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Sonar Image Processing System for an Autonomous Underwater Vehicle(AUV)

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High Technology Letters 1995年第1期1卷 71-75页

作者： wen, x. Yuling, W. Weiqing, Zh. Academia Sinica Beijing China

Sonar image processing system is an important intelligent system of Autonomous Un-derwater *** on TMS320C30 high speed DSP,it is used to realize sonar imagecompression and underwater object detections including obstacle recognition in real *** paper,the software and hardware designs of this system are introduced and the ex.eri-mental results are given.

关键词： Autonomous underwater vehicle Sonar image processing Digital signal processor

Characterization of genetic relationships of Rosa rox.urghii Tratt and its relatives using morphological traits, RAPD and AFLP markers

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Characterization of genetic relationships of Rosa roxburghii...

Ex.erimental study on CBGA assembly in various environmental temperatures using moire interferometry

作者： By x. P. wen, x. M. PANG and x. x. DENG National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China Bioengineering Center, Guizhou University, Guiyang 550025, China

Cili (Rosa rox.urghii Tratt) is of great interest due to its high content of vitamin C, very high superox.de disrautase (SOD) activity, attractive senescence-retarding and cancer-preventing effects, together with immunity to rose blackspot disease. Thirty-six.morphological traits, 251 RAPD markers amplified with 29 arbitrary primers, and 1685 AFLP markers generated from 54 primer combinations were employed to discriminate between 15 accessions, and to evaluate the relatedness of cili with a sample set of its relatives. The genotypes could be efficiently identified by genotypespecific RAPD or AFLP markers, yielded from the four most polymorphic primers: OPAN-07, OPB-11,OPAF-16 and OPW-02, or the six.most polymorphic primer combinations: EA01/MC04, EA01/MC05, EA01/MC06, E02/MC01, EA05/MC04 and EA06/MC03, respectively. Compared with the relatives, very close relationships were found among the genotypes of cili. Furthermore, a high relatedness was strikingly obtained between R. sterilis S. D. Shi and R. hiveichowensis Yu and Ku with the three kinds of data. Using the Mantel correspondence test, significant correlations between the three kinds of data were observed, among which matrices of RAPD and AFLP were the most highly correlated: r= 0. 7154 (Px.urghii Tratt, while seedless cili presumably originates from a completely male-sterile strain of R. kweichonensis.

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Experimental study on CBGA assembly in various environmental...

Ex.loring gut microbiota as a novel therapeutic target in Crohn’s disease: Insights and emerging strategies

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作者： W. N. Wang, Y. P. Yang, x. M. wen, x. L. Jiang, F. L. DaiDept. of Physics, Capital Normal Univ. Beijing, China Dept. of Mechanical Engineering,Tsinghua Univ. Beijing, China

＜正＞ Solder joints between a ceramic ball grid array （CBGA） and a printed circuit board （PCB） generally suffer important thermal strains and stresses during the operation of devices as well as under temperature variations. Mainly, these tend to increase the thermal stress concentration in solder joints. In this study, moire interferometry is used to measure the power-induced thermal displacement in the CBGA assembly. The ex.erimental study is performed under various environmental temperatures using different power levels. Two types of thermal strain distributions are found in the assembly, depending on the thermal loadings. The stress concentrations are located in the CBGA assembly. Then, based on the relative displacement between the CBGA and the PCB, the shear stress on the solder ball is determined. Moreover, the effects of different thermal loadings on the CBGA as well as their impact on the reliability of CBGA solder balls are discussed in details.

关键词： Moire Interferometer ceramic ball grid array environmental temperature power cycle thermal displacement

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World Journal of Gastroenterology 2025年第2期31卷 147-156页

作者： Tong Qiao x.an-Hui wen Department of Clinical Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Life Science and Technology Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Ex.ensive research has investigated the etiology of Crohn’s disease(CD),encompassing genetic predisposition,lifestyle factors,and environmental ***,the gut microbiome,recognized as the human body’s second-largest gene pool,has garnered significant attention for its crucial role in the patho-genesis of *** paper investigates the mechanisms underlying CD,focusing on the role of‘creeping fat’in disease progression and ex.loring emerging therapeutic strategies,including fecal microbiota transplantation,enteral nutri-tion,and therapeutic *** fat has been identified as a unique patho-logical feature of CD and has recently been found to be associated with dysbiosis of the gut *** characterize this dysbiotic state by identi-fying key microbiome-bacteria,fungi,viruses,and archaea,and their contributions to CD ***,this paper reviews contemporary therapies,empha-sizing the potential of biological therapies like fecal microbiota transplantation and dietary *** elucidating the complex.interactions between host-microbiome dynamics and CD pathology,this article aims to advance our under-standing of the disease and guide the development of more effective therapeutic strategies for managing CD.

关键词： Crohn’s disease Gut microbiome Dysbiosis Creeping fat Fecal microbiota transplantation

Real-world evidence on the efficacy and safety of vonoprazanamox.cillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen Li Hui Ye x.e-Zhi Zhang Jian-x.ang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amox.cillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amox.cillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amox.cillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were ex.luded due to loss to follow-up,lack of re-ex.mination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients ex.erienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amox.cillin Dual therapy Elderly

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： x.n Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

A mini review： Shape memory polymers for biomedica applications

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Frontiers of Chemical Science and Engineering 2017年第2期11卷 143-153页

作者： Kaojin Wang Satu Strandman x. x. Zhu Departement de Chimie Universite de Montreal Montreal QC H3C 3J7 Canada

Shape memory polymers （SMPs） are smart materials that can change their shape in a pre-defined manner under a stimulus. The shape memory functionality has gained considerable interest for biomedical applications, which require materials that are biocompatible and sometimes biodegradable. There is a need for SMPs that are prepared from renewable sources to be used as substitutes for conventional SMPs. In this paper, advances in SMPs based on synthetic monomers and bio-compounds are discussed. Materials designed for biomedical applica- tions are highlighted.

关键词： shape memory polymer biodegradability biocompatibility biomedical application bile acids

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial tox.city

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang Lian-Lian Wang wen-wen Liu x.n Yang Ming-Zhao x.ao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to ex.lore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To ex.mine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial tox.city(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox.regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(Px.regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial tox.city

Advancing treatment strategies:Insights from network meta-analysis of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 252-255页

作者： Chun-Han Cheng wen-Rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan City 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei City 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung City 404328TaiwanChina

This study ex.mines the pivotal findings of the network meta-analysis of Zhou et al,which evaluated the efficacy of hepatic arterial infusion chemotherapy and combination therapies for advanced hepatocellular carcinoma(HCC).This meta-analysis suggests that therapeutic combinations have greater efficacy than do standard *** article highlights the key insights that have the potential to shift current clinical practice and enhance outcomes for patients with advanced ***,this article discusses further research that can be conducted to optimize these treatments and achieve personalized care for patients with HCC.

关键词： Hepatic arterial infusion chemotherapy Advanced hepatocellular carcinoma Combination therapy Network meta-analysis Treatment efficacy