Bronchoalveolar lavage fluid assessment facilitates precision medicine for lung cancer

作     者：Hantao Zhang Dan Deng Shujun Li Jing Ren Wei Huang Dan Liu Weiya Wang Hantao Zhang;Dan Deng;Shujun Li;Jing Ren;Wei Huang;Dan Liu;Weiya Wang

作者机构：Department of PathologyWest China HospitalSichuan UniversityChengdu 610000China West China BiobankWest China HospitalSichuan UniversityChengdu 610000China Department of Respiratory and Critical Care MedicineClinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610000China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2024年第21卷第3期

页      面：230-251页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Grant No.82173182) the Sichuan Science and Technology Program(Grant No.2021YJ0117 to Weiya Wang Grant No.2023NSFSC1939 to Dan Liu) the 1·3·5 project for Disciplines of Excellence–Clinical Research Incubation Project,West China Hospital,Sichuan University(Grant Nos.2019HXFH034 and ZYJC21074) 

主　　题：Lung cancer bronchoalveolar lavage fluid extracellular vesicles liquid biopsy precision medicine 

摘      要：Lung cancer is the most common and fatal malignant disease worldwide and has the highest mortality rate among tumor-related causes of *** diagnosis and precision medicine can significantly improve the survival rate and prognosis of lung cancer *** present,the clinical diagnosis of lung cancer is challenging due to a lack of effective non-invasive detection methods and biomarkers,and treatment is primarily hindered by drug resistance and high tumor *** biopsy is a method for detecting circulating biomarkers in the blood and other body fluids containing genetic information from primary tumor *** lavage fluid(BALF)is a potential liquid biopsy medium that is rich in a variety of bioactive substances and cell *** contains information on the key characteristics of tumors,including the tumor subtype,gene mutation type,and tumor environment,thus BALF may be used as a diagnostic supplement to lung *** this review,the current research on BALF in the diagnosis,treatment,and prognosis of lung cancer is *** advantages and disadvantages of different components of BALF,including cells,cell-free DNA,extracellular vesicles,and micro RNA are *** particular,the great potential of extracellular vesicles in precision diagnosis and detection of drug-resistant for lung cancer is *** addition,the performance of liquid biopsies with different body fluid sources in lung cancer detection are compared to facilitate more selective studies involving BALF,thereby promoting the application of BALF for precision medicine in lung cancer patients in the future.