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Despite shared susceptibility loci, esophageal squamous cell carcinoma embraces more familial cancer than gastric cardia adenocarcinoma in the Taihang Mountains high-risk region of northern central China

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Chinese Medical Journal 2013年第1期126卷 55-60页

作者： wen Deng-gui YANG Yi wen xiao-duo SHAN Bao-en Department of Oncology Hebei Tumor Hospital and the Fourth Hospital of Hebei Medical University Shijiazhuang Hebei 050011 China Department of Tumor Image Hebei Tumor Hospital and the Fourth Hospital of Hebei Medical University Shijiazhuang Hebei 050011 China

Background In China, esophageal squamous cell carcinoma （ESCC） and gastric cardia adenocarcinoma （GCA） share susceptibility loci, but different rates of multiple primary cancer and male/female ratio suggest the proportion of familial cancer is not equal. Methods The percent of cases with a positive family history, median onset age, rate of multiple primary cancer, and male/female ratio associated with upper, middle, lower third ESCC and GCA were compared to reveal the proportion of familial cancer. The 7267 subjects analyzed constituted all ESCC and GCA cases in whom the cancer was resected with cure intention between 1970 and 1994 at the 4th Hospital of Hebei Medical University. Results A positive family history for cancer was most often associated with the multiple primary ESCC and/or GCA cases, e.g. with 42% of the males and 59% of the females. For upper, middle, lower third ESCC and GCA, the percent of cases with a positive family history decreased by 38.5%, 26.3%, 26.5%, and 11.2% in males （P 〈0.000） and 25.0%, 22.3%, 23.9%, and 9.8% in females （P 〈0.0001）. Median onset age increased from 49, 52, 55, to 56 years old in males and from 50, 53, 55, to 56 years old in females （ both P 〈0.0001） for upper, middle, lower third ESCC and GCA. Male/female ratio increased from 2.2, 2.1, 2.2, to 6.2：1 for upper, middle, lower third ESCC and GCA （P〈0.0001）. For upper, middle, lower third ESCC and GCA, the percent of multiple primary cancers decreased from 21.2%, 2.3%, 2.2%, to 1.5% in males and from 14.3%, 2.4%, 3.4%, to 3.1% in females. The preponderance of males, smoking, drinking, or onset-age 〉50 years was significantly higher in GCA than in ESCC, and the difference in the rates of multiple primary cancers between the preponderant and the non-preponderant cases was significant in GCA, but not in ESCC, suggesting non-equal requirement for genetic susceptibility when environmental hazards did not exist. Conclusions The proportion of familial cancer in upper gastrointestin

关键词： esophageal squamous cell carcinoma gastric cardia adenocarcinoma multiple primary cancer onset age family history male/female ratio

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Readout electronics for the gamma detector of the HIRFL-CSR external target facility

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Nuclear Science and Techniques 2025年第2期36卷 71-81页

作者： Xian-Qin Li Hai-Bo Yang xiao-Meng Ma Chao-Jie Zou Tao Liu Xian-Cai Zhou duo Yan Yang-Zhou Su Shu-wen Tang Shi-Tao Wang Yu-Hong Yu Zhi-Yu Sun Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China School of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China

The Cooling Storage Ring of the Heavy Ion Research Facility in Lanzhou(HIRFL-CSR)was constructed to study nuclear physics,atomic physics,interdisciplinary science,and related *** External Target Facility(ETF)is located in the main ring of the *** gamma detector of the ETF is built to measure emitted gamma rays with energies below 5 MeV in the center-of-mass frame and is planned to measure light fragments with energies up to 300 *** readout electronics for the gamma detector were designed and *** readout electronics consist of thirty-two front-end cards,thirty-two readout control units(RCUs),one common readout unit,one synchronization&clock unit,and one sub-trigger *** using the real-time peak-detection algorithm implemented in the RCU,the data volume can be significantly *** addition,trigger logic selection algorithms are implemented to improve the selection of useful events and reduce the data *** test results show that the integral nonlinearity of the readout electronics is less than 1%,and the energy resolution for measuring the 60 Co source is better than 5.5%.This study discusses the design and performance of the readout electronics.

关键词： HIRFL-CSR Gamma detector External target facility Readout electronics Readout control unit Common readout unit Peak-detection algorithm

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Synthesis of ordered mesoporous crystalline boron phosphate scaffold with double diamond surface structure

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Science China Chemistry 2025年第2期 590-600页

作者： Chao Wang wen-duo Lu Jiao Wang Shunai Che An-Hui Lu Lu Han School of Chemical Science and Engineering Tongji University State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical EngineeringDalian University of Technology School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Metal Matrix CompositesShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong University

Ordered mesoporous materials have received great attention due to their well-defined pore structures and potential applications in catalysis,adsorption,separation,drug delivery,*** various compositions of mesoporous solids have been successfully prepared,the preparation of crystalline non-metallic oxyacid salts with ordered mesoporosity remains a major ***,we report the synthesis of a mesoporous solid acid crystalline boron phosphate（BPO4） catalyst with a bicontinuous shifted double diamond（SDD） hyperbolic surface *** BPO4scaffold was obtained by synergistic selfassembly in a mixed solvent of water and tetrahydrofuran using the diblock copolymer poly（ethylene oxide）-block-polystyrene as template and phosphoric acid and orthoboric acid as inorganic *** structure consists of two sets of diamond networks adjacent to each other with a mesostructural scale tetragonal symmetry（space group I41/amd） with unit cell parameters of a=80 nm and c=113 nm,which affords the scaffold a specific surface area of 44 m2/*** a solid acid catalytic material,the SDD BPO4scaffold exhibited excellent catalytic activity at room temperature with a conversion of furfural to 2-（dimethoxymethyl）furan over 70% and can be reused after recovery without serious loss of *** the propane oxidative dehydrogenation reaction,SDD BPO4demonstrated high olefin productivity and selectivity while maintaining high reaction *** study provides ideas for the preparation of ordered mesoporous crystalline catalytic materials and demonstrates their potential for practical applications.

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调整优化农业结构,加快饲草产业发展

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草业学报 2025年第2期34卷 211-220页

作者：王加亭撒多文邵麟惠王宗礼全国畜牧总站北京100125 中国农业科学院草原研究所内蒙古呼和浩特010010

随着城乡居民生活水平的不断提高,农产品的消费结构正逐步转变,肉类食物的比重逐年增加,口粮作物占比逐步减少。从农业供给侧结构性改革的历史背景出发,回顾了农业供给侧结构性改革前后,粮食生产、饲草种植、畜牧养殖和畜产品供给的变化... 详细信息

随着城乡居民生活水平的不断提高,农产品的消费结构正逐步转变,肉类食物的比重逐年增加,口粮作物占比逐步减少。从农业供给侧结构性改革的历史背景出发,回顾了农业供给侧结构性改革前后,粮食生产、饲草种植、畜牧养殖和畜产品供给的变化,总结了粮改饲政策在农业供给侧结构性改革中的成效,解读草食畜牧业发展规划和政策,从优化“粮―经―饲”三元结构,增饲草、增牛羊以及提升饲草科技支撑水平等方面展望了饲草产业发展的前景,为我国草牧业高质量发展和农牧业现代化建设政策研究提供了理论支撑。

关键词：饲草产业农业供给侧结构性改革农业结构粮改饲

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SOLO分类理论视角下的初中物理作业分层设计与实施建议

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物理教学探讨 2025年第1期43卷 46-49页

作者：屈铎沈文炳中国人民大学附属中学丰台学校北京100074 湖北省鄂南高级中学湖北咸宁437100

物理作业对于学生的知识理解、思维发展有不容忽视的促进作用,分层作业的实施不仅契合“双减”的政策精神,更能让因材施教落地,因此,要尽快推行作业的分层设计与实施。基于SOLO分类理论将作业划分为六个层次,并以动态电路专题为例,给出... 详细信息

物理作业对于学生的知识理解、思维发展有不容忽视的促进作用,分层作业的实施不仅契合“双减”的政策精神,更能让因材施教落地,因此,要尽快推行作业的分层设计与实施。基于SOLO分类理论将作业划分为六个层次,并以动态电路专题为例,给出了各层次习题的示例及特征,最后针对作业分层的实施提出了建议。

关键词： SOLO分类理论作业分层动态电路

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山区高压埋地天然气管道泄漏扩散的三维模型及危害边界

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科学技术与工程 2025年第1期25卷 165-175页

作者：陈利琼赵奎许铎张开马国光詹文文西南石油大学石油与天然气工程学院成都610500 中国石油宝鸡钢管研究院宝鸡721008

随着中国山区输气管道规模的不断增加,天然气泄漏导致的环境破坏和人员伤亡等事故日益频繁。为了研究高压埋地天然气管道泄漏后在山区环境中的扩散行为及垂向危害距离,基于计算流体力学建立了管道-土体-空气的三维模型,分别研究了不同... 详细信息

随着中国山区输气管道规模的不断增加,天然气泄漏导致的环境破坏和人员伤亡等事故日益频繁。为了研究高压埋地天然气管道泄漏后在山区环境中的扩散行为及垂向危害距离,基于计算流体力学建立了管道-土体-空气的三维模型,分别研究了不同泄漏方向、泄漏孔形状、土壤类型、土壤埋深、障碍物类型对天然气管道泄漏扩散及危害距离的影响。结果表明:随着泄漏方向与浮力方向夹角的变大,气体泄漏后扩散到地面的速率及垂向危害距离相应变小;三角形和正方形的泄漏孔扩散和危害范围均大于圆形;泄漏气体在土壤中的扩散速度随着土壤颗粒度和孔隙度的增加而不断增加;不同的土壤埋深将影响泄漏气体到达地面的时间,同一时间的垂向危害距离随土壤埋深的增大而缩小;障碍物将改变泄漏气体的扩散路径并加快垂向危害距离的增长,而暗沟将使天然气在沟内积聚形成高浓度区。

关键词：山区天然气管道埋地管道泄漏扩散规律危害范围运输安全

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中国式现代化背景下残疾人职业教育供给侧改革的样态与路径

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教育理论与实践 2025年第6期45卷 31-35页

作者：潘中多郭文斌农冠军陕西师范大学教育学部陕西西安710062 广西机电职业技术学院马克思主义学院广西南宁530000

供给侧结构性改革有助于推动残疾人职业教育实现内部的转型升级与高质量发展,但当下残疾人职业教育供给侧改革还存在供给主体分散、供给制度滞后、供给方式相对单一、供给内容失衡的问题。中国式现代化背景下,残疾人职业教育供给侧改革... 详细信息

供给侧结构性改革有助于推动残疾人职业教育实现内部的转型升级与高质量发展,但当下残疾人职业教育供给侧改革还存在供给主体分散、供给制度滞后、供给方式相对单一、供给内容失衡的问题。中国式现代化背景下,残疾人职业教育供给侧改革的基本样态应以构建多元供给主体的育人模式为总抓手,以建立更加公平可持续供给制度为方向盘,以“产科教”融合供给方式为新动能,以优质教育资源共享的供给内容为安全带。在选择和制定残疾人职业教育供给侧改革的路径与策略上,应建设中国式多主体协同治理模式,增强供给主体联动性;把制度优势更好转化为治理效能,促进供给制度长效化;以“产科教”融合推进供给能力现代化,加强供给方式多样化;打出区域优质教育资源组合拳,实现供给内容均衡化。

关键词：中国式现代化残疾人职业教育供给侧改革协同治理治理效能 “产科教”融合教育资源

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Ecological risks linked with ecosystem services in the upper reach of the Yellow River under global changes

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Journal of Integrative Agriculture 2025年第03期 966-983页

作者： Ruowei Li Jian Sun Guodong Han Zixuan Qi Yunhui Li Junhe Chen wen He Mengqi Zhang Chaowei Han Jieji duo State Key Laboratory of Tibetan Plateau Earth System Science (LATPES) Institute of Tibetan Plateau Research Chinese Academy of Sciences Key Laboratory of Grassland Resources of the Ministry of Education College of Grassland Resources and Environment Inner Mongolia Agricultural University Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds School of Ecology Environment and Resources Guangdong University of Technology Institute for Disaster Management and Reconstruction Sichuan University–The Hong Kong Polytechnic University Institute of Grassland Research Chinese Academy of Agricultural Sciences Haixi Forest Pest Control and Quarantine Center

There is growing interest in introducing ecological risks(ERs) and ecosystem services(ESs) into environmental policies and practices. However, the integration of ESs and ERs into actual decision-making remains *** simulated the spatiotemporal dynamics of ESs(e.g., carbon storage, water yield, habitat quality, and soil conservation) and ERs in the upper reach of the Yellow River(URYR) from 2000 to 2100. Additionally, we explored their relationships by combining the InVEST model and a landscape ecological risk model with CMIP6 data. Our main findings showed that regional ERs change in response to land use and environmental dynamics. Specifically,the ER area decreased by 27,673 m2 during 2000–2020, but it is projected to increase by 13,273, 438, and 68 m2under the SSP1-2.6, SSP2-4.5, and SSP5-8.5 scenarios, respectively. We also observed remarkable spatial differences in ESs and ERs between past and future scenarios. For instance, the source area of the URYR exhibited high ESs and low ERs(P<0.001), while the ESs and ERs are declining and increasing, respectively, in the northeastern URYR(P<0.05). Finally, we proposed a spatial optimization framework to improve ESs and reduce ERs, which will support regional sustainable development.

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Designing reduced beacon trajectory for sensor localization

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1971-1982页

作者： HUANG wen-liang LI Shi-jian LIU duo School of Computer Science Zhejiang University Hangzhou 310027 China Graduate School Zhejiang University Hangzhou 310027 China

Localization is one of the substantial issues in wireless sensor networks. The key problem for the mobile beacon localization is how to choose the appropriate beacon trajectory. However, little research has been done on it. In this paper, firstly, we deduce the number of positions for a beacon to send a packet according to the acreage of ROI (region of interest); and next we present a novel method based on virtual force to arrange the positions in arbitrary ROI; then we apply TSP (travelling salesman problem) algorithm to the positions sequence to obtain the optimal touring path, i.e. the reduced beacon trajectory. When a mobile beacon moves along the touring path, sending RF signals at every position, the sensors in ROI can work out their position with trilateration. Experimental results demonstrate that the localization method, based on the beacon reduced path, is efficient and has flexible accuracy.

关键词： Sensor network Sensor localization Mobile beacon Virtual force

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Isolated interrupted aortic arch in an adult:A case report

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World Journal of Clinical Cases 2021年第4期9卷 992-998页

作者： Shu-wen Dong duo-duo Di Guan-Xun Cheng Medical Imaging Department Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Medical Imaging Department Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Interrupted aortic arch(IAA)is a rare congenital heart disease defined by an interruption of the lumen and anatomical continuity between the ascending and descending major *** is usually found within a few hours or days of *** surgery,the chances of survival are *** IAA patients have an effective collateral circulation established,they can survive into ***,IAA in adults is extremely rare,with few reported *** SUMMARY A 27-year-old woman presented with a 6-year history of progressively worsening shortness of breath and chest tightness on *** had cyanotic lips and clubbing of the fingers.A transthoracic echocardiogram revealed an enlarged heart and dilation of the main pulmonary *** was an abnormal 9 mm passage between the descending aorta and pulmonary *** ventricular septal outflow tract had a 14 mm *** ultrasound suggested a patent ductus arteriosus and computed tomographic angiography showed the absence of the aortic *** diagnoses were ventricular septal defect,patent ductus arteriosus,and definite interruption of the aortic *** surgical correction was recommended,the patient declined due to the surgical risks and was treated with medications to reduce pulmonary artery pressure and treat heart *** condition has been stable for 12 mo of *** Although rare,IAA should be considered in adults with refractory hypertension or unexplained congestive heart failure.

关键词： Interrupted aortic arch Diagnostic imaging Multimodal imaging Patent ductus arteriosus Ventricular septal defect Case report

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