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Glutamine supplementation attenuates intestinal apoptosis by inducing heat shock protein 70 in heatstroke rats

世界急诊医学杂志(英文) 2023年第1期14卷 37-43页

作者： li-wen du Bao-qing Xu Kai Xun Fang-qi Zhang Department of Emergency Ningbo No.2 HospitalNingbo 315000China Department of Pathology the 900th Hospital of Joint Logistics Support Force of Chinese PLAFuzhou 350025China Department of Pulmonary and Critical Care Medicine the 987th Hospital of Joint Logistics Support Force of Chinese PLABaoji 721000China

BACKGROUND:Heatstroke is the most hazardous heat-related illness and has a high fatality *** investigated whether glutamine supplementation could have a protective effect on heatstroke ***:Twenty-five 12-week-old male Wistar rats(weight 305±16 g)were randomly divided into a control group(n=5),heatstroke(HS)group(n=10),and heatstroke+glutamine(HSG)group(n=10).Seven days before heat exposure,glutamine(0.4 g/[kg·d])was administered to the rats in the HSG group by gavage every *** hours after heat exposure,serum samples were collected to detect white blood cells,coagulation indicators,blood biochemical indicators,and inflammatory cytokines in the *** small intestine tissue was stained to analyze pathological structural changes and ***,immunohistochemistry and Western blotting were used to analyze the expression levels of heat shock protein 70(HSP70).Multiple comparisons were analyzed by using one-way analysis of variance,and the Bonferroni test was conducted for the post hoc ***:After heat exposure,the core temperature of the HS group(40.65±0.31°C)was higher than the criterion of heatstroke,whereas the core temperature of the HSG group(39.45±0.14°C)was lower than the *** supplementation restored the increased white blood cells,coagulation indicators,blood biochemical indicators,and inflammatory cytokines that were induced by heatstroke to normal *** intestinal mucosa was injured,and the structure of tight junctions was damaged in the HS group;however,the structure of intestinal mucosal epithelial cells was stable in the HSG *** supplementation alleviated intestinal apoptosis and up-regulated HSP70 ***:Glutamine supplementation may alleviate intestinal apoptosis by inducing the expression of HSP70 and have a protective effect on heatstroke rats.

关键词： Heatstroke Glutamine Core temperature Intestinal apoptosis Heat shock protein 70

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Common carotid artery distortion before percutaneous dilatational tracheostomy

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World Journal of Emergency Medicine 2022年第3期13卷 242-244页

作者： li-wen du Kai Xun Lei-lei Zhu Peng liu Emergency Department Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010China Ningbo Institute of life and Health Industry University of Chinese Academy of SciencesNingbo 315010China

Dear editor,The neck is rich in blood *** origins are rarely seen in clinical practice,but some are found accidentally during relevant imaging examinations,autopsy,and *** neck vessels are mostly asymptomatic;however,approximately 10%of patients with abnormal blood vessels may have clinical manifestations due to the compression of adjacent tissues and organs.

关键词： organs clinical surgery

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Gear walk instability caused by brake-disc friction characteristics

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Chinese Journal of Aeronautics 2024年第2期37卷 343-359页

作者： Xiaoqiong du Bin li wen CAI linyin LUO School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering University of MichiganAnn Arbor 48109USA AVIC General Huanan Aircraft Industry Co.Ltd. Zhuhai 519040China

A multi-body dynamic rigid-flexible coupling model of landing gear is established to study the gear walk instability caused by the friction characteristics of the brake *** validating the model with the experimental results,the influence of the landing gear structure and braking system parameters on gear walk is further *** the above factors,the slope of the graph for the friction coefficient of the brake disc and the relative velocity of brake stators and rotors is the most influential factor on gear walk *** trajectory analysis verifies that gear walk occurs when the coupling of multiple factors causes the system to exhibit an equivalent negative damping *** consider a more realistic braking case,a back propagation neural network method is employed to describe the nonlinear behavior of the friction coefficient of the brake *** the realistic nonlinear model of the friction coefficient,the maximum error in predicting the braking torque is less than 10%and the effect of the brake disc temperature on gear walk is *** results reveal that a more negative friction slope may contribute to a more severe unstable gear walk,and reducing the braking pressure is an effective approach to avoid gear walk,which provides help for future braking system design.

关键词： Gear walk Friction characteristics of brake disc Brake-induced vibration Negative damping Rigid-flexible coupling Negative slope of braking torque

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Padéapproximant approach to singular properties of quantum gases:the ideal cases

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Communications in Theoretical Physics 2021年第6期73卷 131-139页

作者： Yuan-Hong Tian wen-du li Yao Shen Wu-Sheng Dai Department of Physics Tianjin UniversityTianjin 300350China College of Physics and Materials Science Tianjin Normal UniversityTianjin 300387China School of Criminal Investigation and Forensic Science People's Public Security University of ChinaBeijing 100038China

In this paper,we show how to recover the low-temperature and high-density information of ideal quantum gases from the high-temperature and low-density approximation by the Padé*** virial expansion is a high-temperature and low-density expansion and in practice,often,only the first several virial coefficients can be *** Bose gases,we determine the BEC phase transition from a truncated virial *** Fermi gases,we recover the low-temperature and high-density result from the virial expansion.

关键词： approximate analytic continuation virial expansion Padéapproximant quantum gas

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Vancomycin dosing in an obese patient with acute renal failure:A case report and review of literature

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World Journal of Clinical Cases 2022年第18期10卷 6218-6226页

作者： Kun-Yan Xu Dan li Zhen-Jie Hu Cong-Cong Zhao Jing Bai wen-li du Department of Pharmacy Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Intensive Care Unit Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Vancomycin is the most commonly used drug for methicillin-resistant Staphylococcus *** empirical clinical doses of vancomycin based on non-obese patients may not be optimal for obese *** SUMMARY This study reports a case of vancomycin dosing adjustment in an obese patient(body mass index 78.4 kg/m2)with necrotizing fasciitis of the scrotum and left lower extremity accompanied with acute renal *** adjustment was performed based on literature review and factors that influence pharmacokinetic parameters are *** results of the blood drug concentration monitoring confirmed the successful application of our dosing adjustment strategy in this obese *** body weight is an important consideration for vancomycin administration in obese patients,which affects the volume of distribution and clearance of *** alterations of pharmacokinetic parameters dictate that vancomycin should be dose-adjusted when applied to obese *** the same time,the pathophysiological status of patients,such as renal function,which also affects the dose adjustment of the patient,should be *** Monitoring vancomycin blood levels in obese patients is critical to help adjust the dosing regimen to ensure that vancomycin concentrations are within the effective therapeutic range and to reduce the incidence of renal injury.

关键词： Vancomycin Obesity Acute renal failure Pharmacokinetics Case report

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Tuning heterogeneous microstructures to enhance mechanical properties of nano-TiN particle reinforced Haynes 230 composites by laser powder bed fusion

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Rare Metals 2024年第9期43卷 4548-4565页

作者： wen-Jie liu Hui li Qian-Xing Yin He-Jun du School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

Laser powder bed fusion(LPBF)is considered to be one of the most promising additive manufacturing technologies for producing components with geometries and high geometrical precision that are unattainable by traditional *** superalloy exhibits exceptional mechanical and high-temperature performances,rendering it a prime candidate for advanced aero-engine *** the high demand for LPBF-manufactured superalloys,the superalloy is one of the materials manufactured difficultly by LPBF due to their large laser absorptivity fluctuation,poor molten pool stability and sharp temperature ***,superalloys are characterized by severe pores,undesirable coarse columnar grains and poor mechanical *** this work,the effect of nano-TiN particles on defects,molten pool characteristics and microstructure and performance of the composites were *** 4.5 wt%TiN/Haynes230 samples exhibited exceptional nanohardness and elastic modulus with maximum values reaching 5.53 GPa and 240.03 GPa,*** superior mechanical properties were attributed to the combined effects of spatter and gas pore inhibition,grain refinement and duplex nanophases ***,the stability of molten pool was enhanced,and spatter was effectively suppressed by adding nano-TiN particles,while grain refinement and columnar to equiaxed transitions were ***,the matrix exhibited a high dislocation density due to a significant hindrance of dislocation movement caused by massive nano-phases(e.g.,TiN and M_(23)C_(6)),resulting in the formation of extensive dislocation tangles and *** work offers novel insights into the role of nanoparticles reinforced superalloy composites by LPBF.

关键词： Composites Laser powder bed fusion Molten pool characteristics Microstructure Mechanical properties

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Multi-Material Topology Optimization of 2D Structures Using Convolutional Neural Networks

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1919-1947页

作者： Jiaxiang Luo Weien Zhou Bingxiao du Daokui li wen Yao College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China Defense Innovation Institute Chinese Academy of Military ScienceBeijing100071China Intelligent Game and Decision Laboratory Chinese Academy of Military ScienceBeijing100071China

In recent years,there has been significant research on the application of deep learning(DL)in topology optimization(TO)to accelerate structural ***,these methods have primarily focused on solving binary TO problems,and effective solutions for multi-material topology optimization(MMTO)which requires a lot of computing resources are still ***,this paper proposes the framework of multiphase topology optimization using deep learning to accelerate MMTO *** framework employs convolutional neural network(CNN)to construct a surrogate model for solving MMTO,and the obtained surrogate model can rapidly generate multi-material structure topologies in negligible time without any *** performance evaluation results show that the proposed method not only outputs multi-material topologies with clear material boundary but also reduces the calculation cost with high prediction ***,in order to find a more reasonable modeling method for MMTO,this paper studies the characteristics of surrogate modeling as regression task and classification *** the training of 297 models,our findings show that the regression task yields slightly better results than the classification task in most ***,The results indicate that the prediction accuracy is primarily influenced by factors such as the TO problem,material category,and data ***,factors such as the domain size and the material property have minimal impact on the accuracy.

关键词： Multi-material topology optimization convolutional neural networks deep learning finite element analysis

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A strained π-extended[10]cycloparaphenylene carbon nanoring

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Chinese Chemical Letters 2024年第5期35卷 171-174页

作者： Kang Wei Jiayu li wen Zhang Bing Yuan Ming-De li Pingwu du Key Laboratory of Precision and Intelligent Chemistry Anhui Laboratory of Advanced Photon Science and TechnologyDepartment of Materials Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063China

Herein,we report the facile synthesis of a highly strained hexabenzocoronene-containing carbon nanoring,cyclo[4]-paraphenylene[2]-2,11-hexabenzocoronenylene([4,2]CPHBC),as the segment of a[10,10]single-walled carbon nanotube([10,10]SWNT).[4,2]CPHBC was synthesized based on the platinummediated assembly of diborylbiphenyl and diborylhexabenzocoronene,forming a tetranuclear platinum complex,followed by reductive *** nanoring molecule was confirmed by NMR and HRMS,and its photophysical properties were studied using steady-state and time-resolved ***,the selective supramolecular host-guest interaction between[4,2]CPHBC and C_(60) was also investigated.

关键词： CPP Hexabenzocoronene Fullerene Supramolecular chemistry

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Optimization design of the hydro-pneumatic suspension system for high clearance self-propelled sprayer using improved MOPSO algorithm

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 109-122页

作者： Fan Yang Yuefeng du Changkai wen Zhen li Enrong Mao Zhongxiang Zhu College of Engineering China Agricultural UniversityBeijing 100083China Beijing Key Laboratory of Optimized Design for Modern Agricultural Equipment China Agricultural UniversityBeijing 100083China

Large high clearance self-propelled sprayers were widely used in field plant protection due to their high-efficiency operation *** by the characteristics of field operations such as high power,heavy weight,high ground clearance,and fast operation speed,the comprehensive requirements for the ride comfort,handling stability and road friendliness of the sprayer were increasingly *** the present stage,the chassis structure of the high clearance selfpropelled sprayer that attaches great importance to the improvement of comprehensive performance still has the problems of severe bumps,weak handling performance and serious road damage in complex field ***,this paper proposes an optimization design method for hydro-pneumatic suspension system of a high clearance self-propelled sprayer based on the improved MOPSO(Multi-Objective Particle Swarm Optimization)algorithm,covering the entire process of configuration design,parameter intelligent optimization,and system verification of the high clearance self-propelled sprayer ***,chassis structure of the hydro-pneumatic suspension suitable for the high clearance self-propelled sprayer was designed,and a design method combining the improved MOPSO algorithm based on time-varying fusion strategy and adaptive update with the parameter optimization of hydro-pneumatic suspension based on this algorithm was proposed,and finally the software simulation and bench performance verification were carried *** results show that the optimized hydropneumatic suspension has excellent vibration reduction effect,and the body acceleration,suspension dynamic deflection and tire deflection were increased by 16.5%,9.9%and 0.9%respectively,compared with those before *** comprehensive performance of the hydro-pneumatic suspension designed in this study is better than that of the traditional suspension.

关键词： high clearance self-propelled sprayer vibration reduction hydro-pneumatic suspension MOPSO multi-objective optimization

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Sequential Propagation of Chaos for Mean-Field BSDE Systems

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 11-40页

作者： Xiaochen li Kai du Shanghai Center for Mathematical Sciences Fudan UniversityShanghai 200433China. Shanghai Artificial Intelligence Laboratory 701 Yunjin RoadShanghai 200433China

A new class of backward particle systems with sequential interaction is proposed to approximate the mean-field backward stochastic differential *** is proven that the weighted empirical measure of this particle system converges to the law of the McKean-Vlasov system as the number of particles *** on the Wasserstein met-ric,quantitative propagation of chaos results are obtained for both linear and quadratic growth ***,numerical experiments are conducted to validate our theoretical results.

关键词： Backward propagation of chaos Particle system Sequential interaction McKean-Vlasov BSDE Convergence rate

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