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基于多源同步数据的闽江下游悬浮物定量遥感

环境科学 2008年第9期29卷 2441-2447页

作者：温小乐徐涵秋福州大学环境与资源学院空间数据挖掘与信息共享教育部重点实验室福州350002

利用2006-09-18的同步Landsat TM数据、水面实测光谱数据和现场水样数据,研究了闽江下游的悬浮物,在这3种同步数据的基础上建立了分别基于实测光谱与影像光谱的悬浮物遥感预测模型.结果表明,实测光谱数据在690nm波长处,归一化光谱反射... 详细信息

利用2006-09-18的同步Landsat TM数据、水面实测光谱数据和现场水样数据,研究了闽江下游的悬浮物,在这3种同步数据的基础上建立了分别基于实测光谱与影像光谱的悬浮物遥感预测模型.结果表明,实测光谱数据在690nm波长处,归一化光谱反射率与悬浮物浓度达到最大正相关,由690nm和530nm二处的反射率构成的比值预测模型与实测悬浮物浓度的拟合精度最高,最佳拟合模型可表达为SS=116.2(R690/R530)-***影像各波段中以(TM2+TM3)2波段组合与实测悬浮物浓度的相关性最佳,由其所建立的影像光谱预测模型与实测悬浮物浓度的拟合精度最高,最佳拟合模型可表达为SS=3793.7(RTM3+RTM2)2-16.5.模型的精度评价表明,实测光谱模型的预测能力要强于影像光谱模型,但二者差异不大,在缺乏地面实测光谱数据时,基于影像光谱的遥感定量模型仍不失为一种预测悬浮物浓度的有效方法,其对闽江下游悬浮物浓度的反演结果能较准确地反映出该区域悬浮物浓度分布的空间差异,具有较高的实用性.

关键词：实测光谱 TM影像悬浮物闽江

Liver histopathological lesions is severe in patients with normal alanine transaminase and low to moderate hepatitis B virus DNA replication

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World Journal of Gastroenterology 2023年第16期29卷 2479-2494页

作者： Su-wen Jiang Xiang Lian Ai-Rong Hu Jia-Lin Lu Zhe-Yun He Xiao-Jun Shi De-dong Zhu Zong-Yi Wang Guan-Cheng Huang Ningbo Institute of Liver Diseases Ningbo No.2 HospitalNingbo 315020Zhejiang ProvinceChina Department of Infectious Diseases Xiangshan Hospital Affiliated to Wenzhou Medical UniversityNingbo 315020Zhejiang ProvinceChina Department of Infectious Diseases The First Hospital of Ninghai CountyNingbo 315000Zhejiang ProvinceChina Department of Infectious Diseases The Affiliated Yang-Ming Hospital of Ningbo UniversityNingbo 315400Zhejiang ProvinceChina

BACKGROUND Chronic hepatitis B virus(HBV)infection remains a major global public health *** hepatitis B(CHB)patients can be divided into treatment indication and non-treatment indication individuals according to alanine transaminase(ALT),HBV DNA,serum hepatitis B e antigen status,disease status[liver cirrhosis,hepatocellular carcinoma(HCC),or liver failure],liver necroinflammation or fibrosis,patients’age,and family history of HCC or *** example,normal ALT patients in‘immune-tolerant’phase with HBV DNA higher than 10^(7)or 2×10^(7)IU/mL,and those in‘inactive-carrier’phase with HBV DNA lower than 2×10^(3)IU/mL do not require antiviral ***,is it reasonable to set the defined values of HBV DNA as the fundamental basis to estimate the disease state and to determine whether to start treatment?In fact,we should pay more attention to those who do not match the treatment indications(grayzone patients both in the indeterminate phase and in the‘inactive-carrier’phase).AIM To analyze the correlation of HBV DNA level and liver histopathological severity,and to explore the significance of HBV DNA for CHB with normal *** From January 2017 to December 2021,a retrospective cross-sectional set of 1299 patients with chronic HBV infection(HBV DNA>30 IU/mL)who underwent liver biopsy from four hospitals,including 634 with ALT less than 40 U/*** of the patients had received anti-HBV *** degrees of liver necroinflammatory activity and liver fibrosis were evaluated according to the Metavir *** the basis of the HBV DNA level,patients were divided into two groups:Low/moderate replication group,HBV DNA≤10^(7)IU/mL[7.00 Log IU/mL,the European Association for the Study of the Liver(EASL)guidelines]or≤2×10^(7)IU/mL[7.30 Log IU/mL,the Chinese Medical Association(CMA)guidelines];high replication group,HBV DNA>10^(7)IU/mL or>2×10^(7)IU/*** factors(demographic characteristics,laboratory parameters and noninvasive models)for liver h

关键词： Chronic hepatitis B Hepatitis B virus DNA Histology Risk factors

Efficacy of acupuncture at ghost points combined with fluoxetine in treating depression:A randomized study

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World Journal of Clinical Cases 2022年第3期10卷 929-938页

作者： Yi Wang Yu-Wei Huang Dilnur Ablikim Qun Lu Ai-Jia Zhang Ye-Qing dong Fei-Cui Zeng Jing-Hua Xu wen Wang Zhi-Hai Hu Department of Acupuncture and Moxibustion Shanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Acupuncture and Moxibustion Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Clinical Laboratory Shanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Traditional Chinese Medicine Jiangwan HospitalShanghai 200081China Department of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200081China

BACKGROUND Depression affects more than 350 million people *** China,4.2%(54 million people)of the total population suffers from *** has been shown to change cognition,improve personality,and enhance the ability to cope with difficulties and *** pharmacotherapy can reduce symptoms,it is also associated with adverse reactions and relapse after drug ***,there has been an increasing emphasis placed on the use of non-pharmacological therapies for *** hypothesis of this study was that acupuncture at ghost points combined with fluoxetine would be more effective than fluoxetine alone for the treatment of *** To investigate the efficacy of acupuncture at ghost points combined with fluoxetine for the treatment of patients with *** This randomized controlled trial included patients with mild to moderate depression(n=160).Patients received either acupuncture at ghost points combined with fluoxetine(n=80)or fluoxetine alone(control group,n=80).Needles were retained in place for 30 min,5 times a week;three treatment cycles were *** Mann–Whitney U test was used to compare functional magnet resonance imaging parameters,Hamilton depression rating scale(HAMD)scores,and self-rating depression scale(SDS)scores between the acupuncture group and control *** There were no significant differences in HAMD or SDS scores between the acupuncture group and control group,before or after 4 wk of *** acupuncture group exhibited significantly lower HAMD and SDS scores than the control group after 8 wk of treatment(P<0.05).The acupuncture group had significantly lower fractional Amplitude of Low Frequency Fluctuations values for the left anterior wedge leaf,left posterior cingulate gyrus,left middle occipital gyrus,and left inferior occipital gyrus after 8 *** acupuncture group also had significantly higher values for the right inferior frontal gyrus,right insula,and ri

关键词： Traditional Chinese medicine Acupuncture Ghost point Fluoxetine Depression Resting state magnetic resonance

Complex geometric modeling and tooth contact analysis of a helical face gear pair with arc-tooth

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Journal of Central South University 2022年第4期29卷 1213-1225页

作者： MO Shuai SONG wen-hao ZHU Sheng-ping FENG Zhi-you TANG wen-jie GAO han-jun School of Mechanical Engineering Tiangong UniversityTianjin 300387China Tianjin Key Laboratory of Modern Electromechanical Equipment Technology Tianjin 300387China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China The State Key Laboratory of Virtual Reality Technology and Systems Beijing University of Aeronautics and AstronauticsBeijing 100083China

A complex geometric modeling method of a helical face gear pair with arc-tooth generated by an arc-profile cutting(APC)disc is proposed,and its tooth contact characteristics are ***,the spatial coordinate system of an APC face gear pair is established based on meshing *** the coordinate transformation matrix and the tooth profile of the cutter,the equations of the curve envelope of the APC face gear pair are *** the surface equations are solved to extract the point clouds data by programming in MATLAB,which contains the work surface and the fillet surface of the APC face gear *** the complex geometric model of the APC face gear pair is built by fitting its point *** last,through the analysis of the tooth surface contact,the sensitivity of the APC face gear to the different types of mounting errors is *** results show that the APC face gear pair is the most sensitive to mounting errors in the tooth thickness direction,and it should be strictly controlled in the actual application.

关键词： arc-tooth face gear complex geometric modeling point clouds mounting errors tooth contact analysis

The effects of genistein on transforming growth factor-β1-induced invasion and metastasis in human pancreatic cancer cell line Panc-1 in vitro

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Chinese Medical Journal 2012年第11期125卷 2032-2040页

作者： han Lei ZhanG Hong-wei ZHOU wen-ping CHEN Guang-ming GUO Ke-jian Department of General Surgery College of Clinical Medical Sciences China Medical University Shenyang Liaoning 110004 China Department of Hepatobiliary ＆ Pancreas Surgery the General Hospital of Shenyang Military Region Shenyang Liaoning 110016 China Department of General Surgery the Tianjin Dongli Hospital Tianjin 300000 China

Background Pancreatic cancer is a devastating disease with the worst mortality rate. Therefore, a rational strategy for future drug development is critical. Genistein is a small, biologically active flavonoid that is found in high amounts in soy. This important compound supports a wide variety of biological activities, but is best known for its ability to inhibit cancer progression. Methods Transwell chamber assay was performed to determine the effect of genistein on the invasion of the human pancreatic cancer cell line Panc-1 induced by transforming growth factor-β1 （TGF-β1） in the different condition （5 ng/ml 24 hours and 10 ng/ml 48 hours）; Reverse transcription-polymerase chain reaction （RT-PCR） was used to estimate the mRNA levels of urinary plasminogen activator （uPA）, matrix metallopeptidase 2/9 （MMP-2/9）, Smad4, E-Cadherin and Vimentin; Western blotting was used to detect the protein levels of uPA, E-Cadherin, ERK1/2, P38 and P-P38, and the activity of MMP-2/9 protein were detected by gelatin zymography assay method. Cells structure was observed and analyzed by microscopy. Results Genistein can inhibit effectively TGF-β1-induced invasion and metastasis in Panc-1 by Transwell assay, which is through regulating the mRNA and protein expression of uPA and MMP2, but not MMP9 by RT-PCR / Western blotting, and is positively correlated with the concentration of genistein. At the same time, genistein also could improve the progress of epithelial-mesenchymal transition （EMT） via morphology observation using light microscopy / transmission electron microscopy （TEM）, which is mediated by the down-regulation of E-cadherin and the up-regulation of vimentin. Conclusions TGF-β1 mediates EMT process via numerous intracellular signal transduction pathways. The potential molecular mechanisms are all or partly through Smad4-dependent and -independent pathways （p38 MAPK） to regulate the antitumor effect of genistein.

关键词： genistein transforming growth factor invasion metastasis pancreatic cancer

Thermal Breath Design of Micro-processor and SOC in DOCSIS Network

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机械工程与设计（中英文版） 2014年第4期3卷 34-37页

作者： Hujiao Wang Yong Peng Shibo dong Weihua wen Mechanical Engineer/Cisco System/200233 China Hardware Engineer/Cisco System/200233 China

Relationship between T-cell receptor α gene polymorphisms and symptomatic differences in patients with narcolepsy type 1

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Chinese Medical Journal 2019年第15期132卷 1796-1801页

作者： Hui Ouyang Fang han Ze-Chen Zhou Qi-wen Zheng Yang-Yang Wang Jun Zhang Department of Clinical Neurology Peking University People's Hospital Beijing 100044 China Department of Clinical Pulmonology Peking University People's Hospital Beijing 100044 China Department of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing 100191 China

Background:Recent genome-wide association studies have identified an important role of T-cell receptor α(TRA) gene in the development of narcolepsy type ***,the role of TRA haplotype polymorphisms in the symptomatic diversity of narcolepsy remains *** study aimed to investigate whether TRA polymorphisms can influence the symptomatic diversity of ***:Totally,903 patients with narcolepsy type 1 were included in the *** were divided into different groups according to their ***,13 genotyped single nucleotide polymorphisms in the TRA were assessed for their association with symptoms of *** used the Chi-square test to determine differences in genotype frequencies in patients with ***,we identified the haplotypes and variations of the TRA and tested their association with the symptoms of narcolepsy using a logistic regression ***:According to the results of the logistic regression,TRA haplotypes TG and CT were significantly associated with auditory hallucination,with odds ratios of 1.235 (95% confidence interval [CI],1.012-1.507) and 1.236 (95% CI,1.012-1.511),respectively (P hanisms.

关键词： Narcolepsy T-cell receptor α gene Symptomatic subtype Haplotype Precision medicine

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侧卧位的角度与纠正枕后位的关系探讨

中国妇幼保健 2011年第14期26卷 2197-2198页

作者：陈东东陈佳权韩文牡丹江医学院附属二院妇产科黑龙江牡丹江157010

目的:探讨孕妇侧卧位的角度与纠正枕后位的关系。方法:选择2004年1月～2010年1月于牡丹江医学院附属二院妇产科分娩经彩超及产科检查确诊为枕后位、无明显产道异常或头盆不称、年龄20～32岁的初产妇200例,随机平均分为观察组和对照组。... 详细信息

目的:探讨孕妇侧卧位的角度与纠正枕后位的关系。方法:选择2004年1月～2010年1月于牡丹江医学院附属二院妇产科分娩经彩超及产科检查确诊为枕后位、无明显产道异常或头盆不称、年龄20～32岁的初产妇200例,随机平均分为观察组和对照组。两组宫缩时均取跪位,宫缩间歇时,观察组同侧俯卧位(同侧俯卧>90°);对照组对侧俯卧位(对侧俯卧>90°且向对侧旋转后儿头枕部超过12:00)。结果:观察组90%转为枕前位经阴道分娩,10%剖宫产;对照组78%转为枕前位经阴道分娩,20%剖宫产。结论:侧卧位的角度与纠正枕后位的成功率关系密切。纠正枕后位时可采取跪位(180°)、同侧俯卧位(>90°)、同侧卧位(90°)、及对侧俯卧位(对侧俯卧>90°且儿头枕部超过12:00);若对侧俯卧90°但儿头枕部不超过12:00,胎儿将继续向枕后位旋转;若对侧俯卧胎儿枕部位于12:00,胎位不变。

关键词：侧卧位枕后位成功率

Enhanced lithium leaching from lepidolite in continuous tubular reactor using H_(2)SO_(4)+H_(2)SiF_(6) as lixiviant

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Transactions of Nonferrous Metals Society of China 2021年第7期31卷 2165-2173页

作者： Hui GUO Ge KUANG Huan LI wen-tao PEI Hai-dong WANG School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Institute of Chemical Technologies College of Chemical EngineeringFuzhou UniversityFuzhou 350108China School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Western Australian School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWA 6102Australia

An acidic mixture of sulfuric and fluosilicic acid(H_(2)SO_(4)+H_(2)SiF_(6))was employed as lixiviant to enhance leaching of lithium from *** H_(2)SiF_(6) was obtained as a byproduct of anhydrous hydrofluoric acid production,aiming to provide HF *** was found that the HF molecules were the main reaction component and played a key role in strengthening the dissolution of *** factors,including mass ratio of ore/H_(2)SO_(4)/H_(2)SiF_(6),concentrations of H_(2)SO_(4) and H_(2)SiF_(6),leaching temperatures(40−80℃)and time(15−75 min),were ***,an efficient tubular reactor was employed to improve this acid leaching *** the optimal conditions(ore/H_(2)SO_(4)/H_(2)SiF_(6) mass ratio of 1:0.8:1.6,80 wt.% H_(2)SO_(4),15 wt.% H_(2)SiF_(6),80℃,15 min),97.9% of Li,96.4% of K,97.6% of Rb,96.7% of Cs and 81.4% of Al(mass fraction)were ***,a two-step thermal process was proposed to remove fluorine of leaching *** acid treatment using an acidic mixture of H_(2)SO_(4) and H_(2)SiF_(6) in a continuous tubular reactor shows potential as an alternative process to extract lithium from lepidolite.

关键词： lepidolite lithium extraction continuous tubular reactor fluosilicic acid fluorine chemical method