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Reprogramming immunosuppressive myeloid cells by activated T cells promotes the response to anti-PD-1 therapy in colorectal cancer

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Signal Transduction and Targeted Therapy 2021年第2期6卷 447-460页

作者： Jing Chen Hong-Wei Sun Yan-Yan Yang Hai-Tian Chen Xing Juan Yu wen chao wu Yi-Tuo Xu LiLian Jin Xiao-Jun wu Jing Xu Limin Zheng State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouChina MOE Key Laboratory of Gene Function and Regulation School of Life SciencesSun Yat-sen UniversityGuangzhouChina First Afliated Hospital Sun Yat-sen UniversityGuangzhouChina Department of Medical Oncology Dana Farber Cancer InstituteBostonMA.USA

Overcoming local immunosuppression is critical for immunotherapy to produce robust anti-tumor ***-derived suppressor cells(MDSCS)are key regulators of immunosuppressive networks and promote tumor ***,it remains unclear whether and how tumor-infltrating MDSCS are shaped in response to anti-PD-1 treatment and what their impact on therapeutic efficacy is in colorectal cancer(CRC).In this study,the levels of infltrating MDSCS were significantly higher in the non-responding organoids and were selectively reduced in the responding group,with MDSCS showing increased apoptosis and attenuated functional activity after anti-PD-1 treatment.A negative correlation between T-cell activation and MDSC function was also observed in fresh human CRC *** studies revealed that autocrine IFN-α/B upregulated TRAIL expression on activated T cells to elicit MDSC apoptosis via the TRAIL-DR5 interaction and acted synergistically with TNF-α to inhibit MDSC function of suppressing the T-cell response through the JNK NMDAR-ARG-1 ***,blockade of IFNa/βand TNF-α abolished the therapeutic efficacy of anti-PD-1 treatment by preserving the frequency and suppressive activity of infltrating MDSCS in a CRC mouse *** result suggested that reprogramming MDSCS by IFN-α/βand TNF-α from activated T cells was necessary for succesful anti-PD-1 treatment and might serve as a novel strategy to improve the response and efficacy of anticancer therapy.

关键词： colorectal cancer programming

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Circulating hematopoietic stem and progenitor cells are myeloidbiased in cancer patients

Circulating hematopoietic stem and progenitor cells are myel...

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第九届全国免疫学学术大会

作者： wen-chao wu Hong-Wei Sun Limin Zheng 中山大学肿瘤防治中心

Cancer is associated with a profound perturbation in myelopoiesis that results in the accumulation of myeloid-derived suppressor cells(MDSCs)to promote disease *** studies in mice suggest that tumor-derived factors could regulate the differentiation of hematopoietic stem and progenitor cells(HSPCs)in the bone marrow and subsequently contribute to dysregulation of ***,the nature and role of HPSCs in patients with cancer remain *** we show,in detailed studies of the peripheral blood from 133 untreated patients with seven different types of tumors,that the composition of circulating HSPCs was significantly altered in patients with solid *** frequencies of circulating granulocyte-monocyte progenitors(GMPs)were increased four to seven fold in all types of tumors examined,and the circulating hematopoietic precursors exhibited myeloid bias with a skew toward granulocytic differentiation in patients with solid *** myeloid precursors are selectively enriched in tumor tissues,and the high levels of circulating GMPs were positively correlated with disease *** using cord blood-derived CD34+cells,we developed an in vitro short-term culture model to effectively induce the rapid generation of *** found that,among the factors produced by various tumors,GM-CSF,granulocyte colony stimulating factor,and IL-6 could not only promote the myeloid-biased differentiation,but also induce the differentiation of myeloid precursors into functional *** next investigated the influence of tumors on the differentiation of HSPCs in hematopoietic niches Both the expression of CXCL12 on bone marrow cells and its concentration in BM serum of tumor bearing mice were dramatically down-regulated,indicating the BM niche and its ability to maintain HSPCs were *** findings suggest that the altered HSPCs may serve as an important link between dysregulated bone marrow hematopoiesis and accumulated MDSCs in patients with c

关键词： hematopoietic stem and progenitor cells myeloid-derived suppressor cells tumor environment bone marrow niche extramedullary hematopoiesis

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Cardiomyocyte differentiation of amniotic epithelial cells:synergism of biochemical and biomechanical stimuli

Cardiomyocyte differentiation of amniotic epithelial cells:s...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： Jun Feng Xiao-jing Liu Xiao-yu Han wen-chao wu Liang Li Laboratory of Cardiovascular Diseases West China HospitalSichuan University

Objective:Amniotic epithelial cells(AECs) possess several advantages over embryonic and adult stem cells,and have been expected to be a good cell source for stem cell-based cardiac ***,efficient induction of AECs differentiation into cardiomyocytes remains a *** arising from endoderm are essential to induce cardiogenesis in adjacent mesoderm,and embroyonic stem cells can be induced cardiomyocyte differentiation by co-culture with visceral-endoderm like cell line,the END-2 cells Mechanical stimulus is an effective technology for regenerative medicine,and our previous study has showed that physical stimuli com-

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Vertical gradients of neutral winds observed by ICON and estimated by the Horizontal Wind Model during the geomagnetic storm on August 26−28,2021

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Earth and Planetary Physics 2025年第1期9卷 69-80页

作者： JiaWei wu chao Xiong YuYang Huang YunLiang Zhou Department of Space Physics School of Electronic InformationHubei Luojia LaboratoryWuhan UniversityWuhan 430072China

The Michelson Interferometer for Global High-resolution Thermospheric Imaging(MIGHTI)onboard the Ionospheric Connection Explorer(ICON)satellite offers the opportunity to investigate the altitude profile of thermospheric *** this study,we used the red-line measurements of MIGHTI to compare with the results estimated by Horizontal Wind Model 14(HWM14).The data selected included both the geomagnetic quiet period(December 2019 to August 2022)and the geomagnetic storm on August 26-28,*** the geomagnetic quiet period,the estimations of neutral winds from HWM14 showed relatively good agreement with the observations from *** to the ICON observations,near the equator,zonal winds reverse from westward to eastward at around 06:00 local time(LT)at higher altitudes,and the stronger westward winds appear at later LTs at lower *** around 16:00 LT,eastward winds at 300 km reverse to westward,and vertical gradients of zonal winds similar to those at sunrise hours can be *** the middle latitudes,zonal winds reverse about 2-4 h *** winds vary more significantly than zonal winds with seasonal and latitudinal *** to the ICON observations,in the northern low latitudes,vertical reversals of meridional winds are found at 08:00-13:00 LT from 300 to 160 km and at around 18:00 LT from 300 to 200 km during the June *** reversals of meridional winds are found at 04:00-07:00 LT from 300 to 160 km and at 22:00-02:00 LT from 270 to 200 km during the December *** the southern low latitudes,meridional wind reversals occur at 08:00-11:00 LT from 200 to 160 km and at 21:00-02:00 LT from 300 to 200 km during the June *** the December solstice,reversals of the meridional wind appear at 20:00-01:00 LT below 200 km and at 06:00-11:00 LT from 300 to 160 *** the northern middle latitudes,the northward winds are dominant at 08:00-14:00 LT at 230 km during the June *** winds persist until

关键词： horizontal neutral winds vertical gradients Ionospheric Connection Explorer satellite Horizontal Wind Model 14 geomagnetic storm

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利用MAP评估提高表面等离子体结构光照明技术成像质量

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光子学报 2018年第4期47卷 15-21页

作者：余慕欣周文超吴一辉中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室长春130033

经典的恢复算法不能有效地恢复被观测物的全频域信息,空间频率的缺失导致超分辨图像伴有较为严重的旁瓣.本文提出利用最大后验概率(MAP)评估解决表面等离子体结构光照明技术中的光学旁瓣问题.结果表明MAP评估恢复算法可以有效恢复物质... 详细信息

经典的恢复算法不能有效地恢复被观测物的全频域信息,空间频率的缺失导致超分辨图像伴有较为严重的旁瓣.本文提出利用最大后验概率(MAP)评估解决表面等离子体结构光照明技术中的光学旁瓣问题.结果表明MAP评估恢复算法可以有效恢复物质的高空间频率信息,并且通过合理选择优化参数达到抑制光学旁瓣的目的.在波长520nm,数值孔径1.3下,可获得半高全宽65nm的横向分辨力,约为传统荧光显微镜的3.6倍.该技术在生命科学观测中具有潜在应用价值.

关键词：显微荧光显微超分辨表面等离子体金属光学图像重建技术

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu chao Fang Qiuxia Peng wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Osteogenic Differentiation of Amniotic Epithelial Cells:Synergism of Pulsed Electromagnetic Field and Biochemical Stimuli

Osteogenic Differentiation of Amniotic Epithelial Cells:Syne...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： Qian Wang wen-chao wu Xiao-yu Han Ai Zheng Song Lei Jiang wu Huai-qing Chen Cheng-qi He Feng-ming Luo Xiao-jing Liu Department of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine of Sichuan ProvinceWest China HospitalSichuan University Laboratory of Cardiovascular Diseases Regenerative Medicine Research Center West China HospitalSichuan University

Pulsed electromagnetic field(PEMF)is a non-invasive physical treatment used in the clinic rehabilitation,which facilitates the osteogenesis by direct actions on *** evidence suggests an important role of PEMF in the osteogenic differentiation of bone marrow mesenchymal stem cells(BM-MSCs) in *** epithelial cells(AECs) have been proposed as a potential source of stem cells for cell ***,whether PEMF could modulate the osteogenic differentiation of AECs is unknown. In the present study,the effects of PEMF on the osteogenic differentiation of AECs were in-

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高瓦斯易自燃煤层采空区自燃与瓦斯综合防治研究

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煤炭工程 2018年第3期50卷 63-66,70页

作者：曹文涛吴超张连昆运城职业技术学院矿山工程系山西运城044000

阐述了高瓦斯易自燃煤层采空区自燃与瓦斯灾害难题,以N2202工作面为工程背景,通过室内实验、数值模拟和井下工业性试验等手段,研究了注入CO_2气体进行防治采空区自燃发火以及提高瓦斯抽采效率综合方法技术。结果说明,CO_2气体的注入使... 详细信息

阐述了高瓦斯易自燃煤层采空区自燃与瓦斯灾害难题,以N2202工作面为工程背景,通过室内实验、数值模拟和井下工业性试验等手段,研究了注入CO_2气体进行防治采空区自燃发火以及提高瓦斯抽采效率综合方法技术。结果说明,CO_2气体的注入使得采空区内CH_4气体浓度梯度分布向采空区深部移动,采空区中窒息带范围增大,进而减小了采空区氧化自燃的可能性;同时,采空区内原吸附于煤体中的部分CH_4气体被置换出来,提高了采空区内游离状态瓦斯浓度,使瓦斯抽采浓度由原平均浓度35.61%增高至49.25%。研究成果为高瓦斯易自燃煤层采空区综合防治提供了一定借鉴意义。

关键词：高瓦斯采空区自燃水平分支井 CO_2 CH_4

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun wenwen Guan Cailing Chen chao wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-chao Chen Xie Liu Changqing Xu Da-Jian wu Ying Cheng Xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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