

Role of Hepatocyte Nuclear Factor 4α in Regulating Hepatic Differentiation and the Inflammatory Response in HCC

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Journal of Nutritional Oncology 2019年第3期4卷 115-120页

作者： wen li zhou Zhan Wang Ming Yong Miao Yuan Sheng Zang Department of Medical Oncology Changzheng HospitalNavy Medical UniversityShanghai 200070China Department of Biochemistry and Molecular Biology Navy Medical UniversityShanghai 200433China

limited treatment options are available for hepatocellular carcinoma(HCC),especially in the advanced stage,which is associated with a poor *** studies have demonstrated that hepatocyte nuclear factor 4α(HNF 4α)plays an important role in hepatic differentiation and the carcinogenesis of *** 4αcritically regulates hepatic differentiation by controlling a large number of genes involved in hepatic functions including metabolism,xenobiotic detoxification,bile acid synthesis,and serum protein *** has also been confirmed to play an important role in the inflammatory environment in ***,HNF 4αis considered to be a promising target for the treatment of *** studies have demonstrated that regulating HNF 4αexpression in HCC had beneficial effects in in vivo and in vitro *** herein review the role of HNF 4αin regulating hepatic metabolism and the inflammatory response,aiming to provide some ideas on induced hepatic differentiation therapy and regulating the inflammatory microenvironment for the treatment of advanced HCC.

关键词： Hepatocyte nuclear factor 4α(HNF 4α) Metabolism Inflammation Hepatic differentiation Hepatocellular carcinoma(HCC)

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin li Xiaowei zhou Wei Chen Aidong wen Minna liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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斜视手术后屈光状态的变化

国际眼科杂志 2018年第10期18卷 1819-1821页

作者：周文轲张黎重庆医科大学附属第一医院眼科眼科学重庆市重点实验室重庆市眼科研究所中国重庆市400016

斜视是指任何一眼视轴偏离的临床现象,可因双眼单视异常或控制眼球运动的神经肌肉异常或各类机械性限制引起。手术治疗是斜视矫正的重要方法,最初人们的关注点只在眼位,但随着对手术患者逐渐深入地观察及随访,有研究发现斜视手术可能改... 详细信息

斜视是指任何一眼视轴偏离的临床现象,可因双眼单视异常或控制眼球运动的神经肌肉异常或各类机械性限制引起。手术治疗是斜视矫正的重要方法,最初人们的关注点只在眼位,但随着对手术患者逐渐深入地观察及随访,有研究发现斜视手术可能改变眼球原本的屈光状态。本文从斜视手术后受术者屈光状态、眼球参数的改变、其可能的发生机制以及影响因素等作一综述,希望能对斜视手术有更为全面的认识,同时为确定术后验光配镜的理想时间提供依据。

关键词：斜视手术屈光散光

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“营改增”背景下地方税主体税种选择研究

内蒙古社会科学 2018年第2期39卷 125-131页

作者：温立洲李金荣天津财经大学经济学院天津300222 河北经贸大学财政税务学院河北石家庄050061

1994年分税制改革,初步确定中央和地方财政分配关系,地方税体系基本形成,但是不够完善;2016年,随着"营改增"税制改革的完成,地方税体系中的矛盾更加突出,主体税种缺失,地方财力减少,增加了地方政府实现其职能的难度,进而可能会影响地方... 详细信息

1994年分税制改革,初步确定中央和地方财政分配关系,地方税体系基本形成,但是不够完善;2016年,随着"营改增"税制改革的完成,地方税体系中的矛盾更加突出,主体税种缺失,地方财力减少,增加了地方政府实现其职能的难度,进而可能会影响地方经济的发展。因此,完善地方税体系迫在眉睫,对于地方税主体税种的选择更是重中之重。鉴于当前我国的实际情况,提出了应在完善税收法律体系、简化政府层级、合理划分事权和税权的前提下选择主体税种,并提出分级选择地方税主体税种的设置方案。

关键词：地方税主体税种消费税房地产税资源税