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Upregulation of hypoxia inducible factor 1α mRNA is associated with elevated vascular endothelial growth factor expression and excessive angiogenesis and predicts a poor prognosis in gastric carcinoma

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World Journal of Gastroenterology 2007年第11期13卷 1680-1686页

作者： Jie Ma Li Zhang Guo-Qing Ru Zhong-Sheng Zhao wen-juan xu Department of Pathology Wenzhou Medical College Wenzhou 325000 Zhejiang Province China Department of Pathology Zhejiang Provincial Hospital Hangzhou 310014 Zhejiang Province China Shaoxing University Medical College Shaoxing 312000 Zhejiang Province China

AIM： To investigate the implication of the hypoxia inducible factor HIF-1α mRNA in gastric carcinoma and its relation to the expression of vascular endothelial growth factor （VEGF） protein, tumor angiogenesis invasion/metastasis and the patient＇s survival. METHODS： In situ hybridization was used to examine expression of HIF-1α mRNA, and immunohistochemical staining was used to examine expression of VEGF protein and CD34 in 118 specimens from patients with gastric carcinoma. RESULTS： The positive rates of HIF-1α mRNA and VEGF protein were 49.15% and 55.92%, respectively. Positive expressions of HIF-1α and VEGF in stage T3-T4 tumors and those with vessel invasion, lymph node metastasis and distant metastasis were dramatically stronger than stage T1-T2 cases and those without vessel invasion, lymph node metastasis and distant metastasis. The mean microvascular density （MVD） in stage T3-T4 tumors and those with vessel invasion, lymph node metastasis and distant metastasis was significantly higher than stage T1-T2 tumors and those without vessel invasion, lymph node metastasis and distant metastasis. The mean MVD in tumors with positive HIF-1α and VEGF expression was significantly higher than that in tumors with negative HIF-1α and VEGF expression. The expression of HIF- 1α was positively correlated with VEGF protein. There were positive correlations between MVD and expression of HIF-1α and VEGF. The mean survival time and the S-year survival rate in cases with positive expression HIF-1α and VEGF and MVD value ≥ 41.5/0.72 mm^2 were significantly lower than those with negative expression of HIF-1α and VEGF and MVD value 〈 41.5/0.72 mm^2. CONCLUSION： Overexpression of HIF-1α is found in gastric carcinoma. HIF-1α may induce the angiogenesis in gastric carcinoma by upregulating the transcription of VEGF gene, and take part in tumor invasion and metastasis. They can be used as prognostic markers of gastric cancer in clinical practice.

关键词： Gastric carcinoma HIF-1α Vascularendothelial growth factor Microvascular density Prognosis

Effect of salvianolate on intestinal epithelium tight junction protein zonula occludens protein 1 in cirrhotic rats

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World Journal of Gastroenterology 2012年第47期18卷 7040-7047页

作者： Dan-Hong Yang Zai-Yuan Ye Yuan-Jun Xie xu-Jun He wen-juan xu Wei-Ming Zhou Department of Infection Zhejiang Provincial People's Hospital Department of Surgery Zhejiang Provincial People's Hospital the Third School of Clinical Medicine Zhejiang Traditional University Key Laboratory of Gastroenterology and Pathology Zhejiang Provincial People's Hospital Department of Animal Care Zhejiang Traditional University

AIM:To study the effect of salvianolate on tight junctions(TJs) and zonula occludens protein 1(ZO-1) in small intestinal mucosa of cirrhotic ***:Cirrhosis was induced using carbon *** were randomly divided into the untreated group,low-dose salvianolate(12 mg/kg) treatment group,medium-dose salvianolate(24 mg/kg) treatment group,and high-dose salvianolate(48 mg/kg) treatment group,and were treated for 2 *** 10 healthy rats served as the normal control *** changes in liver tissue samples were observed under a light *** evaluated morphologic indices of ileal mucosa including intestinal villi width and thickness of mucosa and intestinal wall using a pathological image analysis *** changes in small intestinal mucosa were investigated in the five groups using transmission electron *** changes in ZO-1 expression,a tight junction protein,were analyzed by *** staining index was calculated as the product of the staining intensity score and the proportion of positive ***:In the untreated group,hepatocytes showed a disordered arrangement,fatty degeneration was extensive,swelling was obvious,and disorganized lobules were divided by collagen fibers in hepatic tissue,which were partly improved in the salvianolate treated *** the untreated group,abundant lymphocytes infiltrated the fibrous tissue with proliferation of bile ducts,and collagen fibers gradually decreased and damaged hepatic lobules were partly repaired following salvianolate *** with the untreated group,no differences in intestinal villi width between the five groups were *** villi height as well as mucosa and intestinal wall thickness gradually thickened with salvianolate treatment and were significantly shorter in the untreated group compared with those in the salvianolate treatment groups and normal group(P < 0.01).The number of microvilli decreased and showed irregular l

关键词： Salvianolate Cirrhosis Gut barrier Tight junction Zonula occludens protein 1

Salvianolate inhibits cytokine gene expression in small intestine of cirrhotic rats

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World Journal of Gastroenterology 2011年第14期17卷 1903-1909页

作者： Dan-Hong Yang Zai-Yuan Ye Bo Jin xu-Jun He wen-juan xu Huo-Xiang Lu Qin Zhang Wei-Ming Zhou Department of Infection Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China Department of Surgery Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China Department of Molecular Biology Zhejiang Traditional University Hangzhou 310053 Zhejiang Province China Key Laboratory of Gastroenterology and Pathology Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China Department of Gastroenterology Zhejiang Hospital of Traditional Chinese Medicine Hangzhou 310006 Zhejiang Province China Department of Animal Care Zhejiang Provincial People's Hospital Hangzhou 310014 Zhejiang Province China

AIM:To study the effect of salvianolate on expression of tumor necrosis factor (TNF)-α and interleukin (IL)-6 mRNA in small intestine of cirrhotic rats. METHODS:Cirrhosis in rats was induced using CCl4 (0.3 mL/kg). Rats were randomly divided into non-treatment group,low-dose salvianolate (12 mg/kg) treatment group,medium-dose salvianolate (24 mg/kg) treatment group,and high-dose salvianolate (48 mg/kg) treatment group,and treated for 2 wk. Another 10 healthy rats served as a normal control group. Mortality of cirrhotic rats in each group was evaluated after treatment with salvianolate. Serum samples were taken from portal vein for the detection of endotoxin. Morphological changes in tissue samples from the ileocecum were observed under a light microscope. Expression of TNF-α and IL-6 mRNA in the small intestine of rats was analyzed by real-time reverse-transcriptase polymerase chain reaction. RESULTS:The mortality of cirrhotic rats in the nontreatment group was 37.5%. No cirrhotic rat died in the high-dose salvianolate treatment group. The serum endotoxin level was significantly higher in the non-treatment group than in the salvianolate treatment and normal control groups. The intestinal mucosal and villous atrophy,necrosis and shedding of the intestinal mucosal epithelium,observed in the non-treatment group,were reversed in different salvianolate treatment groups. The TNF-α and IL-6 mRNA expression levels in small intestine were significantly lower in different salvianolate treatment groups than in the non-treatment group. CONCLUSION:Salvianolate can reduce the endotoxin level,ameliorate the injury of intestinal mucosa,and inhibit the expression of TNF-α and IL-6 mRNA in small intestine of cirrhotic rats.

关键词： Salvianolate Cirrhosis Endotoxin Intestinal mucosa Tumor necrosis factor-α Interleukin-6

Unconditionally stable Crank-Nicolson algorithm with enhanced absorption for rotationally symmetric multi-scale problems in anisotropic magnetized plasma

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Journal of Systems Engineering and Electronics 2024年第1期35卷 65-73页

作者： wen Yi WANG Junxiang xu Hongbing School of Automatic Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Beijing Institute of Aerospace Systems Engineering Beijing 100076China

Large calculation error can be formed by directly employing the conventional Yee’s grid to curve *** order to alleviate such condition,unconditionally stable CrankNicolson Douglas-Gunn(CNDG)algorithm with is proposed for rotationally symmetric multi-scale problems in anisotropic magnetized *** the CNDG algorithm,an alternative scheme for the simulation of anisotropic plasma is proposed in body-of-revolution *** perfectly matched layer(CPML)formulation is proposed to efficiently solve the open region *** example is carried out for the illustration of effectiveness including the efficiency,resources,and *** the results,it can be concluded that the proposed scheme shows considerable performance during the simulation.

关键词： anisotropic magnetized plasma body-of-revolution(BOR) Crank-Nicolson Douglas-Gunn(CNDG) finite-difference time-domain(FDTD) perfectly matched layer(PML) rotationally symmetric multi-scale problems

CdS/LaFeO_(3) heterojunctions with improved optical properties for visible-light catalytic applications

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Journal of Rare Earths 2024年第5期42卷 879-888,I0003页

作者： Jiaqi Wei wen Zhu xuelian xu Xiao xu Junjiang Zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile University ChemistryWuhan430200China

Construction of heterojunctions is a normal and effective strategy to improve the photocatalytic performances of semiconductors,through which both the lifetime and the redox ability of electrons/holes can be improved,as co mpared to the respective *** this basis,we constructed Z-scheme CdS/LaFeO_(3) heterojunctions(CdS/LFO),by in-situ growing different amounts of CdS on the surface of LaFeO_(3),for photocatalytic degradation of tetracycline hydrochloride(TC)in aqueous solution at room *** crystal structure,surface morphology and optoelectronic properties of the COS/LFO heterojunctions were systemically characterized to correlate the reaction *** tests indicate that the CdS/LFO heterojunctions exhibit promising activity for TC degradation under visible light irradiation(λ≥420 nm),with 85%TC conversion obtained at reaction time of 45 min,which is 3.4 and 1.9 times higher than that of CdS and LaFeO_(3).The CdS/LFO heterojunctions are also stable in the reaction and can be reused for four cycles with no appreciable activity *** applicability of CdS/LFO to photocatalytic degradation of organic dyes,as well as the reaction mechanism,was also explored.

关键词： LaFeO_(3) CdS Photocatalytic degradation Tetracycline hydrochloride Reaction mechanism Rare earths

ZnO Additive Boosts Charging Speed and Cycling Stability of Electrolytic Zn–Mn Batteries

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Nano-Micro Letters 2024年第4期16卷 293-304页

作者： Jin Wu Yang Tang Haohang xu Guandie Ma Jinhong Jiang Changpeng Xian Maowen xu Shu‑juan Bao Hao Chen Institute for Clean Energy&Advanced Materials School of Materials and EnergySouthwest UniversityChongqing 400715People’s Republic of China

Electrolytic aqueous zinc-manganese(Zn–Mn) batteries have the advantage of high discharge voltage and high capacity due to two-electron reactions. However, the pitfall of electrolytic Zn–Mn batteries is the sluggish deposition reaction kinetics of manganese oxide during the charge process and short cycle life. We show that, incorporating ZnO electrolyte additive can form a neutral and highly viscous gel-like electrolyte and render a new form of electrolytic Zn–Mn batteries with significantly improved charging capabilities. Specifically, the ZnO gel-like electrolyte activates the zinc sulfate hydroxide hydrate assisted Mn^(2+) deposition reaction and induces phase and structure change of the deposited manganese oxide(Zn_(2)Mn_(3)O_8·H_(2)O nanorods array), resulting in a significant enhancement of the charge capability and discharge efficiency. The charge capacity increases to 2.5 mAh cm^(-2) after 1 h constant-voltage charging at 2.0 V vs. Zn/Zn^(2+), and the capacity can retain for up to 2000 cycles with negligible attenuation. This research lays the foundation for the advancement of electrolytic Zn–Mn batteries with enhanced charging capability.

关键词： Electrolytic aqueous zinc-manganese batteries Electrolyte pH value ZnO electrolyte additive Fast constant-voltage charging ability

Nonlinear Extrapolation Estimates of π

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 91-108页

作者： wen-qing xu Sha-sha Wang Da-chuan xu Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing100124China Department of Mathematics and Statistics California State UniversityLong BeachCalifornia90840USA Department of Mathematics and Physics Shijiazhuang Tiedao UniversityShijiazhuang050043China

The classical Archimedean approximation of π uses the semiperimeter or area of regular polygons inscribed in or circumscribed about a unit circle in R~2 and it is well-known that by using linear combinations of these basic estimates,modern extrapolation techniques can greatly speed up the approximation ***,when n vertices are randomly selected on the circle,the semiperimeter and area of the corresponding random inscribed and circumscribing polygons are known to converge to π almost surely as n→∞,and by further applying extrapolation processes,faster convergence rates can also be achieved through similar linear combinations of the semiperimeter and area of these random *** this paper,we further develop nonlinear extrapolation methods for approximating π through certain nonlinear functions of the semiperimeter and area of such *** focus on two types of extrapolation estimates of the forms χ_n=S_n~αA_n~β and Y_n(p)=(αS_n~p+βA_n~p)~(1/p) where α+β=1,p≠0,and Sn and An respectively represents the semiperimeter and area of a random n-gon inscribed in the unit circle in R~2,and Xn may be viewed as the limit of Y_n(p) when p→*** deriving probabilistic asymptotic expansions with carefully controlled error estimates for Xn and Y_n(p),we show that the choice α=4/3,β=-1/3 minimizes the approximation error in both cases,and their distributions are also asymptotically normal.

关键词： Archimedean polygons random polygons approximations ofπ extrapolation processes asymptotic convergence

Aerodynamic characteristics of a pitching airfoil with leading-edge morphing

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Chinese Journal of Aeronautics 2024年第7期37卷 81-92页

作者： Chaoyuan wen Yuting DAI Yuntao xu Chao YANG School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Tianmushan Laboratory Hangzhou 311115China

This paper focuses on the effect of the phase offset of Leading-Edge(LE)morphing on the aerodynamic characteristics of a pitching NACA0012 *** an unstretched camber and using polynomial interpolation,an explicit expression for LE nonlinear morphing is proposed and implemented for the large pitching motion of the *** field results and aerodynamic forces are obtained by solving the unsteady Reynolds-averaged Navier-Stokes equations for both the airfoil’s pitching motion and LE ***,the index of instantaneous aerodynamic power is used to quantify the work done by the airflow in a dynamic *** to the instantaneous aerodynamic power and energy map,which denotes the energy transfer between the airfoil’s oscillation and flow field,the airfoil is subject to stall *** results show that LE morphing with an optimal phase offset of 315°reduces the energy extraction from the flow field,suppressing the stall flutter *** optimal phase offset is effective at different pitching axis positions of the *** results signify that LE morphing can suppress stall flutter by advancing the occurrence of the first LE vortex and increasing the nose-down moment during the upstroke period.

关键词： Aerodynamics Computational fluid dynamics Leading-edge morphing OpenFOAM Dynamic stall Dynamic mesh

Distributed dynamic task allocation for unmanned aerial vehicle swarm systems:A networked evolutionary game-theoretic approach

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Chinese Journal of Aeronautics 2024年第6期37卷 182-204页

作者： Zhe ZHANG Ju JIANG Haiyan xu wen-An ZHANG College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China

Task allocation is a key aspect of Unmanned Aerial Vehicle(UAV)swarm collaborative *** an continuous increase of UAVs’scale and the complexity and uncertainty of tasks,existing methods have poor performance in computing efficiency,robustness,and realtime allocation,and there is a lack of theoretical analysis on the convergence and optimality of the *** paper presents a novel intelligent framework for distributed decision-making based on the evolutionary game theory to address task allocation for a UAV swarm system in uncertain scenarios.A task allocation model is designed with the local utility of an individual and the global utility of the ***,the paper analytically derives a potential function in the networked evolutionary potential game and proves that the optimal solution of the task allocation problem is a pure strategy Nash equilibrium of a finite strategy ***,a PayOff-based Time-Variant Log-linear Learning Algorithm(POTVLLA)is proposed,which includes a novel learning strategy based on payoffs for an individual and a time-dependent Boltzmann *** former aims to reduce the system’s computational burden and enhance the individual’s effectiveness,while the latter can ensure that the POTVLLA converges to the optimal Nash equilibrium with a probability of *** simulation results show that the approach is optimal,robust,scalable,and fast adaptable to environmental changes,even in some realistic situations where some UAVs or tasks are likely to be lost and increased,further validating the effectiveness and superiority of the proposed framework and algorithm.

关键词： Task allocation Unmanned Aerial Vehicles(UAV) Game theory Log-linear learning Distributed optimization algorithm