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Micropatterned composite membrane guides oriented cell growth and vascularization for accelerating wound healing

Regenerative Biomaterials 2023年第1期10卷 344-353页

作者： Jiaqi Li Xulong Liu weiyong tao Yan Li Yingying Du Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and TechnologyWuhan 430074China NMPA Research Base of Regulatory Science for Medical Devices&Institute of Regulatory Science for Medical Devices Huazhong University of Science and TechnologyWuhan 430074China Institute of Biomaterials and Medical Devices Wuhan Institute of Industrial Innovation and DevelopmentWuhan 430074China Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan 430074China

Skin defect is common in daily life,but repairing large skin defects remains a *** biomaterials to deliver biochemical or physical factors to promote skin tissue regeneration is of great significance for accelerating wound *** surface micropatterns on biomaterials could affect cell behavior and tissue ***,few studies have focused on the construction of wound healing biomaterials with surface micropatterns and their role in skin tissue *** the present study,gelatin-polycaprolactone/silk fibroin composite membranes with different micropatterns were fabricated by photolithography,including line,grid and plane *** vitro cell experiments demonstrated that the line micropattern on the composite membrane could guide cell-oriented growth,and more importantly,promote the expression of angiogenesis-related markers andα-smooth muscle actin(α-SMA)at both gene level and protein *** the rat full-thickness skin defect model,the composite membrane with line micropatterns increasedα-SMA production and neovascularization in wounds,leading to accelerated wound contraction and *** current study not only suggests that composite membranes with specific micropatterns can be promising wound repair materials but also provides new insights into the importance of biomaterial surface topology for tissue regeneration.

关键词： topology cell behavior wound healing gelatin polymer biomaterials

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Theoretical and numerical simulation of critical gas supply of refuge chamber

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International Journal of Mining Science and Technology 2016年第3期26卷 389-393页

作者： Shao Hao Jiang Shuguang tao weiyong Wu Zhengyan Zhang Weiqing Wang Kai School of Safety Engineering China University of Mining & Technology State Key Laboratory of Coal Resources and Safe Mining

The personnel in refuge chamber absorb O_2 and exhale CO_2 all the time. Supplying O_2 and removing CO_2 are the basic function of refuge chamber. After disaster occurs, the supply of the compressed air or oxygen for personnel in refuge chamber is limited. Thus, how to effectively use the compressed air and oxygen and try to improve the time of supply has a great significance. Supplying more oxygen will result in waste, while supplying less oxygen will cause its concentration to be lower, and harm life safety. This research uses the theoretical calculation and numerical simulation, finds critical gas supply for refuge chamber, and illuminates the change law of gas concentration with critical gas supply in refuge chamber,which provides theoretical guidance for effective use of compressed air and oxygen in refuge chamber.

关键词： Refuge chamber Theoretical calculation Critical gas supply Numerical simulation

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3D micropattern force triggers YAP nuclear entry by transport across nuclear pores and modulates stem cells paracrine

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National Science Review 2023年第8期10卷 180-193页

作者： Yan Li Zhenyu Zhong Cunjing Xu Xiaodan Wu Jiaqi Li weiyong tao Jianglin Wang Yingying Du Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and Technology Department of Biomedical Engineering Huazhong University of Science and Technology Research Base of Regulatory Science for Medical Devices National Medical Products Administration&Institute of Regulatory Science for Medical Devices Huazhong University of Science and Technology

Biophysical cues of the cellular microenvironment tremendously influence cell behavior by mechanotransduction. However, it is still unclear how cells sense and transduce the mechanical signals from 3D geometry to regulate cell function. Here, the mechanotransduction of human mesenchymal stem cells(MSCs) triggered by 3D micropatterns and its effect on the paracrine of MSCs are systematically investigated. Our findings show that 3D micropattern force could influence the spatial reorganization of the cytoskeleton, leading to different local forces which mediate nucleus alteration such as orientation,morphology, expression of Lamin A/C and chromatin condensation. Specifically, in the triangular prism and cuboid micropatterns, the ordered F-actin fibers are distributed over and fully transmit compressive forces to the nucleus, which results in nuclear flattening and stretching of nuclear pores, thus enhancing the nuclear import of YES-associated protein(YAP). Furthermore, the activation of YAP significantly enhances the paracrine of MSCs and upregulates the secretion of angiogenic growth factors. In contrast, the fewer compressive forces on the nucleus in cylinder and cube micropatterns cause less YAP entering the *** skin repair experiment provides the first in vivo evidence that enhanced MSCs paracrine by 3D geometry significantly promotes tissue regeneration. The current study contributes to understanding the in-depth mechanisms of mechanical signals affecting cell function and provides inspiration for innovative design of biomaterials.

关键词： bioactive materials tissue regeneration 3D micropattern force paracrine mechanotransduction

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Albumin-assembled copper-bismuth bimetallic sulfide bioactive nanosphere as an amplifier of oxidative stress for enhanced radio-chemodynamic combination therapy

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Regenerative Biomaterials 2022年第1期9卷 585-596页

作者： weiyong tao Zhan Tuo Feige Wu Ketao Mu Cunjing Xu Yuxiao Shi Zeyu Sun Yifan Wang Yan Li Zhenyu Zhong Lei Zhou Jianglin Wang Jie Liu Yingying Du Shengmin Zhang Advanced Biomaterials and Tissue Engineering Center Huazhong University of Science and TechnologyWuhan 430074China NMPA Research Base of Regulatory Science for Medical Devices&Institute of Regulatory Science for Medical Devices Huazhong University of Science and TechnologyWuhan 430074China Department of Biomedical Engineering Huazhong University of Science and TechnologyWuhan 430074China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510006China

The tumor microenvironment with overexpressed hydrogen peroxide(H_(2)O_(2))and reinforced antioxidative system(glutathione,GSH)becomes a double-edged sword for the accessibility of *** reactive oxygen species(ROS)are easily quenched by the developed antioxidative network,ROS-based treatments such as chemodynamic therapy(CDT)and radiotherapy(RT)for killing cancer cells are severely *** overcome such limitations,a bioactive nanosphere system is developed to regulate intracellular oxidative stress for enhanced radio-chemodynamic combination therapy by using bovine serum albumin(BSA)based bioactive nanospheres that are BSA assembled with in situ generated copper-bismuth sulfide nanodots and diallyl trisulfide(DATS).The copper-bismuth sulfide nanodots react with H_(2)O_(2)to produce·OH and release Cu^(2+).Then,the Cu^(2+)further depletes GSH to generate Cu^(+)for more·OH generation in the way of Fenton-like *** a cascade reaction can initiate·OH generation and GSH consumption to realize *** elevation of ROS triggered by the DATS from BBCD nanospheres further augments the breaking of redox balance for the increased oxidative stress in 4T1 *** the sensitization of increased oxidative stress and high Z element Bi,an enhanced radio-chemodynamic combination therapy is *** current work provides an enhanced radio-chemodynamic combination treatment for the majority of solid tumors by using the co-assembled bioactive nanospheres as an amplifier of oxidative stress.

关键词： bioactive materials nanosphere assembly bismuth-copper radio-chemodynamic therapy

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Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： tao Zou Yanwu Dong Zhouhua Jiang Shuyang Du Yushuo Li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

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改进AHP在大柳塔矿通风系统评价中的应用

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矿业研究与开发 2014年第2期34卷 73-76,95页

作者：赵红红蒋曙光王云航陈国明陶卫勇煤炭资源与安全开采国家重点实验室江苏徐州市221008 中国矿业大学安全工程学院江苏徐州市221116 中国民航大学计算机科学与技术学院天津300300

为更合理的确定影响大柳塔煤矿通风系统影响因素的权重,通过分析其特点,并结合在试验平台的实践,建立了通风系统层次评价指标体系。在层次分析法(AHP)判断矩阵的构造上,采用3标度法对传统的9标度法进行改进,克服了9标度法采用模糊字眼... 详细信息

为更合理的确定影响大柳塔煤矿通风系统影响因素的权重,通过分析其特点,并结合在试验平台的实践,建立了通风系统层次评价指标体系。在层次分析法(AHP)判断矩阵的构造上,采用3标度法对传统的9标度法进行改进,克服了9标度法采用模糊字眼表示两元素关系的困难,并运用matlab数值模拟快速确定了评价指标体系中准则层和子准则层各指标的权重。对比分析表明,改进AHP法提高了煤矿通风系统评价的效率和准确度,具有更强的实用性。

关键词：通风系统改进层次分析法评价指标标度权重

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From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen Xin Zhang Lingcong Chao Liang Chen Ding Zhang tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye tao Song Shuai Huang Jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian Yin Fan Wen Zhigang tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu Wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of Xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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