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De Novo Dissecting the Three‑Dimensional Facial Morphology of 2379 Han Chinese Individuals

Phenomics 2024年第1期4卷 1-12页

作者： hui Qiao Jingze Tan Shaoqing wen Menghan Zhang Shuhua Xu Li Jin State Key Laboratory of Genetic Engineering Center for Evolutionary BiologyCollaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of Contemporary Anthropology Human Phenome InstituteZhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Institute of Archaeological Science Fudan UniversityShanghai 200433China Institute of Modern Languages and Linguistics Fudan UniversityShanghai 200433China Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Phenotypic diversity,especially that of facial morphology,has not been fully investigated in the Han Chinese,which is the largest ethnic group in the *** this study,we systematically analyzed a total of 14,838 facial traits representing 15 categories with both a large-scale three-dimensional(3D)manual landmarking database and computer-aided facial segmented phenotyping in 2379 Han Chinese *** results illustrate that homogeneous and heterogeneous facial morphological traits exist among Han Chinese populations across the three geographical regions:Zhengzhou,Taizhou,and *** identifed 1560 shared features from extracted phenotypes,which characterized well the basic facial morphology of the Han *** particular,heterogeneous phenotypes showing population structures corresponded to geographical *** greatest facial variation among these geographical populations was the angle of glabella,left subalare,and right cheilion(p=3.4×10^(−161)).Interestingly,we found that Han Chinese populations could be classifed into northern Han,central Han,and southern Han at the phenotypic level,and the facial morphological variation pattern of central Han Chinese was between the typical diferentiation of northern and southern Han *** result was highly consistent with the results revealed by the genetic *** fndings provide new insights into the analysis of multidimensional phenotypes as well as a valuable resource for further facial phenotype-genotype association studies in Han Chinese and East Asian populations.

关键词： Phenotypes Three-dimensional facial imaging Facial morphology Han Chinese

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Orthopedic revolution:The emerging role of nanotechnology

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World Journal of Orthopedics 2024年第10期15卷 932-938页

作者： wen-Jie Ruan Si-Si Xu Dong-hui Xu Zhi-Peng Li Department of Sports Medicine Zhejiang Provincial People's Hospital(The Affiliated People's Hospital)Hangzhou 310000Zhejiang ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina The Second Department of Orthopedics The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450015Henan ProvinceChina

This review summarizes the latest progress in orthopedic nanotechnology,ex-plores innovative applications of nanofibers in tendon repair,and evaluates the potential of selenium and cerium oxide nanoparticles in osteoarthritis and osteo-blast *** review also describes the emerging applications of inje-ctable hydrogels in cartilage engineering,emphasizing the critical role of inter-disciplinary research and highlighting the challenges and future prospects of in-tegrating nanotechnology into orthopedic clinical *** comprehensive approach provides a holistic perspective on the transformative impact of nanote-chnology in orthopedics,offering valuable insights for future research and clinical applications.

关键词： Cerium oxide nanoparticles Injectable hydrogels Interdisciplinary research Orthopedic nanotechnology Selenium nanoparticles

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Oleanonic acid inhibits glioma growth by inactivating STAT3 via upregulating SIRT6 in nude mice

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Food Science and Human Wellness 2024年

作者： Jiancun Wang Yuanyuan Wang hui Gao Qin Sun wen Li Neurosurgery Department of the First Affiliated Hospital of Soochow University Department of Neurosurgery， the Third Affiliated Hospital of Naval Medical University Department of anesthesiology， General Hospital Of Eastern Theater Command Department of Pharmacology， School of Medicine， Shaoxing University

Patients with glioma have a very high mortality rate， thus improving the poor prognosis of glioma has been the goal in the therapeutic field. Searching for more effective drugs for gliomas from natural compounds is a promising strategy. In this study， both oleanonic acid and oleanolic acid inhibited proliferation of glioma cells and reduced expression of cyclin D1 and E1， but the former has a lower IC50 than the latter. Oleanonic acid reduced the expression of p-STAT3 but not p-STAT1 and 5， and also reducing the expression of STAT3 in the nucleus and its transcriptional activity in glioma cells. Furthermore， knockdown of STAT3 expression inhibited proliferation and migration of glioma cells. Next， the expressions of the upstream regulators such as SIRT6 and p-JAK2 but not SIRT1， p-ERK1/2， p300 were increased by oleanonic acid. The overexpression of SIRT6 not only reduced the expression of p-STAT3 and its transcriptional activity but also inhibited the proliferation and migration of glioma cells. In addition， the effects that oleanonic acid reduced the expression of p-STAT3 and its transcriptional activity and inhibited the proliferation and migration were attenuated by the knockdown of SIRT6. Furthermore， oleanonic acid effectively suppressed glioma growth and extended survival in nude mice bearing intracerebral U87 xenografts， but not in nude mice bearing intracerebral SIRT6-knockdown U87 xenografts. In conclusion， oleanonic acid upregulates the expression of SIRT6 to inactivates STAT3 and then inhibits glioma growth.

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Research status and hotspots of tight junctions and colorectal cancer:A bibliometric and visualization analysis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3705-3715页

作者： hui-Min Li Yin Liu Meng-Di Hao Xiao-Qing Liang Da-Jin Yuan wen-Bin Huang wen-Jie Li Lei Ding Department of Gastrointestinal Oncology Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related *** the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of *** causal relationship between the presence of specific TJ proteins and the development of CRC has also been *** the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been *** To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research *** We searched the Science Citation Index Expanded database for all literature on CRC and TJs from *** used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and ***-authorship,co-citation,and co-occurrence analyses were the main methods of *** and VOSviewer were used to visualize the *** A total of 205 studies were ultimately *** number of publications on this topic has steadily increased since *** and the United States have made the largest contributions to this *** Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this ***-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this *** This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between th

关键词： Colorectal cancer Tight junctions Bibliometric analysis Research trends Hot spots

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Anion-induced differential assembly and structural transformation of supramolecular coordination cages

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Chinese Chemical Letters 2024年第3期35卷 268-272页

作者： Shao-Ping Zheng Yao-Wei Xu Pei-Yang Su Chen-hui Liu Yin-hui Huang Yu-Lin Lu Zhang-wen Wei Zhiwei Jiao Hai-Sen Xu Cheng-Yong Su MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional MaterialsSchool of ChemistrySun Yat-sen UniversityGuangzhou 510006China Institute of Environmental Research at Greater Bay Area Guangzhou UniversityGuangzhou 510006China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

The intimate host-anion interactions will regulate thermodynamics and kinetics in the self-assembly of cationic cages mimicking biological ***,we report construction and transformation of three Pd(Ⅱ)-based metal-organic cages(MOCs)depending on different *** conversions of the lantern-shaped MOC-34 into either octahedral MOC-35 or tricapped trigonal prism MOC-36 are induced by BF_(4)^(–)or NO_(3)^(–),***-36 is kinetically favored and can undergo quantitative conversion to the thermodynamically preferred MOC-35 upon heating,accelerated by excess BF_(4)^(–)to motivate dissociative dynamics of Pd-vertices and lower activation barrier of cage *** guest encapsulation behaviors of MOC-35 and MOC-36 have also been *** results manifest a significance of host-anion dynamics beyond complementary anion template,shedding light on the understanding of intricate anion recognition in nature.

关键词： Supramolecular coordination cage Dynamic host-anion interactions Structural transformation Anion receptor Guest inclusion

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Review of Research on English Translation of Chinese Running Sentences

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Journal of Literature and Art Studies 2024年第7期14卷 624-627页

作者： ZHANG wen-hui University of Shanghai for Science and Technology ShanghaiChina

In order to convey complete meanings,there is a phenomenon in Chinese of using multiple running *** Jingning(2023,p.66)states,“In communication,a complete expression of meaning often requires more than one clause,which is common in human languages.”Domestic research on running sentences includes discussions on defining the concept and structural features of running sentences,sentence properties,sentence pattern classifications and their criteria,as well as issues related to translating running sentences into *** article primarily focuses on scholarly research into the English translation of running sentences in China,highlighting recent achievements and identifying existing issues in the study of running sentence ***,by reviewing literature on the translation of running sentences,it is found that current research in the academic community on non-core running sentences is ***,this paper proposes relevant strategies to address this issue.

关键词： Chinese running sentences topics English-Chinese translation

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Towards adaptable synchrotron image restoration pipeline

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NUCLEAR SCIENCE AND TECHNIQUES 2024年第10期35卷 1-13页

作者： Li, Chun Bi, Xiao-Xue Zhang, Yu-Jun Zhang, Zhen Wang, Li-wen Zhuang, Jian Chen, Dong-Liang Dong, Yu-hui Zhang, Yi Chinese Acad Sci Inst High Energy Phys Beijing Synchrotron Radiat Facil Beijing 100049 Peoples R China Spallat Neutron Source Sci Ctr Dongguan 523803 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Univ Sci & Technol China Natl Synchrotron Radiat Lab Hefei 230029 Peoples R China

Synchrotron microscopic data commonly suffer from poor image quality with degraded resolution incurred by instrumentation defects or experimental conditions. Image restoration methods are often applied to recover the reduced resolution, providing improved image details that can greatly facilitate scientific discovery. Among these methods, deconvolution techniques are straightforward, yet either require known prior information or struggle to tackle large experimental data. Deep learning (DL)-based super-resolution (SR) methods handle large data well, however data scarcity and model generalizability are problematic. In addition, current image restoration methods are mostly offline and inefficient for many beamlines where high data volumes and data complexity issues are encountered. To overcome these limitations, an online image-restoration pipeline that adaptably selects suitable algorithms and models from a method repertoire is promising. In this study, using both deconvolution and pretrained DL-based SR models, we show that different restoration efficacies can be achieved on different types of synchrotron experimental data. We describe the necessity, feasibility, and significance of constructing such an image-restoration pipeline for future synchrotron experiments.

关键词： Synchrotron Deconvolution Deep learning Super-resolution Pipeline SUPERRESOLUTION REGULARIZATION DECONVOLUTION SOFTWARE

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Patterns and drivers of avian taxonomic and phylogenetic beta diversity in China vary across geographical backgrounds and dispersal abilities

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Zoological Research 2024年第1期45卷 125-135页

作者： Jian-Chao Liang Zhi-Feng Ding Chun-Lin Li Yi-Ming Hu Zhi-Xin Zhou Gan-wen Lie Xiao-Nan Niu wen-Bin Huang hui-Jian Hu Xing-Feng Si Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510260China School of Resources and Environmental Engineering Anhui UniversityHefeiAnhui 230601China Guangdong Eco-Engineering Polytechnic GuangzhouGuangdong 510520China huizhou Institute of Forestry(huizhou Botanical Garden Management Service Center) HuizhouGuangdong 516001China Administration of National Nature Reserve for Marine Ecology of Guangdong Nanpeng Islands ShantouGuangdong 515900China Zhejiang Zhoushan Archipelago Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Geographical background and dispersal ability may strongly influence assemblage dissimilarity;however,these aspects have generally been overlooked in previous large-scale beta diversity ***,we examined whether the patterns and drivers of taxonomic beta diversity(TBD)and phylogenetic beta diversity(PBD)of breeding birds in China vary across(1)regions on both sides of the Hu Line,which demarcates China’s topographical,climatic,economic,and social patterns,and(2)species with different dispersal *** and PBD were calculated and partitioned into turnover and nestedness components using a moving window *** representing climate,habitat heterogeneity,and habitat quality were employed to evaluate the effects of environmental *** distance was considered to assess the impact of dispersal *** partitioning analysis was applied to assess the relative roles of these *** general,the values of TBD and PBD were high in mountainous areas and were largely determined by environmental ***,different dominant environmental filters on either side of the Hu Line led to divergent beta diversity ***,climate-driven species turnover and habitat heterogeneity-related species nestedness dominated the regions east and west of the line,***,bird species with stronger dispersal ability were more susceptible to environmental filtering,resulting in more homogeneous *** results indicated that regions with distinctive geographical backgrounds may present different ecological factors that lead to divergent assemblage dissimilarity patterns,and dispersal ability determines the response of assemblages to these ecological *** a single universal explanation for the observed pattern without considering these aspects may lead to simplistic or incomplete ***,a comprehensive understanding of large-scale beta diversity patterns and effective pla

关键词： Beta diversity Environmental filtering Dispersal limitation Hu Line Species dispersal ability Breeding birds

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Nitrite-driven anaerobic ethane oxidation

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Environmental Science and Ecotechnology 2024年第5期21卷 361-368页

作者： Cheng-Cheng Dang Yin-Zhu Jin Xin Tan wen-Bo nie Yang Lu Bing-Feng Liu De-Feng Xing Nan-Qi Ren Guo-Jun Xie State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China Key Laboratory of the Three Gorges Region's Eco-Environment Ministry of EducationCollege of Environment and EcologyChongqing UniversityChongqing400044China Water Innovation and Smart Environment Laboratory School of Civil and Environmental EngineeringFaculty of EngineeringQueensland University of TechnologyBrisbaneQueensland4001Australia

Ethane,the second most abundant gaseous hydrocarbon in vast anoxic environments,is an overlooked greenhouse *** anaerobic oxidation of ethane can be driven by available electron acceptors such as sulfate and ***,despite nitrite being a more thermodynamically feasible electron acceptor than sulfate or nitrate,little is known about nitrite-driven anaerobic ethane *** this study,a microbial culture capable of nitrite-driven anaerobic ethane oxidation was enriched through the long-term operation of a nitrite-and-ethane-fed *** continuous operation,the nitrite removal rate and the theoretical ethane oxidation rate remained stable at approximately 25.0 mg NO_(2) eN L^(-1) d^(-1) and 11.48 mg C2H6 L^(-1) d^(-1),*** tests demonstrated that ethane is essential for nitrite removal in this microbial *** function analysis revealed that a species affiliated with a novel genus within the family Rhodocyclaceae,designated as'Candidatus Alkanivoras nitrosoreducens',may perform the nitrite-driven anaerobic ethane *** the proposed metabolic model,despite the absence of known genes for ethane conversion to ethyl-succinate and succinate-CoA ligase,'***'encodes a prospective fumarate addition pathway for anaerobic ethane oxidation and a complete denitrification pathway for nitrite reduction to *** findings advance our understanding of nitrite-driven anaerobic ethane oxidation,highlighting the previously overlooked impact of anaerobic ethane oxidation in natural ecosystems.

关键词： Anaerobic ethane oxidation Denitrification Microbial culture Fumarate addition pathway Greenhouse gas

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A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon Mgo-C bricks by introducing ZrSiO_(4)

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Journal of Iron and Steel Research International 2024年第6期31卷 1436-1448页

作者： Chun-hui Sun Ling-ling Zhu Hao Yan Wei Zhao Jing-xuan Liu Lin Ren Xian-tang Zhao Xiao-song Tong Shu-wen Yu Beijing Lirr High-Temperature Materials Co. Ltd.Beijing 102211China School of Materials Science and Engineering Henan Province Industrial Technology Research Institute of Resources and MaterialsZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000AnhuiChina

Conventional MgO-C bricks(graphite content>14 wt.%)produce a great deal of greenhouse gas emission,while low-carbon MgO-C bricks have serious thermal shock resistance during high-temperature *** enhance the high-temperature mechanical property and thermal shock resistance of low-carbon MgO-C bricks,a novel route of introducing ZrSiO_(4) powder into low-carbon MgO-C bricks was reported in such refractories with 2 wt.% flaky *** results indicate that the low-carbon MgO-C brick with 0.5 wt.%ZrSiO_(4) addition has the maximum hot modulus of rupture at 1400℃ and the corresponding specimen fired in the carbon embedded atmosphere has the maximum residual strength ratio(98.6%)after three thermal shock *** is found that some needle-like AlON and plate-like Al_(2)O_(3)-ZrO_(2) composites were in situ formed in the matrices after the low-carbon MgO-C bricks were coked at 1400℃,which can enhance the high-temperature mechanical property and thermal shock resistance due to the effect of fiber toughening and particle ***,CO_(2) emission of the newly developed low-carbon MgO-C bricks is reduced by 58.3% per ton steel after using them as the working lining of a 90 t vacuum oxygen decarburization ladle.

关键词： Low-carbon MgO-C brick ZrsiO_(4) Synergistic toughening effect High-temperature mechanical property Thermal shock resistance Vacuum oxygen decarburization ladle

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