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Association of XPG rs2094258 polymorphism with gastric cancer prognosis

World Journal of Gastroenterology 2019年第34期25卷 5152-5161页

作者： Xiao-Qin Wang Paul D Terry Yang Li Yue Zhang wen-jing kou Ming-Xu Wang Department of Public Health Xi’an Jiaotong University Health Science CenterXi’an 710061Shaanxi ProvinceChina Graduate School of Medicine University of Tennessee Medical CenterKnoxvilleTN 37920United States

BACKGROUND The xeroderma pigmentosum group G(XPG)gene at chromosome 13q33 consists of 15 exons,which may be related to the occurrence and development of gastric cancer(GC).AIM To examine the association of several common single nucleotide polymorphisms(SNPs)of the XPG gene with GC risk and *** Five SNPs of XPG(rs2094258,rs751402,rs873601,rs2296147,and rs1047768)were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North *** patients were followed for survival status and,if deceased,cause of *** regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis,*** rs2094258,heterozygous model(CT vs CC),homozygous model(TT vs CC),recessive model(TT vs CT+CC),and dominant model(TT+CT vs CC)were *** None of the examined loci were statistically associated with GC risk,although rs2296147 was marginally associated with GC risk(P=0.050).GC patients with the rs2094258 CT+CC genotype showed worse survival than those with the TT genotype(log-rank test,P=0.028),and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT+CT genotype(log-rank test,P=0.039).The increase in C alleles of rs2094258[hazard ratio(HR)=1.19,95%confidence interval(CI):1.02-1.45,P=0.037]were associated with the long-term survival of GC *** risk factors for survival included tumor differentiation(HR=4.51,95%CI:1.99-8.23,P<0.001),lymphovascular invasion(HR=1.97,95%CI:1.44-3.01,P<0.001),and use of chemotherapy(HR=0.81,95%CI:0.63-0.98,P=0.041).CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients.

关键词： Xeroderma pigmentosum group G Single nucleotide polymorphisms rs2094258 Gastric cancer Prognosis

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Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 289-300页

作者： Xiao-Qin Wang Yang Li Paul D Terry wen-jing kou Yue Zhang Zhao-Zhao Hui Xiao-Han Ren Ming-Xu Wang Department of Public Health Xi’an Jiaotong University Health Science CenterXi’an 710061Shaanxi ProvinceChina Graduate School of Medicine University of Tennessee Medical CenterKnoxvilleTN 37920United States The Nethersole School of Nursing The Chinese University of Hong KongHong KongChina

BACKGROUND The single nucleotide polymorphisms of interleukin-21(IL-21)gene were confirmed to be related to various diseases,but no studies have examined the possible role of IL-21 single nucleotide polymorphisms(SNPs)(rs907715,rs2221903,and rs12508721)in gastric precancerous *** To explore the associations between SNPs of IL-21 gene(rs907715,rs2221903,and rs12508721)and gastric precancerous lesions in a Chinese *** Three SNPs of IL-21 were genotyped using polymerase chain reaction–ligase detection reaction in 588 cases and 290 healthy controls from May 2013 to December 2016 in northwestern *** precancerous lesions were confirmed by endoscopic examination and categorized as non-atrophic gastritis,atrophic gastritis,and intestinal *** statistic and logistic regression were used for data *** IL-21 rs907715 genotype CC and C frequencies were higher in in patients with gastric precancerous lesions than in the controls(OR=1.59,95%CI:1.06-2.38,P=0.013;OR=1.28,95%CI:1.01-2.22,P=0.044,respectively)after adjusting for confounding *** SNP rs907715 in intestinal metaplasia patients,significant differences between cases and controls were observed in the frequencies of genotype CC and C(OR=1.92,95%CI:1.24-2.98,P=0.004;OR=1.53,95%CI:1.04-2.24,P=0.028,respectively);for non-atrophic gastritis and atrophic gastritis patients,the CC and C genotypes showed no significant association with risk in all *** association between either rs2221903 or rs12508721 and gastric precancerous lesions was found in the present *** the haplotype analysis,the TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)were more frequent in the case group than control group(P<0.05).CONCLUSION Our findings indicate that SNP rs907715 of IL-21 gene is associated with gastric precancerous *** TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)increased the risk of gastric pre

关键词： Interleukin-21 gene Single nucleotide polymorphisms rs907715 Gastric precancerous lesions Intestinal metaplasia

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影响结肠镜检查中盲肠插管时间的相关因素

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世界华人消化杂志 2023年第3期31卷 105-112页

作者：王珂许文涛寇文静祁兴顺北部战区总医院消化内科辽宁省沈阳市110840 中国医科大学研究生院辽宁省沈阳市110122 沈阳药科大学研究生院辽宁省沈阳市110016

近年来,我国结直肠癌(colorectal cancer,CRC)发病率和死亡率明显上升,已成为威胁居民健康的主要癌症之一.结肠镜作为诊断CRC的金标准,高质量的结肠镜检查可以有效降低结直肠癌的死亡率.盲肠插管时间(cecal intubation time,CIT)是反映... 详细信息

近年来,我国结直肠癌(colorectal cancer,CRC)发病率和死亡率明显上升,已成为威胁居民健康的主要癌症之一.结肠镜作为诊断CRC的金标准,高质量的结肠镜检查可以有效降低结直肠癌的死亡率.盲肠插管时间(cecal intubation time,CIT)是反映结肠镜检查质量的指标之一,研究已发现多种因素均可影响CIT.本文通过回顾文献介绍了医生、患者、辅助技术、设备等方面可能影响CIT的相关因素,以期提高内镜医师完成结肠镜检查的质量.

关键词：盲肠插管时间结肠镜检查综述

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui kou Zongxue Jin Yusong Yuan Bo Ma wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie Yuan Dongxing kou Zhengji Zhou wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： Cell engineering

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Collapses-revivals phenomena induced by weak magnetic flux in diamond chain

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Chinese Physics B 2020年第1期29卷 148-155页

作者： Na-Na Chang wen-Quan jing Yu Zhang Ai-Xia Zhang Ju-Kui Xue Su-Peng kou Department of Physics Beijing Normal UniversityBeijing 100875China College of Physics and Electronics Engineering Northwest Normal UniversityLanzhou 730070China

We investigate the quantum dynamical behaviors of bosons in a diamond chain with weak magnetic flux(WMF),including Landau–Zener tunnelling,Bloch oscillations,localization phenomenon,and collapses-revivals *** observed that collapses-revivals phenomena can occur in diamond chain with WMF and cannot exist in the strong magnetic flux case as the previous study(Chang N N and Xue J K,2018,***.B 27105203).Induced by WMF,the energy band for the system varies from gapless to gapped *** position of the extrema of probability amplitude for ground state can also be altered by WMF within a single diamond *** a consequence,the transitions between different dynamical behaviors of bosons in diamond chain can be manipulated by WMF,depending on its initial configurations.

关键词： collapses-revivals phenomena Bloch oscillations Landau–Zener tunneling localization phenomenon flat band

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Targeted therapeutic effects of oral magnetically driven pectin nanoparticles containing chlorogenic acid on colon cancer

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Particuology 2024年第1期84卷 53-59页

作者： Huatai Zhu Limei Zhang Fujia kou jingyang Zhao Jiandu Lei jing He Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent ***,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon ***,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the *** order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification *** average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic *** vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer ***,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.

关键词： Pectin Chlorogenic acid Ultrasound-emulsion Magnetically driven Colon cancer Colon targeted

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Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy

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Journal of Rare Earths 2024年第10期42卷 1895-1902页

作者： Kaige Yu Nuo kou Shouqiang Zhang Tianqi Cao Hanqing Wu jing Zhou Department of Chemistry Capital Normal UniversityBejing100048China College of Teacher Education Capital Normal University Beijing100048China

The tumor microenvironment(TME)differs from normal tissue cells in its physiological and biochemical *** construction of TME-responsive nanoplatforms requires a tedious preparation process and complex multicomponent *** this work,Er@EGCG-Cu,a TME-responsive nanoplatform,was simply and rapidly synthesized by combining rare earth-doped nanomaterials(NaLuF_(4):Yb,Er)with EGCG-Cu which is based on the ability of metal ions to coordinate with polyphenols to form a metal-phenolic network(MPN)*** MPN structure is then destroyed under an acidic TME,releasing the chemotherapy(CT)drug EGCG,which can cause apoptosis,Cu_(x)S_(y)is generated by combining Cu^(2+)with H_2S overexpressed in human colorectal cancer cells and can be used for photothermal therapy(PTT).Cell experiments show that laser irradiation improves the CT/PTT synergistic effect of Er@*** study has significance for the construction of TME-responsive nanomedicines with simple and rapid preparation for synergistic therapy.

关键词： Tumor microenvironment Metal-polyphenol networks Synergistic therapy Rare earths Nanomaterials

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Two-dimensional functional materials:from properties to potential applications

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International Journal of Smart and Nano Materials 2020年第3期11卷 247-264页

作者： Yining Wei Xiao Tang jing Shang Lin Ju Liangzhi kou School of Mechanical Medical and Process EngineeringQueensland University of TechnologyBrisbaneAustralia School of Mechanical Medical and Process EngineeringQueensland University of TechnologyBrisbaneQLD 4001Australia

Two-dimensional(2D)materials have been extensively investigated since the exfoliation of *** to the excellent and versatile properties,the promising applications in novel nanodevices have been proposed in the last few ***,we chose three stable 2D materi-als which have been experimentally synthesized and have potential to be used for next-generation nanodevices,namely semiconducting MoS2,Janus MoSSe,and magnetic CrI_(3),to review their electronic/magnetic properties,and reveal the relationship of the propertiesapplications in *** showcase review on property-application is expected to provide new research insights into the investigations of 2D materials.

关键词： Two-dimensional functional materials

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Polymer Supported Synthesis of Multi-substituted Pyrimidine-4-one Derivatives via Pbf-activated Thiourea

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Chemical Research in Chinese Universities 2011年第2期27卷 221-223页

作者： LI Jl-zhen kou jing-ping MI Yu-hua College of Chemistry Jilin University Changchun 130021 P. R. China

Efficient polymer supported synthesis of multi-substituted pyrimidine-4-one derivatives was described. Target products were produced from fluorenylmethoxycarbonyl（Fmoc） protected β-amino acid loaded on hydro- xymethyl resin through deprotection, N-alkylation, guanidine formation, and cleavage of 2,2,4,6,7-pentamethyl dihy-drobenzofuran-sulfonyl（Pbf） by trifluoracetic acid（TFA） followed with cyclization. The procedure has the advantages of easy operation, mild reaction conditions, and forming multiple substituents.

关键词： Guanidine Polymer supported synthesis Pyrimidine Amino acid Thiourea

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