Efficacy of acupuncture at ghost points combined with fluoxetine in treating depression:A randomized study

作     者：Yi Wang Yu-Wei Huang Dilnur Ablikim Qun Lu Ai-Jia Zhang Ye-Qing Dong Fei-Cui Zeng Jing-Hua Xu Wen Wang Zhi-Hai Hu 

作者机构：Department of Acupuncture and MoxibustionShanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Acupuncture and MoxibustionShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Clinical LaboratoryShanghai TCM-Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai 200082China Department of Traditional Chinese MedicineJiangwan HospitalShanghai 200081China Department of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai 200081China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第3期

页      面：929-938页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：Supported by Shanghai Science and Technology Commission TCM Guidance Project,No.19401935500 Shanghai University of Traditional Chinese Medicine Budget Scientific Research Project,No.2020LK079 Medical Innovation Research Special General Project of Shanghai Science and Technology Commission,No.21Y11923500 

主　　题：Traditional Chinese medicine Acupuncture Ghost point Fluoxetine Depression Resting state magnetic resonance 

摘      要：BACKGROUND Depression affects more than 350 million people *** China,4.2%(54 million people)of the total population suffers from *** has been shown to change cognition,improve personality,and enhance the ability to cope with difficulties and *** pharmacotherapy can reduce symptoms,it is also associated with adverse reactions and relapse after drug ***,there has been an increasing emphasis placed on the use of non-pharmacological therapies for *** hypothesis of this study was that acupuncture at ghost points combined with fluoxetine would be more effective than fluoxetine alone for the treatment of *** To investigate the efficacy of acupuncture at ghost points combined with fluoxetine for the treatment of patients with *** This randomized controlled trial included patients with mild to moderate depression(n=160).Patients received either acupuncture at ghost points combined with fluoxetine(n=80)or fluoxetine alone(control group,n=80).Needles were retained in place for 30 min,5 times a week;three treatment cycles were *** Mann–Whitney U test was used to compare functional magnet resonance imaging parameters,Hamilton depression rating scale(HAMD)scores,and self-rating depression scale(SDS)scores between the acupuncture group and control *** There were no significant differences in HAMD or SDS scores between the acupuncture group and control group,before or after 4 wk of *** acupuncture group exhibited significantly lower HAMD and SDS scores than the control group after 8 wk of treatment(P0.05).The acupuncture group had significantly lower fractional Amplitude of Low Frequency Fluctuations values for the left anterior wedge leaf,left posterior cingulate gyrus,left middle occipital gyrus,and left inferior occipital gyrus after 8 *** acupuncture group also had significantly higher values for the right inferior frontal gyrus,right insula,and ri