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Chinese Journal of Integrative Medicine 2025年第2期31卷 153-156页

作者： CHEN Wu HUANG Lin SHI Wei-man MA Ke wen cheng-ping DAI Qiao-ding School of Basic Medical Science Zhejiang Chinese Medical UniversityHangzhou(310000)China The Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province Hangzhou(310000)China Department of Rheumatology and Immunology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou(310000)China

Systemic lupus erythematosus(SLE)is an autoimmune disease that affects multiple organ systems.(1,2)Patients with SLE who undergo long-term immunosuppressive and glucocorticoids therapy are at an elevated risk of devel... 详细信息

关键词： Systemic tuberculosis erythematosus

On Research Progress of Western and Chinese Medicine Treatment on Pre-Rheumatoid Arthritis

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Chinese Journal of Integrative Medicine 2019年第9期25卷 643-647页

作者： KONG Xiang-yu wen cheng-ping Institute of Basic Research in Clinical Medicine College of Basic Medical ScienceZhejiang Chinese Medical University

Pre-rheumatoid arthritis is the inevitable phase before the actual onset of rheumatoid arthritis and has the crucial clinical significance of early controlling and preventing disease progression. Full understanding, from both Western medicine(WM) and Chinese medicine(CM), could offer new ideas for decision making in clinical and mechanism research. This paper reviews the novel studies of WM and CM to discuss the advantages and potential mechanisms working behind.

关键词： pre-rheumatoid arthritis Western medicine Chinese medicine

A novel sensor of potassium ions based on mode-filtered light detection

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Chinese Chemical Letters 2010年第10期21卷 1243-1246页

作者： Xiao Hong Zhao Li ping Yang Suo Zhu Wu wen ping cheng Shao Min Shuang Chuan Dong School of Chemistry and Chemical Engineering Research Center of Environmental Science and Engineering Shanxi University Taiyuan 030006 China Department of Applied Chemistry Taiyuan Institute of Technology Taiyuan 030008 China

A novel potassium ions sensor based on mode-filtered light detection was reported. The analyzer was consisting of an optical fiber immobilized with a dye of bromocresol green and a fused-silica capillary. It was found that mode-filtered light intensity decreased with the concentration of potassium ions and a linear detection range of 0.25-20 mmol/L （R^2 = 0.9977） was obtained with a detection limit of 9 ×10^-5 mol/L as well as fast response, good reproducibility and reversibility in the working concentration range.

关键词： Mode-filtered light Potassium ions Aqueous solution Bromocresol green

Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang Liu Bang-Jiao Ye Zi-wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao Yan Ying-ping Hao Jin-Xing cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

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温成平治疗系统性红斑狼疮临证经验

中华中医药杂志 2018年第1期33卷 156-158页

作者：匡唐洪温成平浙江中医药大学杭州310053

温成平教授对于治疗系统性红斑狼疮积累了丰富经验,重在辨标本缓急,扶正祛邪,分期治疗;熟知病因及发病机制,掌握中药药理,审因论治,辨因选药。治疗注意滋阴与透邪并用,宜清补不宜温补,顾护先后天之本,以平为期。

关键词：温成平辨证论治系统性红斑狼疮临床经验

Effect of Lang-Chuang-Ding Decoction(狼疮定汤)on DNA Methylation of CD70 Gene Promoter in Peripheral Blood Mononuclear Cells of Female Patients with Systemic Lupus Erythematosus

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Chinese Journal of Integrative Medicine 2018年第5期24卷 348-352页

作者： SUN Jing1 SHAO Tie-juan2 ZHANG Dong-yu2 HUANG Xue-qin2 XIE Zhi-jun2 wen cheng-ping2 Department of Rheumatism the Second Hospital Affiliated to Zhejiang Chinese Medical University College of Basic Medical Science Zhejiang Chinese Medical University

Objective: To investigate the effect of Lang-chuang-ding Decoction(狼疮定汤, LCD) on the expression of DNA methylation of CD70 gene promoter in peripheral blood mononuclear cells(PBMCs) of females with systemic lupus erythematosus(SLE). Methods: PBMCs isolated from female patients with SLE or healthy donors were cultured and treated with LCD medicated serum or normal serum for 24 or 48 h. The m RNA expressions of CD70 gene in PBMCs were detected by reverse transcription polymerase chain reaction(PCR); the DNA methylation of the CD70 gene promoter region was detected by methylation-specific PCR. Results: After treated with medicated serum for 48 h, the m RNA expression levels of CD70 in PBMCs of SLE patients were significantly higher than those of healthy donors(P<0.05); the DNA methylation levels of CD70 promoter region in PBMCs of SLE patients treated with medicated serum for 48 h were significantly higher than those treated with fetal bovine serum(P<0.01). Conclusion: LCD could inhibit CD70 gene expression in PBMCs of SLE patients by promoting the DNA methylation of CD70 gene promoter.

关键词： systemic lupus erythematosus Lang-Chuang-Ding Decoction Chinese medicine DNA methylation CD70 patient

The long noncoding RNA ALEX1 confers a functional phase state of ARF3 to enhance rice resistance to bacterial pathogens

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Molecular Plant 2025年第1期18卷 114-129页

作者： Meng-Qi Lei Rui-Rui He Yan-Fei Zhou Lu Yang Zhen-Fei Zhang Chao Yuan wen-Long Zhao Yu cheng Jian-ping Lian Yu-Chan Zhang wen-Tao Wang Yang Yu Yue-Qin Chen Guangdong Provincial Key Laboratory of Plant Stress Biology State Key Laboratory for BiocontrolSchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275P.R.China Guangdong Key Laboratory of Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China Plant Protection Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China

Rice bacterial blight is a devastating disease worldwide,causing significant yield *** how plants defend against microbial infection is critical for sustainable crop *** this study,we show that ALEX1,a previously identified pathogen-induced long noncoding RNA,localizes to the nucleus and directly binds AUXIN RESPONSE FACTOR 3(ARF3).We showed that ARF3 forms the condensates in the nucleus via its intrinsically disordered middle region(MR),and that these ARF3 condensates display solid-like *** further revealed that ALEX1 directly binds the MR of ARF3 to regulate ARF3 condensate dynamics and promote ARF3 *** dispersed,dimeric form of ARF3,referred to as its functional phase state,enhances its ability to transcriptionally repress the expression of downstream target genes such as JAZ13,thereby modulating the jasmonic acid signaling pathway and enhancing pathogen resistance in ***,this study reveals the role of a long noncoding RNA in regulating protein condensation and complex assembly,thus contributing to plant pathogen resistance.

关键词： lncRNA Xoo ARF3 protein condensates

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温成平教授辨证治疗荨麻疹经验

中华中医药杂志 2014年第11期29卷 3460-3462页

作者：鲍玺温成平浙江中医药大学杭州310053

荨麻疹是临床常见的皮肤病。温成平教授从中医角度认为,荨麻疹发病多由感受风邪,侵袭肌表,致水湿、瘀血内停,产生伏邪,郁于皮肤,瘙痒益甚。治疗上以固表祛风、运脾除湿、活血化瘀、凉血解毒为主。用药上活用虫类及花类药,多能获得显著... 详细信息

荨麻疹是临床常见的皮肤病。温成平教授从中医角度认为,荨麻疹发病多由感受风邪,侵袭肌表,致水湿、瘀血内停,产生伏邪,郁于皮肤,瘙痒益甚。治疗上以固表祛风、运脾除湿、活血化瘀、凉血解毒为主。用药上活用虫类及花类药,多能获得显著疗效。

关键词：温成平辨证论治荨麻疹临床经验验案

Reversible Li plating regulation on graphite anode through a barium sulfate nanofibers-based dielectric separator for fast charging and high-safety lithium-ion battery

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Journal of Energy Chemistry 2025年第2期101卷 511-523页

作者： Yaxin Zhang Long cheng Ying-Jie Zhu Jin Wu Han-ping Yu Sida Xie Dandan Li Zhaohui Wang Heng Li State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences College of Materials Science and Engineering Hunan University Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Poor Li plating reversibility and high thermal runaway risks are key challenges for fast charging lithiumion batteries with graphite ***,a dielectric and fire-resistant separator based on hybrid nanofibers of barium sulfate（BS） and bacterial cellulose（BC） is developed to synchronously enhance the battery's fast charging and thermal-safety *** regulation mechanism of the dielectric BS/BC separator in enhancing the Li+ion transport and Li plating reversibility is revealed.（1） The Max-Wagner polarization electric field of the dielectric BS/BC separator can accelerate the desolvation of solvated Li+ions,enhancing their transport kinetics.（2） Moreover,due to the charge balancing effect,the dielectric BS/BC separator homogenizes the electric field/Li+ion flux at the graphite anode-separator interface,facilitating uniform Li plating and suppressing Li dendrite ***,the fast-charge graphite anode with the BS/BC separator shows higher Coulombic efficiency（99.0% vs.96.9%） and longer cycling lifespan（100 cycles vs.59 cycles） than that with the polypropylene（PP） separator in the constantlithiation cycling test at 2 mA *** high-loading LiFePO4(15.5 mg cm-2)//graphite(7.5 mg cm-2) full cell with the BS/BC separator exhibits excellent fast charging performance,retaining 70% of its capacity after 500 cycles at a high rate of 2C,which is significantly better than that of the cell with the PP separator（retaining only 27% of its capacity after 500 cycles）.More importantly,the thermally stable BS/BC separator effectively elevates the critical temperature and reduces the heat release rate during thermal runaway,thereby significantly enhancing the battery's safety.

关键词： Fast charging Graphite anode Ion transport Lithium-ion battery Separator

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中医药生物信息数据库发展述评

中华中医药杂志 2022年第2期37卷 577-580页

作者：黄琳郦琳温成平浙江中医药大学基础医学院杭州310053

文章梳理了中医药生物信息数据库的发展历程,并总结了现有中医药生物信息数据库的不足。中医药生物信息数据库的发展,对中医药的现代化研究产生了深远的影响,同时也促进了中医网络药理学等学科的发展。然而,中医药生物信息数据库发展至... 详细信息

文章梳理了中医药生物信息数据库的发展历程,并总结了现有中医药生物信息数据库的不足。中医药生物信息数据库的发展,对中医药的现代化研究产生了深远的影响,同时也促进了中医网络药理学等学科的发展。然而,中医药生物信息数据库发展至今,显现了构架与技术上的不足,主要表现在数据时效性低,数据库稳定性差,数据主体形式单一,中医特色不突出,数据共享性差。数据库未来仍是中医信息分析学发展的基石,希望未来中医药生物信息数据库的开发能够进一步加强中医辨治规律的探索,同时也期待中医药生物信息数据库能够与人工智能技术进行融合,提供更好的信息分析平台与服务。

关键词：中医药生物信息数据库标准化