Association of XPG rs2094258 polymorphism with gastric cancer prognosis

作     者：Xiao-Qin Wang Paul D Terry Yang Li Yue Zhang Wen-Jing Kou Ming-Xu Wang 

作者机构：Department of Public HealthXi’an Jiaotong University Health Science CenterXi’an 710061Shaanxi ProvinceChina Graduate School of MedicineUniversity of Tennessee Medical CenterKnoxvilleTN 37920United States 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第34期

页      面：5152-5161页

核心收录：

学科分类：10[医学] 

基　　金：Supported by the Fundamental Research Funds for the Central Universities No.zdyf2017007 

主　　题：Xeroderma pigmentosum group G Single nucleotide polymorphisms rs2094258 Gastric cancer Prognosis 

摘      要：BACKGROUND The xeroderma pigmentosum group G(XPG)gene at chromosome 13q33 consists of 15 exons,which may be related to the occurrence and development of gastric cancer(GC).AIM To examine the association of several common single nucleotide polymorphisms(SNPs)of the XPG gene with GC risk and *** Five SNPs of XPG(rs2094258,rs751402,rs873601,rs2296147,and rs1047768)were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North *** patients were followed for survival status and,if deceased,cause of *** regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis,*** rs2094258,heterozygous model(CT vs CC),homozygous model(TT vs CC),recessive model(TT vs CT+CC),and dominant model(TT+CT vs CC)were *** None of the examined loci were statistically associated with GC risk,although rs2296147 was marginally associated with GC risk(P=0.050).GC patients with the rs2094258 CT+CC genotype showed worse survival than those with the TT genotype(log-rank test,P=0.028),and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT+CT genotype(log-rank test,P=0.039).The increase in C alleles of rs2094258[hazard ratio(HR)=1.19,95%confidence interval(CI):1.02-1.45,P=0.037]were associated with the long-term survival of GC *** risk factors for survival included tumor differentiation(HR=4.51,95%CI:1.99-8.23,P0.001),lymphovascular invasion(HR=1.97,95%CI:1.44-3.01,P0.001),and use of chemotherapy(HR=0.81,95%CI:0.63-0.98,P=0.041).CONCLUSION The XPG rs2094258 polymorphism may be associated with overall survival in GC patients.