K3PO4-Promoted Cyclopropanation of Electron-deficient Alkenes with 2-Bromo-1,3-Propanedione Compounds

作     者：CHEN Zhanguo WEN Ting HOU Dan 

作者机构：Key Laboratory for Macromolecular Science of Shaanxi ProvinceSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'an 710119P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2019年第35卷第6期

页      面：1002-1007页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the Natural Science Foundation of Shaanxi Province,China(No.2009JM2001) the Innovation Foundation of Postgraduate Cultivation of Shaanxi Normal University,China(No.2008CXB009) 

主　　题：Cyclopropanation Multisubstituted cyclopropane derivative Electron-deficicent alkene 2-Bromo-l,3-propanedione compound 

摘      要：An easy and efficient method for the synthesis of multisubstituted cyclopropane derivatives from electron-deficicent alkenes with 2-bromo-1,3-propanedione compounds was *** this method,ethylα-cyanocinnamate derivatives 1 andβ,β-dicyanostyrene derivatives 4 can all smoothly reacted with 2-bromo-1,3-propanedione compounds 2 to afford the corresponding multisubstituted cyclopropane derivatives 3 and 5 in good to excellent yields(up to 100%)promoted by anhydrous K3PO4 in DMF at room temperature,respectively.A possible mechanism of this reaction was *** of all the products were confirmed by ^1H NMR,^13C NMR and HRMS.