Cardiomyocyte differentiation of amniotic epithelial cells:synergism of biochemical and biomechanical stimuli
作者单位：Laboratory of Cardiovascular DiseasesWest China HospitalSichuan University
会议名称：《第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议》
会议日期：2012年
学科分类：08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种]
基 金：supported by grants from Natural Science Foundation of China(No.30470437 30870598 10972149)
摘 要：Objective:Amniotic epithelial cells(AECs) possess several advantages over embryonic and adult stem cells,and have been expected to be a good cell source for stem cell-based cardiac ***,efficient induction of AECs differentiation into cardiomyocytes remains a *** arising from endoderm are essential to induce cardiogenesis in adjacent mesoderm,and embroyonic stem cells can be induced cardiomyocyte differentiation by co-culture with visceral-endoderm like cell line,the END-2 cells Mechanical stimulus is an effective technology for regenerative medicine,and our previous study has showed that physical stimuli com-