Role of Hepatocyte Nuclear Factor 4α in Regulating Hepatic Differentiation and the Inflammatory Response in HCC

作     者：Wen Li Zhou Zhan Wang Ming Yong Miao Yuan Sheng Zang 

作者机构：Department of Medical OncologyChangzheng HospitalNavy Medical UniversityShanghai 200070China Department of Biochemistry and Molecular BiologyNavy Medical UniversityShanghai 200433China 

出 版 物：《Journal of Nutritional Oncology》 (肿瘤营养学杂志（英文）)

年 卷 期：2019年第4卷第3期

页      面：115-120页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81300345) 

主　　题：Hepatocyte nuclear factor 4α(HNF 4α) Metabolism Inflammation Hepatic differentiation Hepatocellular carcinoma(HCC) 

摘      要：Limited treatment options are available for hepatocellular carcinoma(HCC),especially in the advanced stage,which is associated with a poor *** studies have demonstrated that hepatocyte nuclear factor 4α(HNF 4α)plays an important role in hepatic differentiation and the carcinogenesis of *** 4αcritically regulates hepatic differentiation by controlling a large number of genes involved in hepatic functions including metabolism,xenobiotic detoxification,bile acid synthesis,and serum protein *** has also been confirmed to play an important role in the inflammatory environment in ***,HNF 4αis considered to be a promising target for the treatment of *** studies have demonstrated that regulating HNF 4αexpression in HCC had beneficial effects in in vivo and in vitro *** herein review the role of HNF 4αin regulating hepatic metabolism and the inflammatory response,aiming to provide some ideas on induced hepatic differentiation therapy and regulating the inflammatory microenvironment for the treatment of advanced HCC.