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[Construction of a 17 β-estradiol sensor based on a magnetic graphene oxide/aptamer separating material]

Se pu = Chinese journal of chromatography 2025年第1期43卷 87-95页

作者： Xin-Yu Jin Le-Yuan chen Ya-Nna Liu wen-Jing Xie Han-Yong Peng State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. University of Chinese Academy of Sciences Beijing 100049 China. School of Environment Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Hangzhou 310024 China.

17-Estradiol (E2) is a natural steroidal estrogen essential for a variety of physiological functions in organisms. However, external E2, which is renowned for its potent biological effects, is also considered to be an endocrine-disrupting compound (EDC) capable of disturbing the normal operation of the endocrine system, even at nanogram-per-liter (ng/L) concentrations. Studies have revealed that medical and livestock wastewater can be contaminated with E2, which poses potential risks to human health. Currently, the primary method for detecting E2 relies on liquid chromatography-mass spectrometry, which is limited with regard to on-site or large-scale sample testing due to instrumental constraints. Herein, we developed a magnetic graphene oxide (MGO)/aptamer separating material. The MGO was synthesized by creating a water-in-oil microemulsion at 90 ℃, an agarose hydrogel to load the FeO nanoparticles, and layered graphene oxide (GO). In contrast to conventional methods, such as chemical co-precipitation and solvothermal approaches, this method is more time-efficient and does not require high temperature or pressure. Moreover, the use of a physical encapsulation technique for enwrapping the FeO nanoparticles and layered GO eliminates the need for chemical modification. This approach reduces the use of harmful chemicals, ensures complete loading, and results in highly efficient encapsulation. The MGO was characterized using Fourier-transform infrared (FT-IR) spectroscopy and transmission electron microscopy (TEM), as well as dynamic light scattering (DLS) and Zeta potential analyses, which revealed that the FeO nanoparticles had been successfully loaded onto the GO to produce MGO particles mainly around 5 μm in size. Additionally, this study demonstrated that the aqueous MGO dispersion is highly stable. This substance was used to develop a fluorescent biosensor that uses a "turn-on" mechanism to rapidly and highly sensitively detect E2. MGO is capable of adsorbing a fl

关键词： 17-estradiol (E2) fluorescence biosensor magnetic graphene oxide (MGO) magnetic solid phase separation

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Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang wentao Jiang Xue-wen Zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He Long chen Qiang chen He-Qi Zheng Yuanjing Cui wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang wen-Hui Wei Shu-Hui Fan Li chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Effects of Scale-Free Topological Properties on Dynamical Synchronization and Control in Coupled Map Lattices

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Communications in Theoretical Physics 2007年第2期47卷 361-368页

作者： chen Wei fang Jin-Qing KANG Ge-wen School of Automation Engineering University of Electronic Science and Technology of China Chengdu 610054 China China Institute of Atomic Energy P.O. Box 275-81 Beijing 102413 China

In the paper, we study effects of scale-free （SF） topology on dynamical synchronization and control in coupled map lattices （CIVIL）. Our strategy is to apply three feedback control methods, including constant feedback and two types of time-delayed feedback, to a small fraction of network nodes to reach desired synchronous state. Two controlled bifurcation diagrams verses feedback strength are obtained respectively. It is found that the value of critical feedback strength γc for the first time-delayed feedback control is increased linearly as e is increased linearly. The GML with SF loses synchronization and intermittency occurs if γ 〉 γc. Numerical examples are presented to demonstrate all results.

关键词： scale-free network coupled map lattice dynamical synchronization feedback control timedelayed feedback

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SnNi nanoneedles assembled 3D radial nanostructure loaded with SnNiPt nanoparticles： Towards enhanced electrocatalysis performance for methanol oxidation

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Nano Research 2017年第11期10卷 3929-3940页

作者： Hao fang Yuting chen Ming wen Qingsheng Wu Quanjing Zhu School of Chemical Science and Engineering Shanghai Key Laboratory of Chemical Assessment and Sustainability Education Ministry Key Laboratory of Yangtze River Water Environment Tongji University 1239 Siping Road Shanghai 200092 China

A desirable methanol oxidation electrocatalyst was fabricated by metal atom diffusion to form an alloy of an assembled three-dimensional （3D） radial nanostructure of SnNi nanoneedles loaded with SnNiPt nanoparticles （NPs）.Herein,metal atom diffusion occurred between the SnNi support and loaded Pt NPs to form a SnNiPt ternary alloy on the catalyst *** as-obtained catalyst combines the excellent catalytic performance of the alloy and advantages of the 3D nanostructure;the SnNiPt NPs,which fused on the surface of the SnNi nanoneedle support,can dramatically improve the availability of Pt during electrocatalysis,and thus elevate the catalytic *** addition,the efficient mass transfer of the 3D nanostructure reduced the onset ***,the catalyst achieved a favorable CO poisoning resistance and enhanced *** atomic interdiffusion,the catalytic activity drastically increased by 45%,and the other performances substantially *** results demonstrate the significant advantage and enormous potential of the atomic interdiffusion treatment in catalytic applications.

关键词： three-dimensional (3D) nanostructure SnNiPt ternary alloy electrocatalysis methanol oxidation reaction direct methanol fuel cell anode catalyst

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Viscoplastic constitutive model of a nickel-based superalloy under multiaxial loading conditions

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Journal of Iron and Steel Research International 2021年第9期28卷 1190-1202页

作者： wen-bin Jia Xin Li Zhi chen Kai Zhao Lei fang Key Laboratory of Aero-Engine Thermal Environment and Structure Ministry of Industry and Information TechnologyJiangsu Province Key Laboratory of Aerospace Power SystemState Key Laboratory of Mechanics and Control of Mechanical StructuresCollege of Energy and Power EngineeringNanjing University of Aeronautics and AstronauticsNanjing210016JiangsuChina

Based on Chaboche constitutive model,a viscoplastic constitutive model of nickel-based alloy under multiaxial loading is proposed by introducing Lemaitre damage model and non-proportional hardening *** damage model can characterize the effect of microscopic defects on the fatigue behavior and non-proportional hardening factor is used to describe non-proportional hardening ***,the stress–strain hysteresis loops at room and high temperatures under different loading conditions are simulated by the proposed constitutive *** between experiments and simulations confirms that the proposed model can reasonably predict the fatigue behavior of nickel-based alloy under different multiaxial *** last,the fatigue life predictions under different multiaxial loadings are investigated,and comparison between experiments and simulations verifies the accuracy of the proposed model.

关键词： Nickel-based alloy Multiaxial loading Viscoplastic constitutive model Lemaitre damage model Non-proportional hardening factor

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碱-酶水解结合分散式固相萃取提高大豆异黄酮活性总量测定的准确性

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分析测试学报 2025年第1期44卷 106-115页

作者：顾文黎晨曼孙震庞月红冯永巍沈晓芳江南大学食品科学与资源挖掘全国重点实验室江苏无锡214122 无锡市食品安全检验检测中心国家市场监管技术创新中心(特殊食品)江苏无锡214142

通过碱性甲醇溶液超声提取,结合杏仁来源β-葡萄糖苷酶水解及聚酰胺分散式固相萃取步骤,建立了超高效液相色谱测定大豆异黄酮活性总量的方法。样品中的丙二酰及乙酰类大豆异黄酮苷在碱性条件下水解成基本型苷,并在β-葡萄糖苷酶的作用... 详细信息

通过碱性甲醇溶液超声提取,结合杏仁来源β-葡萄糖苷酶水解及聚酰胺分散式固相萃取步骤,建立了超高效液相色谱测定大豆异黄酮活性总量的方法。样品中的丙二酰及乙酰类大豆异黄酮苷在碱性条件下水解成基本型苷,并在β-葡萄糖苷酶的作用下进一步脱去糖基转变为相应的苷元。样品中12种不同形式的大豆异黄酮转变为仅含3种大豆异黄酮苷元(大豆苷元、黄豆黄素、染料木素)后,以聚酰胺粉进行分散式固相萃取,C_(18)反相色谱柱(2.1 mm i.d.×50 mm,1.8μm)分离。结果显示,大豆苷元、黄豆黄素及染料木素在3 min内实现基线分离,3种异黄酮苷元的标准曲线相关系数(r^(2))均大于0.999,总异黄酮的回收率为94.3%~102%,相对标准偏差(RSD,n=6)小于5.0%,具有较高的准确度和精密度。该方法通过检测样品中的全部苷元来计算异黄酮总量,有助于降低异黄酮检测在分离度、准确度及检测成本上带来的挑战;考虑异黄酮在体内的转化吸收机制和生理效应,以苷元总量计能更科学地反映实际的异黄酮活性水平,避免因通过苷和苷元的简单加和而造成对异黄酮含量水平的高估。

关键词：大豆异黄酮聚酰胺(PA) 分散式固相萃取(d-SPE) β-葡萄糖苷酶超高效液相色谱(UPLC)

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Decadal expansion and contraction of permafrost in the Three-River Source Region,Qinghaie-Tibet Plateau(1901-2020)

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Advances in Climate Change Research 2023年第2期14卷 226-236页

作者： fang-fang chen Dong-Liang LUO Yi-Ting GAO wen-Jie LEI State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China

Permafrost and its spatiotemporal variation considerably influence the surface and sub-surface hydrological processes,biogeochemical cycles,fauna and flora growth and cold region engineering projects in the Three-River Source Region(TRSR),Qinghai–Tibet ***,the dynamics of permafrost over a relatively long term duration(e.g.>100 years)in the TRSR is not well ***,the spatial and temporal variations of the temperature at the top of the perennially frozen/unfrozen ground(TTOP),active layer thickness(ALT)in permafrost regions and the maximum depth of frost penetration(MDFP)in the seasonally frozen ground of the TRSR during 1901–2020 were simulated using the TTOP model and Stefan equation driven by the widely used reanalysis Climatic Research Unit 4.05 *** revealed that the permafrost in the TRSR over the past 120 years did not degrade monotonically but experienced considerable fluctuations in area with the decadal oscillations of climate warming and cooling:shrinking from 263.9×10^(3)km^(2)in the 1900s to 233.3×10^(3)km^(2)in the 1930s,expanding from 232.3×10^(3)km^(2)in the 1940s to 260.9×10^(3)km^(2)in the 1970s and shrinking again from 254.1×10^(3)km^(2)in the 1980s to 228.9×10^(3)km^(2)in the *** regional average TTOP increased from−1.34±2.74℃in the 1910s to−0.48±2.69℃in the 2010s,demonstrating the most noticeable change for the extremely stable permafrost(TTOP3.0 m by 12%from 1901 to ***,minor changes were observed for the regional average MDFP,probably due to the increase in the area proportion of MDFP3.5 m(owing to the transformation of permafrost to seasonally frozen ground)by 7.39%and 4.77%,*** findings can facilitate an in-depth understanding of permafrost dynamics and thus provide a scientific reference for eco-environment protection and s

关键词： Three-River Source Region Permafrost TTOP model Stefan equation Qinghaie-Tibet Plateau

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High-precision magnetic field measurement system based on a coherent population trapping magnetometer onboard the SATech-01 satellite

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Science China Technological Sciences 2025年

作者： Hongbo XUE Wei SONG Haoran ZHAO Yiteng ZHANG Shanzhi YE Jindong WANG Ran TAO Peng SANG Keli chen Xingzi BI Bingjun chenG Bin ZHOU Yongliang XUE Yingying TANG Liu LIU Jinsong LI Xiaocheng ZHU Baoquan LI Jinguo LIU wen chen Xiaofeng ZHANG Yonghe ZHANG Lei LI State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences Key Laboratory of Solar Activity and Space Weather National Space Science Center Chinese Academy of Sciences Key Laboratory of Electronics and Information Technology for Space Systems National Space Science Center Chinese Academy of Sciences State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Innovation Academy for Microsatellites Chinese Academy of Sciences

On July 27, 2022, a high-precision system for measuring the magnetic field based on a coherent population trapping magnetometer（referred to as the CPT system） was launched onboard the Space Advanced Technology demonstration satellite（SATech-01） by a ZK-1A rocket. The payload comprises a scalar coherent population trapping magnetometer（CPTM）, triaxial anisotropic magnetoresistance magnetometer（AMRM）, and nano star tracker mounted on a non-magnetic telescopic tubular mast. This configuration enables synchronized measurement of scalar and vector geomagnetic fields, as well as the attitude,making the payload with its compact sensors suitable for applications on miniature satellite platforms. On November 7, 2022,the novel telescopic tubular mast was deployed in orbit, extending to a length of 5.28 m. The CPTM, an absolute scalar magnetometer with an omnidirectional sensor, is the first China-developed quantum/atomic magnetometer successfully operating in space. In orbit, the CPTM has sensitivity of ～10 pT/Hz1/2and can automatically operate under complex magnetic field variations. The difference between the scalar fields obtained using the CPTM and CHAOS model has a mean deviation of–3.73 n T and a standard deviation of 26.11 nT（1σ）, without on-orbit calibration or correction. The miniaturized AMRM has a sensitivity of ～0.3 n T/Hz1/2and maintains stable and reliable operation in orbit. The low-power and miniaturized nano star tracker has a measurement uncertainty of 14.23″（1σ） in orbit. The mission has realized the on-orbit technical verification of the integrated and synchronized detection of the vector magnetic field and attitude and fully validated the system's performance,automation level, and reliability.

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Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

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World Journal of Diabetes 2025年第1期16卷 204-210页

作者： fang chen Bo An wen-cheng An Gang Fu Wei Huang Hui-Xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

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