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Brain development in newborns and infants after ECMO

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World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan Lu-Kun Tang Fei-Fan Xiao Peng Zhang Guo-Qiang Cheng Lai-Shuan Wang Chun-Mei Lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng zhou Tian-Tian Xiao Yan Xu Zhao-Qing Yin Gang-Feng Yan Guo-Ping Lu Qi Li wen-hao zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

Epigenetic clocks in the pediatric population:when and why they tick?

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Chinese Medical Journal 2021年第24期134卷 2901-2910页

作者： Jing Wang wen-hao zhou Department of Neonatology Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghai 201102China Center for Molecular Medicine Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghai 201102China

Recent research efforts have provided compelling evidence of genome-wide DNA methylation alterations in *** is currently well established that epigenetic clocks,composed of DNA methylation sites,can estimate the gestational and chronological age of cells and tissues from different ***,extensive research is aimed at their correlation with early life exposure and pediatric *** review aimed to systematically summarize the epigenetic clocks in the pediatric *** were collected from PubMed and Web of Science databases up to Apr *** clocks,DNA methylation clocks,epigenetic age acceleration or deceleration,pediatric and the pediatric population were used as search ***,we first review the currently applicative pediatric epigenetic *** then highlight the interpretation for epigenetic age deviations in the pediatric population and their association with external factors,developmental trajectories,and pediatric *** the remaining unknown of pediatric clocks,research strategies into them are also *** all,pediatric epigenetic clocks may act as potent tools to understand development,growth and diseases in early life.

关键词： Epigenetic clocks DNA methylation Early life Neonates Children Epigenetic age acceleration

New method to implement digital down converter in radar system

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Journal of Systems Engineering and Electronics 2005年第4期16卷 775-780页

作者： Ma Zhigang wen Biyang zhou hao Bai Liyun Radio Propagation Lab Electronics and informations school Wuhan Univ. Wuhan 430079 P. R. China

Digital down converter （DDC） is the main part of the next generation high frequency （HF） radar. In order to realize the single chip integrations of digital receiver hardware in the next generation HF Radar, a new design for DDC by using FPGA is presented. Some important and practical applications are given in this paper, and the result can prove the validity. Because we can adjust the parameters freely according to our need, the DDC system can be adapted to the next generation HF radar system.

关键词： high frequency radar FPGA DDC decimation.

Role of the PTEN signaling pathway in autism spectrum disorder

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Neuroscience Bulletin 2013年第6期29卷 773-778页

作者： Jing-wen Lv Tian-Lin Cheng Zi-Long Qiu wen-hao zhou Department of Neonatology Children's Hospital of Fudan University Institute of Neuroscience Shanghai Institute of Biological SciencesChinese Academy of Sciences

Autism is an etiologically heterogeneous group of neurodevelopmental disorders,diagnosed mostly by the clinical behavioral *** concept that the tumor-related gene PTEN plays a critical role in autism spectrum disorder has emerged over the last *** this review,we focus on the essential role of the PTEN signaling pathway in neuronal differentiation and the formation of neural circuitry,as well as genetic mouse models with Pten ***,accumulated data suggest that the effect of PTEN on neural stem-cell development contributes significantly to the pathophysiology of autism spectrum disorders.

关键词： PTEN TSC1/2 autism synapse neural stem cells

Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis

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Neuroscience Bulletin 2015年第6期31卷 763-768页

作者： Jing-Jing zhou Cheng Cheng Zilong Qiu wen-hao zhou Guo-Qiang Cheng Department of Neonatology Children's Hospital of Fudan University Institute of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of Sciences

Neonatal sepsis is common in neonatal intensive care units, often complicated by injury to the immature brain. Previous studies have shown that the expression of the gap junction protein connexin 43 （Cx43） in the brain decreases when stimulated by neuro-inflammatory drugs such as lipopolysaccharide （LPS）. Here we showed that partial deletion of Cx43 in astrocytes resulted in weakened inflammatory responses. The up-regulation of pro-inflammatory cytokines was significantly reduced in mice with partial deletion of Cx43 in astrocytes compared with wild-type littermates after systemic LPS injection. Moreover, microglial activation was inhibited in mice with partial deletion of Cx43. These results showed that Cx43 in astrocytes plays a critical role in neuro-inflammatory responses. This work provides a potential therapeutic target for inhibiting neuro- inflammatory responses in neonatal sepsis.

关键词： astrocyte gap junction Cx43 neonatalsepsis

What can we learn from neonates with COVID-19?

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World Journal of Pediatrics 2020年第3期16卷 280-283页

作者： Tian-Tian Xiao Kai Yan Lai-Shuan Wang wen-hao zhou National Clinical Research Center for Children's Hospital of Fudan University ShanghaiChina Department of Neonatology Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China

The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global *** on epidemiological and clinical characteristics of patients with COVID-19 have indicated that children are susceptible to SARS-CoV-2 [1-3].To date,the largest study in China reported that over 90% of 2143 children with COVID-19 were asymptomatic,or had mild or moderate illness,and that 5.8% presented critical illness [3].Although the data of neonates are limited and only six neonates with COVID-19 have been reported thus far,several important points should be addressed from these neonatal cases.

关键词： acute respiratory nates

Status of the neonatal follow‑up system in China:survey and analysis

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World Journal of Pediatrics 2023年第11期19卷 1104-1110页

作者： Qi zhou Yun Cao Lan Zhang Nurya Erejep wen‑Long Xiu Jing‑Yun Shi Rui Cheng wen‑hao zhou Shoo KLee Department of Neonatology Children’s Hospital of Fudan University399 Wanyuan RdMinhang DistrictShanghai 201102China Department of Neonatology Children’s Hospital of XinjiangUrumqiChina Department of Neonatology Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouChina Department of Neonatology Gansu Provincial Maternal and Child Care HospitalLanzhouChina Department of Neonatology Nanjing Children’s HospitalNanjingChina Department of Pediatrics Mount Sinai HospitalTorontoONCanada

Background There is little information about neonatal follow-up programs(NFUPs)in *** study aimed to conduct a survey of hospitals participating in the Chinese Neonatal Network(CHNN)to determine the status of NFUPs,including resources available,criteria for enrollment,neurodevelopmental assessments,and duration of *** We conducted a descriptive study using an online survey of all 72 hospitals participating in CHNN in *** survey included 15 questions that were developed based on the current literature and investigators’knowledge about followup practices in *** Sixty-four(89%)of the 72 hospitals responded to the survey,with an even distribution of children’s(31%),maternity(33%)and general(36%)*** but one(98%)hospital had NFUPs,with 44(70%)being established after *** criteria for follow-up were variable,but common criteria included very preterm infants<32 weeks or<2000 g birth weight(100%),small for gestational age(97%),hypoxic ischemic encephalopathy(98%)and postsurgery(90%).The average follow-up rate was 70%(range:7.5%–100%).Only 12%of hospitals followed up with patients for more than 24 *** was significant variation in neurodevelopmental assessments,follow-up schedule,composition of staff,and clinic facilities and *** of the staff had received formal training,and only four hospitals had sent staff to foreign hospitals as *** There is significant variation in eligibility criteria,duration of follow-up,types of assessments,staffing,training and facilities *** and standardization are urgently needed.

关键词： Follow-up Neonate Survey

Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China

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World Journal of Pediatrics 2021年第3期17卷 253-262页

作者： Ling-Kong Zeng Hua-Ping Zhu Tian-Tian Xiao Si-Cong Peng wen-hao Yuan Jian-Bo Shao Lai-Shuan Wang Fei-Fan Xiao Shi-wen Xia Shoo K.Lee Kai Yan wen-hao zhou Department of Neonatology Wuhan Children's Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Neonatology Maternal and Child Health Hospital of Hubei ProvinceWuhanChina National Children’s Medical Center Children’s Hospital of Fudan UniversityShanghaiChina Department of Neonatology Chengdu Women's and Children's Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina Department of Neonatology Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Maternal-Infant Care Research Center(MiCARE)and Department of Pediatrics Mount Sinai HospitalTorontoONCanada Department of Pediatrics Department of Obstetrics and Gynecology and Dal la Lana School of Public HealthUniversity of TorontoTorontoONCanada

Background Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an emerging *** consequences of SARS-CoV-2 exposure in infants remain ***,this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain *** This multicenter observational study was conducted at two designated maternal and children's hospitals in Hubei Province,China's Mainland from February 1,2020 to May 15,*** born to mothers with COVID-19 were *** magnetic resonance imaging(MRI)findings,and volumes of grey and white matters,and physical growth parameters were observed at 44 weeks corrected gestational *** Of 72 neonates born to mothers with COVID-19,8(11%)were diagnosed with COVID-19,8(11%)were critically ill,and no deaths were *** the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks,five neonates were diagnosed with *** these five neonates,three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2,delayed myelination and brain dysplasia in newborn 3,and abnormal signal in the bilateral periventricular in newborn *** other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age(P>0.05).Physical growth parameters for weight,length,and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all *** Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical *** findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2,but further study is required to evaluate the association between the abnormal MRI findings and the exposure

关键词： Coronavirus disease 2019 Follow-up Neonate Severe acute respiratory syndrome coronavirus 2

Pediatric patients in the new wave of SARS‑CoV‑2 infection in Shanghai,China

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World Journal of Pediatrics 2022年第9期18卷 579-581页

作者： Jian‑Guo zhou Yan‑Ming Lu Li‑Bo Wang Hui Yu Ting Zhang Yi‑Wei Chen wen‑hao zhou Department of Neonatology Children’s Hospital of Fudan UniversityShanghaiChina Department of Pediatrics Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina Department of Respiratory Disease Children’s Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityShanghaiChina Department of Gastroenterology Hepatology and NutritionShanghai Children’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardiology Shanghai Children’s Medical CenterAfliated to Shanghai Jiaotong University School of MedicineShanghaiChina Molecular Medical Center Shanghai Key Laboratory of Birth DefectsDepartment of NeonatologyChildren’s Hospital of Fudan University399 Wanyuan RoadShanghai 201101China

Since March 28,2022,Shanghai has become the new COVID-19 epicenter in China,with more than 500,000 COVID-19 cases until May 5th,2022,of which more than 90%are *** than 12,000 children in Shanghai were infected with COVID-19 during the current Omicron wave,which was characterized by family *** an increasing number of symptomatic children are required to be hospitalized,four major pediatric medical centers in Shanghai and other general hospitals were designated for admitting symptomatic pediatric COVID-19 cases in the early *** were approximately 3,500 pediatric cases admitted from April 1st until May 5th,2022.

关键词： admitted wave centers