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Chinese Journal of Chemistry 2015年第7期33卷 756-764页

作者： Haoyun Zhu weizhi wang State Key Laboratory of Molecular Engineering of Polymers Collaborative Innovation Center of Polymers and Polymer Composite Materials Department of Maeromoleeular Science Fudan University Shanghai 200433 China

We report a considerably promising method based on agarose gel electrophoresis （AGE） to separate single-walled carbon nanotubes by adding a water-soluble polyfluorene （w-PFO） as surfactant into the agarose gel. In this effective method, the AGE/w-PFO gel network will trap more semiconducting single-walled carbon nanotubes （SWNTs） with the assistance ofw-PFO, for the strong interaction between w-PFO and semiconducting species. The optical absorbance, photoluminescence emission and resonant Raman scattering characterization were used to ver- ify the separation effect. The purity of separated semiconducting species is as high as （98±1）%. The demonstrated field effect transistors give the on/off ratio and mobility about 27000 and 10.2 cm^2·V^-1·s^-1, respectively.

关键词： agarose gel electrophoresis field effect transistors semiconducting single-walled carbon nanotubes water-soluble polyfluorene

Dual-Hop Deep Space-Terrestrial FSO/RF Communication under Solar Scintillation: Performance Analysis and Challenges

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China Communications 2020年第7期17卷 27-37页

作者： Guanjun Xu Zhengqi Zheng weizhi wang Shanghai Key Laboratory of Multidimensional Information Processing East China Normal UniversityShanghai 200241China Peng Cheng Laboratory Shenzhen 518052China Engineering Center of SHMEC for Space Information and GNSS East China Normal UniversityShanghai 200241China School of Communication and Electronic Engineering East China Normal UniversityShanghai 200241China

Deep space communication has been a fundamental guarantee for space exploration but encounters solar scintillation during superior solar *** this paper,a paradigm for deep space-terrestrial free space optical(FSO)/radio frequency(RF)communication is proposed,and the outage probability performance of the dual-hop amplify-and-forward(AF)based FSO/RF communication system is ***,the asymmetric dual-hop channel models are considered,where the Gamma-Gamma distribution characterizes the FSO link between the deep space probe and a relay satellite that undergoes coronal turbulence,while the RF link between the satellite and the terrestrial receiver follows the shadowed-Rician fading model due to the shadowing ***,the closed-form expressions of the outage probability for both channel state information(CSI)-assisted and fixed gain relay systems are presented with the consideration of multiple antennas equipped on the destination,which provide practical insights to the link *** results present the validation of our theoretical expressions and highlight a strategy for the improvement of the outage probability performance for deep space-terrestrial ***,some open issues and research directions that should be further investigated for the actual deep space communication system during superior solar conjunction are identified.

关键词： FSO Deep terrestrial

A composite peptide-supramolecular microneedle system for melanoma immunotherapy

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Nano Research 2023年第4期16卷 5335-5345页

作者： Mengzhen Li Minxuan wang Lingyun Li Limin Zhang Bing Ma weizhi wang Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologyKey Laboratory of Cluster Science of Ministry of EducationBeijing Key Laboratory of Photoelectronic/Electro-photonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Despite recent advances in melanoma treatment through the use of antibody immunotherapy,the clinical benefit remains restricted by its inefficient infiltration and immunosuppression within the tumor microenvironment(TME).In addition,immunerelated adverse events(irAEs)have often occurred due to the off-target binding of therapeutic drugs to normal tissues after systematic ***,we constructed an integrated and cascaded drug delivery system for the treatment of *** addition to blocking the programmed cell death protein 1 or its ligand(PD-1/PD-L1)axis,the PD-L1 targeting peptide(FE)with spherical micelle self-assembly characteristics could also effectively encapsulate the immune adjuvant resiquimod(R848),and form a complete nano ***^(R)was further integrated into tumor-responsive microneedles(MNs)to establish FE^(R)@MN and could reach the cascaded ***^(R)could be sustainedly released from the MN system and disassemble into monomers,achieving PD-1/PD-L1 axis blockade whilst reprogramming the immunosuppressive ***,FE^(R)@MN permits the controllable release and retention enhancement of the targeting peptide in the TME,thus causing prolonged PD-L1 blockade *** is demonstrated that this synergistic treatment could efficiently inhibit melanoma growth,providing a new strategy for the combination treatment of melanoma.

关键词： targeting peptide cascaded drug delivery microneedle immune checkpoint blockade self-assembly

A novel PD-L1 targeting peptide self-assembled nanofibers for sensitive tumor imaging and photothermal immunotherapy in vivo

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Nano Research 2022年第8期15卷 7286-7294页

作者： Linping Fu Jianhu Zhang Chenchen Wu weizhi wang Dong wang Zhiyuan Hu Zihua wang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Key Laboratory of Standardization and Measurement for NanotechnologyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China School of Nanoscience and Technology Sino-Danish CollegeUniversity of Chinese Academy of SciencesBeijing 100049China Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhou 350122China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China

Programmed death 1(PD-1)and its ligand PD-L1 are two typical immune ***-based immune checkpoint blockade(ICB)strategy targeting PD-1/PD-L1 achieved a significant therapeutic effect on ***,due to the impenetrability of antibody drugs and the occurrence of immune-related adverse events,only a minority of patients benefit from this *** multimerization has been widely proved to be an effective method to improve receptor binding affinity through a multivalent synergistic *** this study,we report a novel peptide-aggregation-induced emission(AIE)hybrid supramolecular TAP,which can self-assemble into nanofibers through non-covalent interactions such as hydrogen bonds,with a specific nanomolar affinity to PD-L1 in vivo and in *** with near-infrared agents,it can be used for tumor imaging and photothermal therapy,which enables photothermal ablation of cancer cells for generating tumor-associated antigen(TAA)and triggering a series of immunological ***,our work suggests that synthetic self-assembled peptide nanofibers can be developed as attractive platforms for active photothermal immunotherapies against cancer.

关键词： programmed death 1(PD-1) targeting peptide self-assembly immune checkpoint blockade photothermal therapy

An Energy-Efficient UAV Deployment Scheme for Emergency Communications in Air-Ground Networks with Joint Trajectory and Power Optimization

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China Communications 2022年第7期19卷 67-78页

作者： Shuo Zhang Shuo Shi weizhi wang Zhenyu Xu Xuemai Gu School of Electronic and Information Engineering Harbin Institute of TechnologyHarbin 150001China Peng Cheng Laboratory Shenzhen 518055China Department of Intelligent Engineering Huizhou Engineering Vocational CollegeHuizhou 516023China

The space-air-ground integrated network(SAGIN)has gained widespread attention from academia and industry in recent *** is widely applied in many practical fields such as global observation and mapping,intelligent transportation systems,and military *** an information carrier of air platforms,the deployment strategy of unmanned aerial vehicles(UAVs)is essential for communication systems’*** this paper,we discuss a UAV broadcast coverage strategy that can maximize energy efficiency(EE)under terrestrial users’*** to the non-convexity of this issue,conventional approaches often solve with heuristics algorithms or alternate *** this end,we propose an iterative algorithm by optimizing trajectory and power allocation ***,we discrete the UAV trajectory into several stop points and propose a user grouping strategy based on the traveling salesman problem(TSP)to acquire the number of stop points and the optimization ***,we use the Dinkelbach method to dispose of the fractional form and transform the original problem into an iteratively solvable convex optimization problem by variable substitution and Taylor *** results validate our proposed solution and outperform the benchmark schemes in EE and mission completion time.

关键词： SAGIN UAV energy efficiency(EE)maximization trajectory optimization power allocation

UAV-Assisted FSO Communication System with Amplify-and-Forward Protocol under AOA Fluctuations:A Performance Analysis

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China Communications 2023年第11期20卷 111-130页

作者： Maozhe Xu Guanjun Xu Youran Dong weizhi wang Qinyu Zhang Zhaohui Song Shanghai Key Laboratory of Multidimensional Information Processing East China Normal UniversityShanghai 200241China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710126China Space Information Research Institute Hangzhou Dianzi UniversityHangzhou310018China Peng Cheng Laboratory Shenzhen 518052China Communication Engineering Research Center Harbin Institute of TechnologyShenzhen 518055China

Free space optical(FSO)communication has recently aroused great interest in academia due to its unique features,such as large transmission band,high data rates,and strong anti-electromagnetic *** the aim of evaluating the performance of an FSO communication system and extending the line-of-sight transmission distance,we propose an unmanned aerial vehicle(UAV)-assisted dual-hop FSO communication system equipped with amplifyand-forward protocol at the relay ***,we consider impairments of atmospheric absorption,pointing errors,atmospheric turbulence,and link interruptions due to angle-of-arrival fluctuations in the relay *** Gamma-Gamma and Malaga distributions are used to model the influence of atmospheric turbulence on the source-to-UAV and UAVto-destination links,*** derive closedform expressions of the probability density function(PDF)and cumulative distribution function(CDF)for the proposed communication system,in terms of the Meijer-G *** on the precise PDF and CDF,analytical expressions for the outage probability,average bit error rate,and ergodic capacity are proposed with the aid of the extended generalized bivariate Fox’s H ***,we show that there is a match between the analytical results and numerical results,and we analyze the influence of the system and channel parameters on the performance.

关键词： amplify-and-forward protocol angle-ofarrival fluctuations FSO communication Malaga distribution UAV relay

An Improved Attention Parameter Setting Algorithm Based on Award Learning Mechanism

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计算机科学 2002年第Z2期29卷 195-197页

作者： Fang Xiuduan Liu Binhan wang weizhi Department of Computer Science and Technology Fuzhou Universtiy Fujian 350002 Department of Computer Science and Technology Fuzhou Universtiy Fujian 350002 Department of Computer Science and Technology Fuzhou Universtiy Fujian 350002

The setting of attention parameters plays a role in the performance of synergetic neural network based on PFAP model. This paper first analyzes the attention parameter setting algorithm based on award-penalty learning mechanism. Then, it presents an improved algorithm to overcome its drawbacks. The experimental results demonstrate that the novel algorithm is better than the original one under the same circumstances.

关键词： Synergetic Neural Network(SNN), Attention parameter, Award-penalty learning mechanism

Graphene Nanoribbons from Tetraphenylethene-Based Polymeric Precursor： Chemical Synthesis and Application in Thin-Film Field-Effect Transistor

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Chinese Journal of Chemistry 2015年第12期33卷 1380-1388页

作者： Ji Ma Haoyun Zhu Wei Huang Tingting Lin Xiaoyong Pan weizhi wang State Key Laboratory of Molecular Engineering of Polymers Collaborative Innovation Center of Polymers andPolymer Composite Materials Department of Macromolecular Science Fudan University Shanghai 200433 China Institute of Materials Research and Engineering A ＊STAR (Agency for Science Technology and Research) 2 Fusionopolis Way Innovis #08-03 Singapore 138634 Singapore

Graphene nanoribbons （GNRs） with a non-zero bandgap are regarded as a promising candidate for the fabrica- tion of electronic devices. In this study, large-scale solution synthesis of narrow GNRs was firstly achieved by the intramolecular cyclodehydrogenation of kinked tetraphenylethene （TPE） polymer precursors prepared by A2B2-type Suzuki-Miyaura polymerization. After the cyclization reaction, the nanoribbons have a better conjugation than the twisted polymer precursor, resulting in obvious red shift in UV/vis absorption and photoluminescence （PL） spectra. The efficient formation of conjugated nanoribbons was also investigated by Raman, FTIR spectroscopy, and micro- scopic studies. Furthermore, such structurally well-defined GNRs have been successfully developed for top-gated field-effect transistor （FET） by directly solution processing. The AFM images show that the prepared-GNRs thin films form crystalline fibrillar intercalating networks, which can effectively facilitate the charge transport. These FET devices with ion-gel gate dielectrics exhibit low-voltage operation （〈5 V） with excellent mobility up to 0.41 cm2·V-1·s-1 and an on-off ratio of 3 × 104, thus opening up new opportunities for flexible GNRs-based electronic devices.

关键词： graphene nanoribbons transistor tetraphenylethene device

Kinetics of hydrogen constrained graphene growth on Cu substrate

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Nano Research 2024年第11期17卷 9284-9292页

作者： Xiucai Sun Shuang Lou weizhi wang Xuqin Liu Xiaoli Sun Yuqing Song Weimin Yang Zhongfan Liu Beijing Graphene Institute (BGI) Beijing 100095 China College of Mechanical and Electrical Engineering Beijing University of Chemical Technology Beijing 100029 China School of Instrument and Electronics North University of China Taiyuan 030051 China Center for Nanochemistry Beijing Science and Engineering Center for Nanocarbons Beijing National Laboratory for Molecular Science College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

Chemical vapor deposition (CVD) has shown great promise for the large-scale production of high-quality graphene films for industrial applications. Atomic-scale theoretical studies can help experiments to deeply understand the graphene growth mechanism, and serve as theoretical guides for further experimental designs. Here, by using density functional theory calculations, ab-initio molecular dynamics simulations, and microkinetic analysis, we systematically investigated the kinetics of hydrogen constrained graphene growth on Cu substrate. The results reveal that the actual hydrogen-rich environment of CVD results in CH as the dominating carbon species and graphene H-terminated edges. CH participated island sp2 nucleation avoids chain cyclization process, thereby improving the nucleation and preventing the formation of non-hexameric ring defects. The graphene growth is not simply C-atomic activity, rather, involves three main processes: CH species attachment at the growth edge, leading to a localized sp3 hybridized carbon at the connecting site;excess H transfer from the sp3 carbon to the newly attached CH;and finally dehydrogenation to achieve the sp2 reconstruction of the newly grown edge. The threshold reaction barriers for the growth of graphene zigzag (ZZ) and armchair (AC) edges were calculated as 2.46 and 2.16 eV, respectively, thus the AC edge grows faster than the ZZ one. Our theory successfully explained why the circumference of a graphene island grown on Cu substrates is generally dominated by ZZ edges, which is a commonly observed phenomenon in experiments. In addition, the growth rate of graphene on Cu substrates is calculated and matches well with existing experimental observations.

关键词： graphene growth chemical vapor deposition theoretical calculation Cu substrate hydrogen constraint effect

N6-methyladenosine modification of CENPF mRNA facilitates gastric cancer metastasis via regulating FAK nuclear export

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Cancer Communications 2023年第6期43卷 685-705页

作者： Penghui Xu Jing Yang Zetian Chen Xing Zhang Yiwen Xia Sen wang weizhi wang Zekuan Xu Department of General Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsuP.R.China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsuP.R.China

Background:N6-methyladenosine(m^(6)A)modification is the most common modification that occurs in *** substantial effort has been made in the prevention and treatment of gastric cancer(GC)in recent years,the prognosis of GC patients remains *** regulatory mechanism between m^(6)A modification and GC development needs to be *** this study,we examined m^(6)A modification and the downstream mechanism in ***:Dot blotting assays,The Cancer Genome Atlas analysis,and quantitative real‑time PCR(qRT-PCR)were used to measure the m^(6)A levels in GC *** RNA-immunoprecipitation sequencing and RNA sequencingwere performed to identify the targets ofm^(6)*** blotting,Transwell,wound healing,and angiogenesis assays were conducted to examine the role of centromere protein F(CENPF)in GC in ***,immunohistochemistry,and in vivo metastasis experiments were conducted to examine the role of CENPF in GC in *** RNA-immunoprecipitation-qPCR,RNA immunoprecipitation-qPCR and RNA pulldown assays were used to verify the m^(6)A modification sites of ***/loss-of-function and rescue experiments were conducted to determine the relationship between CENPF and the mitogen-activated protein kinase(MAPK)signaling pathway in GC ***,mass spectrometry,qRT-PCR,and immunofluorescence assays were performed to explore the proteins that interact with CENPF and elucidate the regulatory mechanisms between ***:CENPF was upregulated in GC and facilitated the metastasis of GC both in vitro and in ***,increasedm^(6)A modification of CENPF was mediated by methyltransferase 3,and this modified molecule could be recognized by heterogeneous nuclear ribonucleoprotein A2/B1(HNRNPA2B1),thereby promoting its mRNA *** addition,the metastatic phenotype of CENPF was dependent on the MAPK signaling ***,CENPF could bind to FAK and promote its local

关键词： CENPF epithelial-mesenchymal transition FAK gastric cancer MAPK metastasis N6-methyladenosine