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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu Bian Yu-Fang Feng wen-ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

云南省城市土地利用效率与土地生态安全耦合协调研究

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国土与自然资源研究 2025年第1期 1-7页

作者：温婷杨诗琴云南财经大学国土资源与持续发展研究所云南昆明650221

为深入探究城市土地利用效率与土地生态安全之间的关系,探索出一条既能实现土地高效合理利用又能保护土地生态安全的可持续发展之路。以云南省为例,在构建城市土地利用效率及土地生态安全相应指标体系的基础上,综合运用SBM-Undesirable... 详细信息

为深入探究城市土地利用效率与土地生态安全之间的关系,探索出一条既能实现土地高效合理利用又能保护土地生态安全的可持续发展之路。以云南省为例,在构建城市土地利用效率及土地生态安全相应指标体系的基础上,综合运用SBM-Undesirable模型、综合指数法及耦合协调度模型测算云南省城市土地利用效率与土地生态安全水平及两者的耦合协调度及其时空变化特征。结果表明,(1)2006-2021年云南省城市土地利用效率呈现波动上升的变化趋势,研究期间均值为0.92,总体状况较好。(2)2006-2021年云南省城市土地生态安全水平总体呈现上升趋势,经历了“不安全-较不安全-临界安全-较安全”四个阶段,由2006年的0.18提升至2021年的0.77,土地生态安全水平显著提升。(3)2006-2021年,云南省城市土地利用效率与土地生态安全耦合协调度呈现波动上升的趋势,经历“轻度失调-初步协调-中级协调-良好协调-优质协调”5个阶段,空间格局上呈现西北、中部高,西南、东部地区较低的特征。总体来看,研究期间云南省大部分地区城市土地利用效率与土地生态安全处于协调阶段。

关键词：城市土地利用效率城市土地生态安全耦合协调

Dechlorination of carbon tetrachloride by the catalyzed Fe-Cu process

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Journal of Environmental Sciences 2007年第7期19卷 792-799页

作者： XU wen-ying GAO ting-yao The National Engineering Research Center for Urban Pollution Control Tongji University Shanghai 200092 China.

The dectrochemical reduction characteristics of carbon tetrachlofide （CT） were investigated using cyclic voltammetry in this study. In addition, the difference in reduction mechanisms of CT between Master Builders＇ iron and the catalyzed Fe-Cu process was discussed. The results showed that CT was reduced directly on the surface of copper rather than by atomic hydrogen produced at the cathode in the catalyzed Fe-Cu process. The reduction was realized largely by atomic hydrogen in Master Builders＇ iron. The entire CT in 350 ml aqueous solution with 320 mg/L was reduced to trichloromethane and dichloromethane in 2.25 h when 100 g of scrap iron with Fe/Cu ratio of 10：1 （w/w） were used. Moreover, the reduction rate slowed with time. CT could be reduced at acidic, neutral and alkaline pH from solution by Fe-Cu bimetallic media, but the mechanisms were different. The degradation rate was not significantly influenced by pH in the catalyzed Fe-Cu process; in Master Builders＇ iron it clearly increased with decreasing pH. The kinetics of the reductions followed pseudo-first order in both cases. Furthermore, the reductions under acidic conditions proceeded faster than that under the neutral and alkaline conditions. The catalyzed Fe-Cu process was superior to Master Builders＇ iron in treating CT-containing water and this advantage was particularly noticeable under alkaline conditions. The reduction was investigated in the cathode （Cu） and anode （Fe） compartments respectively, the results showed that the direct reduction pathway played an important role in the reduction by the catalyzed Fe-Cu process. The catalyzed Fe-Cu process is of practical value.

关键词： carbon tetrachloride electrochemical reduction characteristics catalyzed Fe-Cu process reduction mechanisms

On Minimization of Upper Bound for the Convergence Rate of the QHSS Iteration Method

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Communications on Applied Mathematics and Computation 2019年第2期1卷 263-282页

作者： wen-ting Wu State Key Laboratory of Scientific/Engineering Computing Institute of Computational Mathematics and Scientific/Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of Sciences. P.O. Box 2719. Beijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

For an upper bound of the spectral radius of the QHSS (quasi Hermitian and skew-Hermitian splitting) iteration matrix which can also bound the contraction factor of the QHSS iteration method,we give its minimum point under the conditions which guarantee that the upper bound is strictly less than one. This provides a good choice of the involved iteration parameters,so that the convergence rate of the QHSS iteration method can be significantly improved.

关键词： System of linear equations Non-Hermitian matrix QHSS iteration method Convergence rate

Micro-management of pluripotent stem cells

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Protein & Cell 2014年第1期5卷 36-47页

作者： wen-ting Guo Xi-wen Wang YangmingWang Peking-Tsinghua Center for Life Sciences Institute of Molecular Medicine Peking University Beijing 100871 China

Embryonic and induced pluripotent stem cells （ESCs and iPSCs） hold great promise for regenerative medi- cine. The therapeutic application of these cells requires an understanding of the molecular networks that regu- late pluripotency, differentiation, and de-differentiation. Along with signaling pathways, transcription factors, and epigenetic regulators, microRNAs （miRNAs） are emerging as important regulators in the establishment and maintenance of pluripotency. These tiny RNAs control proliferation, survival, the cell cycle, and the pluripotency program of ESCs. In addition, they serve as barriers or factors to overcome barriers during the reprogramming process. Systematic screening for novel miRNAs that regulate the establishment and mainte- nance of pluripotent stem cells and further mechanistic investigations will not only shed new light on the biology of ESCs and iPSCs, but also help develop safe and efficient technologies to manipulate cell fate for regen- erative medicine.

关键词： stem cells miRNA pluripotency,reprogramming

Local intraseasonal air-sea relationship over the North Indian Ocean and western North Pacific during the spring-to-summer transition

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Atmospheric and Oceanic Science Letters 2017年第1期10卷 65-72页

作者： HU wen-ting LI ting State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics（LASG） Institute of Atmospheric PhysicsChinese Academy of Science

This study investigates the local air-sea relationship associated with the two dominant intraseasonal oscillation（ISO） components during the spring-to-summer transition and compares their properties using multiple air-sea variables in the period *** amplitude of percentage variance in SST in periods of 10-20 and 30-60 days are comparable,but the locations of the maxima differ.A strong percentage variance in the 10-20-day SST is evident in the equatorial western Pacific,whereas for the 30-60-day SST the strongest ratio occurs in the North Indian Ocean（NIO）,South China Sea（SCS）,and North *** the NIO,SCS,and Philippine Sea,there are significant correlations between SST and precipitation for both 10-20-day and 30-60-day *** contrast,the correlations between SST and surface heat fluxes cover a broader region and have larger ***,the atmospheric variables and surface heat fluxes show larger variations within the higher frequency ***,the amplitude of the correlation coefficients between SST and surface heat fluxes,and SST and rainfall,is greater in the lower frequency *** corresponding time lags for the different variables reveal that a strong local air-sea interaction is indicated over the NIO,SCS,and western North Pacific,from April to June in both timescales;however,the strength of the air-sea relationship depends on the region and variable.

关键词： Air-sea relationship intraseasonal oscillation spring-to-summer transition North Indian Ocean western North Pacific

The Subvariety Lattice of the Join of Two Semigroup Varieties

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Acta Mathematica Sinica,English Series 2009年第6期25卷 971-982页

作者： wen ting ZHANG Yan Feng LUO Department of Mathematics Lanzhou University Lanzhou 730000 P. R. China

The join A ∨ B of two semigroup varieties A and B is investigated. The latrine of subvarieties of A ∨ B is completely described, It is shown that this lattice is finite and non-modular and that all varieties in it a... 详细信息

关键词： semigroups varieties identities lattice

K3PO4-Promoted Cyclopropanation of Electron-deficient Alkenes with 2-Bromo-1,3-Propanedione Compounds

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Chemical Research in Chinese Universities 2019年第6期35卷 1002-1007页

作者： CHEN Zhanguo wen ting HOU Dan Key Laboratory for Macromolecular Science of Shaanxi Province School of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'an 710119P.R.China

An easy and efficient method for the synthesis of multisubstituted cyclopropane derivatives from electron-deficicent alkenes with 2-bromo-1,3-propanedione compounds was *** this method,ethylα-cyanocinnamate derivatives 1 andβ,β-dicyanostyrene derivatives 4 can all smoothly reacted with 2-bromo-1,3-propanedione compounds 2 to afford the corresponding multisubstituted cyclopropane derivatives 3 and 5 in good to excellent yields(up to 100%)promoted by anhydrous K3PO4 in DMF at room temperature,respectively.A possible mechanism of this reaction was *** of all the products were confirmed by ^1H NMR,^13C NMR and HRMS.

关键词： Cyclopropanation Multisubstituted cyclopropane derivative Electron-deficicent alkene 2-Bromo-l,3-propanedione compound

Chemical Investigation of Potassium Methyl Siliconate as Deacidification and Strengthening Agent for Preservation of Aged Papers

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Chinese Journal of Polymer Science 2015年第12期33卷 1672-1682页

作者： Shu-juan Zhang 张小岗 wen-ting Shang Department of Chemistry Renmin University of China

Potassium methyl siliconate （PMS） was investigated as a simple physicochemical modification in aged paper using silane coupling technique. The PMS-based solution was shown to favor penetration in the cellulose fibers on the paper with suitable uptakes being achieved at low concentrations. The studies of the physicochemical properties of the treated paper （mechanical strength and alkalinity） demonstrated that, besides the required deacidification feature and high level of alkali reserves, the immersion treatment by PMS allowed the enhancement of the mechanical intensities of paper arising from the interaction between Si--OH generated in hydrolysis of PMS and C--OH of cellulose on the paper. Adding ethanol into PMS solution could significantly improve mechanical properties of the aged paper treated by the formula apart from modifying the flatness of the paper. Optimized treatment process was achieved by altering the ratio of ethanol to water in PMS-based solutions. Contact angle measurements indicated the occurrence of hydrophobic character of the papers in immersion treatment with PMS-based solutions. The easy availability of the materials and simplicity of the method rendered it convenient for treatment for aged paper documents.

关键词： Potassium methyl siliconate Paper Deacidification Reinforcement Ageing.