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Bronchoalveolar lavage fluid assessment facilitates precision medicine for lung cancer

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Cancer Biology & Medicine 2024年第3期21卷 230-251页

作者： Hantao Zhang Dan Deng Shujun Li Jing Ren Wei Huang Dan Liu weiya wang Department of Pathology West China HospitalSichuan UniversityChengdu 610000China West China Biobank West China HospitalSichuan UniversityChengdu 610000China Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610000China

Lung cancer is the most common and fatal malignant disease worldwide and has the highest mortality rate among tumor-related causes of *** diagnosis and precision medicine can significantly improve the survival rate and prognosis of lung cancer *** present,the clinical diagnosis of lung cancer is challenging due to a lack of effective non-invasive detection methods and biomarkers,and treatment is primarily hindered by drug resistance and high tumor *** biopsy is a method for detecting circulating biomarkers in the blood and other body fluids containing genetic information from primary tumor *** lavage fluid(BALF)is a potential liquid biopsy medium that is rich in a variety of bioactive substances and cell *** contains information on the key characteristics of tumors,including the tumor subtype,gene mutation type,and tumor environment,thus BALF may be used as a diagnostic supplement to lung *** this review,the current research on BALF in the diagnosis,treatment,and prognosis of lung cancer is *** advantages and disadvantages of different components of BALF,including cells,cell-free DNA,extracellular vesicles,and micro RNA are *** particular,the great potential of extracellular vesicles in precision diagnosis and detection of drug-resistant for lung cancer is *** addition,the performance of liquid biopsies with different body fluid sources in lung cancer detection are compared to facilitate more selective studies involving BALF,thereby promoting the application of BALF for precision medicine in lung cancer patients in the future.

关键词： Lung cancer bronchoalveolar lavage fluid extracellular vesicles liquid biopsy precision medicine

A case of large-cell neuroendocrine carcinoma harboring rare ALK fusion with initial response to the ALK inhibitor crizotinib and acquired F1174L mutation after resistance

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Precision Clinical Medicine 2019年第1期2卷 71-75页

作者： Ye wang Panwen Tian weiya wang Yalun Li Yu wang Weimin Li Department of Respiratory and Critical Care Medicine Sichuan UniversityChengdu 610041China Lung Cancer Treatment Center Sichuan UniversityChengdu 610041China Department of Pathology of West China Hospital Sichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China

A 51-year-old,male,non-smoker with a 3.4 cm mass in the right middle lobe was diagnosed with large cell neuroendocrine carcinoma(LCNEC).Fluorescence in situ hybridization revealed anaplastic lymphoma kinase(ALK)gene translocation,in agreement with the immunohistochemistry result obtained with use of *** examinations showed both bone and brain *** two cycles of chemotherapy consisting of etoposide and cisplatin,the patient achieved stable disease,and was subsequently switched to *** computed tomography and magnetic resonance imaging revealed partial response after 4 months of crizotinib,but progressed after treatment for 10 months,when several hard lymph nodes were palpable in the left supraclavicular *** node biopsy showed similar histology of tumor cells and targeted next-generation sequencing revealed ALK F1174L on exon 23 with two rare forms of ALK *** case provides evidence of responsiveness of ALK inhibitors for a rare pattern of ALK-rearranged LCNEC,and suggests that F1174L,a common resistant mutation found in non-small-cell lung cancer,also causes crizotinib resistance in LCNEC.

关键词： anaplastic lymphoma kinase large cell neuroendocrine carcinoma next-generation sequencing

Concordance between four PD-L1 immunohistochemical assays and 22C3 pharmDx assay in esophageal squamous cell carcinoma in a multicenter study

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Journal of the National Cancer Center

Journal of the National Cancer Center 2024年第2期4卷 162-168页

作者： Liyan Xue Yuan Li Lili Jiang Chao Liu Na Cheng Changyuan Guo Yan Jin Ping Zhou Xuemin Xue Yue wang weiya wang Yanhui Liu Jianming Ying Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Institute of Thoracic Oncology Fudan UniversityShanghaiChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Pathology Guangdong General Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina

Background:The prediction of response to immunotherapy mostly depends on the programmed death-ligand 1(PD-L1)immunohistochemistry(IHC)status,and the 22C3 pharmDx assay has been approved in esophageal squamous cell carcinoma(ESCC).However,the widespread use of the 22C3 pharmDx assay is limited due to its ***,alternative PD-L1 assays are *** aimed to investigate the analytical and clinical diagnostic performances of four PD-L1 assays and to compare their concordances with the 22C3 pharmDx ***:The PD-L122C3 pharmDx assay was performed on the Dako Autostainer Link 48 platform,three testing assays(PD-L1 E1L3N XP antibody[Ab],PD-L1 BP6099 Ab and PD-L1 CST E1L3N Ab)on the Leica BOND-MAX/III platform,and one testing assay(PD-L1 MXR006 Ab)on the Roche VENTANA Benchmark Ultra platform.A total of 218 ESCC cases from four centers were included in this retrospective *** from each center stained and read the IHC slides independently and determined the combined positive score(CPS)and the tumor proportion score(TPS).Results:Regarding analytical performance,the four testing assays demonstrated good correlations with the 22C3 pharmDx assay when evaluated by the TPS or CPS(𝜌>0.8 for all four assays).Regarding diagnostic performance(CPS≥10 was used as the cutoff),the four testing assays showed moderate concordances with the 22C3 pharmDx assay(kappa>0.7 for all four assays).The overall percent agreements between each testing assay and the 22C3 pharmDx assay was at least 87.2%.Conclusion:This study provides insight into the potential interchangeability of the four PD-L1 assays with the 22C3 pharmDx assay.

关键词： Consistency evaluation Immunotherapy Esophageal squamous cell carcinoma PD-L1

Partial treatment response to alectinib in metastatic non-small cell lung cancer with KIDINS220-ALK fusion

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Precision Clinical Medicine 2023年第2期6卷 116-118页

作者： Yanna Lei Shasha Zeng Xiaoyu Li Pei Shu weiya wang Yongsheng wang Division of Thoracic Tumor Multimodality Treatment Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Clinical Trial Center NMPA Key Laboratory for Clinical Research and Evaluation of Innovative DrugsWest China HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Biotherapy Sichuan UniversityChengdu 610041China Department of Pathology West China HospitalSichuan UniversityChengdu 610041China

Dear Editor,Anaplastic lymphoma kinase(ALK)rearrangement is a key driver gene in non-small cell lung cancer(NSCLC),and the effectiveness of targeted therapies directed at ALK fusion has been confirmed.1 However,the activity of ALK-tyrosine kinase inhibitors(ALK-TKIs)against rare ALK rearrangements is variable,with limited clinical ***,we reported the case of a novel kinase D interacting substrate 220(KIDINS220)-ALK fusion that showed favorable response to alectinib.

关键词： lung cancer KID

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基于退化模型的失效机理一致性检验方法

航空学报 2015年第3期36卷 889-897页

作者：王浩伟徐廷学王伟亚海军航空工程学院兵器科学与技术系烟台264000 海军航空工程学院指挥系烟台264000

有效的加速试验必须保证产品的失效机理不变。针对加速退化试验(ADT)可靠性建模的特点,提出了一种基于退化模型的失效机理一致性检验方法。以基于随机过程和基于退化轨迹拟合的退化模型为例,通过加速系数的2种等效定义分别建立了模型参... 详细信息

有效的加速试验必须保证产品的失效机理不变。针对加速退化试验(ADT)可靠性建模的特点,提出了一种基于退化模型的失效机理一致性检验方法。以基于随机过程和基于退化轨迹拟合的退化模型为例,通过加速系数的2种等效定义分别建立了模型参数与失效机理不变的内在联系,进一步推导出其参数在不同应力下须满足的关系。在合理假定检验样本服从正态分布的基础上,利用t统计量对样本的一致性进行检验。通过2个ADT实例验证了所提检验方法的合理性与可行性。

关键词：可靠性失效机理一致性退化模型加速系数 t统计量

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智能配电系统分区电压控制技术研究综述

电力系统保护与控制 2017年第1期45卷 146-154页

作者：张玮亚王紫钰南京供电公司江苏南京210000 徐州供电公司江苏徐州221000

配电系统电压控制已经成为配电运行控制系统中最重要的功能之一。有效的电压控制可以降低线损,改善馈线电压水平以及提高系统安全性。在对DG接入配电系统带来的复杂电压波动问题产生的原因进行分析的基础上,分析配电系统电压控制的主要... 详细信息

配电系统电压控制已经成为配电运行控制系统中最重要的功能之一。有效的电压控制可以降低线损,改善馈线电压水平以及提高系统安全性。在对DG接入配电系统带来的复杂电压波动问题产生的原因进行分析的基础上,分析配电系统电压控制的主要手段,指出分层电压控制是智能配电系统中广泛使用的电压控制方案,而其中的分区电压控制层是提高系统电压质量、提升系统电压调节速度、保障系统电压稳定的中坚环节,同时也是连接中央电压控制和本地电压控制的关键环节。继而对分区电压控制在微网和主动配电网中的研究成果进行针对性的回顾与评述。最后对智能配电系统分区电压控制技术发展方向进行了展望。

关键词：微网主动配电网分布式电源分区电压控制

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Amicor抗菌纤维混纺针织纱的生产

棉纺织技术 2007年第5期35卷 37-39页

作者：王维亚广东纺织职业技术学院

为了顺利纺制Amicor抗菌纤维、涤纶、粘胶混纺针织纱,并且避免后工序高温染色对Amicor纤维抗菌性能的不良影响,对白色Amicor纤维、白色粘胶和有色涤纶的混纺工艺进行了实践。针对所纺纤维的特性,以粘胶/Amicor/黑涤/蓝涤57/25/15/3 18.5... 详细信息

为了顺利纺制Amicor抗菌纤维、涤纶、粘胶混纺针织纱,并且避免后工序高温染色对Amicor纤维抗菌性能的不良影响,对白色Amicor纤维、白色粘胶和有色涤纶的混纺工艺进行了实践。针对所纺纤维的特性,以粘胶/Amicor/黑涤/蓝涤57/25/15/3 18.5 tex纱为例,探讨了产品配色设计、混色方法及各工序的纺纱工艺和关键技术措施,指出生产过程中的注意事项。结果表明:Amicor、涤纶、粘胶混纺色纱的成纱质量满足织造要求,外观色彩分布富有层次感,风格独特。

关键词： Amicor抗菌纤维针织纱色纺纱配色设计混和工艺

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自然杀伤细胞治疗急性髓系白血病的研究进展

中国肿瘤临床 2020年第1期47卷 43-46页

作者：王薇雅卢绪章(综述) 陈涛(审校) 南京医科大学附属常州第二人民医院血液科江苏省常州市213000

自然杀伤细胞(natural killer cell,NK)为一种存在于天然免疫系统中的淋巴细胞,具有杀伤肿瘤细胞和抗病毒感染的能力,在天然免疫和过继免疫治疗中发挥重要作用。随着NK细胞的特征和功能越来越被熟知,其已被广泛应用于临床抗肿瘤治疗,特... 详细信息

自然杀伤细胞(natural killer cell,NK)为一种存在于天然免疫系统中的淋巴细胞,具有杀伤肿瘤细胞和抗病毒感染的能力,在天然免疫和过继免疫治疗中发挥重要作用。随着NK细胞的特征和功能越来越被熟知,其已被广泛应用于临床抗肿瘤治疗,特别是血液系统恶性肿瘤如急性髓系白血病(acute myeloid leukemia,AML)、淋巴瘤等治疗。目前,基于NK细胞的免疫治疗主要包括自体NK细胞输注、异体NK细胞输注、嵌合抗原修饰NK(chimeric antigen receptor,CAR)细胞输注以及基于NK细胞的其他免疫治疗等。以NK细胞为基础的免疫治疗旨在增强NK细胞的抗肿瘤能力以及克服肿瘤免疫逃逸。随着研究进展,NK细胞将成为治疗AML的有效方法。

关键词： NK细胞细胞输注免疫治疗急性髓系白血病

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基于目标距离的末制导雷达最优搜索图模型

航空学报 2010年第3期31卷 620-625页

作者：王光辉宋艳波王伟亚谢宇鹏海军航空工程学院指挥系山东烟台264001 海军航空工程学院研究生管理大队山东烟台264001

深入研究了反舰导弹末制导雷达目标捕捉模型,以末制导雷达第一方位搜索周期捕捉概率和全程搜索捕捉概率为约束条件,建立了以末制导雷达第一方位搜索周期扫描面积为目标函数的末制导雷达最优搜索图求取模型,解决了基于目标距离的末制导... 详细信息

深入研究了反舰导弹末制导雷达目标捕捉模型,以末制导雷达第一方位搜索周期捕捉概率和全程搜索捕捉概率为约束条件,建立了以末制导雷达第一方位搜索周期扫描面积为目标函数的末制导雷达最优搜索图求取模型,解决了基于目标距离的末制导雷达最优搜索图参数求取问题,并利用多项式拟合,得到了最优搜索图参数工程实现方法,该方法易编程、计算量小、占用内存少,是一种简单、实用的中远程反舰导弹末制导雷达最优搜索图参数实现方法。

关键词：反舰导弹末制导雷达捕捉概率目标距离搜索图